Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TAF9BP1
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:25754901-25757540  UCSC
Coordinates (T2T) chr3:25757764-25760403  UCSC
Coordinates (hg19) chr3:25796392-25799031  UCSC
Strand +
Parental Sequence NM_015975.5
Parental seq. overlap 2259 bp
Parental seq. overlap (%) 83.9%
Genomic Region Intragenic (NGLY1)
Retrocopy Summary TAF9BP1, located on chr3:25754901-25757540, is a retrocopy of the parental gene TAF9B. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TAF9B
Full Name TATA-box binding protein associated factor 9b
Also known as DN-7|DN7|TAF9L|TAFII31L|TFIID-31
Coordinate chrX:78129748-78139650
Strand -
Gene summary Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TAF9BP1
Bonobo Pan paniscus TAF9BP1
Gorilla Gorilla gorilla TAF9BP1
Orangutan Pongo abelii TAF9BP1
Gibbon Nomascus leucogenys TAF9BP1
Green monkey Chlorocebus sabaeus TAF9BP1
Crab-eating macaque Macaca fascicularis TAF9BP1
Rhesus Macaca mulatta TAF9BP1
Baboon Papio anubis TAF9BP1
Golden snub-nosed monkey Rhinopithecus roxellana TAF9BP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TAF9BP1
CCGGATAACGAGTGGCTGGATAACATGGAATTGGGCAAGATGGCACTTCCCAAGAACGCTCCTAGGGATGCCTTGGTGATGGCACAGATCTCGAAGGATATGGGAATCACAGACTACAAACCAAAGGTTATAAATCAAATTTTGGAATTTGCTTTCCGAAATGTGACTACAATTCTGGATGATGCAAAAATTTATTCGAGCCATGCTAAGAAACCTAATGTTGATGCAGATGATGTGAGACTGGCAATCCAGTGTCGTGCTGATCTTTTTACCTCTCTTCCCCCAAGAGGTTTCTTACTGGATATTGCAAGGCAGAAAAATCAAACCCCTTTGCCACTGATTAAGCCATATGCAGGACCTAGACTCCCACCTGATAGATACTGCTTAACAGCTCCAAACTATAGGCTGAAGTCCTTAATTAAAAAGGGACCTAACCAAGGGAGGCTAGTTCTACGATTGACTGTTGGTGCTGTTAGTAGCAAACCTACCACTCCTACTATAGTGACCCCACAAACAGTGTCTGTCCCAAATAAAGTTTCAACTCCAATGTCAGTGACAAGCCAAAGATTTAACAGTGCAGATTCCACCTTCTCGGTCCACACCTGTCAAACCAGTTCCTGCAATAACTGCAGTTCAAAATGTTCCAACTAATCCCTCAATGATTGGGCCCAAAAATATTCTTATTCCCATCAACATGGTTTCATCATAGAACACAGCCAATGAAGCAAACCCACTGAAGAGAAAAACATGAAGATGATGATGACAATGATACTATGTAAGGAATTATAGTCTAGTCTAGATGCATTTCAAAAGGAAAGCTGGTTTTGAGCCCAATATACTGAACTAGAATATTCTAGATCTTCTCGTTTTACCTTAAAAGACTTTCATATTAGTTAAAACTGTTAGATCTCTTTAGTAAACACACAAAATGTGCTTTTCATTAGGCTTCAATTACAAACAGTTAAGTACTTGTTTCTTAATAGTTTCATTAATGTTGAGTCCTTATATGGCAATTCTGTTTTTGAGACACTTTTCTGCCTTTTATCACTGACAGCAGCACCTAAGTTTTAGGTTCTACAGCCTGGTCAGCAGATTTATCTTTTACAGCATGATTTCTAATCTACATTTAAATACTACTTTATTTTATAAGGTAATATAGCCACTTTTGTTGTCACTAGCTTTTTTATTTTTACCAAATCTCTCAATTTAGGAAACATTTTTGGAAAGAGTGGATTTAGAGGAGAGATTCTAAATCCATTTTGAATGTTTTTGTTTCTTGGCCTTCCTTAATTCCCCAACTGAACTCCCTTTCTAAATCCCATTCATTTTCTGCACCTACCCCATAGGTTTGTTTCTCTCCATTGTTCTTAAATGTAAAAGGCCATACCTGGAATTTAAAAAATATCATTCCTGGTAATACAGCTCAGTGTCATTTTCATATTTTTAAAACATTCTCTATATGCCTAATGTTTTGTGATTCACTTTAACCTGATGGCTTGCATTTGCTGTTTTTCACTCTATGTCAGAACAGTTGGGTTTTACTCCTTAGTTTTTATGCCTGTTGAGCTTTCTGTGCTTTTGACAGGTAGTTTTGGGTCAGTTACAGTTTTAGTCTTATATTCCAAGTTGATAACTCTACCATATTTCACATTTCTAAATTTAACAGAGATGCTATAGGTTAAAATTTGTTTTGATAAGTAATTACACTGGACCTAGGCAAAACCAATGAAGAACAAGTGTTTTCTTCCCTTTTACCACATACACGTATGTTTTGATCACTGCTGCTTGAGTCCTCCAATTGGTATAATTCAGATCACATTTTTAGCTAGTTGCTGAGGATATCACATATAAGATGGGATCAAACCTGAAAGTAAGACACTAATGGTTCTCCATCCTCTAAAAGGCCAACAAAGAAAATAAACTAGTGTGGCGTGATGTGACTTGCATTTATGTGCACTCTGCATTGGTTTCCCAATAATACTGTAATATTGCTGAACACTTTCCCAGTTTTCCTCTTATACACATCTTAAAGTCATATTGGGAAAGATGGAAAGCTTTCGAGAATATAAACAGACCTGTTTTGTTTTTCTTAAGTTCAACATATATTTGCAGACTTTTGTAAAATAAATGTTCATATCATAATTTAGAATTTATAGCCAAGGATCCTCAAAACAGAAGTTTCATCTTAGGCTAGTGCTTGATATATCTAAGAAAAAGTCCAGTAACAGAGAAGAAATGTCTCAAATGTCTCATCAGTTTTAAAGTTTTTTGATATTAGGGAAAGGTAATAGAAAAACAGGTAAAATGTATAAAAATAGACCTGATCAACTTCATAGGAGATAAATATTTGTTATATAGCATAGGATATCATTACTTGAATGTTCTCAGGGAGGAAGCAaATGTATTTGTTCCAAGGCTATTAATAAAAATTTGAGCTTA
>NM_015975.5
CTCTCCTCTGTCTCCGCGGATGACGAGTGGCTGGATAACATGGAGTCGGGCAAGATGGCGCCTCCCAAGAACGCTCCGAGAGATGCCTTGGTGATGGCACAGATCCTGAAGGATATGGGAATCACAGAGTATGAACCAAGGGTTATAAATCAAATGTTGGAATTTGCTTTCCGTTATGTGACTACAATTCTGGATGATGCAAAAATTTATTCGAGCCATGCTAAGAAACCTAATGTTGATGCAGATGATGTGAGACTGGCAATCCAGTGTCGTGCTGACCAATCTTTTACCTCTCCTCCCCCAAGAGATTTTTTACTGGATATCGCAAGGCAGAAAAATCAAACCCCTTTGCCACTGATTAAGCCATATGCAGGACCTAGACTGCCACCTGATAGATACTGCTTAACAGCTCCAAACTATAGGCTGAAGTCCTTAATTAAAAAGGGACCTAACCAAGGGAGACTAGTTCCACGATTAAGTGTTGGTGCTGTTAGTAGCAAACCTACTACTCCTACTATAGCAACCCCACAAACGGTGTCTGTCCCAAATAAAGTTGCAACTCCAATGTCAGTGACAAGCCAAAGATTTACGGTGCAGATTCCACCTTCTCAGTCCACACCTGTCAAACCAGTTCCTGCAACAACTGCAGTTCAAAATGTTCTGATTAATCCTTCAATGATTGGGCCCAAAAATATTCTTATTACCACCAACATGGTTTCGTCACAGAACACAGCCAATGAAGCAAACCCACTGAAGAGAAAACatgaagatgatgatgacaatgatattatgTAAGGAATATAGTCTAGTCTAGATGCATTTCAAAAGGAAAGTTGGTTTTGAGCCCAGTATACTGAACTAGAATATTCTAGATCTTGTTTTACCTTAAAAGACTGAAATGTAGCTGCAGTATTTTTCGTCAGTTAAAACTGTTAGATCTCTTTAGTAAACATACAAATGTGTTTTTCAGTAGGCTTCAATTACAAACAGTTAAGTACTTGTTTCTTAATAGTTTCATTAATGTTGAGTCCTAATATGGCAATTCTGTTTTTGAGACACTTTTCTGCCTTCTATCACTGATAGTAGCATTTAAGTTTCAGATTCTACAGCCTAGTCAGCAGATTTATCTTTGACAGCATAATTTCTGATCTACATTTAAATACTACTTTATTTTATAAGGTAATATAGTTACTTACTGTCACTAGCTAATTTTTTTTTTTTTACCAAATCTCTCAATATAGGAAACATTTTTTGGAAAGGATGGATTTAGAGGAGAGATTCTAAATCCATTTTGGATGTATTTGTTTCTTTGACTTCCTTAACTTCCAAACTCAACTCCCTTTCTAGATCCCATTCATTTTCTGCACCTCCCCCATAGGCTTGTTTCTCTCCATTGCTATTAAATGTAGAAGGCCATACCTGGAATTTTAAAAATATTATTCCTGGTAATACAGCTCAGTGTCATTTTCCTATTTTTAAAACATGCTCTACATGCCTAATGTTTTGTGATTCACTTTAACCTGATGGTTTGCATTTGCTGTTTTTCACTCTTATGTCAGAGCAGTTGGGTTTTACCCCTTAGTTTTTATGCCTGTTAAGCTTTACTGTGCTTTTGACAGGTAGTTTTGGGTCAGTTATATTCAGTTTTAGTATTGTATTCCAAGTTGATAACTCTTCCATGTTTCACATTTCTAAATTTAACAGAGATGCTGTAGCTTAAAACATGTTTTGATAAGTAATTACACTGGACCTAGGCAAAACCACTGAAGAACAAGTGTTCCTTTTTACCACATACATATTATGTTTTGATCACTGCTGCTTGAGCCCCGCTATTGGTATAATTCAGATCATTTTAGCTTGTTGCTGAGGATGTCACATATAAGACAGGATCAAACCTGAAAGACACTAATGGTTCATCCTCTATAAGGCCAACAAAGAAAACAAATTAATGTGATGTAACTTGCATTTATGTGCACTCTGCATAGGTTTCCCAATAATACTGTAATGTTGCTGAACACCTTTCCCTGTTTTCCATTTATACACATATTAAAGTCATATTGGGAAAGATGGCAAAGCTTTTGAGAATATAAACACACCTGTTTTGTTTTTCTTAAGTTCAACATACTTTTGTAGAATTTGTAAAATAAATGTTCGTATCATAATTGAGAATTTATAGCCAAGGATCCTCAAAACAGAAGTTTCATCTTAGGATAGTGTTTGATATATCTAAGAAAGTCCAGTAACAGAGAAGAAATGTCTCAAATGTCTCGTATCAGTTTTAGTGTTTTTCAGTATTAGGGAAAGGTAATATAAAAACAGGTAAAATGTATAAAAATAGACCTGATCAACATCATAGGAGATAAATATTCATTATATAGCATAGGATATTATTACTTGAATGTTCTCAGGGAGGCAGCAagtcagaaggcctaggttctagtcctagctccatcatttaccaactgtgtgaccttacttcacctcttagccttgttctcctcactagcagtaggaaagtaacacctaccctgcctacctcacagggctgttgtgagggttcaattggtatatgtgaaaattctttcagaattgtaaaatgctatatgactgtaaggaattattGCATTTGTTCCAAGGTTAATAAAAATTTGAGCTTA

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