Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name FHL1P1
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:169944259-169946878  UCSC
Coordinates (T2T) chr3:172728543-172731162  UCSC
Coordinates (hg19) chr3:169662047-169664666  UCSC
Strand -
Parental Sequence NM_001449.5
Parental seq. overlap 1715 bp
Parental seq. overlap (%) 60.9%
Genomic Region Intergenic
Retrocopy Summary FHL1P1, located on chr3:169944259-169946878, is a retrocopy of the parental gene FHL1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name FHL1
Full Name four and a half LIM domains 1
Also known as FCMSU|FHL-1|FHL1A|FHL1B|FLH1A|KYOT|RBMX1A|RBMX1B|SLIM|SLIM-1|SLIM1|SLIMMER|XMPMA
Coordinate chrX:136147533-136211359
Strand +
Gene summary This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes FHL1P1
Bonobo Pan paniscus FHL1P1
Gorilla Gorilla gorilla FHL1P1
Orangutan Pongo abelii FHL1P1
Gibbon Nomascus leucogenys FHL1P1
Green monkey Chlorocebus sabaeus FHL1P1
Crab-eating macaque Macaca fascicularis FHL1P1
Rhesus Macaca mulatta FHL1P1
Baboon Papio anubis FHL1P1
Golden snub-nosed monkey Rhinopithecus roxellana FHL1P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>FHL1P1
TGCATGAAAATATTCTAGCCCTTTCAGATGTTCCTGTAGTGTTGAAATTCATCCTATGGAAGTAACTGCAAAACTCTATAGGGGGAGTTGAGCAGGTGCCAGGACTGTCATCAACATGGATATGACAGTACAGAGCAGTGGTGAGTTGAATCCCTTGTAACGCAGTTGTCTGCTCTTTGTCCATGTGTTAATGAGGGCTGCAAAGTCCCTCCTATAGCGATTCCTAGGAATTTTCCTCAAGAGGAAATGCGGATTTCCACCTACCACTTACCTGAAATACAGGATCACCTACTTACTGTATTCTACATTATTTTATGATATAATGAGACAATATCAAAAGTAAACATGTAATGACTATGTGTACTAACATTCTTGTAGGAGTGGTTAGAGAAGCTGATGTCTCATTTCTACATTCTGTCATTAGCTGTTATCGTCTAATGTTTCAGTGTATCCTTATGGAAATAAAGCAGCATATGAATTCAGCTGTGCGGGTGAGCATCCCCAGGCAGCACGTTGGAAGTTGTTTTCAACCATATCCAGCCCTTGCCAAATACATCCTGTTTGTCACACATCCAAAGTGAGGTCCCTCCAGCTATAAGGTGGGCACCATGGCAGAGAAGTTTTTGACTGTCTCTACTGCAGGGACCCCTTGCAGAGGAAAAAGTATGTGCAGAAGGGTGACCACCACTGCTGCCTGAAATGCTTTGACAGGTTCTGTGCCAACACCTGCGTGGAATGCTGCAAGCCCATCCATGTGGACTCCAAGGAGGTGCACTATAAAAACTGCTCCTGGCATGACCCCTGCTTCCACTGTGCCAAGTGCCTTCACCCCTTGCCAATGAGACCTTTGTGGCCAAGGACAACAAGATCCTGTGCAACAAGTTTGCCACTCAGGAGGACTCTCCCAAGTGTAAGGGGTGCTTCAAGGCCTTTGTGGCAGGAGATCAAAAATGGAGTACAAGGGGACCATCTCGCACAAAGACCGCTTCACCTGTAGCAACTGCAAGCAAGTCATGGGGACTGGAAGCTTCTTCTCTAAAGGGAAGGACTTCTACTGTGTGACTTGCCATGAGACCAAGTTTGCTAAGCATTGTGTGAAGTGCAACAAGGCCATCGCATCTTGGGGAGTCACTTACTAGGATGAGCCCTGGCATGCCGAGGGCTTTGTATGTGTTACCTGCTCTAAGAAGCTGGCTGTGCAGCATTTCACCACTGTGGAGGACCAGTAATACTGTGTGGATTGCTACAAGAACTTTGTGGCCAAGAAGTGTGCTGGATGCAAGCACCCCATCACTGGGTTTGGTAAAGGCTCCAGTGTGGTGGCCTATGAAGGACAATCCTGGCACGACTGCTGCTTCCACTGCAAAAAATGCTCTGTGAATCTGGCCAACAAGCACTTTGTTTTCCACGAGGAGCAAGTATATTGCCCTGACTGTGCCAAAAAGTTGTAAACTGACAGGGGCTCCTGCCCTGTAAAATGGAATTTGAATTTTGCTCTTTGTGTCCTTACTCTCTGCCCTATACCATCAATGGGGAAGAGTGGTCTTTCCCCTCTTTAAAGGTCTCCTGTCTTTTCTCCCGTTTTACAGTATTACTCAAATAAGGGCACACAGTGATCATATTAGGATTTAGCAAAAAGCAACCCTGCAGCAAAGTGAATTTCTGTCCAGCTGCAACTGAAAAACGAAAATTTAAGTAGATTGACTCTTCTGCATGTTTCTCACAGAGCAGAAAAGTGCTAGTCATTTAGCCACTTAGTGATGTAAGCAAGAAGCATATGAGATAAAGCCCCCACTGAGATGCCTCTTGCGGCTCAGCTGGGACCTACCGTGTAGTCACGCGACATGCAAGAGTTGTAGTGGCTGCTTCAACTCGCTGCTCACCCTCTTCTGTGAGCAGGAAAAGAACTTACTGACGTGCATGATTTAACTTCCTCATCAAAACTCTGACCTTCCTTCTGTTATTTTGTGCTTTCAAATGACTAATATGCACTTCCAGAAAATTAACATTTGAACTTAGCTGTAATTCTAAACTGACCTTTCCCCATACTAATGTTTGATTTCCCCATGTGGCATGTTTTCTGAGTGTTCCTACCTTAAAGCATGGAACATGCAGGTGATTTGGGAAGTGTAGGCAGATCTGAGAAAACGAGCCTGTTTCAGAGGAACATTGTCACAGCAAATACTTCTGGAAACTTAACAAAACCAACCCTGATGTCCTTTTTATTGTTTTTAATTAGGAATATTTTTGTTTTAATTGATAGCAAAATAGTTTATAGGTTTGGAAACATCCATGAAAATATTCTATTTAt
>NM_001449.5
AGTccgcagccgccgccgccaccgccgcgcctcggcctcggtgcaggcagcggccgccgccgccgAGACAGCTGCGCGGGCGAGCATCCCCACGCAGCACCTTGGAAGTTGTTTTCAACCATATCCAGCCTTTGCCGAATACATCCTATCTGCCACACATCCAGCGTGAGGTCCCTCCAGCTACAAGGTGGGCACCATGGCGGAGAAGTTTGACTGCCACTACTGCAGGGATCCCTTGCAGGGGAAGAAGTATGTGCAAAAGGATGGCCACCACTGCTGCCTGAAATGCTTTGACAAGTTCTGTGCCAACACCTGTGTGGAATGCCGCAAGCCCATCGGTGCGGACTCCAAGGAGGTGCACTATAAGAACCGCTTCTGGCATGACACCTGCTTCCGCTGTGCCAAGTGCCTTCACCCCTTGGCCAATGAGACCTTTGTGGCCAAGGACAACAAGATCCTGTGCAACAAGTGCACCACTCGGGAGGACTCCCCCAAGTGCAAGGGGTGCTTCAAGGCCATTGTGGCAGGAGATCAAAACGTGGAGTACAAGGGGACCGTCTGGCACAAAGACTGCTTCACCTGTAGTAACTGCAAGCAAGTCATCGGGACTGGAAGCTTCTTCCCTAAAGGGGAGGACTTCTACTGCGTGACTTGCCATGAGACCAAGTTTGCCAAGCATTGCGTGAAGTGCAACAAGGCCATCACATCTGGAGGAATCACTTACCAGGATCAGCCCTGGCATGCCGATTGCTTTGTGTGTGTTACCTGCTCTAAGAAGCTGGCTGGGCAGCGTTTCACCGCTGTGGAGGACCAGTATTACTGCGTGGATTGCTACAAGAACTTTGTGGCCAAGAAGTGTGCTGGATGCAAGAACCCCATCACTGGGTTTGGTAAAGGCTCCAGTGTGGTGGCCTATGAAGGACAATCCTGGCACGACTACTGCTTCCACTGCAAAAAATGCTCCGTGAATCTGGCCAACAAGCGCTTTGTTTTCCACCAGGAGCAAGTGTATTGTCCCGACTGTGCCAAAAAGCTGTAAACTGACAGGGGCTCCTGTCCTGTAAAATGGCATTTGAATCTCGTTCTTTGTGTCCTTACTTTCTGCCCTATACCATCAATAGGGGAAGAGTGGTCCTTCCCTTCTTTAAAGTTCTCCTTCCGTCTTTTCTCCCATTTTACAGTATTACTCAAATAAGGGCACACAGTGATCATATTAGCATTTAGCAAAAAGCAACCCTGCAGCAAAGTGAATTTCTGTCCGGCTGCAATTTAAAAATGAAAACTTAGGTAGATTGACTCTTCTGCATGTTTCTCATAGAGCAGAAAAGTGCTAATCATTTAGCCACTTAGTGATGTAAGCAAGAAGCATAGGAGATAAAACCCCCACTGAGATGCCTCTCATGCCTCAGCTGGGACCCACCGTGTAGACACACGACATGCAAGAGTTGCAGCGGCTGCTCCAACTCACTGCTCACCCTCTTCTGTGAGCAGGAAAAGAACCCTACTGACATGCATGGTTTAACTTCCTCATCAGAACTCTGCCCTTCCTTCTGTTCTTTTGTGCTTTCAAATAACTAACACGAACTTCCAGAAAATTAACATTTGAACTTAGCTGTAATTCTAAACTGACCTTTCCCCGTACTAACGTTTGGTTTCCCCGTGTGGCATGTTTTCTGAGCGTTCCTACTTTAAAGCATGGAACATGCAGGTGATTTGGGAAGTGTAGAAAGACCTGAGAAAACGAGCCTGTTTCAGAGGAACATCGTCACAACGAATACTTCTGGAAGCTTAACAAAACTAACCCTGCTGTCCTTTTTATTGTTTTTAATTAATATTTTTGTTTTAATTGATAGCAAAATAGTTTATGGGTTTGGAAACTTGCATGAAAATATTTTAGCCCCCTCAGATGTTCCTGCAGTGCTGAAATTCATCCTACGGAAGTAACCGCAAAACTCTAGAGGGGGAGTTGAGCAGGCGCCAGGGCTGTCATCAACATGGATATGACATTTCACAACAGTGACTAGTTGAATCCCTTGTAACGTAGTAGTTGTCTGCTCTTTGTCCATGTGTTAATGAGGACTGCAAAGTCCCTTCTGTTGTGATTCCTAGGACTTTTCCTCAAGAGGAAATCTGGATTTCCACCTACCGCTTACCTGAAATGCAGGATCACCTACTTACTGTATTCTACATTATTATATGACATAGTATAATGAGACAATATCAAAAGTAAACATGTAATGACAATACATACTAACATTCTTGTAGGAGTGGTTAGAGAAGCTGATGCCTCATTTCTACATTCTGTCATTAGCTATTATCATCTAACGTTTCAGTGTATCCTTACAGAAATAAAGCAGCATATGAATAA

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