Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HSP90AA5P
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr14). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:184115336-184118003  UCSC
Coordinates (T2T) chr3:186924903-186927569  UCSC
Coordinates (hg19) chr3:183833124-183835791  UCSC
Strand +
Parental Sequence NM_005348.4
Parental seq. overlap 1918 bp
Parental seq. overlap (%) 58.4%
Genomic Region Intergenic
Retrocopy Summary HSP90AA5P, located on chr3:184115336-184118003, is a retrocopy of the parental gene HSP90AA1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HSP90AA1
Full Name heat shock protein 90 alpha family class A member 1
Also known as EL52|HEL-S-65p|HSP86|HSP89A|HSP90A|HSP90N|HSPC1|HSPCA|HSPCAL1|HSPCAL4|HSPN|Hsp103|Hsp89|Hsp90|LAP-2|LAP2
Coordinate chr14:102080742-102139749
Strand -
Gene summary The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HSP90AA1P2
Bonobo Pan paniscus HSP90AA1P2
Green monkey Chlorocebus sabaeus HSP90AA1P2
Crab-eating macaque Macaca fascicularis HSP90AA1P2
Rhesus Macaca mulatta HSP90AA1P2
Baboon Papio anubis HSP90AA1P2
Golden snub-nosed monkey Rhinopithecus roxellana HSP90AA1P1
Marmoset Callithrix jacchus HSP90AA1P7
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HSP90AA5P
TGGTCCCTTAGCCAAGCTGCCTGAGGAAACCCAGACCCAAAACCAACCGATGGAGGAAGAAGAGGTTGAGATGTTTGCCTTTCAAGCAGAAACTGTCCAGTTGATGTCACTGATCATCAATACTTTCTACTTGAACAAAGAAACCTTTCTGAGAGAGCTCATTTCAGCATCAAGAGAGCTCATTTCAAATTCATCAGATGCTTTGGACAAAACCTGATATGAAACCTTGACGGATCCCAGTAAATTAGACGCTGGGAAAGAGCTCCACGTTAATCTTATGCCAAGCACACAAGATCAAACCCTTACTATTATGGATACTGAAACTGGAATGACCAAGGCTGACTTGATCAATAACCTTGGTACTGTCGCCAGTCTGGGACCAAAGCATTCATGGAAGTTTTCCAGGCTGGTGCAGAATCTCTATGATTGGCAAGTTCGGTGCTGGTTTTTATTCTGCTTATTTGGTTGCTGAGAAAGTAACTGTGATCACCAAACATAAACATGAGCAGCATGCTCGGGAGTCCTCCTCAGGGGGATCACTCACAGTTAGGACTGACACAGTGAACCTATGGGGCATGGAGCAAAGGGCACCCTGCACTTGAAAGAAGACCTGAGTATTTGGAGGAAAGAAGAATAAAAGAGATTGTGAAGAAGCATTCTCAGTTTATTGGCTATCCCATTACTCTTTTTGTGGAGAAGAAACGTAATAAACAAGTCAGTGATGCTGAGGCTGAAAAAAAGGAAGATAAGAGGAAGAAAAAGAAAGAGTCCAATGACAAACCTGAAATTGAAGATGTTGGTTCTTACATTGATCAAGAACTCAACAAAACAAAGCCTATCTGGACCAGAAATCCTGACGCTATTACTAACGAGGAGTATGGAGAGTTCCATCAGAGCTTGACCAATAACTGGGAAGATCACTTGGCAGTGAAGCACTTTTCAGTTGAAGGGCAGTTGGAAGAGTTGAAGGACAGTCGAAGAGTTTAGAAGAGCTCTTTTTGTTTCAAGATGTGCTCCTTTTGACCTATTTGAAAACAGAAAGAAAAAGAACAACATTCAGTTGTATGTACACAGAGTTTTCATCATGGGTAACTGTGAGGAGCTAATCCCTGAATACCTGAACTTCATTAGAGGGGTGATGGACTCAGAGGATCTCCCTCTAAATATTTTTTCTGAGATGTTGCAACAAAGCAAAATTTTGAAAGTTATTAGGAAGAATTTGGTCAAAACATACTTAGAACTCTTTGCTGAACTGGCAGAGGATAAAAAGAACTACAAAAAGTTCCACGAGAAGTTATCTGAAAACATAAATCTTTGAATATATAGACTCTCAAAATCAGAAGAAGCTTTCAGAGCTGTTGAAATAGTGCACATCTGCCTCTCGTGATGAGATGGTTTATCTCATTGTGTTTTCCAGAATGAAGGCAAACCAGAAACATATCTATTACATTACAGGTGAGACCAAGGACCAAGTAGCTAACTCAGCCTTTGTGGAATGTCTTCAGAAGCATGGCTTAGAAGTGATCTATATGATCGAGTTGATTGATAAGTACTGTGTCCAGCAGCTGAAGGAACTTGAGAGTAAGACTGTAGTGTCAGTTGCCAAAGAGGGTTgTTGGAGAAAAAAGTCAAAAAGGTGGTTGTGTCAAACTGGTGACATCCCCATGCTGTATTGTCACAAGCACATATGGCTGGACAGCAAACATGGAAAGAATCATGAAAGCTCAAGCCCGGTAAGACAACTCAACAATGGGCTACGTGGCAGCAAAGAAACACCTGGAGATAAACCCTGACCATTCATGATTGAAACCTTAAGGCAAAAGGCAGAGGCTGATAAGAACAACAAGTCAGTGAAGGATCTGGTCATCTTGCTTTACTAAACTGCACTCCCATCTCCTGGCTTCAGTATGGAAGACCCTCAGAGACATACTAACAAGATCTATAGGATGATCAAACTTGGTCTGGGTGTTGATGAATATGATCCTACTGCTAATGATATCAATGCCGCTATAACTAAAGAAATGCCGCCCCTCAGAGGAGGTGATGACACATCACGCATGGAAGAAGTAGGCGGCTCTGGCTGAGGAATGACTTGTACATGTGTTCAATACTCTATCTTCATTCTCTCTGATAATATATTTTCAGGATTATTTTAGTTATTTTTGTTAACATTTAAAAAGTCTGTATGG
>NM_005348.4
AGTTGCTTCAGCGTCCCGGTGTGGCTGTGCCGTTGGTCCTGTGCGGTCACTTAGCCAAGATGCCTGAGGAAACCCAGACCCAAGACCAACCGATGGAGGAGGAGGAGGTTGAGACGTTCGCCTTTCAGGCAGAAATTGCCCAGTTGATGTCATTGATCATCAATACTTTCTACTCGAACAAAGAGATCTTTCTGAGAGAGCTCATTTCAAATTCATCAGATGCATTGGACAAAATCCGGTATGAAAGCTTGACAGATCCCAGTAAATTAGACTCTGGGAAAGAGCTGCATATTAACCTTATACCGAACAAACAAGATCGAACTCTCACTATTGTGGATACTGGAATTGGAATGACCAAGGCTGACTTGATCAATAACCTTGGTACTATCGCCAAGTCTGGGACCAAAGCGTTCATGGAAGCTTTGCAGGCTGGTGCAGATATCTCTATGATTGGCCAGTTCGGTGTTGGTTTTTATTCTGCTTATTTGGTTGCTGAGAAAGTAACTGTGATCACCAAACATAACGATGATGAGCAGTACGCTTGGGAGTCCTCAGCAGGGGGATCATTCACAGTGAGGACAGACACAGGTGAACCTATGGGTCGTGGAACAAAAGTTATCCTACACCTGAAAGAAGACCAAACTGAGTACTTGGAGGAACGAAGAATAAAGGAGATTGTGAAGAAACATTCTCAGTTTATTGGATATCCCATTACTCTTTTTGTGGAGAAGGAACGTGATAaagaagtaagcgatgatgaggctgaagaaaaggaagacaaagaagaagaaaaagaaaaagaagagaaagagtcggaagacaaacctgaaattgaagatgttggttctgatgaggaagaagaaaagaaggatggtgacaagaagaagaagaagaagattaaggaaaagtacatcgatcaagaagaGCTCAACAAAACAAAGCCCATCTGGACCAGAAATCCCGACGATATTACTAATGAGGAGTACGGAGAATTCTATAAGAGCTTGACCAATGACTGGGAAGATCACTTGGCAGTGAAGCATTTTTCAGTTGAAGGACAGTTGGAATTCAGAGCCCTTCTATTTGTCCCACGACGTGCTCCTTTTGATCTGTTTGAAAACAGAAAGAAAAAGAACAACATCAAATTGTATGTACGCAGAGTTTTCATCATGGATAACTGTGAGGAGCTAATCCCTGAATATCTGAACTTCATTAGAGGGGTGGTAGACTCGGAGGATCTCCCTCTAAACATATCCCGTGAGATGTTGCAACAAAGCAAAATTTTGAAAGTTATCAGGAAGAATTTGGTCAAAAAATGCTTAGAACTCTTTACTGAACTGGCGGAAGATAAAGAGAACTACAAGAAATTCTATGAGCAGTTCTCTAAAAACATAAAGCTTGGAATACACGAAGACTCTCAAAATCGGAAGAAGCTTTCAGAGCTGTTAAGGTACTACACATCTGCCTCTGGTGATGAGATGGTTTCTCTCAAGGACTACTGCACCAGAATGAAGGAGAACCAGAAACATATCTATTATATCACAGGTGAGACCAAGGACCAGGTAGCTAACTCAGCCTTTGTGGAACGTCTTCGGAAACATGGCTTAGAAGTGATCTATATGATTGAGCCCATTGATGAGTACTGTGTCCAACAGCTGAAGGAATTTGAGGGGAAGACTTTAGTGTCAGTCACCAAAGAAGGCCtggaacttccagaggatgaagaagagaaaaagaagcaggaagagaaaaaaacaaagtttgagaacctctgcaaaatcatgaaagacatATTGGAGAAAAAAGTTGAAAAGGTGGTTGTGTCAAACCGATTGGTGACATCTCCATGCTGTATTGTCACAAGCACATATGGCTGGACAGCAAACATGGAGAGAATCATGAAAGCTCAAGCCCTAAGAGACAACTCAACAATGGGTTACATGGCAGCAAAGAAACACCTGGAGATAAACCCTGACCATTCCATTATTGAGACCTTAAGGCAAAAGGCAGAGGCTGATAAGAACGACAAGTCTGTGAAGGATCTGGTCATCTTGCTTTATGAAACTGCGCTCCTGTCTTCTGGCTTCAGTCTGGAAGATCCCCAGACACATGCTAACAGGATCTACAGGATGATCAAACTTGGTCTGGGTATTGATGAAGATGACCCTACTGCTGATGATACCAGTGCTGCTGTAACTGAAGAAATGCCACCCCTTGAAGGAGATGACGACACATCACGCATGGAAGAAGTAGACTAATCTCTGGCTGAGGGATGACTTACCTGTTCAGTACTCTACAATTCCTCTGATAATATATTTTCAAGGATGTTTTTCTTTATTTTTGTTAATATTAAAAAGTCTGTATGGCATGACAACTACTTTAAGGGGAAGATAAGATTTCTGTCTACTAAGTGATGCTGTGATACCTTAGGCACTAAAGCAGAGCTAGTAATGCTTTTTGAGTTTCATGTTGGTTTATTTTCACAGATTGGGGTAACGTGCACTGTAAGACGTATGTAACATGATGTTAACTTTGTGGTCTAAAGTGTTTAGCTGTCAAGCCGGATGCCTAAGTAGACCAAATCTTGTTATTGAAGTGTTCTGAGCTGTATCTTGATGTTTAGAAAAGTATTCGTTACATCTTGTAGGATCTACTTTTTGAACTTTTCATTCCCTGTAGTTGACAATTCTGCATGTACTAGTCCTCTAGAAATAGGTTAAACTGAAGCAACTTGATGGAAGGATCTCTCCACAGGGCTTGTTTTCCAAAGAAAAGTATTGTTTGGAGGAGCAAAGTTAAAAGCCTACCTAAGCATATCGTAAAGCTGTTCAAAAATAACTCAGACCCAGTCTTGTGGATGGAAATGTAGTGCTCGAGTCACATTCTGCTTAAAGTTGTAACAAATACAGATGAGTTAAAAGATATTGTGTGACAGTGTCTTATTTAGGGGGAAAGGGGAGTATCTGGATGACAGTTAGTGCCAAAATGTAAAACATGAGGCGCTAGCAGGAGATGGTTAAACACTAGCTGCTCCAAGGGTTGACATGGTCTTCCCAGCATGTACTCAGCAGGTGTGGGGTGGAGCACACGTAGGCACAGAAAACAGGAATGCAGACAACATGCATCCCCTGCGTCCATGAGTTACATGTGTTCTCTTAGTGTCCACGTTGTTTTGATGTTATTCATGGAATACCTTCTGTGTTAAATACAGTCACTTAATTCCTTGGC

Publications

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