Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SETP11
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:151269449-151271005  UCSC
Coordinates (T2T) chr3:154020512-154022068  UCSC
Coordinates (hg19) chr3:150987237-150988793  UCSC
Strand +
Parental Sequence NM_001374326.1
Parental seq. overlap 1245 bp
Parental seq. overlap (%) 45.3%
Genomic Region Intragenic (MED12L)
Intragenic (P2RY14)
Retrocopy Summary SETP11, located on chr3:151269449-151271005, is a retrocopy of the parental gene SET. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SET
Full Name SET nuclear proto-oncogene
Also known as 2PP2A|I2PP2A|IGAAD|IPP2A2|MRD58|PHAPII|TAF-I|TAF-IBETA
Coordinate chr9:128683424-128696396
Strand +
Gene summary The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SETP4
Bonobo Pan paniscus SETP4
Gorilla Gorilla gorilla SETP4
Orangutan Pongo abelii SETP4
Gibbon Nomascus leucogenys SETP5
Crab-eating macaque Macaca fascicularis SETP6
Rhesus Macaca mulatta SETP7
Baboon Papio anubis SETP5
Golden snub-nosed monkey Rhinopithecus roxellana SETP2
Green monkey Chlorocebus sabaeus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SETP11
GAGACTTAATGAACAAGCCAGTGGGGAGATTGTGAAAGCAGAACAGAAGTATAACAAATTCTGCCAACCATTTTTTGGAAGAGGTCAAAATTGATTGCCCAAATTTCAAATTTTTGGGTAACAGCATTTGTCAGCCATCCACAAGTGTCTACATTACTTGGGGAGGAAGACAAAGAGGCACTGTATTATTTGACGAGTTGAAGTGACAGAATTTGGAGGTATTAAATCAGGTTACAGAAAGATTTTTATTTTGATGAAAATCTTTAGTTTGAAAATAAAGTTCTCTCCAAGGAATTTCATCTGAATGAGAGTGGTGATCTATTTTTAGAGTCCACTGAAGTCAAATGCAAATCTGGAAAGGATATAATGAAAACGTTCCAGTCAAACGCAGAGTAAAGTCAGCAGGAAGAGGCAGCACGAAGAACCAGAGAGCTTCTTTACCTGGTTTACTGACCGTTCTGATGCAGGTGTTGTTGAGTTGGGAGAGTTCATCAAAGATAATACTTGGACAAATCCATTACAGTACTACTTGGTTTTCAATATGAGGGGGTGAAGGAGAAAATGACTAATAGAACACTGATAGGTTCCAACCTTTTTAAAAATTTTCTCCAGTTCCTGGGAGCAAGCTGTCtTTTCTTTTGGGCTCAGCTGCCTTGTTCTTGAGGTCTTTTTTTCTCTACACCACAGCTCTCAACTTATTTGGGGGGAAAATAACTTGAGCAGAATACAATGGGAAAAGGATCTCTACCCCTTTCTGTTCCAAATTCATTTTTATCCCTTCTTGTCTGAACAAAAACTGTATGGATTTAATACCACTGAACTCTCTGGGGAAAAAAGAAAAACCTCCCTTTGCTCTGCTGGAATTTGCATGGTGCTAAGCCCCTGTGTATTAGTGCACAGAATTTTAGCGCTTTTCTTCCTTTCTCTGTGTATTATGCTCAGAACACTGTGTCTCTGCGTGAATATGGATAGTTAGCATTTGCCAACATGTATCTGTCTACTTTCTCTTGTTTAAAAAAAGACAAAACAAAAAATGGGACTATGTAAGGTCAGCAAAGGGTGAGTTTGAGATGTTTGGGTGGGTTAAGTGTGTATTTTGACAACATGGCTTCTCCTTTGGCATATTTAATTGTGATGTTTAATGGGCATCTTTGCAGTTTAACATGACACATTTAAAATAAGTTCTCTCCAGTGATGACTCTTGCCCTGCCACTCGATGGGACAATCCACAGAACCTGCAGGATATTATTTAGAATTCACATTCTCTGTTGTACTTTTGTACCTGTCTATTTTAAAATTTTCTTTTTATTTCACTGGAAAGGAAAGATGACACTTAGTTTTAAATGTTAAAAGTGTACAAGTTGCTTTGTTAGAATAAAACTAAATGTGTACACA
>NM_001374326.1
