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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CDC42P7
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:38270349-38270829  UCSC
Coordinates (T2T) chr3:38276059-38276539  UCSC
Coordinates (hg19) chr3:38311840-38312320  UCSC
Strand -
Parental Sequence NM_044472.3
Parental seq. overlap 415 bp
Parental seq. overlap (%) 28.8%
Genomic Region Intragenic (SLC22A13)
Retrocopy Summary CDC42P7, located on chr3:38270349-38270829, is a retrocopy of the parental gene CDC42. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CDC42
Full Name cell division cycle 42
Also known as CDC42Hs|G25K|TKS
Coordinate chr1:22052709-22101360
Strand +
Gene summary The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CDC42P1
Bonobo Pan paniscus CDC42P1
Gorilla Gorilla gorilla CDC42P1
Orangutan Pongo abelii CDC42P1
Gibbon Nomascus leucogenys CDC42P2
Green monkey Chlorocebus sabaeus CDC42P3
Crab-eating macaque Macaca fascicularis CDC42P1
Rhesus Macaca mulatta CDC42P1
Baboon Papio anubis CDC42P1
Golden snub-nosed monkey Rhinopithecus roxellana CDC42P1
Marmoset Callithrix jacchus CDC42P11
Mouse lemur Microcebus murinus CDC42P1
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CDC42P7
GGAGAAGCTGAGGTCAACATCAAGTTCGAAATATTTAAAGTAAATACAAAACTATTTCAGCAATGCAGACCATTAAGTGTGCTGTTGTAAGCAATGATGCCATTGGTAAAACATACCGATATCCTACACAACAAACAAATTTACATCTGAAAATGTACCAACTATTTCTAACAACTATGTGGTCATGGTTATGGTTGGTGGAGAGCCATATGCTCTTGGACTTTTTGACACTTCTGGGCAAGAGGGTTATAAAAGATTGCAATTGCTAAGTATCTACAAACAGATGTATTTCTAGTCAGTTTTTCAGTGGTATCTCCGTCCTCATTCAAAAATGTGAAAGAAAAGTGGGTGCCTGTGATAACTCACCGCTATCCAAAGATTCCTTTCTTGCTTGTCGAGACCCAAATTCATCTCAGAGAATGATCCCTCTACTCTTGTAAAACTTGCCAAGAACAAAAAACAGAAGCCTATCACTCCAGAC
>NM_044472.3
GCAGTGCTGCCAACGCCCCGGTGGAGAAGCTGAGGTCATCATCAGATTTGAAATATTTAAAGTGGATACAAAACTATTTCAGCAATGCAGACAATTAAGTGTGTTGTTGTGGGCGATGGTGCTGTTGGTAAAACATGTCTCCTGATATCCTACACAACAAACAAATTTCCATCGGAATATGTACCGACTGTTTTTGACAACTATGCAGTCACAGTTATGATTGGTGGAGAACCATATACTCTTGGACTTTTTGATACTGCAGGGCAAGAGGATTATGACAGATTACGACCGCTGAGTTATCCACAAACAGATGTATTTCTAGTCTGTTTTTCAGTGGTCTCTCCATCTTCATTTGAAAACGTGAAAGAAAAGTGGGTGCCTGAGATAACTCACCACTGTCCAAAGACTCCTTTCTTGCTTGTTGGGACTCAAATTGATCTCAGAGATGACCCCTCTACTATTGAGAAACTTGCCAAGAACAAACAGAAGCCTATCACTCCAGAGACTGCTGAAAAGCTGGCCCGTGACCTGAAGGCTGTCAAGTATGTGGAGTGTTCTGCACTTACACAGAGAGGTCTGAAGAATGTGTTTGATGAGGCTATCCTAGCTGCCCTCGAGCCTCCGGAAACTCAACCCAAAAGGAAGTGCTGTATATTCTAAACTGTTTTCTCCTTCCCTTCTTTGCTGCTGCTTCCTGTCCCACTACTGTAGAAAGATCGTTTAAAAACAAAGGAATAAAACCATCCTGTTTGAAAGCCTCTGCGTCTTTTTACTCACCACCTTAGAGCAACCTCTGTATTAGTTTTTGATCAAGAATGCAATATCATATAAATTTTTTGTGATCAGTAGTCAAGTTGGACTTGTTTTAACGTTCTGCTGCTTGAGTTGCCTGATGCTCAGAGCTTTTTGGTTTGGATTACTATTGCAAAAGGGAACTTGGTCTGGCTTTAAGAATGTCCTCTTGGAGAAAATAACAAGAGTTTTAACACTTCTAGATCTTAGTTCTAGATGGAGAAAGTAACACAAACATCATTTTACTCTTATGATCAATTGTTAATTGTAATTGCATGACAAACCTTATGGAAAAGGGGTGACCTAGTAGAGTGTAATGGGGAAGGGAGGATTCTTTTCTGGTTTTCCTTTGTGCGGTGAAACTTTGTGTTGCTGTTGCTTTGGCTGTCTGTGCTGTAGTGGAGTATTTGTCAGTCTGGGGTGGGGAAGATATTGATGTATCTGCTACTGCTTTATGAGTTCATTTGTTACATTATCTTTTAAGAATAACATCCATTTAAACAGTTGACTTACAGTTTGTTAATGCTGAGATGTAAAGCTGCCACCTTTATATTTTCCTGCTTCTGATTTTATTGTGAGGGAAATATACAATTGTGGTTACCTTCAAATTTTGAAATTAAAAATATACAACCGTTTGTATAAA

Publications

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