Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DSTNP4
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr20). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:39214112-39214749  UCSC
Coordinates (T2T) chr3:39227048-39227685  UCSC
Coordinates (hg19) chr3:39255603-39256240  UCSC
Strand +
Parental Sequence NM_006870.4
Parental seq. overlap 566 bp
Parental seq. overlap (%) 16.6%
Genomic Region Intergenic
Retrocopy Summary DSTNP4, located on chr3:39214112-39214749, is a retrocopy of the parental gene DSTN. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DSTN
Full Name destrin, actin depolymerizing factor
Also known as ACTDP|ADF|HEL32|bA462D18.2
Coordinate chr20:17569173-17609919
Strand +
Gene summary The product of this gene belongs to the actin-binding proteins ADF family. This family of proteins is responsible for enhancing the turnover rate of actin in vivo. This gene encodes the actin depolymerizing protein that severs actin filaments (F-actin) and binds to actin monomers (G-actin). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DSTNP1
Bonobo Pan paniscus DSTNP1
Gorilla Gorilla gorilla DSTNP1
Orangutan Pongo abelii DSTNP1
Green monkey Chlorocebus sabaeus DSTNP4
Crab-eating macaque Macaca fascicularis DSTNP1
Rhesus Macaca mulatta DSTNP1
Golden snub-nosed monkey Rhinopithecus roxellana DSTNP1
Gibbon Nomascus leucogenys Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DSTNP4
ACGCAGCTGTGAAGAGGACACTCCGCAGACTCGGTGCCCACCAGCGGCCTCCCCTGTGTCCCTGTGACCGTGGCGGCAAAGACGGACTCAGGAGTGCAAGTTGCTGATGAAGTATGTCACATTTTTTGTGACATAAAAGTTCATAAATGCTCCACATCAGAAGAAATCAAGAAAAGAAAGAAGACTGTCATTTTTTGTCTCAGTGCAGACAAAAAGTGCATCATTGTAGAAGAGGGCAAAGAGATCTCAGCTGGAGATATTGGTGTAACCATAACTGGTCCTTTCAAGCACTTTGTGGGAATGCTTCCTGAAAAAGATTGCTGCTATGCTTTATATGATGCAAGCTTTGAAACGAAGAAATCCGGAAGAGTATTGTTTGTTTGTTTGTTTTTGTGGGCACCAGAACTACCACCTCTGAAAAGTAAAATGATCTTCACAAGCTGTAAGGATGCAATCAAAAAGAAATTTCAAGCAAATGGACCAGAAGATCTCAACTGGGCTTGTATTGCTGAAAAGTTAGATGGGTACTTAATTGCAGCTTTTGAAGGATGCTCTGTGTAGGCCATCATTCAGTGCCACAAATGGAAAGCTTCCATGTTTAATGTTATCCGCTTGCTATATAAATAAAGCAAACATAT
>NM_006870.4
GCCCCGGGGTAAGCTCGCGCCGCCGCGTCAGCTCAGCGCTGGGTCTCTCGGTCCCGCAGCCGTGAGGAGGACGGTCTGCATACTCGCTGCCCGCCGGCTCCCTCCCCCGCGTCCCTGCGACCGCCGCGGCGAAGATGGCCTCAGGAGTGCAAGTAGCTGATGAAGTATGTCGCATTTTTTATGACATGAAAGTTCGTAAATGCTCCACACCAGAAGAAATCAAGAAAAGAAAGAAGGCTGTCATTTTTTGTCTCAGTGCAGACAAAAAGTGCATCATTGTAGAAGAAGGCAAAGAGATCTTGGTTGGAGATGTTGGTGTAACCATAACTGATCCTTTCAAGCATTTTGTGGGAATGCTTCCTGAAAAAGATTGTCGCTATGCTTTGTATGATGCAAGCTTTGAAACAAAAGAATCCAGAAAAGAAGAGTTGATGTTTTTTTTGTGGGCACCAGAACTAGCACCTCTGAAAAGTAAAATGATCTATGCAAGCTCCAAGGATGCAATTAAAAAGAAATTTCAAGGCATAAAACATGAATGTCAAGCAAATGGACCAGAAGATCTCAATCGGGCTTGTATTGCTGAAAAGTTAGGTGGATCCTTAATTGTAGCCTTTGAAGGATGCCCTGTGTAGATTATTCAGTGCCACAAATTGAAAGCTTCCATGTTTAATGTTATCCTCTTGCTATATAAATAAAGCAAATATATTTAGGCCAGGGTCTCACTGAGGGGGAGCTGTCTTGTCATCTTTTAGAGTAAACTATTCTATAAACATATGCAAACAGCCCTAAATAAATCTAAAGTCTAAAGTTTTATTGATGTGAAATTAAATTCTTATTGGCCAAATGCCTGTTTTGATGAGTTGATTTATAAAGATTTTTGTTAAGCTCAGGATTTTAAATTACACAGTTCACAAACAGTAAAGGCCATGTGAAGAGAATTATTACATCTTTATTAACCTCAGCATTTACTTTGTTTCTTTTGCTTAGGAAATTGCTCATAATCTGGTTATAATTTTGGTCCAAATTCTTTATTCTTCCTTGAGCTAAGCAGAATAATGGAATATAATATGTCTTCATAATATAACAACACTAATACACTAATAGTAAGATTAAGTTAGGCAGTCTTCTACCAAATGTGTAATGGAGATTGCCTCAAAATTGTGTCCACATAATCCACGCTCATCTTGCAAAGCGCTATTTCAGGCACATCATTGGAATACAGGAAGTAGCCCTGCACCTGCCAGTGAGCTCGCCATTCACTGATTGGAAGAGTGACCTGGCATCTTGGAAATCATTGTGTGTCTTCAGGAGAATGTGCAGTGTCTTGTAACAACTAATTATAATGCAAATTAGGGCTACATTGTAATCTGCTTTGTTAATGAAAATGATAAAACAGAATATTGACAAGCTAGGACACCTGTGGTATCTTTAATTGTATCTCCTTCAGAAGTTTGCTTCTTATGGTATAATAAAGTATGGAAGAATATTGAGTATATGTTTACTCTGGGCCTGGGAGAACTTAACTTTCTAGAGCAGTTTGTTGACTTGTGTGCAATGGGGAGAGGTACCATGATGACACTCACAGGGAGCCACTGTTCACTGACACTTGGAAGCGGTCATTGTTAATATCACGGGCGTAACACTTTGAACGATATAGAGATGCACAAACAGTTGAACTTAGAAGTAGCAGTATTGGCTTTATGTAATAAAGGAAGCATTTTTGACTTACCTCTCGTGTAATTTTCATGTGTGAATTGGGAATACAGGATTTTGCCTTCCATATGGGGTAAGGCATTGAGGTTTGGGTATTTCCAATAATTAAGAGTTAAGGTTggctgagtgtggtggctcactcctgtaatcccagcattttgggaggccgaggcaagaggatagtttgaggccaggagtttgacaatcagcgtgggcaacatagtgggatctcatctactaaaaataaacaaaattagccgggtgtggtggtgcacgtcagtagtcccagctactttggatgctgaggtgggaggatcacttgagcccaggaggtgagctgagatcgtgccactgtactccagcctggatgacagagcaagaccttgtctcaaaaaaaaaaaaaaaaGTCACAACTCCCTCTGGTGAATAAGAAAGTTGGTGTAAAAGTTGGGAACGTTTTCAATGTTTATTACACTATAAGTGTAAtaaatattatacaaaattataaattcacatttaaaatttagaaAATAGAGAAAAGGGAAATTATACATTGTCCTACCACATGCCATCACATGGTTAGCATTTTGATACACAGCTGTGCATTATTACATGTCAAAgactgcatatactatggtggtcccatacaattataatgtattttctactgtaattagatacacaaataccattgtgttacagttgccgacagtattcagtatagtaacgtgctgtccaggtttgtggtctaggagtaataggctctaccatacagcctaggtgtgtagtaggctatgccactaggtttaagtgcagtctagggtgGGGAACATTTTAATGTTGATCCACATGCCAGGTGTTTGTGAGACAAGATTATGCTTTAATCAAAATATTTTGGAATTGTCTAGAAAATAGTGCTGGCTGCTTGTCATTCATCCTGAATTGCTTGTTTCTTTACTTTGTAGCAATGCTTTTAGTGTGGGttttgttttttgagacagggtctcactctttcccccaggctagagtgcagtggtgcaatcataactcactgcatccttgaactcttgggctccagcaagcctcctgccttggcctcctaaagtgctgtgattacaggtgtgagccactgtgtcctgcTAGTGATTGTGATTAACAGGCCTCCAGGGAAGTGCCATAAGCCCAAGACTGCCGTACTCAAAAGTCAGCCATGTAGGTAAAGCAAGATATTTGGTCAAGGAGTTTTAGAAGGAGATTTTTCCTGTGGTGTTGGCTTAAGTGTGGCACTGTTGTGCGTGTGTGAGGTGTCTTCTGTGGGAAGGATTTCAAACAGTACAAAGGGATGTGATGTAAGCATCCAGAACTCACTCCAGAAATTGAATAAAATGCTAGTAGTTAGTCTCTAGGGGAACTTTTGAGAAAGTCTCAGTGGATTCCtgaggcccaagaattgtgctaacaagcactcaaggcgattctggtacataattagggttcagaCCTCAGCTGATTGGTCTACTGTTGGTCAGGAACAAAACTGCAAGTATACTCTGTTTCCAGAAAATACGTTTACCTCTTCACAAATGCTAACACACTGCAAAAATATGTTTGTGGAAAGCTGACTTAGTCTCATCTAGCGGTTACTCTCTTGCCCTGACAAAGCAGCAAATAAAGCCATTGCTAACAATTCAA

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