Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MTAPP2
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:189969029-189969912  UCSC
Coordinates (T2T) chr3:192785408-192786291  UCSC
Coordinates (hg19) chr3:189686818-189687701  UCSC
Strand -
Parental Sequence NM_002451.4
Parental seq. overlap 822 bp
Parental seq. overlap (%) 13.6%
Genomic Region Intragenic (P3H2)
Retrocopy Summary MTAPP2, located on chr3:189969029-189969912, is a retrocopy of the parental gene MTAP. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MTAP
Full Name methylthioadenosine phosphorylase
Also known as BDMF|DMSFH|DMSMFH|HEL-249|LGMBF|MSAP|c86fus
Coordinate chr9:21802636-21867081
Strand +
Gene summary This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage pathway of both adenine and methionine. The encoded enzyme is deficient in many cancers. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2021]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MTAPP1
Bonobo Pan paniscus MTAPP1
Gorilla Gorilla gorilla MTAPP1
Orangutan Pongo abelii MTAPP1
Gibbon Nomascus leucogenys MTAPP1
Green monkey Chlorocebus sabaeus MTAPP1
Crab-eating macaque Macaca fascicularis MTAPP1
Rhesus Macaca mulatta MTAPP1
Baboon Papio anubis MTAPP1
Golden snub-nosed monkey Rhinopithecus roxellana MTAPP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MTAPP2
TTCCCTTAGTCCCGAGTGCTCGCCCACTGCAGCTTCCTTTCCTGTGCGGACATGGCCTCAAGCACCACCACCACTGCCATGAAGATTGGAATAATTGGTGGAACAGGCCTGGATGATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCCATTTGATGTCTTAATTTTGGGGAAGATAAAAAATGTTGATTGTGTCCTCCTTGCAAGGCATGGGAGGCAGCACACCATCCTGGCTTCCAAGGTCAACTACCAGGCGACCATCTGGGCTTTGAAGGAAGAGGGCTGTACACATGTCATAGGGACCACAGCTTGTGGCTCCTTGAGGGAGGAGATTCAACCTGGCGATATTGTCATTATTGATCAGTTCATTGACAGGACCAGTATGAGACCTCAGTCCCTCTATGATGGAAGTCATTGTTGTGCTAGAGGAGTGTGCCATATTCCAATGGGGGCCAAGCCCCCAAACGAGAGACGTTCTTATAGAGACTGCTAAGAAGCTAGGACTCTGGTGACATTCAAAGGGGACAATGGTCACAACTGAGGGACCTCGTTTTATCTCTTGAGCAGAAAGCTTCATGTTCTGCACCTGGGGGGTGGATGTTATCAACATGACCACAGTTCCAGAGGTGGTTCTCACTAAAGAGGCTGGAATTTGTTATGCGAGTATTGCCATGGTGACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGTTTTGGTGGACCGGGACTTACAGACCCCGAAAGAAAATGCTAGTAAAGCCAAAAGTTTACTGCTCACTGCCATACCTCAGATAGGATCCATGGAATGGTCAAAAACCCTCCATGGCCTGAAGAATATAGCCCAGTTTTCTGTTTTa
>NM_002451.4
CTCCGCACTGCTCACTCCCGCGCAGTGAGGTTGGCACAGCCACCGCTCTGTGGCTCGCTTGGTTCCCTTAGTCCCGAGCGCTCGCCCACTGCAGATTCCTTTCCCGTGCAGACATGGCCTCTGGCACCACCACCACCGCCGTGAAGATTGGAATAATTGGTGGAACAGGCCTGGATGATCCAGAAATTTTAGAAGGAAGAACTGAAAAATATGTGGATACTCCATTTGGCAAGCCATCTGATGCCTTAATTTTGGGGAAGATAAAAAATGTTGATTGCGTCCTCCTTGCAAGGCATGGAAGGCAGCACACCATCATGCCTTCAAAGGTCAACTACCAGGCGAACATCTGGGCTTTGAAGGAAGAGGGCTGTACACATGTCATAGTGACCACAGCTTGTGGCTCCTTGAGGGAGGAGATTCAGCCCGGCGATATTGTCATTATTGATCAGTTCATTGACAGGACCACTATGAGACCTCAGTCCTTCTATGATGGAAGTCATTCTTGTGCCAGAGGAGTGTGCCATATTCCAATGGCTGAGCCGTTTTGCCCCAAAACGAGAGAGGTTCTTATAGAGACTGCTAAGAAGCTAGGACTCCGGTGCCACTCAAAGGGGACAATGGTCACAATCGAGGGACCTCGTTTTAGCTCCCGGGCAGAAAGCTTCATGTTCCGCACCTGGGGGGCGGATGTTATCAACATGACCACAGTTCCAGAGGTGGTTCTTGCTAAGGAGGCTGGAATTTGTTACGCAAGTATCGCCATGGCGACAGATTATGACTGCTGGAAGGAGCACGAGGAAGCAGTTTCGGTGGACCGGGTCTTAAAGACCCTGAAAGAAAACGCTAATAAAGCCAAAAGCTTACTGCTCACTACCATACCTCAGATAGGGTCCACAGAATGGTCAGAAACCCTCCATAACCTGAAGAATATGGCCCAGTTTTCTGTTTTATTACCAAGACATTAAAGTAGCATGGCTGCCCAGGAGAAAAGAAGACATTCTAATTCCAGTCATTTTGGGAATTCCTGCTTAACTTGAAAAAAATATGGGAAAGACATGCAGCTTTCATGCCCTTGCCTATCAAAGAGTATGTTGTAAGAAAGACAAGACATTGTGTGTATTAGAGACTCCTGAATGATTTagacaacttcaaaatacagaagaaaagcaaatgactagtaaacatgtgggaaaaaatattacattttaagggggaaaaaaaaacccaccattctcttctccccctattaaatttgcaacaataaagggtggagggtaatctctactttcctatactgccaaagaatgtgaggaagaaatgggactctttggttatttattgatgcgactgtaaattggtacagtatttctggagggcaatttggtaaaatgcatcaaaagacttaaaaatacggacgtactttgtgctgggaactctacatctagcaatttctctttaaaaccatatcagagatgcatacaaagaattatatataaagaagggtgtttaataatgatagttataataataaataattgaaacaatctgaatcccttgcaattggagGTAAATTATGTCTTAGTTATAATTAGATTGTGAATCAGCCAACTGAAAATCCTTTTTGCATATTTCAATGTCCTAAAAAGACACGGTTGCTCTATATATGAAGTGAAAAAAGGATATGGTAGCATTTTATAGTACTAGTTTTGCTTTAAAATGCTATGTAAATATACaaaaaaactagaaagaaatatatataaccttgttattgtatttgggggagggatactgggataatttttattttctttgaatctttctgtgtcttcacatttttctacagtgaATTTAATCAAATAGTAAAGTTGTTGTAAAAATAAAAGTGGATTTAGAAAGATCCAGTTCTTGAAAACACTGTTTCTGGTAATGAAGCAGAATTTAAGTTGGTAATATTAAGGTGAATGTCATTTAAGGGAGTTACATCTTTATTCTGCTAAAGAAGAGGATCATTGATTTCTGTACAGTCAGAACAGTACTTGGGTTTGCAACAGCTTTCTGAGAAAAGCTAGGTGTTTAATAGTTTAACTGAAAGTTTAACTATTTAAAAGACTAAATGCACATTTTATGGTATCTGATATTTTAAAAAGTAATGTTTGATTCTCCTTTTTATGAGTTAAATTATTTTATACGAGTTGGTAATTTTTGCTTTTTAATAAAGTGGAAGCTTGCTTTTTTAACTCTTTTTTTATTGTTATTTTATAGAAATGCTTTTTGTTggccgggcacagttgctcatccatgtaatcccagcactgtgggaggccgagacgggtggatcacaaggtcaggagatcgagaccatcctggctaatgcgttgaaactccgtctctactaaaaatacaaaaaattagctgggcgtggtggtgggcacctgtagtcccagctactcaggaggctgaggcaggagaatggtgtgaacctgggaggtggagcttgcagtgagcagagcttgcagtgagacgagcttgtgccactgcactccagcctgggcaacagagtaagactcagtctcaaaaaaaaaaaaaaGAGTGAAATGCTTTTTGTTTGCTTCAGTTTTTTATCATGGGGAGATCTTTTTCCTCAGAATTGTTTTCTTTTCACTGTAGGCTATTACAGGATACTTCAGGATCAAGATACAGAACCTTTTATTTAAAGAGTTTGTAAAGTCAATGTGTTTGTTTGTGTCTCTGAGATTGACTTCAAGATAATAAGCTGCTAATTGTAAACAAAACAGTTACCCTCCAGTATTAATATGACTCATTAGTGTGAGCCATTTGGGTCAAGTATGATTATGACCCTTGGACTTCCTGATGTAGTATTAAATTTCAACTCTGGTTATCCATTAGCAATCTGTAGAGAACTTAATGAACCTGAACCCAGGCTTCTCTAGCTCTGGTAACGTGTGATTGTTTTCACTACAATATGATACATAGATGGTACCTTACTTTTCCTCATTCTTAATAGGTGTCTAAGAATGTCAGGGCAAAAGTATGGGCATTTTTCTTGCTATGTTCAGAAAGTACAGTTCTCTCCAACTTGCAGAGGTACTTTTCTTGATTAAATAGCCTTCTCTAGCAACATCATTTTCAGACTAACTAAATGAATGCAGTATACTCTTTTCTTTGTTCTCAATCATTCACTCCTTATGCAAAGCCAATATAATTTTCCTCATACCTTATGCTTGAGGATATTGTTGAAGAACACTTCCTGGAACACTTCTCACTTGTGATGCTGTACTAATTTTTTTTTTTTAATTTAAGCTAGTATACTAAGTGAACACCATGGTCAGTTGTGAGCATTTTGGTTTCCGCAAAGGATGGATGGTGAGCATCATGGGAAAGCTGTAGTTTAGTGACTTAGCCCTTAGTGATTAATAGATTTGCATGTACATAGAAGTCTTTGTTGGCCTTATAATCTGCTGTTATATTTGGCATGGATTTTCATGGTTTTGAGAATGACATCCTGGCCCTGTGGTCCCCGAGGGTCATGGTCCTTGTGACCTGGCCCCTGTTCACTGCCCCCTTCGCTAGCACGAGTTGCTGTGCAGGGCTGGAGGTAGCTACCATGGCTTGTTTCAAGGAAGGAAACTCTGGTACGGTGGCACCCTCAGGAGTGGAGGACAGTGAACTTCCTTGAAGAGGGAGTGACTAAGGTGACCTCCAACCTGCCCTGAGCCAGCTGCCCTGCAGGTGCCACGTGAGCCTGCTCTGGCATCCACAGGATGCTCCTGGAGCCTCTTCTCTGGCTGCTACCTCAGGGCATGGTTGTGGCCCCACCAACACCTATTTTCCAAATAATTATTCATTCTTGTGACAGTGGCCTGAACATGTTTTTAATTTTCTCAACAAGCATTTAGCCAGCACTTATCCAGTGAAACAATTTGATAAGGTTTCAAGGAGTATCTGATGGGTTAGGAAGTCACGAAATGAGGAGTTCTTGCCACATTTGCAGAGTCCCTCCTtgataaggtttggcggtgtccccacccaaatctcatgttgaattgtagttcccataatccccacatgttgtgggagggacccagtgggaggtaattaaatcatgggggtggttacccccacactgctgttctcatgatactgagttctcacaagtcctgtttgttttataaggggcttttcccccttttgctcaacacttcttcctgccatcatgtgaagaaggacgtgtttgtttccccttctgccacgattgtaagtttcctgaggccttcccagctatgtggaactgtgagttaattaaacctctttcctttataaattacccagtcatgggcagtcctttacagcagcatgagaatggactaatacaCTCCTCAAATGTTTTGAAGATTGTTGCACCTTGGAACTACCAGTGTGCACACAATCTGGCTCAATGTATATATTGGCCCAGCAAGGCAAAGAACTGAAGTTCCAGGATGGAAGAACCTGTGTTCTCCTCATAATAGTATAGAATAATTCAAGATAGGCAAGAAGGACAGCAGTAAATGAAGACCATGGAAGAAAAGAAGGAATGCCAAAGATCGAGGAAATCTACCAAGACTAGTAGGGTAGTCCAGAAGAAGCTGTTTCAGGGCCTGTTGCCAGCTATGCCTTTGAGAACCTCGGGATCCCAAAGAATGAGGGGAATTTCTTCAGAAAGACAATCTCGGCATGCATTATTTCTTtgttttgaagattcactcatgttgcatgcatctgtagcttgtgccttttttattgcctagtagtattctgtcatatgcctatcttacaatttgattatctattcacctgttgatgaatgtttgaattttttccatttgaggaattttatgaataaagctgctataagcatgaaattacaagtctttttgtgaacatattttcacttgtgcaaatgcctatactcccaccagtaatttgtaagaattcttgacaaagcttggtattgtcagcgtttttaattttagccattctattgggtatattttgatatctcgtggttttgatttgcatttttctgattaaagatgttgaacttcttttcatgtgcttattggccattcacatatttcgtgaactatctgtacaaatatttttgtttattaaaaaattagattgttttgttttattattgaatagtaagaattgtttatatattctggatacactctttttcagatatgtgtgttgtgactattcttagtctttagcttgccttttcattttcttaattatgtctttcaaagaacaagtttttcattttgacgaagcctagtttatcaattttttttatggttggtgctttttgtgtgttccaagaaatctttgcctactcatttaattacctgtgtgcccttgtcaaaatcatttaattttgactactcacttaattaccttgcctactcatttaattacctgtgtgcccttgtcaaaatttactgtttatctgtgaatctggatgatctatttatgtcatttatctatgtgtctcttcttatgccagtaccccactgtcttgattattgtggctttatggtgtcttgaaattaagtattgttaagctttgcaatcttttccaagattgttttggctataggtcctttctttataaagtttatattaagcttctccatttttctttaagaaaaaatctgctggaatggcactgaatttttaggtcgatttgggaagaattgacaatattgaacctttcaatcgatggacatggtatgtttctgcatttatttgggccttttaaaatttatctcagcaatattttgtagttttagtgaagaagtcttgtatatatcttttgttaaatgtattcctaaatattttgtggaaatgttactgtaaatagtactttaatttcatttttaagtttattgctggtatacagaaatatgttttatttttgtatattgactttatattctgtaatcttattaaattcacttagttcagta

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