Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name MESTP4
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:29087334-29089616  UCSC
Coordinates (T2T) chr3:29089358-29091640  UCSC
Coordinates (hg19) chr3:29128825-29131107  UCSC
Strand +
Parental Sequence NM_177524.2
Parental seq. overlap 2030 bp
Parental seq. overlap (%) 81.9%
Genomic Region Intergenic
Retrocopy Summary MESTP4, located on chr3:29087334-29089616, is a retrocopy of the parental gene MEST. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MEST
Full Name mesoderm specific transcript
Also known as PEG1
Coordinate chr7:130486175-130506465
Strand +
Gene summary This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15. [provided by RefSeq, Dec 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MESTP1
Bonobo Pan paniscus MESTP1
Gorilla Gorilla gorilla MESTP1
Orangutan Pongo abelii MESTP1
Gibbon Nomascus leucogenys MESTP3
Golden snub-nosed monkey Rhinopithecus roxellana MESTP1
Marmoset Callithrix jacchus MESTP6
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MESTP4
AGCATGCACAACCGGTTCCCCCAAACATGGAGTCCTGCAGCCCAGTTCTTACCTGAATCAGGATGGAGGGTGTGGTGGGTCCAAGTGGAGCTGTTGGCCATGTGCCTACTTGCTGCGTACCTGCAGATCCCACTCCCTCAGGTCTCCCTGGCCCTTCACTCTTGGAAGTCTTCAGGCAAATTTTTCACTTACGAGGGACTGCATATATTCTACCAAGACTCTGTGGGTGTGGTTGGAAGTCTGGAGATAGCTGTGCTTTTACACAGCCTTCCAACATCCAGCTATGATTGGTACAAGATTTGGGAAGGTCTGACCTTGAGGTTTCATCAAGTTCTTGTGCTTGATTTCTTAGGCTTTGGCTTCAGTGACAATCCACAACCACATCACTATTCCATATTTGAGCAGGCCAGCATTATGGAAGTGCTTTTGTGGCATCTGGGGCTCCAGAACCACAGGACCAACCTTTTGTCTCATGACTATGGAGATATTGTTGCTCAGGAGCTCCTCTACCAGTACAAGCAGAATCAATCTGGTAGGCTTACCATAAAGAGTATCCATCTGTCAAATGGAGGTATCTTTCCTGAGACTCACCGTCCACTCCTTCTCCAAAAGATACTCAAAGATGGAGGTGTGCTGTCACCCATCCTCACGTGGCTGATGAACTTCTTTGTATTCTCGATGTCTCACCCCAGTCTTTGGGCCATGTACTTGGCCCTCTGAGAGTGAGCTGTGGGATGGTACATGTGGGCAGTCCCATCCCACAGCTGCAACAATGATGGGAACTTAGTCATTGTCAATCTCTTACAGTACATCATCAATCAGAGAAGTTTAGAAGACACCGAGTGGGAGCTCTTGCCTCTGAAACTAACCCCATTGATTTTATCTATGAGCCACTGGATCCTGTAAATCCCTATCCAGAGTTTTTCGAGCTGTACAGGAAAATGCTGTCACGGTCCATGATGTCAATTCTGGATGACCACATTAGCCACGATCCACAGCTAGAGGATCCCATGGGCTTCCTGAATGCATACCTGGGCTTCATCAAGTCCTTTTGAGTTGGAAAGAGTAGATTCACTGTATTACCTCCCCTACCCCCTTATCCATTGCGTATTCCACTTAAGAAGAAATGCCCAAAAGAGGTCCTGGCCATCAAACACTGTTCTCTCACAAAGTCCACTTTACTCAAATTGGTGAACAGTATATAGGAAGAAGCCAGCAGGAGCTCTGGCTAAGGTTGACATAATAGTCCACCTCCCATTACTTTGACATCTGATCAAATGTACAGACTTGCCTTTGTTTTTATGTTTCTAGGAAATTCTGATTAGTACTACTATTCACTGATGCAGAAAGACATTCTTTTGCATAAAAGACTGTTTAACACTCTGGACTTTTCTAAAGTATTTAGTAGTGCTAATTTCTGGCCCAGCCCTAATAGGAATTCTGCGGTAAGAATGATGAGAAGGGCCTCCTTCCTTCTCCTCGAATGGCTTTATGCGCACATGCTTTTTAAAAGTTCTTTAAGCAAGACAGAGCTGAGTCTTATTTGTCATACCTTGGGATTTAGTTTCACCAGCTGTTTTTAATTATAAACATAGCATTAAAATAGATATTGGTTTAAATAATGTAGTATTCTTAGTATGATTTAAGACTTATGATTTACCTACATATTATACATATTTGATAAGAATGCTAAATCAATATACCCTTACTCTGCCAGTGAACATAATTAAACATGTTTCATTTCTGAATAAATTTAAGTAGATCCAAACTATTTACTGAATTTACTAAAATCACAGGACATTAAGGACCAGTAGCATCTATGCCAGAGATTTACCGTTATTGCCAGTAAGACCGATTCTAACAGCAAATAACAGTCTGAGACTCCTCATACCTCAGTGCTTAGAAGCATGTCTCTCTTGAGCTACCATAGAGGGGAACGGATGGTTTTGTTGTCCAAGCCACCATATGCAACGTACATTGATTCCTTTATGATGACTGCTTAACTCCCCATTGCCTGTCCCAGAGAAGCTTTCTCATGTAGCTTGGTAATTCCTGTACTTTACAGACAGAAAAGTTCCAGAAACTTTAAGAACAAATTCTGAGAGACCTATGAGCAAATGATGCTGAATACTTTTTTTAAGCCACATTTCACTGTCTTAGTCAAAGCAGGATTATTAAGTGACTATTTAAAATTCATTTTTTAAATTAGCAACTTCAAGTATGGCAACTTTGAGACTGGAATAAGTATTTATTTTCTGTAAATAAAAATGAATTG
