Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SAP18P3
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr13). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:20007863-20008157  UCSC
Coordinates (T2T) chr3:20011931-20012225  UCSC
Coordinates (hg19) chr3:20049355-20049649  UCSC
Strand -
Parental Sequence NM_005870.4
Parental seq. overlap 260 bp
Parental seq. overlap (%) 11.3%
Genomic Region Intragenic (PP2D1)
Retrocopy Summary SAP18P3, located on chr3:20007863-20008157, is a retrocopy of the parental gene SAP18. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SAP18
Full Name Sin3A associated protein 18
Also known as 2HOR0202|SAP18P
Coordinate chr13:21140514-21149085
Strand +
Gene summary Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SAP18P2
Bonobo Pan paniscus SAP18P2
Gorilla Gorilla gorilla SAP18P2
Orangutan Pongo abelii SAP18P2
Green monkey Chlorocebus sabaeus SAP18P2
Baboon Papio anubis SAP18P1
Golden snub-nosed monkey Rhinopithecus roxellana SAP18P1
Marmoset Callithrix jacchus LOC100414167P3
Gibbon Nomascus leucogenys Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SAP18P3
TAACAGCCGCCGCCACCGAATGGTCGAGTTCTCCGGATGAAACATACCGTCCAGCGTGCTGGCGACCTACACTTGGATAGATGCAACCTTGAAAGAACTGAGCTTAGTAAAATAAGTCTATCCAGAGGCTAGAAAGAAGGGCACACATTTCAATTTTATAGGTTTTTACAGATATTAAAAGATCTGGCTATCGAGTTAAGGAGATTGGCAGCGCCACATCTGGCAGAAAGGGGACTGGTGATTCCATGACCCCTGCAGTCACAGAAGTTACAACTAGGAGATTATTCGGACATAA
>NM_005870.4
TAAAGTGTCGAGCTTCTCCTCGCGAGAGACTTAGTGCTCATGCTCGCTGCAGGGGTCGGAGGTCAGGGCGAGCGTCTCGCAGGCCGTAGGAGGAAGATGGCGGTGGAGTCGCGCGTTACCCAGGAGGAAATTAAGAAGGAGCCAGAGAAACCGATCGACCGCGAGAAGACATGCCCACTGTTGCTACGGGTCTTCACCACCAATAACGGCCGCCACCACCGAATGGACGAGTTCTCCCGGGGAAATGTACCGTCCAGCGAGTTGCAGATCTACACTTGGATGGATGCAACCTTGAAAGAACTGACAAGCTTAGTAAAAGAAGTCTACCCAGAAGCTAGAAAGAAGGGCACTCACTTCAATTTTGCAATCGTTTTTACAGATGTTAAAAGACCTGGCTATCGAGTTAAGGAGATTGGCAGCACCATGTCTGGCAGAAAGGGGACTGATGATTCCATGACCCTGCAGTCGCAGAAGTTCCAGATAGGAGATTACTTGGACATAGCAATTACCCCTCCAAATCGGGCACCACCTCCTTCAGGGCGCATGAGACCATATTAAATTCTATTTACTATTTGTTGAATTTATTTTTCCGTCAGTTATGTAAAATAAACATACTCTTCTTCCTCCCCTGATTATTGCCATTAAGCCTTTAAATTCTAAACAAATTATAATGCATCATCTATTTAGGAGTTAGATTTGGATGTGCTATTGTATGATTACGAATAGTCTGTATGTTTCAAGCCCTTCTGTAAAATATGAAGAAAAGTGCTCTTAGCATTCTGTGTAAAACTGTACTGTTAAATATATGTGTGTAATCAGCCTGAGTGTGAAAGTTAATGGAGGCCTGGGAACAGGGTTTATACTAAGTAGTGGAGGAGCGTATGGTTAAGCCCAAAGGGGCAGAACAAGAAAGCCACGGGATTGTATGAAATCAAACATGAGTTTGTGGTGTAGACTGCTGTATGCAGTTGGAAAGGACACGTGAGAGTGAGCTCAAGTGGCAGCAGAGGCAGTTTGGAATAAGCTGCGGCAAGTTGAAGAAGCTGTGTTGGACGAGATTGCCCCGCCTTGATCAGGGTACCATGACATAAAAGGTTAAAGAACAGGCAACACAATGAGCACTTAAGTTTTTAACATGTGGGGAATAGGGCATTTTAAAGGCTGGAACCAGTTCAGAGGAAACAAGGGTTTGGGTAGAGGTAGAAAGGTTTAATTAACCCTGGAGATCTGCAAATGGAGGGAGGGGTGAAGGAGGAATCTTAAGACCGAGGGAGAAGAGCCAAGGACAAGGTCAGGTTGAATGAGTAGGAGGTGTTCACACATCCTCTTGTGTGCTAGGTAGTGGCGTGCATCTGATCTGAGAGGCAGTAAAGCAGTGATGAAGACAGTGCAGCAGAACATTGAAGTCCTGATTGCAGCAGTGActctgcaaccttggataaattatttcaatctttattttgtaaaacggagataacggcctataggattgttaagactgaatattttaaaagagcttagaatggtgcctgacaaatgagaaacaataaatactgattattGGCCATAAAGTGGTATTAAAACTGGATCTCTTTTCTTCCATGGCACTACTCTCATTTTGAAGTTTATGAACAGTACGACAGTGTATTGTAAATTCCCTTTAGTTTGTTACAGTAGCCAATTGAAAATGTATATCCCAAAATTTAAAAAAAAAAGTACCAGCAGCAATAAAATTGCACTAGTTTTATCTGGTACATACAAAAACAGCCATTTAAAATCTGATGATTCTGTGGAATTGGTGTCCCTGTTAGCAATGGCAGAGACCAGCCTGGAGCCTAGATCTGGTGCTTCTTCTGTGCTGTGGTTTACCCCAAACCTTTAGGTTGTTTATTCATTCAGATTAGATAGACTGGAGCCATAAAGTTAATTTGCACCTAGCTTTTTGGAGAATAGCCATGATTAACTGCTATTCGTGGTGGGGGTGGGGGGGAACCCTATGATTTACTATGCAGATGAAGAGGGTAGGAACTAAATAAAGGACTTTGTAAGCCAAAGTGGTTGGGCTGCTTTGTCAAATTCCACCCTTTGCTTGGTTCCAACATGGAATTTCTCCTTTAAAGATTTCAATATCCCATCAAAAGTACAGTTAGAGAATACCTAGTGAATTTATTGAATATAATGCTAAGAATCAAAAGACTTGTACTAGTTTACCTCTGGCTTTGGTAAGTGTGGCTTTGAGTAATAACTGAGCTGTTTCCCCGCATATAAAATAGAAATAAATAAGTAGTCATCATGACAGCA

Publications

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