Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name EIF2AK1P1
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:142450130-142452337  UCSC
Coordinates (T2T) chr3:145197414-145199621  UCSC
Coordinates (hg19) chr3:142168972-142171179  UCSC
Strand +
Parental Sequence NM_001134335.2
Parental seq. overlap 1745 bp
Parental seq. overlap (%) 38.7%
Genomic Region Intragenic (MMAB)
Intragenic (SERPINA2)
Intragenic (ATR)
Intragenic (ANTXR1)
Retrocopy Summary EIF2AK1P1, located on chr3:142450130-142452337, is a retrocopy of the parental gene EIF2AK1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name EIF2AK1
Full Name eukaryotic translation initiation factor 2 alpha kinase 1
Also known as HCR|HRI|LEMSPAD|hHRI
Coordinate chr7:6022247-6059175
Strand -
Gene summary The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes EIF2AK1P1
Bonobo Pan paniscus EIF2AK1P1
Gorilla Gorilla gorilla EIF2AK1P1
Orangutan Pongo abelii EIF2AK1P1
Gibbon Nomascus leucogenys EIF2AK1P1
Green monkey Chlorocebus sabaeus EIF2AK1P2
Crab-eating macaque Macaca fascicularis EIF2AK1P1
Rhesus Macaca mulatta EIF2AK1P1
Baboon Papio anubis EIF2AK1P1
Golden snub-nosed monkey Rhinopithecus roxellana EIF2AK1P1
Marmoset Callithrix jacchus EIF2AK1P2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>EIF2AK1P1
AAAGAGGAGGGCCACGGGGTGGAGACTGTTGCTGTGCCATCTGCCATCGACTTTTCCGCCAAGAGCCTGGACTCCAAATATGACTTATGTTCCAGCAGAACTCCAGGTATTAAAATAACCCCTACAACAGCCAACTTTCCCTTTTGCAGTTGCAAACCAGCTGCCGCTTATTTCTTTGGTGAAGCACTTGAGCCATGTGCGTGAACCAAACCCAGTTCATTCAAGACAGTGTTTAAGTTACTTTGCCAGACCTTTATCAAAATGGGGCTGCTGTCTTCTTTCACTTGTGACAAGTTTAGCTCATTGAGACTACATCACCACAGAGCTATTACTCACTTAATGAGGTCCACTAAAGAGAGAGTTCATCAGGATCCTTGTGAGGCTATTTCTCATATCCAGAAAATCAGATCAAGGGAAGTACCCTTTGAAGCACAAACTTCACGTTACTTAAATGAATTTGAAGAACTTGCCATCTTAGGAAAAGGTGGATATGGAAGAGTATACAAGGTCAGGAATAAATTAGATGGTCAGTATTATGCAATTTAAAAAATCCTGATTAAGGGTGCAACAAAAACACATTACATGAAAGAACTACGGGGAATGAAGGTGCTGGCAGGTCTTCAGCACCCTAATATCATTCGTTATCACACTGCGTGGACAGAACATGTTCAAGTGGTCCAACCACAAGCAGACAGAGCTTCCGTTCAGTTGCCATTTCTGGAAGTGTTCTCCGACCAAGCAGACAGATACCAATACGGTGTTAAAAATGGTGAAAATAGCAGCTCACCCATTATCTTCGCGGAGCTCACCTCAGAAAAGAAAAACCCTTTGCAGAATCTGACACTCAAAATCAGAACAACAAGCTGTGAACTACACCATCAATTCCGTCTTAAGAGACACCAGTGAATATGAATCATCCCTGGAGCTCCAGGAAAATGGCCTGGCTGGTTTGTCTACCTGGTCAATTGTGAAACAGCCCCTGCTGCTCAGGTGTAATTCCCTCCTAGAGGAGAATTTCACATCCACTGAGGAATCTTCCAAAGAAAACTTCAACTTGTTGGGGATCGAGGTGCAGTACCACCTGATGCTGCACATCCAGATGCAGGTGTGCAAGCTCCAGCTGTGGGACTGGCTAGCTGAGAGAAACAAACAGGGCCAAGAGTGTGTGGGCAAGTTTGCCTGTCCTTATGGCCAGTGTTGCAACAAAAAATTTTCAAGATTTAGTGGAAGGTGTGTTTTACATACATAACATGGGTATTGTAAACAGAGATCTGAAGCCTAGAAATATTTTTCTTCATGGCCCTGATCAGCAAGTAAAAATAGGAGACTTTGGTCTGGCTTGCCCAGACATCTTACAAAAGAACACAGACTGGACCCATAGAAACAGAAAGAGAACACCAACACCTATATCCAGAGTGGGCACTTGTCTGTATGCTTCATCCCAGCAGTTGGAAGGATCTGAGTATGATGCCAtAAAAAAAAACAAAAACTATTTGTAGAGACCAGGGCTGGCTTTGTCCAGTTAGATATGTATATAGCTTGAGTGTGATCCTGCTAGAGCTCTTTCAGCTGTTTAGAACAGAAATGGAGCGAGCAGAAGTTTTAACAGGTTCAAGAACTGGTCAGATATTGGAATCCCTCAGTAAAAGGTATCCAGTACAAGCCAAGTATATCTATCACTTAACGAAAAGGAACATGTCCCAGAGACCATCTGCTCTTCAACTGCTACAGAGTGAATTTTTCCACAATTCTGGAAATATTAATCTCACCCTACAGATGAAGATAATAGAGCAAGAAAAAGAAATTTTTCTTTTAGTTCTTTTAGAAGAACTAAAGAAGCAGCTAAACCTTCTTTCTCAAGACAAAGGGTTAAGGATGACATGAAGGATGGGGGCGTACAGGTCTAGCCTTCCTCGAGCTATATCAGTAGGATGAAAGTGGACTTAAACTCTTTAGGTAGTTAACTGGAATGTAAATTTTTAATCTTTATTAGCATATAGTTGGTATAATTCATTGTATTTAGTAAGCCTGTACAAGACTTATTAAAGATGTAAGAGTGCCCC
>NM_001134335.2
ACTTCCGGGTCGGACGGCGCTAGCTGCAGCATCGGAGTGTggcagtgctgggctggccggcgggctgggctgcggcCCGCGCGCGGCCGGCGATGCAGGGGGGCAACTCCGGGGTCCGCAAGCGCGAAGAGGAGGGCGACGGGGCTGGGGCTGTGGCTGCGCCGCCGGCCATCGACTTTCCCGCCGAGGGCCCGGACCCCGAATATGACGAATCTGATGTTCCAGCAGAAATCCAGGTGTTAAAAGAACCCCTACAACAGCCAACCTTCCCTTTTGCAGTTGCAAACCAACTCTTGCTGGTTTCTTTGCTGGAGCACTTGAGCCACGTGCATGAACCAAACCCACTTCGTTCAAGACAGGTGTTTAAGCTACTTTGCCAGACGTTTATCAAAATGGGGCTGCTGTCTTCTTTCACTTGTAGTGACGAGTTTAGCTCATTGAGACTACATCACAACAGAGCTATTACTCACTTAATGAGGTCTGCTAAAGAGAGAGTTCGTCAGGATCCTTGTGAGGATATTTCTCGTATCCAGAAAATCAGATCAAGGGAAGTAGCCTTGGAAGCACAAACTTCACGTTACTTAAATGAATTTGAAGAACTTGCCATCTTAGGAAAAGGTGGATACGGAAGAGTATACAAGGTCAGGAATAAATTAGATGGTCAGTATTATGCAATAAAAAAAATCCTGATTAAGGGTGCAACTAAAACAGTTTGCATGAAGGTCCTACGGGAAGTGAAGGTGCTGGCAGGTCTTCAGCACCCCAATATTGTTGGCTATCACACCGCGTGGATAGAACATGTTCATGTGATTCAGCCACGAGACAGAGCTGCCATTGAGTTGCCATCTCTGGAAGTGCTCTCCGACCAGGAAGAGGACAGAGAGCAATGTGGTGTTAAAAATGATGAAAGTAGCAGCTCATCCATTATCTTTGCTGAGCCCACCCCAGAAAAAGAAAAACGCTTTGGAGAATCTGACACTGAAAATCAGAATAACAAGTCGGTGAAGTACACCACCAATTTAGTCATAAGAGAATCTGGTGAACTTGAGTCGACCCTGGAGCTCCAGGAAAATGGCTTGGCTGGTTTGTCTGCCAGTTCAATTGTGGAACAGCAGCTGCCACTCAGGCGTAATTCCCACCTAGAGGAGAGTTTCACATCCACCGAAGAATCTTCCGAAGAAAATGTCAACTTTTTGGGTCAGACAGAGGCACAGTACCACCTGATGCTGCACATCCAGATGCAGCTGTGTGAGCTCTCGCTGTGGGATTGGATAGTCGAGAGAAACAAGCGGGGCCGGGAGTATGTGGACGAGTCTGCCTGTCCTTATGTTATGGCCAATGTTGCAACAAAAATTTTTCAAGAATTGGTAGAAGGTGTGTTTTACATACATAACATGGGAATTGTGCACCGAGATCTGAAGCCAAGAAATATTTTTCTTCATGGCCCTGATCAGCAAGTAAAAATAGGAGACTTTGGTCTGGCCTGCACAGACATCCTACAGAAGAACACAGACTGGACCAACAGAAACGGGAAGAGAACACCAACACATACGTCCAGAGTGGGTACTTGTCTGTACGCTTCACCCGAACAGTTGGAAGGATCTGAGTATGATGCCAAGTCAGATATGTACAGCTTGGGTGTGGTCCTGCTAGAGCTCTTTCAGCCGTTTGGAACAGAAATGGAGCGAGCAGAAGTTCTAACAGGTTTAAGAACTGGTCAGTTGCCGGAATCCCTCCGTAAAAGGTGTCCAGTGCAAGCCAAGTATATCCAGCACTTAACGAGAAGGAACTCATCGCAGAGACCATCTGCCATTCAGCTGCTGCAGAGTGAACTTTTCCAAAATTCTGGAAATGTTAACCTCACCCTACAGATGAAGATAATAGAGCAAGAAAAAGAAATTGCAGAACTAAAGAAGCAGCTAAACCTCCTTTCTCAAGACAAaggggtgagggatgacggaaaggatgggggcgtgggatgaAAGTGGACTTAACTTTTAAGGTAGTTAACTGGAATGTAAATTTTTAATCTTTATTAGGGTATAGTTGGTACAATGCTTCGTTGTATTTAGTAAGCCTTTACAAGACTTGTTAAAGATGTCAGAGTGCCCCAAGCTGCCGTTCCTTCCCTTCCTGCCCCACAAGCTCCTTTTCCTGAATTTCCTACCTAAATATTAACCATATGCCTAGTCTCTGAAACTAAAAACTTGGACCTCATCCTCAATTATTTTCTCCTTTCAACTCTGTTGACCCTCTGTCTGGTCTTCCTCTAGAAGGTACCGCAGAAATTGATGTGTGCTCCCTGCCCTCGTCACTGCCCAAGCCCGGGCCTGCACATACTCACTGGACTGTTCCAGTTTTGACAGCTGCCAGTCTTCCTGCCCCTTTCACACTGCAGCTGAAGTTCATTACCTGAAGGACGCCTCATCATTTCATTCCTTGGCTCCAAACCTTCTGCTGCCTCTAAGATAAAAGCTCAACTTCTTAACAGTGTACAGTGTGCAACTTCCAACCTTTTTATCTGTTCTCTCCACCTTCAGTTTAGCGTCATTCCAAAACCACACCCTTGCAAAGCTTTGTACTCCGCACCCCAGATGATCTCCAGGCAGCTCAGATCTCTTTCCTGCCTTTGCCCTGCACTGTTCCCCGGTACTTCCTCCTTTATTGTAGCACTCAGCTCCCCAGCCAATCTGTACATCCCTCAGAGGCAGCGATCTGATGAATTGGTTTTTGAATCCCAGAAAGGGTCTGCCATGGAGTTGGCAGTCATCACGGTAGATGGCGTATGATTTTGCTGAATTTTAAATAAAATGAAAACCATAAATTACATGATGCTTTTATTGACACTTGACAACTGGCCTAAATAAAAAGACTCTGACTCTAATACAAGTCCCCTTACTGATAATAGGCATGAAAGAGCACCATTCTTAAAATCTAAACCCTTTAAAATCAGTTACGGCAATTCACTTAAGGAGCTTGAGGGCCGTGTTAAAAGGAGCCAGGTTTTCACAAGACCTCATCCACCTCTGCACATTGGCTGGCACTGTCACACTGCAGCCTCCGATCTGCTGGAGTACAGACCACAGCACCACGTCTGCTACGGTGAGTTCATTCCCAGCGAGCCAAGGGCTCTTCCCAAGAGCAGAGTTCATGGAGCGGAAAACAGCGGCTTTTTCTTTACTGCTTCCCTCTTTTAACTGAAAAATCGCAATATCTACCCAGCTATCTATAAGGGTTGCGTTGACAGCATTATGCTTCTGGCCAAACAGAGAGAACAAGAAACGTGCAATGTTCCCTTCGCCTTCGATGGGGCACATCGTCTGGATGCTGAATTTCATCTGCGTCTTCGGCACTGAAAAGAAAAAACACGCCAGGTAGCATCACCAGAGCAGCCCTGAGGGAAGTACTCGCACAGTGGGGAAGGGGACAGTCACCAAACACCACAGACTGATGACATGGGAAAGGGTGTTTTCAAGAAGAACATCACATTTTCAGTCTGTCTCTAAGATGCTTACTACTGAAAAGGGTTTAAGTGCAAACTATGTTAAAAAAGTAACCAAAGAGTCATTCCTGGTATTTGATTATGACACTTCTGAAGCTAGAAGGGACCTCAGACCACCTGCTCCAATCCCTGCTGCCTAAGGTTTTGGGGGCTGAGGGCTGGAAACCCAGGAGCTGCATCTCCCAGGCTCTTGGCCTCATAATCGCCTTCTGTGAGACTGAGGGCAATTAAGATATGAATGACATGAACTCGCTTATCTCCATATCAACATAAACCAGAAGAGGCATACATCTGTGGGATAGTCAATACATAACATCCTATCTTTATATGGCCATATGAGAAGATAACTTCAGTGTCCCTATGATGGTAAGTTCTTGAATGTGAGGGCAAGATGGCTGTGATAGCCATGACTCCCCGCTTTGCCTGGTTGGACAGAACCCCCTTCCCCAAATGCTCACAGTCCCCCCCTTGAGCTGTGTCTCACTCAGAGACCCTAAATTTTGCAGACGAACAAGGGCATCTTTGCGTTGCTTCATCTCTGCTCCTCCTCTAGAACTATCCCACAGGCTTTCTAGACTTAGAATATCTGACCTGATGCAAATCGCTATGTGGCCAGTATGCCACAGAATGTCCTAAACCCTTGCTGCCTCTTATCAAAACCATGTTGCACATCTCATCATATAGTAcagctaacccttgaacagtgggggggttagggacactgacccccgactgctgtgcagtcgaaaatccacataaaacttctgactccttcaaaacttaagcactaatagcctactattcatgggaagccttacccatcacagttgattaacacgttttgtatggtctgtatattatatgctatattcttacaataaacttgagaaaatgttaagaaaataa

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