Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name OPHN1P1
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:23615105-23617229  UCSC
Coordinates (T2T) chr3:23620169-23622293  UCSC
Coordinates (hg19) chr3:23656596-23658720  UCSC
Strand -
Parental Sequence NM_002547.3
Parental seq. overlap 802 bp
Parental seq. overlap (%) 10.5%
Genomic Region Intergenic
Retrocopy Summary OPHN1P1, located on chr3:23615105-23617229, is a retrocopy of the parental gene OPHN1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name OPHN1
Full Name oligophrenin 1
Also known as ARHGAP41|MRX60|MRXSBL|OPN1
Coordinate chrX:68042344-68433841
Strand -
Gene summary This gene encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Rho proteins are important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis. Mutations in this gene are responsible for OPHN1-related X-linked cognitive disability with cerebellar hypoplasia and distinctive facial dysmorhphism. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes OPHN1P1
Bonobo Pan paniscus OPHN1P1
Gorilla Gorilla gorilla OPHN1P1
Orangutan Pongo abelii OPHN1P1
Gibbon Nomascus leucogenys OPHN1P1
Green monkey Chlorocebus sabaeus OPHN1P1
Crab-eating macaque Macaca fascicularis OPHN1P1
Rhesus Macaca mulatta OPHN1P1
Baboon Papio anubis OPHN1P1
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>OPHN1P1
GAAAAACCCAATAAGTATCAGTTATATGGGACGATAGGGCTGGATTCAGAGGGGAGCCCAGTTTTCAACTCTTCTTTGAAATTCCTGCTTCCTCAAAAGGCCACTGAGCTCTGAAAGATTTGGGACTAAAGACCTATCTCAGGAATCTTCCCCTGAGCTAAAGGCCACTTGAGTTGGGGCCATTACTTACCTTGGTTGGACGGGGGTAGCAATGCTTGATGCACATGGGAGAGTCTTAACATGCGTCTTACGGAGGAGATGGACACTGGTGCAGGGTTGGCACTCTGGTGCTGCATATGTTGCCAAGAGCCTGTCTGCTCCTACCGGGCCAGGTAGCATGAGTGATGCCCCCACAGCTCCTCCCTGTGGACTTAGGAAGGTGCCCCTACTCTTGCACAAAGCCACTTAGGGCAAATCTGCAGAGCATATTTTGCATGTCGAAGCATAGGTCTATTTGGATTATCCTTCTTCTATTTTCTCCTGACAGCTTCCTTTCCAAGAAATCAAGAAAGAAAACAAAAGCTAGTTCATTAAAAACAAAAAACATATAATTTACAAATTTAATTCCCACGCATATCATATTTGACTTGTATAGGAAAATAAAGATCCTGTTGCATCTTGAACATGATCTAGAAAAAATGTTTATACTAGAACCAGCTTCTTTGAACCAGCTTCCTGAAAAACAGGAAGTTCTCAAGGCCGACTTCCTGGAGATGGAAGCTGAGACTACAGATTGTAAAAGCCTTGGCCTCAGGGGACCATCTCCAGGTTCTGCAAGGGGCTTCTTCAAACCTCTGTGTGTGGAGTCATTTTGTGCTGAGGAGCAGCTCCTTCCTGGCCCTGCACCTTCAAGCTCTCCCTGGGATGCTACAACATAAGGGGCACACGTTCTAGACACATGTTTATTTTTATTTCTCTTTGGCATCCTGTCTTCATCCCCTCAGAAGGTCTGTCTTGAGTTCCTATAACACTGTGACTCGCTCAAGCCAGACTCTGCCAAAACCAAGATACCCACTTACCTGAGTGGAAGAGG
>NM_002547.3
AAGGAAGTCTTCCGCTCGCTCCGGAGCGAGGAGCCTGTAGAGAGGCTGTTCCCAGCTCCAGCTCTAACCTCGCCTACACCTTGGGCGGGCCCAAGTGTCACGTTTGCAATTGCTCAGGAAGGATCCGGCCCGTCTCCGGAGGCAAGTCGGGCTGCGGTTTTTGCTGCTTATCTGGGAAGGCGATGCCTAAGGGACATGCTGCTTGCTAGGCAGCACCCTGCCGGGATCCGACTGCGATAGTTAGCTCTCCCTGGCCCTGAAGCCATCGCCGGGGCGCCTGTTCTCTGTCCGGACCAGCCAGCGCTCCTCAGGAGTCTCACTGAAACAGAACCATGGGTCATCCCCCGCTGGAGTTCAGCGACTGCTACCTGGACAGCCCCGATTTCCGCGAGAGGCTCAAGTGTTATGAGCAGGAACTGGAGAGGACCAACAAATTCATCAAAGACGTAATCAAAGACGGCAACGCGCTTATCAGCGCTATGAGAAATTATTCTTCTGCTGTTCAGAAATTTTCCCAGACGCTGCAGTCATTTCAGTTTGATTTCATTGGAGACACTCTGACTGATGATGAAATTAACATCGCTGAATCCTTCAAGGAATTTGCTGAATTGCTCAACGAGGTAGAAAATGAGAGGATGATGATGGTACACAATGCTAGTGATTTGCTGATTAAACCCTTGGAAAATTTCCGGAAGGAACAAATAGGCTTCACCAAGGAGCGGAAAAAGAAATTTGAAAAGGATGGTGAGAGGTTTTATTCTTTACTGGATCGGCACTTACACCTGTCTTCAAAAAAGAAAGAATCTCAGTTACAAGAGGCAGACCTACAGGTGGACAAGGAGAGGCACAATTTTTTCGAGTCCTCTCTTGATTATGTTTATCAAATCCAGGAAGTTCAGGAGTCCAAGAAGTTCAATATTGTGGAGCCTGTCTTGGCCTTTCTTCATAGTCTGTTCATTTCTAACAGCCTGACTGTGGAGCTCACACAGGATTTCCTCCCATACAAACAACAGCTCCAACTCAGTTTACAGAATACAAGAAATCATTTCTCCAGTACCCGGGAAGAGATGGAAGAACTTAAGAAAAGGATGAAAGAAGCTCCCCAGACATGCAAACTTCCAGGACAGCCAACTATTGAAGGCTATCTCTATACACAAGAGAAATGGGCTTTAGGAATATCCTGGGTGAAATACTATTGCCAGTATGAGAAAGAGACCAAAACACTGACCATGACGCCTATGGAGCAGAAGCCAGGTGCTAAGCAGGGGCCCTTGGACTTAACACTGAAGTACTGTGTGAGAAGGAAGACGGAGTCTATCGACAAGAGGTTCTGTTTTGACATAGAAACTAATGAAAGGCCAGGAACCATCACTCTGCAGGCCCTTTCAGAAGCTAACAGAAGGCTATGGATGGAAGCCATGGATGGGAAAGAACCTATCTACCACAGCCCTATAACAAAACAGCAAGAAATGGAGCTAAATGAAGTGGGCTTCAAGTTTGTCAGGAAGTGCATCAATATTATTGAGACCAAAGGGATCAAGACAGAAGGGTTGTACCGCACTGTGGGCAGCAATATTCAGGTTCAGAAGCTGCTGAATGCCTTTTTTGATCCTAAATGCCCAGGAGATGTTGATTTTCATAATAGTGACTGGGACATTAAGACAATCACCAGCTCCTTGAAATTCTACCTCAGGAATCTTTCTGAACCTGTCATGACCTATAGACTTCACAAAGAGCTGGTCTCTGCTGCCAAGTCTGACAACCTGGATTACCGCCTAGGAGCTATTCACTCCCTGGTATATAAGCTACCAGAAAAGAACCGAGAGATGCTGGAACTTCTGATAAGACACTTGGTCAATGTGTGTGAGCACAGCAAAGAGAATCTTATGACCCCCTCCAACATGGGAGTAATCTTTGGGCCCACCCTGATGAGAGCTCAGGAGGACACTGTGGCCGCCATGATGAACATCAAATTCCAGAACATAGTGGTGGAAATACTAATCGAGCACTTTGGCAAGATCTATTTAGGTCCACCTGAGGAAAGCGCTGCACCGCCAGTGCCTCCGCCTCGGGTGACAGCAAGAAGGCACAAACCAATCACGATTTCAAAGCGCTTGCTGCGAGAAAGGACGGTTTTCTATACTTCTTCCCTGGATGAAAGCGAAGATGAAATCCAACATCAAACACCGAATGGTACTATCACCAGCAGCATAGAACCCCCCAAGCCACCACAACACCCCAAACTACCTATTCAGAGGAGTGGGGAAACTGATCCTGGGAGGAAGTCCCCAAGCAGGCCTATTTTGGATGGCAAGTTGGAGCCCTGCCCAGAGGTGGACGTGGGGAAGTTGGTGTCTAGGCTGCAGGATGGAGGGACCAAGATCACCCCAAAGGCCACCAATGGACCCATGCCAGGCTCTGGGCCCACCAAGACCCCCTCTTTCCACATAAAGAGACCAGCTCCCCGGCCCCTGGCCCACCACAAGGAGGGGGATGCTGACAGTTTCAGCAAAGTGCGGCCTCCAGGAGAAAAGCCAACCATCATCCGCCCCCCAGTGAGGCCCCCAGATCCTCCCTGCCGGGCAGCTACTCCCCAAAAGCCAGAACCAAAGCCAGATATTGTGGCTGGCAATGCGGGGGAAATCACATCATCTGTGGTGGCTTCCAGGACCAGGTTTTTTGAAACAGCTTCCCGGAAAACAGGAAGTTCTCAAGGCAGACTTCCTGGAGATGAAAGTTGAGGCTACAGGTTTTAAAAGCCTTGGCCTCAGAGGACCCTTTCCAGGTTCTGAAAGAGTCTTTCTTCTTCAAACCTTTGTGTGCGGAGTCATTTTGTGTTGAAGAGCAGCTCCTTCCTAGCCTTGCACTTTCAGACTCTCTCTGGGAGGCCATAAAATAAGGAGCATATGTCCTAGACAGGTGTTTATATCTCCTTTGTATTCTGTCTTCATCCCCTCAGAAGGTCTGTTTTGAGTTCCTATAACACTGTGAAGAGCTGGACTCCCTCAAGCCAGACTCTGCCAAAACCAAGATATCCACTTACCTGAGTTGAAGAGGGGAGCTCAGTTTTCAACTCTTCCCTGAACTTCCTGCTTCCTCAGAGGGCCATTGAACTCTGAGAGATTTGGGGCTAAAGACTGATCTCAGGGGTCTTACCTTGAACTGAAGGCCACTTGAGTTGGGGCCATTGCTTACCTTGGTTGGAAGGGAATAGAAATGTTTGCTGAACATTGGAGAATCTCAACATGTCTCCTACTGAGGATATGGACACTGGTGCCATGTCAGCGCTCTGGTGCTGCAGTATGTTGCCAAGAGCCCGTCTGCTCCTGCGAGGCTATGAGTGGGATGAGTGATGCCCCCACAGCACCTCCATGTGGACTTAGGAAGGTGGCCTTCCTGCTGTTACATGCAGCCACTTAGGACAAATCTGCAAAGCATGTTTTGCATGTAAAAGCCTAGGTCTATTTGGATTATTCTTTCTCCTTTTTTTTGACAGCTTCCTGTCAAGCAATCAAGAAACAAACAAAAGCTGAACACATTTCTTTTTAAAAAAAGGAGACTGTGTTTGGTCCTGTAGGAGTTCTATTTTGGGGTCAAATGCTAGAAAAATTGTTAAGGTGGATTGAGGCCAGGCAGCTGTCACTGCTGCTTCATGTTTGCCTTCTGCACATAAACTCTTTTATCTCCTGAAAAAAGCAgttcttaacccagtgtccatggactcagaaactccatgatgcccctgagatggtatgcacaattccatgacaatatgccctttctggggagatagtccataatgttctgctaaatttcaaatgggctcgtgacccaaaaaagtcaagaaccacAGCACTTGAGTAAAATACTCTTTTTACAATCCATATAAGCCCTTGATtggaagggcttttcaaaatcatttagtctaacaactgcccagtttccagtcgggggaactgaggcagagcaaggtagtgaTCACACCAGTACAAGATCTCAGGTCCCAGGCTCCTATGCAAGTTTTTTTTCCCCATTATATCACACTTATCTAGCAAGGGACCTTGTGGTTTGTGGCTTTAGTGGCCATCATTTCTGGGGGTTGGCTTTTACCCTTTTTCTTGAATATTTGCCACCAAGTGAAAAATGTTAGGACATAAACCCTTGCCAGGTCCCTTTCATTTGCTATCTCTATTATTGGAAAGGACCTAAAAATTGGTGTAATGGGGCAGAAATCTGAGGAATGGACATTTCTAATTCCTGTTTGTTGAAGGGAAGTTGCTGGAAAGAGCATCAGTACTTGTTTCTATGCAGATGCCTGGGCCGTAGCTTGTCTGTAGCGTCTGTATAATTATAATGTTGCCCAGTGTGAGGGAAAGAGCTTTCCTACTTGCACTCTTCTACCAAGGCCCTGTTAGTGCACTGATTATAGTACTGACAGATAAACCTAGATAAAGAGATAGAGAGTGAGTACATGCACACTCATGTGCAAACCCACTCAGAGATGCATTTGGAACAGTGCTACTGAAAGGCAGTAGTCATTTTCAAGACTGAATTCCAAACATGGTTTATTGGTGAGTTAGGAACATGTAAGGCCAAGTACACTGAGAGCCTTTTTGAAAGTAATTGAGTGGAAACTTGATGCCATTCTAAATCAAGGCATATCCAGGTGGCCCGGTTGAACTCACTCCACTGTACCCAGTCTCAAAGGCCAGGTTGCTAAGAAACCAGGAGTAAAAGAGTCAAGTGACCATCATTTCACCTGCTGCTTGCCCCCAATAGTAGTCTCTGTGAGGCCTTACTGACCTCACCTAGGAAGTGATTTTTGAGCCCTTGTTTCAGGGCTGTGGCCTCCCTGCTCTATCCTGAATAAAGCAGACAGGTGTGCAGATTTTGGCCATGAAAGCATGGCTAATAGGGCCACAGTCCCTTTAAAGAAACATGGTTTGACTCTGGTTTTCTTGGGGGAAAATACCACAATCACCGATGCAAACATTGGAAGATTATTGAGAGCCCTAGAAAGCTGCTGTGATCCCAGTAGAAAATATGTCCCAGAAATGTCATGAGATTGCTGTGTGTTGCCTGGGACACAGATCAAGGGCCTATCTTGGAGAGCTGGGGACCAGCAGTCTGCCTGGAGGCCAGGGAGCAGTGGCTGAGTAGCTCTGCCTTTGCTCTGGTCTATACCTTAAGAATGCCAAAGAATGAATTTCAACGCCTGCCTTTGGCACTCTGACTTAAAGTGCAAAAAGCTTCTGTGGCGAGGCATGCTATCATGGAATGAGACTGGCTTGCCCTAGGCTTAATGGATGGGCAGTCATTTTGCAGAGGCTATGGGAAGAGGGTGATAATAGAAGAGTGGCAGCTATAGGAAATTATCAACATACCTTGGCCAGCAAGTTAGAGAATCTGGCAATGGATGAACTGAAAGTGATGAACTGGCAGGGATAACAAAGAACCTAACATTTATTAAGCACGTATTTATTAACTGCTCAGTGTTTCATATTCATGCAAGTATTctcattttacagagaaagaaattatggcccagggggctaaagtaaacaactcaagggcacatagaaagtaaataaaaggactgtgatttgaatccaggccactcttagcccatgctgttttccctttgccacactgTGGTAGGTGTTTGAACAGAGGCCACATTACTAGAGTTGGCATGACTCTTGACTCTTGCCTGCCTAACAAAATATTGAAAGGCAAACATTTGAAGGAGGGAGGGGGTGCAGGTTCAGTTTATATGGAAATGCAAACTGGGCTGGAAGATATTCCTGAGTTAGGCTTTCTCTTCATATTCAGCTTGCACATTTGGTAATGTTTTTAAGATGATCATCTAATTTTATTTTGTGAAGTGAAGGATTTGTGTTTTAGTTGGCAGTTGTTAAGTCCTTGGCTTGCCATTTTTCAAAAAGTAAAAAGGTCCTCACAGGTGTCTCCATACTTCGCCAAGGTTGTAGCATGGGCAGTTTCAGTTTCAGCCTAAGAGACTGGTGACATCCACAAATGCAGTTTTAGAAGCAGAAAAGGTCTTGGTGCCTCTGCAGTACTTGATGTATTGGGGTCAAATCTCTACAAATTTTTCTGTGGTGATAGCAAAATCAAGAGATGGCTTACAAAAAGAAATATTGAATTTTTATTTTTGAAGTTTTTGTTTTTTAAAAGGTTGGGGGTGTTCAGCCACTGAGGGACAAAACTTAGCATCTAATTTCAATTATAGTGTCATGCAGAGTATTTCTAAAGTAATTGGTTATCATGGGAAAGTATTCTCTTTTCAAGAAGTTCTTTGATTCTGTAATAACTAGAACAAATAAAGTAGTAAAAGAAGAAATAGTTCTGTGACTAGGAAAAAATTGCTTTTGAGAGAACATAGATCAATTATACTACTTCTAAGGTAGCTGCAGATAAGTGGCCTTGACACATTACAAGCCTGGAAAAAAACATCAGAAATAATAAAAAATTTCAGAGAGAATCAAGATACCtttttttttcttttttttttcttttttttattatactctaagttttagggtacatgtgcacattgtgcaggttagttacatatgtatacatgtgccatgctggtgcgctgcacccactaatgtgtcatctagcattaggtatatctcccagtgctatccctcccccctcccccgaccccaccacagtccccagagtgtgatattccccttcctgtgtccatgtgatctcattgttcaattcccacctatgagtgagaatatgcggtgtttggttttttgttcttgcgatagtttactgagaatgatggtttccaatttcatccatgtccctacaaaggatatgaactcatcattttttatggctgcatagtattccatggtgtatatgtgccacattttcttaatccagtctatcattgttggacatttgggttggttccaagtctttgctattgtgaatagtgccgcaataaacatacgtgtgcatgtgtctttatagcagcatgatttatactcatttgggtatatacccagtaatgggatggctgggtcaaatggtatttctagttctagatccctgaggaatcgccacactgacttccacaatggttgaactagtttacagtccaaccaacagtgtaaaagtgttcctatttctccgcatcctctccagcacctgttgtttcctgactttttaatgattgccattctaactggtgtgagatgatatctcatagtggttttgatttgcatttctctgatggccagtgatgatgagcatttcttcatgtgttttttggctgcataaatgtcttcttttgagaagtgtctgttcatgtccttcgcGAAGGACAAGATACCTTAAAGATAAGTTTTCGATAAAGAAAAGCCTTCATTTTCCTGGGGGAAATGAAGCACTTGATGCCAAGGACATTAGTAGAGGGCTAGAAAGATTGCCTGTGTGAAAGACATATGCTATATCCAAATAATAAAACAAACGAGATCCTGGGGCTCATTCATGTGACTTTCAATAAAGTATGTAGACTGTCTAATATAA

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