>NM_177524.2
GGCGCTGACGCCTGGCAGGGAGAAGGCGGCAGCACATGCTGGGCTCGGGGGCGATGGGCTTGTGCGCGGACCTGGCGACGCTCTAGCCCCGAGCCGCGTATTCGTGGCCGGGTCCTCCCTGGGAACAGGGTGAAGGCCGAGAACCTCTGGCCTCAGGAAGCGCATGCGCAACCGGTTCTCCGAAACATGGAGTCCTGTAGGCAAGGTCTTACCTGAATCAGGATGAGGGAGTGGTGGGTCCAGGTGGGGCTGCTGGCCGTGCCCCTGCTTGCTGCGTACCTGCACATCCCACCCCCTCAGCTCTCCCCTGCCCTTCACTCATGGAAGTCTTCAGGCAAGTTTTTCACTTACAAGGGACTGCGTATCTTCTACCAAGACTCTGTGGGTGTGGTTGGAAGTCCAGAGATAGTTGTGCTTTTACACGGTTTTCCAACATCCAGCTACGACTGGTACAAGATTTGGGAAGGTCTGACCTTGAGGTTTCATCGGGTGATTGCCCTTGATTTCTTAGGCTTTGGCTTCAGTGACAAACCGAGACCACATCACTATTCCATATTTGAGCAGGCCAGCATCGTGGAAGCGCTTTTGCGGCATCTGGGGCTCCAGAACCGCAGGATCAACCTTCTTTCTCATGACTATGGAGATATTGTTGCTCAGGAGCTTCTCTACAGGTACAAGCAGAATCGATCTGGTCGGCTTACCATAAAGAGTCTCTGTCTGTCAAATGGAGGTATCTTTCCTGAGACTCACCGTCCACTCCTTCTCCAAAAGCTACTCAAAGATGGAGGTGTGCTGTCACCCATCCTCACACGACTGATGAACTTCTTTGTATTCTCTCGAGGTCTCACCCCAGTCTTTGGGCCGTATACTCGGCCCTCTGAGAGTGAGCTGTGGGACATGTGGGCAGGGATCCGCAACAATGACGGGAACTTAGTCATTGACAGTCTCTTACAGTACATCAATCAGAGGAAGAAGTTCAGAAGGCGCTGGGTGGGAGCTCTTGCCTCTGTAACTATCCCCATTCATTTTATCTATGGGCCATTGGATCCTGTAAATCCCTATCCAGAGTTTTTGGAGCTGTACAGGAAAACGCTGCCGCGGTCCACAGTGTCGATTCTGGATGACCACATTAGCCACTATCCACAGCTAGAGGATCCCATGGGCTTCTTGAATGCATATATGGGCTTCATCAACTCCTTCTGAGCTGGAAAGAGTAGCTTCCCTGTATTACCTCCCCTACTCCCTTATGTGTTGTGTATTCCACTTAGGAAGAAATGCCCAAAAGAGGTCCTGGCCATCAAACATAATTCTCTCACAAAGTCCACTTTACTCAAATTGGTGAACAGTGTATAGGAAGAAGCCAGCAGGAGCTCTGACTAAGGTTGACATAATAGTCCACCTCCCATTACTTTGATATCTGATCAAATGTATAGACTTGGCTTTGTTTTTTGTGCTATTAGGAAATTCTGATGAGCATTACTATTCACTGATGCAGAAAGACGTTCTTTTGCATAAAAGACTTTTTTTTAACACTTTGGACTTCTCTGAAATATTTAGAAGTGCTAATTTCTGGCCCACCCCCAACAGGAATTCTATAGTAAGGAGGAGGAGAAGGGGGGCTCCTTCCCTCTCCTCGAATGACGTTATGGGCACATGCCTTTTAAAAGTTCTTTAAGCAACACAGAGCTGAGTCCTCTTTGTCATACCTTTGGATTTAGTGTTTCATCAGCTGTTTTTAGTTATAAACATTTTGTTAAAATAGATATTGGTTTAAATGATACAGTATTTTAGGTATGATTTAAGACTATGATTTACCTATACATTATATATATTTTATAAAGATACTAAACCAGCATACCCTTACTCTGCCAGAGTAGTGAAGCTAATTAAACACATTTGGTTTCTGAATAAATTGAACTAAATCCAAACTATTTCCTAAAATCACAGGACATTAAGGACCAATAGCATCTGTGCCAGAGATGTACTGTTATTAGCTGGGAAGACCAATTCTAACAGCAAATAACAGTCTGAGACTCCTCATACCTCAGTGGTTAGAAGCATGTCTCTCTTGAGCTACAGTAGAGGGGAAGGGATTGTTGTGTAGTCAAGTCACCATGCTGAATGTACACTGATTCCTTTATGATGACTGCTTAACTCCCCACTGCCTGTCCCAGAGAGGCTTTCCAATGTAGCTCAGTAATTCCTGTTACTTTACAGACAGGAAAGTTCCAGAAACTTTAAGAACAAACTCTGAAAGACCTATGAGCAAATGGTGCTGAATACTTTTTTTTTAAAGCCACATTTCATTGTCTTAGTCAAAGCAGGATTATTAAGTGATTATTTAAAATTCGTTTTTTTAAATTAGCAACTTCAAGTATAACAACTTTGAAACTGGAATAAGTGTTTATTTTCTATTAATAAAAATGAATTGTGACAAAAGTGGA

Publications

PMID - Link Title