Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CBX3P10
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:36878853-36880446  UCSC
Coordinates (T2T) chr3:36880211-36881794  UCSC
Coordinates (hg19) chr3:36920344-36921937  UCSC
Strand -
Parental Sequence NM_007276.5
Parental seq. overlap 1049 bp
Parental seq. overlap (%) 44.9%
Genomic Region Intragenic (TRANK1)
Retrocopy Summary CBX3P10, located on chr3:36878853-36880446, is a retrocopy of the parental gene CBX3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CBX3
Full Name chromobox 3
Also known as HECH|HP1-GAMMA|HP1Hs-gamma
Coordinate chr7:26201443-26213607
Strand +
Gene summary At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CBX3P3
Bonobo Pan paniscus CBX3P3
Gorilla Gorilla gorilla CBX3P2
Orangutan Pongo abelii CBX3P2
Gibbon Nomascus leucogenys CBX3P3
Rhesus Macaca mulatta CBX3P1
Baboon Papio anubis CBX3P1
Golden snub-nosed monkey Rhinopithecus roxellana CBX3P1
Marmoset Callithrix jacchus CBX3P13
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CBX3P10
AGTTTTCTTTCTTTTTTTTTTTAAACAATTGCCAAAACCAAAGTCCCAGGTAAGCCCATGTTTCTAATATGCCATCATTCTGAGCAATGTAAGAGATAAATCACTTCCAGATAAATTGAAAATTTTCCTGAAGCCATGTGTATCAAGTGAAATAAATGATTCTAATTAATCAGACAATTTAAATTGATATTTTAAAAGCATTTATATATAAAAATGCAATGGTTTGTTAGCAAAATTCCTTAAAGAAAAATTTTATTGTTGCCAACAACCCAGCAGCCTCCCTATCCAGATGAGGAAACTAGGAAAATCCTAGTACGTTTTAATCTTTATCTCACAGTAAATCTGATGAGAGCAAATCAAAGGAAAGAGATGCTGCTGAGAAACCAAGAGGGCTGGCTAGAGGTCTTAATCCTGAAAGAATAATTGGTGCCACAGACAGCAGTGGAGAATCGATGTTTCTCATGAGGTGGAAAGACTCAAATGGGGCCAACTTGATGCTGGCAAAAGAGACAAGTGTGAAGGGTCCTTAAATTGTAATTGCTTTTTATGAAGAAAGACTAACTTGGCATTCTCGTCCAGAAGATGATGTAATTGTTCACATTGTTTTAtatatatatatatttatgtttatatatatttatatgtttatatatatttatatatgtttatatatatttatatatgtttatatatatttGCATGTTTACATATATTTGTATGTTTACATATATTTGCATGTTTACATATATTTGCATGTTTACATATATTTGCATGTTTACATATATTTGCATGTTTACATATATTTGCATGTTTACATATATTTGCATGTTTACATATATTTGCATGTTTACATATATTTGCATGTTTACATATATTTGCATGTTTACATATATTTGTATGTTTACatatatttgtatatttacatatatttgtatatttacatatatttgtatatttacatatatttgtatatttatatatttacatatttatatatatttatatatatttatatatatttatatatttgtatatttatatatatttatatatttatatatttatatttatatttatatatttatatatttatatatttatatatatttatatatttatatatatttgtatatttatatatatttatatatatttgtatatttatatatatttatatatttgtatatttatatatatttatatatttatatatttatatagatatatttataCAAAATCTGGGTCTTGGTTTTTTATTTGCTAGTGTGAAGAAATAACTACATTCTAATGAAAATCAAGTTTGATATGTTCATTTTGAAATGGTATTGGGAGAGTTGTTGGGTTTGTTGTTTTTTTTCATCAGTAGAACTGGTTACTTTGAACAAAGAAACAAAAGCTCTCTGTAGTTGCTTCCTTTATCAGTAAAGAGCATTCAATACCATGGTATATTATTTCCTCTGCAGTAGGGAACAGATTTTCTAAATGTTGGGGAAAATTCTCATAGTCATTAATCATAACTTGGCTTCTCATAAGCCTAAGGATCATTCTGGTTGTTTt
