Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MAF1P1
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:133490734-133491904  UCSC
Coordinates (T2T) chr3:136235824-136236994  UCSC
Coordinates (hg19) chr3:133209578-133210748  UCSC
Strand +
Parental Sequence NM_032272.5
Parental seq. overlap 998 bp
Parental seq. overlap (%) 57.8%
Genomic Region Intergenic
Retrocopy Summary MAF1P1, located on chr3:133490734-133491904, is a retrocopy of the parental gene MAF1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MAF1
Full Name MAF1 homolog, negative regulator of RNA polymerase III
Also known as -
Coordinate chr8:144104461-144107611
Strand +
Gene summary This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MAF1P1
Bonobo Pan paniscus MAF1P1
Gorilla Gorilla gorilla MAF1P1
Orangutan Pongo abelii MAF1P1
Gibbon Nomascus leucogenys MAF1P1
Green monkey Chlorocebus sabaeus MAF1P1
Crab-eating macaque Macaca fascicularis MAF1P1
Rhesus Macaca mulatta MAF1P1
Golden snub-nosed monkey Rhinopithecus roxellana MAF1P1
Marmoset Callithrix jacchus MAF1P2
Baboon Papio anubis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MAF1P1
AGGCCTGATTTAGCCCCACCAGGCAGGCAGCAATGGCCCCTCTCAAGCATGGAGCTCCCTCCCTGAGACAGGAAGCTATTGGAGAACTGGGCTTTGAAGCCATCAACTCACAGCTAACTGTAGAGAGCAAAGATACCCACATTATCAGCAGGATTGAGAGCTACTCACGTAAGATAGCAGGAGACGACAAACACTGTTCTGACAGGAGGGCGGCCCACATACTGAAGGCTCTCTCCCCATCCCAGACCTCAGGCCTCAGCCCCAGCAGCCTGAGCAAGAACCAAGGTGGCAAGGACAAGGGCCCCCCTCAGGGACAAGTGCAATTGCAAGACCCTCTTCCACTTGATTGTCATGCTCAGCGAGTCCTTTCAGGCCTGACTATGACCTCAGCACAGCCCGCAGCCATGGGTTCAGCCGGAAGCCCAGCCTCAGGTGGGTGGTGAATGCAGTCAACCGCAGTCTGTTCTCAGCTGCGTGGGGGGACATCAAGGTCCTAGAACACAGCTGTGGAACACAGTGGATGAGGAGATCCACCTGGCTTAATGAGACACCCACAGCTATAACCCAGACATGGACCCAGATGCCTTCAGAGAAGAAGATACCCTCTGGTCCTTCAACTACTTCTTCTACAACAAAGGGCTCAAGCAAATTGTTTTCTTCAGCCACCGCTCCATTAGCAGCTCCACCTGCACACCCTCAGAGGCAGGCAACGAGATGGACCTGGAACTGGGGGAAGAGGAGGAAGAGAAAGGAAGCAGAGGTGGAGGCAGTGAGGGTGGGGCCGAAGAGACCAGACCAAGGAGGACAGGTTCCCAGTGATTTGTATGTGATGAGGAGTAGCACAGGCCCCAGCTTCATCCAGCTTCAACCAATGCCTGGACCTGCCCACCTGAGAGGCCCTGAGGCCTCCCCAGCTGCAGGCCAGACCCTGGTGCTGTCAGAGTCTCAGCACTGCCCAAGGCCACACCTGCCTGGCCCTTTGGCTCCAGCCTGTAGGTGTCCACTCAACCCCATAGGCTTCTGCTGCCCACGCTGTGGCTGGACTAGACAGCACAGGACCTGCTGCAAAGAGTAACCACCTTGCCCAAACGAACTACCACAGGCAGGGACAGCTAGACCACAGAGTTTATTTTTGTATTTCTGCTGGGCCTGCACACTCCAGCCCAAAGGG
