Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name RANP7
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:22904652-22905497  UCSC
Coordinates (T2T) chr3:22909500-22910345  UCSC
Coordinates (hg19) chr3:22946143-22946988  UCSC
Strand +
Parental Sequence NM_006325.5
Parental seq. overlap 690 bp
Parental seq. overlap (%) 27.7%
Genomic Region Intergenic
Retrocopy Summary RANP7, located on chr3:22904652-22905497, is a retrocopy of the parental gene RAN. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RAN
Full Name RAN, member RAS oncogene family
Also known as ARA24|Gsp1|TC4
Coordinate chr12:130871879-130877678
Strand +
Gene summary RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RANP2
Bonobo Pan paniscus RANP3
Gorilla Gorilla gorilla RANP2
Orangutan Pongo abelii RANP2
Gibbon Nomascus leucogenys RANP2
Green monkey Chlorocebus sabaeus RANP6
Rhesus Macaca mulatta RANP1
Baboon Papio anubis RANP1
Golden snub-nosed monkey Rhinopithecus roxellana RANP1
Marmoset Callithrix jacchus RANP13
Crab-eating macaque Macaca fascicularis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RANP7
aCCAACAAAGGGCCCATTAAGTTCAATGGATGGGACACAGCTGGCCCGGAGAAATTTGGCAAACTGAGAGATGGCTGATGGCTATTATATCCAAGCCCAGGGTGCCCTAATGCTTAATGTAACATCAAGAGTTACAAGAAGGTGCCTGACGTAGAGATCTGGTATGAGTGTATGAAAACACCCCCATCATGTTTTGTGGCAAAAAAAAAAAGGATGTTAAGCCAGAAAATGAAGACAAAGTTTACTCTCTTCTATTAAACAAAGAGTCTTTAGTACTATAACATTTATGTCAAAAATAACTACAACTTTGAAAAGTCCTTCCTCTGGCCTGCTAAGAAGCTCACTGAAGACCCCAGCCTGAAGTTTGTAGCCATGCCTGCTCTTGCCCCACCACAGGTTTTCCTGGACCCAGCTTTGGCAGTGCAATATGAGCATGATTTAGAGGTTGCTCAGACAACTGCTCTCCTGGATGAGAAGGATGACCTGTGAGAAAATAAAGCTGGAGCCCAGAGTCAGAAGTCTAACTTCATAGGCAACTGTCCTGTGATGTCGTGGTTGAGCATGTTTGCCACTTTATTATACAGCTAAGCAGAAGGTCTGCTTTAACTTTGGGATACTGAAGGAGATAAATGGACTTCAGAGTAAATGTAACCACTAAAAAAAAATTTTTTTTGAGCCTGCATAATTAGCTGTTTTGGAACACAGCTGTTTCCTTCCTGAGTTTCAAACGCTGTATAAGACCTATACAGTCGCAACACAGTATTCAACAGTGAAATGTTTCTTACTCTTATTCTCATCCCTTTTTGTTTAGAATCATAATAAAGTTGTATTTCAAATATCTAA
>NM_006325.5