>NM_007276.5
GCGCCAGCCGCTGAGGCTGCCAAGCAGAAAAGCCACCGCTGAGGAGACTCCGGTCACTGTCCTCGCCCCGCCTCCCCCTTCCCTCCCCTTGGGGACCACCGGGCGCCACGCCGCGAACGTAATAGCTCTTCAAGTCTGCAATAAAAAATGGCCTCCAACAAAACTACATTGCAAAAAATGGGAAAAAAACAGAATGGAAAGAGTAAAAAAGTTGAAGAGGCAGAGCCTGAAGAATTTGTCGTGGAAAAAGTACTAGATCGACGTGTAGTGAATGGGAAAGTGGAATATTTCCTGAAGTGGAAGGGATTTACAGATGCTGACAATACTTGGGAACCTGAAGAAAATTTAGATTGTCCAGAATTGATTGAAGCGTTTCTTAACTCTCAGAAAGCTGGCAAAGAAAAAGATGGTACAAAAAGAAAATCTTTATCTGACAGTGAATCTGATGACAGCAAATCAAAGAAGAAAAGAGATGCTGCTGACAAACCAAGAGGATTTGCCAGAGGTCTTGATCCTGAAAGAATAATTGGTGCCACAGACAGCAGTGGAGAATTGATGTTTCTCATGAAATGGAAAGATTCAGATGAGGCAGACTTGGTGCTGGCGAAAGAGGCAAATATGAAGTGTCCTCAAATTGTAATTGCTTTTTATGAAGAGAGACTAACTTGGCATTCTTGTCCAGAAGATGAAGCTCAATAATTGTTCACATTGTTCTTTtatatatatttatatatatatataAAAATTGGGTCTTAGATTTTGATTTACTAGTGTGACAAAATAACTACATCCTAATGAAAATCAAGTTTGATATGTTTGTTTTGAAAGTAGCGTTGGAAGAGTTGTTGGGGGTTTTTTGCATCCATAGCACTGGTTACTTTGAACAAATAAATAAAAGCTTTCTGTAGTTGCTTCCTTTATCAGAAAAGAACATTTGATACCATGGTATATCATTTCCTCTTCATTAAAGAACAGCTTTTCTAAATGTTGGGGGAAATGTCCATAGTCATTACTCAGTCAAAACTTGTGTTCTCATGAGCCTAAGGACCATTCTAGATTTATTACGTGTTTTTtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtATCCATAAAATGCATATGTAAATTTTTTTTTGTTTTTAAGCATTCACCCAAACAAAAAAATCACAGGTAAACCCATGTTTCTGAGATGCCATTATTCCAAGCAAAATAAGAGATAATCCCTTCAAGTTAAATTGAAAATTTTCCTGAAACCATACATTTCAAGTGAAATAAGTAATTCTAGATAGGACAATTTAAATTGGATAATTTTAAAGTGTCTATAATTGCAGTGGTTTATTTGCAAAATTCCTAAAAGGAAAAATTTTATCACTGCCATCACAGCAGGTTTCCTCATCCAGATGAGGAAACTAGACAAATGCTAGTGTGTTTTAACTAGCTAAACAAAACTAAGTTAAATGAACATTTAAAAGTTTCCCTAGCGGGCCATTCCTTAGCAAAATGTTGGAATCCCTGTTGCTACATTGACTAAAAGGTCATGATGAATGGAATATGTAAGACTTGGCTCATAGAAACCTAATCAGATGGTTAGAGGTGTTGGCAGTTTAGGACCTGCTGTCATAAATGTGTGAACAACCTTTTGTAACCTAACCTATTGACCTGCATGTTTTTTCTTTACCCCAATTCATTACATGGAGGCTCAATCTTGAGTTTGCTTTACTGGTTCAGCAAAAGCCAGGAAGAACAACTTTGTAGTAATCAAAATGTTATCCAACTGTATATTGTTTACTTTATTGTAAATACTGGTGAACAGTGGTTAATAAATAGTTTTATATTCCTTTATGCAATTATTAGACTTTTTTCTTTATTTGATATGCCTTTACAGTAGAAATAGAAATGCCCACACTCATTGGATTATCTTTGTTTATAAGTTAGATGATACCAGTAAGGCATTACAGTACATATCCTAGATCTTTTGAGCTTACGAGTTTTAAACTTGAATATGTATTTCCACAGGAATGTTTCCACAGTTGGGAAATAAAAGTTTCATGTGATGCCTAGGGTCAATTGTCTCATTAAAATGAGGTTTTAAATTCTG

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