Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name EIF4EP3
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr4). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:182459771-182461072  UCSC
Coordinates (T2T) chr3:185264487-185265788  UCSC
Coordinates (hg19) chr3:182177559-182178860  UCSC
Strand -
Parental Sequence NM_001130679.3
Parental seq. overlap 1216 bp
Parental seq. overlap (%) 48.1%
Genomic Region Intergenic
Retrocopy Summary EIF4EP3, located on chr3:182459771-182461072, is a retrocopy of the parental gene EIF4E. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name EIF4E
Full Name eukaryotic translation initiation factor 4E
Also known as AUTS19|CBP|EIF4E1|EIF4EL1|EIF4F|eIF-4E
Coordinate chr4:98879276-98929133
Strand -
Gene summary The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes EIF4EP1
Bonobo Pan paniscus EIF4EP1
Gorilla Gorilla gorilla EIF4EP1
Orangutan Pongo abelii EIF4EP1
Gibbon Nomascus leucogenys EIF4EP3
Green monkey Chlorocebus sabaeus EIF4EP2
Crab-eating macaque Macaca fascicularis EIF4EP1
Rhesus Macaca mulatta EIF4EP1
Baboon Papio anubis EIF4EP1
Golden snub-nosed monkey Rhinopithecus roxellana EIF4EP1
Marmoset Callithrix jacchus EIF4EP2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>EIF4EP3
CGACTGTCGAACAGGAAACCACCCCTACTTCTAATCCTGTGACTACAGAAAAGGAGAAAACAGAATCTATTCAGGAGGTTGCTAACCCAGAACACTATATTAAACATCCTTTACAGAACAGATGGGCCCTCTGGTTTTTTAAAAATGGTAAAAGCAAAAACTTGGCAAGCAAACCTGTGGCTGATCTCTAAGTTTGATACTGTTTGAAGACTTTTGGGCTCTGTACAACCATATCCAGTTGCCTAGTAATTTAATGCCTGGCTGTGACTACTGACTTTTTAAGGCTGGTATTGAGCCTATGTGGGAAGATGAGAAAAACAAACTGGGAGGACGATGGCTAATTACATTGAACAAATAGCAGAGATGAAGTGACCTCGATTGCTTTTGGCTAGAGACACTGCTGTGCCTTATTGCAGAATCTTTTGATGACTACAGCAATGATGTATGTGGTGCTGTTATTAATGTTAGAGCTAAAGGTGATAAGATAGCAATATGGACTACTGAATGTGAAAACAGAGAAGCTGTTACACATATGGGGAGGGTATACAAGAAAAGGTTAGGACTTCCTCGAAAGATAGTGATTGGTTATCAGTCCCACGCAGACATAGCTACTAAGAATGGCTCCACCACTGAAAATAGGTTTGTTGTTTAAGTAGACACCTTCTGAGTATTCTCATAGGAGACTGCATCAAGCAGTCGAGATTTGGGAGCTGAACCAAAGCCTCTTCCAAAAGCAGAGTGGACTGCATTTAAATTTGATTTCCATCTAAATGTTGCTAAGATATAAGAGAAGTCTCATTCGCCTTTGTCTTGTACTTTGGTGTTCTTTTTTTTGGCTAGCGTGTCCACTATCCCAAACAAAGAATTACAGTACTCATCCCCAGAATCCATGAATGTGTTCCTGTCCCACTCTGTAATAGTTCAGTAGAATTACCGTTAATTACATATACATTTTACCTATCCACAATATTCAGAAAACAACTTGGCATTTTTATACTTTACACACACAAAAAATACGGTTAGTGTTCTATTGTATGCAGGCACATATTTTGCTGGTTTGAAAGATTATGATGCATATAGTTTCTAGCAATTTTCTTTGTTTCTTTTTACAGCATTGTCTTTGCTATACTCTTGCTGATGGCTACTAGATTATAATTTATTTGTTTTTCTACTTGATAACATTAGTGATTCTGATTTCAGTTTTTCATTTGTTTTGCTTTTGTTCTTTTCCTCATGTAACATTGGTGAAGGATCCAGGAATATGACACATAGGTGGAATAAACATTAGCTTTGTGCAA
>NM_001130679.3
