Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name UBE2V2P5
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:16867593-16867932  UCSC
Coordinates (T2T) chr3:16868849-16869188  UCSC
Coordinates (hg19) chr3:16909104-16909443  UCSC
Strand +
Parental Sequence NM_003350.3
Parental seq. overlap 273 bp
Parental seq. overlap (%) 6.3%
Genomic Region Intragenic (PLCL2)
Retrocopy Summary UBE2V2P5, located on chr3:16867593-16867932, is a retrocopy of the parental gene UBE2V2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name UBE2V2
Full Name ubiquitin conjugating enzyme E2 V2
Also known as DDVIT1|DDVit-1|EDAF-1|EDPF-1|EDPF1|MMS2|UEV-2|UEV2
Coordinate chr8:47997527-48064708
Strand +
Gene summary Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Gorilla Gorilla gorilla UBE2V2P3
Orangutan Pongo abelii UBE2V2P3
Cat Felis catus UBE2V2P3
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>UBE2V2P5
AAAATAATTCTAGAGGAATGGTGGATGCATGGAGTGTTCTAATGTTGGCAAAATGGCCAAATTTATGTAGTATTAAAGTTGGACTTTAAGAGCTAAGAAATATAATGACATCCAGAGAAAATACAGTTTTTCATAGCCACCAGAAACACAAATATAGAATGATTAATTTTGGTGTATCTCAAACTTGCTTAAATCAACATATCTTCTACTCTTGTTAATGGTGTGATTAAATGTCATGATGCAAACCACTTACCCATGAAGTAAACGAATCACAGCGGTAACAATGAGCTGGACAGTCATAAGAATTTGTTTAGTATACATACACCCATTATGTTTTCAG
>NM_003350.3
ggctgcgtcgggctgcAGGAGAAGATGGCGGTCTCCACAGGAGTTAAAGTTCCTCGTAATTTTCGCTTGTTGGAAGAACTTGAAGAAGGACAAAAAGGAGTAGGCGACGGTACAGTTAGCTGGGGCCTTGAAGATGATGAAGATATGACACTTACAAGGTGGACAGGCATGATTATTGGGCCACCAAGGACAAATTATGAAAACAGAATATATAGCCTGAAAGTAGAATGTGGACCTAAATACCCAGAAGCTCCTCCGTCAGTTAGATTTGTAACAAAAATTAATATGAACGGAATAAATAATTCCAGTGGGATGGTGGATGCCCGGAGCATACCAGTGTTAGCAAAATGGCAAAATTCATATAGCATTAAAGTTGTACTTCAAGAGCTAAGACGTCTAATGATGTCCAAAGAAAATATGAAGCTTCCACAGCCACCAGAAGGACAAACATACAACAATTAATTTTAGTGGATCTCAAACTTGTCTTAAATCAACAACCTTCTACTCATGTTAATGTCTTGATTAAATATCACAATGCAAAATACACATTAAGTAAAAGAATTCCAGCTGGTAAACATGACCTGGACATTTGTAAGAATATATTTAATATATGTACACCCATTATGTTTTCAGGTAACAGGAGGAAAAATGCAGCACAATTTTTTTTCTCTTGAAAGGCACTGTCATTTAAACATAAACCTGGAGTACTCGAAATAGAATTCAGGTTTACAAGATGAAAGCGTGTGGAGAAGTGTCAGATGGCAGTGGAAGCATGTGTGTTTCTAAAAAGTAAAAATCTCAAGAAAACAGAAATGGCATGCTTTACCCATCTTACTTAGTGAAAGAGAGCTGCAGTTGAAATTGTTTAAAAAGTAGCAGGTACAATGAATATTGTCACAGATGTGTTAATTTTTGAAGCAATGTGGGTGCTGACTACTAGTAGTATCAAAAATATGTTCAGGATTGTTTTGATACCTGTATTTATAATAAAAAATGTTGGGGGGAGTTGATGAATTCCTGTTAAAAGCTGTTCTTGTGTGTTACATGTAACAGACATGGTAAATATTTGTTTACAGTCTTTGTTTAACAAACCATGCATTTAAGTTTAAGTGAAGTCAACAAAAAGGAAATAGGTGTATGGATATGTGATTTTGAGATTAAAGTTAGTCTTAAAATGTAAATAAAATGTGAAACGTGTCCTCAGAGACTGTGCCATTTCTATTATGTTGATGTATATGTACAGTACCTTGCCAGGGAAGCAAAAATTGGAATTATTGTAGCTTTTCATGTATACACACTTTTATTTACCCTATTTTGTGTACTTCTTGTGAATTATAATTTGCAGACTATTTCAGAAAAGAAATTATCTAGTTTAATTTCTTCTTTGGACAAGGAGTCCTAGGTATTATATTTTGAGTTTGATTTCACCAGAAATAATAATATTAAAAAGATCTTTGCATTCTGGCAGTTCTTTTAGGATTATAGGTTGCAAATTATCCAAATATATATCCCATTTTTTAAAGCATAATATCTTTTTTAGTTGTTTTTCTGTGAAGCTTTTGGTTAATAAATAGGGTCAACTAATTGGAGACTTTTCTCTTCCAATTAGGGCTTTTAATACTAACAAGGATAACTTTATTCATTCCTCGTATTCTCTACTCTAACAAATATGAACTCTGAAGTTGAAAAGTCATTTATGTTCCGCTTTCACCAAAGTGACGTGAGGCTTTAGGTCACTGTTTCACTTCAAAGTACTGGATCCAAAGCTTTGTTGAAAATGCTGTTTGATGAATTCACTGAAGAATATAGAAAGGTGGTCAGGTAAAGTCTACTTTTATTTTGTCAAGCTTAATAATTTGTGTCATACTTTACCCCAGTATATATAGGCAAACCAAAACCTTATCAAATATTAAATTAGTTGTTTAAACTTTGCTTATAAAGTATTGGCCATgtggtggctcatgccgctaatcccagcactttgggaggctgagacgggcagatcacttgaggtcaggagcttgagaccagcctggccaacatgatgaaaccctgtctctactaaaaatacaaaaaattagccaggtgtggtggtgggtacttgtagtcccagctactcgggaggctgggcaggagaactacttgaaactggcagacagaggttgcagtgccgagagcgcaccactgctccagcctgggcaacagagcaagactccatctcaaaaaaaaaaaaaaaaagaaaaaTATTAATAATTGACCTTGGCTGTATATTAAAATAGTTACTTTTATAGTAGAGCACATTTCTCAAACATGCCCTGAAAGGCTTTTATCAAGCTCATATAAAGTTAAAGCTTTGAGCTACCTTTTCTTGGCCAATAAAGTCACTGACAGTTTATGTAAACATTAATTTCAACATGGCTGTTGCATTTTAATTATCAAAAATGTTTAAAATGCTTTAAGATGACACATAGAGAACATACACATACATACAAATTAGTGCATTTGTAATTTGTTAAATTTGAAATGAACTATTACCTTGAAATATAGTCTTTAAAAATTTTTAATGGTTAAAGATTAAATTGAATGAAACTGTAGTCTAATGGTAACTGATGATCTGAATCCGTCTCTCTGATAACCTCCTTTCCATTTTGAAAATGTGTCTTATTATACATGGAAGCTAGTAACTACGTGAATGCTGTTGGCAGGATGAGGGTCTGGGTACCTCAGTCTCTTGTCCTGTTTCCTTCCCCCAAATCCACCATTGTGAAGTTGCCAACCCCCTGCCGCCTTCCCCTGCCAAGTACATGTTGTCAGAGTCAGCCCTATAATGTTCATTTCCCCTCTTGTTTGTGGGATTATGGATCTCTGCAGAAATCTGCATGCCAATTAACCCATTTCTAAAGCAGAATCCATTTTGCATGTCACAATCAAGATGTACTTGGCAATCTAAGACACACTGGGAGACTGTAAGAGGAATTAATATAGAAAAGCTCTTAATTATAATAACATTTGGAAGAAATTTTTCCTTTGTTTTGTAAAGTGGCTAAGGTTGTAGGAGTGTGTGGTATTTATTACCTTTTAAATGAACTGTAAATTTGCCTTAGAAATTTGTTTAAAAGGCTAGCAAGTGAGACCCTTGAGGATGATCATATACTAATAAAGATTACCAAAAGAAACTTCTTGTCCTGTTAGGTCAGTGTTATGATTTAATGGTTTTAATTACTTAACCAATTTTAAGAATTGACAATTTTTAAAAATATTTTTTTCTACCATTCTAAAGTAATGTCTTTTGTTGTGGGTTTATGTGTAACTACAGGATTTTGGAACATAAACATTTTGAAGGATAGTCAATGGTATTTAGTCTTGGATATAAAAATAGAGAAAATTTATAGCTTTATGTTATTAAAATAATTTATCACACAGAGTGATTTGAGGTTTTCGCAGAGTAGATTTGTTTGACTCATGGTTTATTAGTCTGGATTACTTAAGAACAATATGTTGATTTTAATGTTAATTCCCACTAAATATATAATATTGATAAATACATGTGAAATTAATATTGTTTGGAAAATGTAGAGGACACAGCTGGGAATTATGAATGCTTTTTTCTTAATAGGTTTGGTGTGTGTGGCTTTGAATGGTTCTGCTGATGCATCATGGAAAGACAGCAGGGAACTGTAGCCTGCCATCAAAACTGTATCAACTCTTTTAATGAGCATGTGACTGTATTAGGTACATTTTGAAGAATATAAGTACTGATGATAAAGTCTAGTATGCATAATAGGATTTTGGAGGCATTTCAGGAATTTTCCTTTTATAGTATGCTTTTTAGGCATCTGTATGTGTAATATCATAGTATCATTTATTGCTGGGATGGATCGAAAAGCACTGCTTTTACTTTTCTGATAAGTATCAAAATGATTTTCCAGTACCAACTTGACTGGCTTTTAATTATTGTCACACACACACAAAATTCAACTCCTCAAGGTTTGGGAAAATTGTGTATTTTTTTGTATACAAGATAAAAGTGTCATAAAAAGGAATGGATGAATTGTTGATAGGAACATTAGCAGTTAATTTTTACCTGATACTGAGTTTACTGTAAAATAGGAAATGCATAGGAAGGAATACCTCCTAAATAATATGCCTTATAGAATGATGAAATCTTACCATAGTTCATACTGAAAATGTTGTTTATTTAAAAGTATTGTGGAGTGTTGAAAATAAAGATACACAATAAGTATTTTCTGAAGAGAAAATTAATGAAGGTATTTAATGATATAGGAAATAAGTGACAAGTTAAAGTCCATTTTGTTTCAATAAAGGAGTTGTGCAAACTCAA

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