GAATTGCGCTTCCGCCATCTTTCCAGCCTCAGTCGGACGGGCGCGGAGACGCTTCTGGAAGGAACGCCGCGATGGCTGCGCAGGGAGAGCCCCAGGTCCAGTTCAAACTTGTATTGGTTGGTGATGGTGGTACTGGAAAAACGACCTTCGTGAAACGTCATTTGACTGGTGAATTTGAGAAGAAGTATGTAGCCACCTTGGGTGTTGAGGTTCATCCCCTAGTGTTCCACACCAACAGAGGACCTATTAAGTTCAATGTATGGGACACAGCCGGCCAGGAGAAATTCGGTGGACTGAGAGATGGCTATTATATCCAAGCCCAGTGTGCCATCATAATGTTTGATGTAACATCGAGAGTTACTTACAAGAATGTGCCTAACTGGCATAGAGATCTGGTACGAGTGTGTGAAAACATCCCCATTGTGTTGTGTGGCAACAAAGTGGATATTAAGGACAGGAAAGTGAAGGCGAAATCCATTGTCTTCCACCGAAAGAAGAATCTTCAGTACTACGACATTTCTGCCAAAAGTAACTACAACTTTGAAAAGCCCTTCCTCTGGCTTGCTAGGAAGCTCATTGGAGACCCTAACTTGGAATTTGTTGCCATGCCTGCTCTCGCCCCACCAGAAGTTGTCATGGACCCAGCTTTGGCAGCACAGTATGAGCACGACTTAGAGGTTGCTCAGACAACTGCTCTCCCGGATGAGGATGATGACCTGTGAGAATGAAGCTGGAGCCCAGCGTCAGAAGTCTAGTTTTATAGGCAGCTGTCCTGTGATGTCAGCGGTGCAGCGTGTGTGCCACCTCATTATTATCTAGCTAAGCGGAACATGTGCTTCATCTGTGGGATGCTGAAGGAGATGAGTGGGCTTCGGAGTGAATGTGGCAGTTTAAAAAATAACTTCATTGTTTGGACCTGCATATTTAGCTGTTTTGGAACGCAGTTGATTCCTTGAGTTTCATATATAAGACTGCTGCAGTCACATCACAATATTCAGTGGTGAAATCTTGTTTGTTACTGTCATTCCCATTCCTTTTCGTTTAGAATCAGAATAAAGTTGTATTTCAAATATCTAAGCAAGTGAACTCATCCCTTGTTTATAAATAGCATTTGGAAACCACTAAAGTAGGGAAGTTTTATGCCATGTTAATATTTGAATTGCCTTGCTTTTATCACTTAATTTGAAATCTATTGGGTTAATTTCTCCCTATGTTTATTTTTGTACATTTGAGCCATGTCACACAAACTGATGATGACAGGTCAGCAGTATTCTATTTGGTTAGAAGGGTTACATGGTGTAAATATTAGTGCAGTTAAGCTAAAGCAGTGTTTGCTCCACCTTCATATTGGCTAGGTAGGGTCACCTAGGGAAGCACTTGCTCAAAATCTGTGACCTGTCAGAATAAAAATGTGGTTTGTACATATCAAATAGATATTTTAAGGGTAATATTTTCTTTTATGGCAAAAGTAATCATGTTTTAATGTAGAACCTCAAACAGGATGGAACATCAGTGGATGGCAGGAGGTTGGGAATTCTTGCTGTTAAAAATAATTACAAATTTTGCACTTTTTTGTTTGAATGTTAGATGCTTAGTGTGAAGTTGATACGCAAGGAAAATGGTCCATGTTTACCCACAGTTTTCAGGTACTCCTAGACTTTAAAGATGTCTTGAACATTTAAGTTCTTCAGCAGTTCACACTACACCGTTTTTTTGTTTTTTTTTCCCCCCCGGGAGGGTTTTTTTGTAGGGCAGCACAGCAGAGCAGGACATGGATGAAATACTAGGAATATGCACAGTGGGGCAGTGTGGGGGCTTCTCAGTAATGGAGAACAGTTGGTGAAACTTTTTTTTTTTTTTAACTAAGCATTTAATTTATCTTGCATATTTTCCACATTTAAAAATGAATTAGGTCTATTAGGATAATTAGGAGTTTGATCCCATCAACACTATTCTTGTAGCAGTTAGGAATCTTGAGCTATTTTTTTCTCATACGATTACTATAGTCCAGTTTACCAAAGTTTTCTTTAGATGTCTGATAATCTTGAGATGATTGCTTACCTTAAAAGGTATAGAAAGGATCACTTAAATATATGGAAAAATGAAATAAGGGTGAAGCTGAATAAAGTTCTACTTACTGTATTAACTGGCAACAGTTGAGTTTCTTAAGATCTGAATTGCTGTGTATGTTACGCTGTATTCAGAACCAGTTTCTAACCAGCCTGTGAGATGGGAAGTTTTTTCCCCATAATTGGGATGAAACCTTTCATTCAGGTATTTTGAATTGAAGGTGTATGTGTTGTTTGTAACCTTGTGGAGATTGCAAGTGGTGTTGACATTCTGGATCTTCTATGTAACAGTTGAAATTTGGAAGTGACGTCACTTACCTGTCTAACGTGGTGTGGGAGAGAATTTACAAGTCCTTTATTGAAAGAATAATTGTTGCAAAATATATTGCTTCTACTTTGCCTGGA

Publications

PMID - Link Title