GTGCGATCAGATCGATCTAAGATGGCGACTGTCGAACCGGAAACCACCCCTACTCCTAATCCCCCGACTACAGAAGAGGAGAAAACGGAATCTAATCAGGAGGTTGCTAACCCAGAACACTATATTAAACATCCCCTACAGAACAGatgggcactcTGGTTTTTTAAAAATGATAAAAGCAAAACTTGGCAAGCAAACCTGCGGCTGATCTCCAAGTTTGATACTGTTGAAGACTTTTGGGCTCTGTACAACCATATCCAGTTGTCTAGTAATTTAATGCCTGGCTGTGACTACTCACTTTTTAAGGATGGTATTGAGCCTATGTGGGAAGATGAGAAAAACAAACGGGGAGGACGATGGCTAATTACATTGAACAAACAGCAGAGACGAAGTGACCTCGATCGCTTTTGGCTAGAGACAagatgggatcttgctatgttgcccaggttggtctcaaacttctggcctcaagtgatcctcccacttcagcctcccaaagtgctggaattacagCTTCTGTGCCTTATTGGAGAATCTTTTGATGACTACAGTGATGATGTATGTGGCGCTGTTGTTAATGTTAGAGCTAAAGGTGATAAGATAGCAATATGGACTACTGAATGTGAAAACAGAGAAGCTGTTACACATATAGGGAGGGTATACAAGGAAAGGTTAGGACTTCCTCCAAAGATAGTGATTGGTTATCAGTCCCACGCAGACACAGCTACTAAGAGCGGCTCCACCACTAAAAATAGGTTTGTTGTTTAAGAAGACACCTTCTGAGTATTCTCATAGGAGACTGCGTCAAGCAATCGAGATTTGGGAGCTGAACCAAAGCCTCTTCAAAAAGCAGAGTGGACTGCATTTAAATTTGATTTCCATCTTAATGTTACTCAGATATAAGAGAAGTCTCATTCGCCTTTGTCTTGTACTTCTGTGTTCAtttttttttttttttttGGCTAGAGTTTCCACTATCCCAATCAAAGAATTACAGTACACATCCCCAGAATCCATAAATGTGTTCCTGGCCCACTCTGTAATAGTTCAGTAGAATTACCATTAATTACATACAGATTTTACCTATCCACAATAGTCAGAAAACAACTTGGCATTTCTATACTTTACAGGAAAAAAAATTCTGTTGTTCCATTTTATGCAGAAGCATATTTTGCTGGTTTGAAAGATTATGATGCATACAGTTTTCTAGCAATTTTCTTTGTTTCTTTTTACAGCATTGTCTTTGCTGTACTCTTGCTGATGGCTGCTAGATTTTAATTTATTTGTTTCCCTACTTGATAATATTAGTGATTCTGATTTCAGTttttcatttgttttgcttttgtttttttCCTCATGTAACATTGGTGAAGGATCCAGGAATATGACACAAAGGTGGAATAAACATTAATTTTGTGCATTCTTTGGTAATTTTTTTTGTTTTTTGTAACTACAAAGCTTTGCTACAAATTTATGCATTTCATTCAAATCAGTGATCTATGTTTGTGTGATTTCCTAAACATAATTGTGGATTATAAAAAATGTAACATCATAATTACATTCCTAACTAGAATTAGTATGTCTGTTTTTGTATCTTTATGCTGTATTTTAACACTTTGTATTACTTAGGTTATTTTGCTTTGGTTAAAAATGGCTCAAGTAGAAAAGCAGTCCCATTCATATTAAGACAGTGTACAAAACTGTAAATAAAATGTGTACAGTGAATTGTCTTTTAGACAACTAGATTTGTCCTTTTATTTCTCCATCTTTATAGAAGGAATTTGTACTTCTTATTGCAAGGCAGTCTCTATATTATGTCTTCTTTTGTGGTGTCTTCCATGTGAACAGCATAAGTTTGGAGCACTAGTTTGATTATTATGTTTATTACAATTTTTAATAAATTGAATAGGTAGTATCATATATATGGAATTAAATTGATGTGGCTATCTTTGTTTTTTTATAAAGTAAGGCACAGTCATTCAGTCTTAGGTAAATAATGTACTCTCTTAATATGTTAATACTCATGAGAATTGGGATCTGATGCATCACCATTTGATTGGTAGCAACAGTGGTTGTAAAACTTGGTTGCTGAATTGAGTTGTTTCTATGTTAAGTGTCAAAATGATAGTGTAGGGAAAGTACAGGTGGTGGGGACATATGCATTAAGAATCTTGTTAGTGTTGCAATCTAAATAGAATGGAATAAACAGGTGTTAAGACATATTTATAGTGGTAAATTGTTGTAGTATGGTATTCTGTAAACTTGAAAACTTGATCTACTCTTTGTAGGTATCATTTGAAAGCAAACTTGAAAATGTTTTGTACATAGTACATACTTGTATAGTCCTGTGAGATGAAGTATGGCTATCAGACCAAAGGATAAGCCAAACTGTAGGTAGCAGAATGGAAATTATTATTTTGAGAGGAAAATTTGTCTTTGAATGGTGATTATGACTTAATCATTTTAAAACTGATAAACTTGACAAAAACCCTGTATGAAATAAACATGAAATTAATAGCA

Publications

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