Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RFKP5
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:158626703-158626955  UCSC
Coordinates (T2T) chr3:161401805-161402057  UCSC
Coordinates (hg19) chr3:158344492-158344744  UCSC
Strand -
Parental Sequence NM_018339.6
Parental seq. overlap 202 bp
Parental seq. overlap (%) 7.8%
Genomic Region Intergenic
Retrocopy Summary RFKP5, located on chr3:158626703-158626955, is a retrocopy of the parental gene RFK. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RFK
Full Name riboflavin kinase
Also known as RIFK
Coordinate chr9:76385526-76394426
Strand -
Gene summary Riboflavin kinase (RFK; EC 2.7.1.26) is an essential enzyme that catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN), an obligatory step in vitamin B2 utilization and flavin cofactor synthesis (Karthikeyan et al., 2003 [PubMed 12623014]).[supplied by OMIM, Nov 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RFKP5
Bonobo Pan paniscus RFKP5
Gorilla Gorilla gorilla RFKP5
Orangutan Pongo abelii RFKP4
Gibbon Nomascus leucogenys RFKP6
Green monkey Chlorocebus sabaeus RFKP2
Crab-eating macaque Macaca fascicularis RFKP7
Rhesus Macaca mulatta RFKP6
Baboon Papio anubis RFKP4
Golden snub-nosed monkey Rhinopithecus roxellana RFKP3
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RFKP5
CGCCCCAGCGGCAGGCAAAGCCCATGCTCCTGCCCCCTGGCTGGTCCAAGGTCCCGGCACCACATTGACGGCAGCTCTGCAAGACACACAGTCCAGGTCCCAGCCTATGCCCTGAGCAGACTACATTATGGGACATCTGCCTTACTTTTGCCAGGGCCAAGTAATACCAGGCCTCAGCCATGGCTCCAAGCAGCTAGGCATCTCTGCAGCTAAGTCTCCTGAGTAGATAATCTTTCAGCTGATATATCCACTA
>NM_018339.6
ACTTACTTCGGCTGTCTCCGCTGCCCTCCAGCGGAGACGCAGCTCCTCAGGCGCCCGGCGGTATTTGTTGGGTCGGCGGCGTCAGGGATTCGCAGTGGCCTGTGGTCGGCGTCGTCCGGCCACTGGTGCGCCCCCGCGGCAGGCAGAGCTCACGCTCCTGTCCCCCGGCTGGTCCGGGGTCTGGGCGCCGCGTCGACGGCGGCTCCGCAGGACGCGCAGACCGGGCCGCAGCCCATTCCCCGAGCGGACTGCATTATGAGGCACCTGCCTTACTTCTGCCGGGGTCAAGTGGTGCGGGGCTTCGGCCGCGGCTCCAAGCAGCTGGGCATCCCCACAGCTAATTTTCCTGAGCAAGTGGTAGATAATCTTCCAGCTGATATATCCACTGGTATTTACTATGGTTGGGCCAGTGTTGGAAGTGGAGATGTCCATAAGATGGTGGTGAGCATAGGATGGAACCCATATTACAAGAATACGAAGAAGTCTATGGAAACACATATCATGCATACCTTCAAAGAGGACTTCTATGGGGAAATCCTCAATGTGGCCATTGTTGGCTACCTGAGACCAGAAAAGAACTTTGATTCTTTAGAGTCACTTATTTCAGCAATTCAAGGTGATATTGAAGAAGCTAAGAAACGACTAGAGTTACCAGAACATTTGAAAATCAAAGAAGACAATTTCTTCCAGGTTTCTAAAAGCAAAATAATGAATGGCCACTGATGAAAAATTGTATTATTTATTCATTCACTGTTTTCTAGTGTTTCTGTGTTTATTACTGTTCAGCATCATCTTGGTTATATACTGAAAATCAAACACTTTACTACAGTTGTGAATTAGTTTAAACCGTACAATGTTGTTATCATATCATGCTTCAACTATTAAATTAAGCCCATCATATCATAGCACTAAAAAGATTGAGTTAAAAATAAGATTTAAAAAATATATATTGATTAAAATGTACCACTAGAAAGGTATTACATGTGTATAAGTATGGGTAAAAAGGCAAGTCACTAGTTTGAGATGAAAACTAAAATTTTCATGGTAAAATGCCAGCATGTATGTACTTGTGTAGTGTGTACTTCTAAACAGAGAAGGCTTATAAAAGTAAATGCATTAAggccaagtgcagtggctcacaccggtaatcccagcactttgggaggccgaggtgggaggattgcttgagctcatgagttcaagaccagcctgggcaacatagcgagactccatctctataaataaaaaaaaaGGAAATGCATTAAATAGAAGGTTGATAGTTTATCATAAACCTGCGGGGAAGAAACTCAGACTTTCTATTTTTGATATTTTGTGCATTAATACATTACAAACATGAAGATGTTTGTAAAGTTTTGTTTTAGTCATTTTCTTTGCAGTCACATCATTGTACCACCTTCATTATTGTATAGAGCTGCTTCAATTCTGAGTCCTCTGGACTTCCCCTGCCTATCTGTTTGTTGTTGTTGTTGAAGACAGTAAAATAAGTGTTTTCAAATCTATATGTCTCCTTTTTGTTGGATAATGTTTCTTCTTTTTAATGGTAAATATTCTTGTTCTTCAACATTTTTCTTTGGTTCTTTTTTCCTTTTTTAGGAAAAACAAAACAACAGACTTCATCCTTAGGTTTTCTCAAGATTTAAGTGAACACATTTACACATATCAATTTCTTAAAGAACACAAAATGTTTCCTCCCTAGCAAAACTATTTAAGAGCCAATTAAACTATGAAATAGTTATAAAATTATTTTTAATATTTAAGGCCTTGAAATTATATTCCAAGGCAAATCTAAATGGGTGTAGTTGTATATGCACGATGTAATTTAATGCTAAAGAGTACTTACAGCTTGAGGGAAAAGCATAAAGTTTTAGTTAAATAGCCTTCATACTGTGGATTTTTCCTCCTACTAACTAATATGTGGGAAATTAAGATTACAGATGCTTTGGGCCCCCTCAAACAGTACATTGCTACAGTTCACTGTAGCAACAGATTTGGTGGTGATGGGGGGATAGAGGTAGAAGCAGATAGAAGGTAATTTTAAAGTTAATTTATTATGAATCATTTTCCCCTAATCTGCATAAATGAATTAGAACTGATTTTAATAAAAATATTCTGTGTAAAAAGTACTCAGAAAAACATCTAAAGCTGTTGGAGAAGAGGGACTCATATAAATAGTTGGATTGCGTTTTGCTTTTTATTTCTTTATAAAAATATGTCAAAAACAGTTTTTAATTTTAGAAATCTTATACTTGAAAGAAACCTCAATTATCAGTGGCTTTATGAAGTAAAGTTAAAAACAAACATAGGAAATGTGAAAATATTTGTGTTTGTTTTGTCTGACTAACTTGCTGCTAAATGCTATCTTTAGGTGTGTGAAAGTTCTTTGATATGTTATTGTCCTTTTACATCTTGTTAAATAGCCATTGCTTTTGAGAATCAGATAGTGTGTTGTTTAGGGGTTAATTGTGTCTATATCTTTCAAAAACTTTTATATTATGTATTATAAGAAGTTACAGTAGTACCATTTTGATTAGTCTGAATGTTTTCAGGCCTTGAAATAAATTTTGACTAAGTGATA

Publications

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