ACTGAGGAATGTTCCAAGCTTAGGCAGGGCGGCTCCAGTGCAGATTTAAGCCGCTGGCACCTGGGGCAGTCTCAGTGTTCAGCCTGCTTCCGGACGGGCGAGGAGACTCGTGGTCTGGTTCTGGGACTTCCCTAACAGCATGGCCCCTAAACGCCAGTCTCCACTCCCGCCTCAAAAGAAGAAACCAAGACCACCTCCTGCTCTGGGACCGGAGGAGACATCGGCCTCTGCAGGCTTGCCGAAGAAGGGAGAAAAAGAACAGCAAGAAGCGATTGAACACATTGATGAAGTACAAAATGAAATAGACAGACTTAATGAACAAGCCAGTGAGGAGATTTTGAAAGTAGAACAGAAATATAACAAACTCCGCCAACCATTTTTTCAGAAGAGGTCAGAATTGATCGCCAAAATCCCAAATTTTTGGGTAACAACATTTGTCAACCATCCACAAGTGTCTGCACTGCTTGGGGAGGAAGATGAAGAGGCACTGCATTATTTGACCAGAGTTGAAGTGACAGAATTTGAAGATATTAAATCAGGTTACAGAATAGATTTTTATTTTGATGAAAATCCTTACTTTGAAAATAAAGTTCTCTCCAAAGAATTTCATCTGAATGAGAGTGGTGATCCATCTTCGAAGTCCACCGAAATCAAATGGAAATCTGGAAAGGATTTGACGAAACGTTCGAGTCAAACGCAGAATAAAGCCAGCAGGAAGAGGCAGCATGAGGAACCAGAGAGCTTCTTTACCTGGTTTACTGACCATTCTGATGCAGGTGCTGATGAGTTAGGAGAGGTCATCAAAGATGATATTTGGCCAAACCCATTACAGTACTACTTGGTTCCCGATATGgatgatgaagaaggagaaggagaagaagatgatgatgatgatgaagaggaggaaggattagaagatattgacgaagaaggggatgaggatgaaggtgaagaagatgaagatgatgatgaaggggaggaaggagagGAGGATGAAGGAGAAGATGACTAAATAGAACACTGATGGATTCCAACCTTCCTTTTTTTAAATTTTCTCCAGTCCCTGGGAGCAAGTTGCAGTCttttttttttttttttttttttttCCCTCTTGTGCTCAGTCGCCCTGTTCTTGAGGTCTCTTTTCTCTACTCCATGGTTCTCAATTTATTTGGGGGGAAATACCTTGAGCAGAATACAATGGGAAAAGAGTCTCTACCCCTTTCTGTTCGAAGTTCATTTTTATCCCTTCCTGTCTGAACAAAAACTGTATGGAATCAACACCACCGAGCTCTGTGGGAAAAAAGAAAAACCTGCTCCCTTCGCTCTGCTGGAAGCTGGAGGGTGCTAGGCCCCTGTGTAGTAGTGCATAGAATTCTAGCTTTTTTCCTCCTTTCTCTGTATATTGGGCTCAGAGAGTACACTGTGTCTCTATGTGAATATGGACAGTTAGCATTTACCAACATGTATCTGTCTACTTTCTCTTGTTTaaaaaaagaaaaaaaaacttaaaaaaaTGGGGTTATAGAAGGTCAGCAAAGGGTGGGTTTGAGATGTTTGGGTGGGTTAAGTGGGCATTTTGACAACATGGCTTCTCCTTTGGCATGTTTAATTGTGATATTTGACAGACATCCTTGCAGTTTAAGATGACACTTTTAAAATAAATTCTCTCCTAATGATGACTTGAGCCCTGCCACTCAATGGGAGAATCAGCAGAACCTGTAGGATCTTATTTGGAATTGACATTCTCTATTGTAATTTTGTTCCTGTTTATTTTTAAATTTTCTTTTTGTTTCACTGGAAAGGAAAGATGATGCTCAGTTTTAAACGTTAAAAGTGTACAAGTTGCTTTGTTACAATAAAACTAAATGTGTACACAAAGGATTTGATGCTTTTCTCTCAGCATAGGTATGCTTACTATGACCTTCCAAGTTTGACTTGTATAACATCACTGTCAAACTTTGTCACCCTAACTTCGTATTTTTTGATACGCACTTTGCAGGATGACCTCAGGGCTATGTGGATTGAGTAATGGGATTTGAATCAATGTATTAATATCTCCATAGCTGGGAAACGTGGGTTCAATTTGCCATTGGTTTCTGAAAGTATTCACATCATTTGGGATACCAGATAGCTCAATACTCTCTGAGTACATTGTGCCCTTGATTTTTATCTCCAAGTGGCAGTTTTTAAAATTGGCCTTTTACCTGGATATAAATTAATTGTGCCTGCCACCACCATCCAACAGACCTGGTGCTCTAATGCCAAGTTATACACGGGACAGTTGCTGGCATGTCTTCATTGGCTATATAAAATGTGGCCAAGAAGATAGGCTCTCAGTAAGAAGTCTGATGGTGAGCAGTAACTGTCCCTGCTTTCTGGTATAAAGCTCTCAAATGTGACCATGTGAATCTGGGTGGGATAATGGACTCAGCTCTGTCTGCTCAATGCCATTGTGCAGAGAAGCACCCTAATGCATAAGCTTTTTAATGCTGTAAAATATAGTCGCTGAAATTAAATGCCACTTTTTCAGAGGTGAATTAATGGACAGTCTGGTGAACTTCAAAAGCTTTTTGATGTATAAAACTTGATAAATGGAACTATTCCATCAATAGGCAAAAGTGTAACAACCTATCTAGATGGATAGTATGTAATTTCTGCACAGGTCTCTGTTTAGTAAATACATCACTGTATACCGATCAGGAATCTTGCTCCAATAAAGGAACATAAAGATTTTTTTTGGA

Publications

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