>NM_032272.5
ATTCAGAGGCGCGGGGCCGGGCCCGGCGGACGCTTGTTGTTGTCCGGCCGGGGGAGGCGGAGGtcgctcgctcgctcgctcggctcgctgactcgcCGGAGCGCTCTGTGGCGGTCGGCGGCAGGTCGGTCGCGAGAGCGGGCTCTGTGGAAGGGGGCGAGGCTATGTCGCGGTGGCAGCCCGGATGGGCCGGCAGGGCCGGGAGTAACGGGACGTCGCCGCGGAGCTTCTTCCCCCGGATACAGTGCGGCCCGAGCGGAGGCCGCGGCGCCGCCCTCCGATCTTGAAGAGCCCGCGCTGCGCGGAGCCCGCCCCCGCCTGCGCACCGGCACCGACGCGGAGCGACCCAGCCCAGCCAGACCCGGCCCGGCGCGGCCTGATCTAACCCAGCCAGGCAGGCAATACTAGCCCCTCTGGAGCACGGAGCTCCTTCCCCAAAGACATGAAGCTATTGGAGAACTCGAGCTTTGAAGCCATCAACTCACAGCTGACTGTGGAGACTGGAGATGCCCACATCATTGGCAGGATTGAGAGCTACTCATGTAAGATGGCAGGAGACGACAAACACATGTTCAAGCAGTTCTGCCAGGAGGGCCAGCCCCACGTGCTGGAGGCACTTTCTCCACCCCAGACTTCAGGACTGAGCCCCAGCAGACTCAGCAAAAGCCAAGGCGGTGAGGAGGAGGGCCCCCTCAGTGACAAGTGCAGCCGCAAGACCCTCTTCTACCTGATTGCCACGCTCAATGAGTCCTTCAGGCCTGACTATGACTTCAGCACAGCCCGCAGCCATGAGTTCAGCCGGGAGCCCAGCCTTAGCTGGGTGGTGAATGCAGTCAACTGCAGTCTGttctcagctgtgcgggaggacttcaaggatctgaaaccacagctgtggaacgcggtggacgaggagatctGCCTGGCTGAATGTGACATCTACAGCTATAACCCAGACTTGGACTCAGATCCCTTCGGGGAGGATGGTAGCCTCTGGTCCTTCAACTACTTCTTCTACAACAAGCGGCTCAAGCGAATCGTCTTCTTTAGCTGCCGTTCCATCAGTGGCTCCACCTACACACCCTCAGAGGCAGGCAACgagctggacatggagctgggggaggaggaggtggaggAAGAAAGCAGAAGCGGGGGCAGTGGGGCCGAGGAGACCAGCACCATGGAGGAGGACAGGGTCCCAGTGATCTGTATTTGATGAGGAGGAGCCGAGGCCCCAGCTTCATCCAGCTTCAACCAATGCCTGGACCTGTCCACCTGAGAGGCCCCTGGGGCCTCCCCAGCTGCTGGCCAGACCCTGGCGCTGCCACAGTCCTGGCACTGCCCAAGGCCATACCTGCCTAGCCCTTTGGCTCCATCCTGTGGATGCCCACTCACCCCTCAGACTCCTGCTGCCCATGCTGTGGCCGGACTTGTCAGCAGGGGGCCTGGTGGGAGGAGCGACTGCCCTGCCCAAATGAACTGCCACAGCAGGGACAGCTGGACCGCAGAGTTTATTTTTGTATTTCTACTGGGCCTGCACACTCCAGCCCAAAGGGTCTGTGGCCGGAGGCCCCACGAGCAGGCCCCAGCAGTCACCGGCTCTGGTCTTGGGCCGGCCCCGGTGCCCACCTGTACCCCCACCTCGCCCATTTGGCCGCGTGCACTGAGTGTCACTTTGCTGCAGCTCGTTTCTTTCCAATAAAAGTTTCTGTGACTTA

Publications

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