Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name NDUFA4P10
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:166721455-166721724  UCSC
Coordinates (T2T) chr3:169504689-169504958  UCSC
Coordinates (hg19) chr3:166439243-166439512  UCSC
Strand +
Parental Sequence NM_002489.4
Parental seq. overlap 239 bp
Parental seq. overlap (%) 11.7%
Genomic Region Intergenic
Retrocopy Summary NDUFA4P10, located on chr3:166721455-166721724, is a retrocopy of the parental gene NDUFA4. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NDUFA4
Full Name NDUFA4 mitochondrial complex associated
Also known as CI-9k|CI-MLRQ|COXFA4|MC4DN21|MISTR1|MLRQ|MRCAF1
Coordinate chr7:10931943-10940153
Strand -
Gene summary The protein encoded by this gene belongs to the complex I 9kDa subunit family. Mammalian complex I of mitochondrial respiratory chain is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NDUFA4P10
Bonobo Pan paniscus NDUFA4P10
Gorilla Gorilla gorilla NDUFA4P9
Orangutan Pongo abelii NDUFA4P8
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NDUFA4P10
TCACTGTATGTCTTGGGTCTGGCATTGTTCAATCCAGATGTTAGATGGGACAGAAAGAATAACCCAGAACCCTGGAACAAACTGAGTCTCAACAATCAATACAACTTCTATTCAGTGAATGTGCATTACAGCAAACTGAAGAAAGAAGGTCCAGATTTCTAACTGAAGTATTTCACTGCTGCTTTAGAATGAATGTCTTCTGGAAGCCATCCACAAATTTTCCCACTTAACCAGGAAATATTTCTCCAATGAATGCATAAAATCATGTTG
>NM_002489.4
GGAAGTCCGTAGTGTCTCATTGCAGATAATTTTTAGCTTAGGGCCTGGTGGCTAGGTCGGTTCTCTCCTTTCCAGTCGGAGACCTCTGCCGCAAACATGCTCCGCCAGATCATCGGTCAGGCCAAGAAGCATCCGAGCTTGATCCCCCTCTTTGTATTTATTGGAACTGGAGCTACTGGAGCAACACTGTATCTCTTGCGTCTGGCATTGTTCAATCCAGATGTTTGTTGGGACAGAAATAACCCAGAGCCCTGGAACAAACTGGGTCCCAATGATCAATACAAGTTCTACTCAGTGAATGTGGATTACAGCAAGCTGAAGAAGGAACGTCCAGATTTCTAAATGAAATGTTTCACTATAACGCTGCTTTAGAATGAAGGTCTTCCAGAAGCCACATCCGCACAATTTTCCACTTAACCAGGAAATATTTCTCCTCTAAATGCATGAAATCATGTTGGAGATCTCTATTGTAATCTCTATTGGAGATTACAATGATTAAATCAATAAATAACTGAAACTTGATATGTGTCACTTTTTTATGCTGAAAGTATGCTCTGAACTTTAGAGTATAGGAAATTAACTATTAGAATTTAAAGAATTTCTTGAATTTCTGTAGTTTGAAAATACGACTTTAAGCTGCTTTAGTAAAACACTTCCATTTTGTGTATAGACTGTTGGTAACTTCACTAGAGCATACATAACAACTGGAACTGGAAATTATACAAAAGTAAATTGGGAAGGATACTCCAGCATCTGACACTGGCAAAATGGAAACCTTTGAGTTTCTCTTACTGGCTGTTGAAGTGTGTGCAGTTTTTAACAATGGTTTTTACTTGGCATCTCTTTGTTGTGATTTTCAAGGTTATAAGTTGCTTTGGTCCTAGGATTGAAGTTGAAATCTGAGTTTATCAGTGCTAACCATGGTGCTAGTAGTCAAGAGATCTTGAGAATTTTGGCTGCTGAGTCTTGGTGCAGGGTGCAGGTtttcttttcttttttcttttttttttttttgagatagtctctgtcacccaggctggagtgcagtggtacaaacatggatcactgcagcctctacctcccgggcttaagtgatcctcctgcctcagcccctaagtagccgggactacaggtatgtgccaccatgcccagttaatttttgtaattttttttagagacagggttttgccatgttgcccaggctggtctcaaactcttgagctcaagcgatccattctcctcagcctcccagggtgctgggattacaggcgtgagccattgcgcttagccATGGTGCAGGTTTTCAAAGGCCAGGAAGTATATTCATAATTTTAAGATGGGGAATATAGCAAGTTTTCACATAGGTGTGTGTAAGTCATCACATCATAGAAACTTGAGGAATTCAGTGACATTAATTTTGGATTTTCATACGTAAGTATACAATTAAATGTTTACAGGGTAGTAGAAGCACATTTTAAATGTCAGGAACTGAACTAAGTATTTGAATTACGTGGATTATCTCAAAAATTTTGAAATTGTTAAACGAGTTGAATTACTTGAATTCATTCTGTTAGTCAAATGGTGGATATTTACACCCATGTAGTTTTGAATTTAGAGTGTGTAGAGTGTTTTCAGTTACCAGACTCCATGCTTTTACCTCCTATGTGTCAGGTATAATTTGAACCTCTAAGAAcagggtttctcaaccttgccactgttgactatttctgaaagacagtttggtttagcagaccatcccatgcgctttagcttgtttagtagctaacttgggctctgccactacagacaaaaagcactctttccctccaattcccacaggctatgagaagaatggagacattaccaaatgtccattggtgggcaaaattgcttcattcctacctctgttgagaattactCTAGATCCTTTGGCACAAATTACCTCAAAGTTTAAAATTGTGTAAACAAACAGTGTGTCATGTAATTGAAAAACATTAAGCAACTCCAAATAAATGCTACATTAAGAAATTAGTAA

Publications

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