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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name NFU1P1
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Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:39644040-39644809  UCSC
Coordinates (T2T) chr3:39657013-39657782  UCSC
Coordinates (hg19) chr3:39685531-39686300  UCSC
Strand +
Parental Sequence NM_015700.4
Parental seq. overlap 710 bp
Parental seq. overlap (%) 52%
Genomic Region Intergenic
Retrocopy Summary NFU1P1, located on chr3:39644040-39644809, is a retrocopy of the parental gene NFU1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NFU1
Full Name NFU1 iron-sulfur cluster scaffold
Also known as CGI-33|HIRIP|HIRIP5|MMDS1|NIFUC|Nfu|NifU
Coordinate chr2:69395750-69439567
Strand -
Gene summary This gene encodes a protein that is localized to mitochondria and plays a critical role in iron-sulfur cluster biogenesis. The encoded protein assembles and transfers 4Fe-4S clusters to target apoproteins including succinate dehydrogenase and lipoic acid synthase. Mutations in this gene are a cause of multiple mitochondrial dysfunctions syndrome-1, and pseudogenes of this gene are located on the short arms of chromosomes 1 and 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NFU1P1
Bonobo Pan paniscus NFU1P1
Gorilla Gorilla gorilla NFU1P1
Orangutan Pongo abelii NFU1P1
Gibbon Nomascus leucogenys NFU1P1
Green monkey Chlorocebus sabaeus NFU1P2
Crab-eating macaque Macaca fascicularis NFU1P2
Rhesus Macaca mulatta NFU1P2
Baboon Papio anubis NFU1P1
Golden snub-nosed monkey Rhinopithecus roxellana NFU1P1
Marmoset Callithrix jacchus NFU1P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Massive Mining of Publicly Available RNA-seq Data from Human and Mouse - (ARCHS4)

Related Sequence

>NFU1P1
aCAGCCTCTGCATCAATTTGTAGAAAGACTACTCTTCCCACTACCTGCAGCCTTTTGTAACCCAGTGAGATACATGTTTATTCAAACACAAGATATCTCAAATCCTAACAGTTTAAAGTTTATACCATGAAAACCAGTTTTTGAGACAAGGCCCATGGATTTTCCCACCCCAGCTGCAGCATTTTGCTCCCCTTTGGCTAGGCAGTTATTTAGGATTGAAGGAGTAAAAAGTGTTTTCTTTGGGCCAGATTTCATCACTGCCACAAAGGAAAATGAAAAATTAGACTGGAATTTACTGAAACCAGATATTTACGCAACAACCACGGACTTCTTTGCATCTGGTTTACCCCTAGTTACTGAGGAAACATCTTCAAGGAGAAGCAGGATGTGAAGATGATGAAGTTGTGGCATTGATTAAGGAAGTGTTAGATACTAGAATGTGGCCAACTGTGCAAGAAGATGGAGGAGACGTAATCTACAAAGGTTTTGAAGATGGTATCGTATGACTGAAACTCCAGGGTTCTTGTACCAGCTGCCCTAGTTCAATCATTACTCTGAAAAATGGAATTCAGAACATGCTGCAGTTTATATTCCAGAGGTAGAAGGTGTAGAACAGGGTATGGATGATGAATCAGATGAAAAGGAAGCAAACTCACCTTAAAATAATCTGGATATTCTTTGGGTACAATAGTCGGACTTATCGATAATATATACCAAGCTGTTATTATTAATATGCTGAAGAACTTGAAGATTAATAAAATATGC
>NM_015700.4
ACTCCGGACTAAGATGGCGGCGACGGCCAGGCGGGGCTGGGGAGCTGCGGCTGTTGCCGCCGGGCTGCGCAGGCGGTAGGTGACGAGCCTGGAGCTCCGAATAGGTGTGCCGCTGGGCTTAGCCAGCGGAGCGGTCGCCGCCTTGCAGACCCTCTCTCGAGGCGGGTTCTGTCATATGTTGAAGAATCCATACACCATTAAGAAACAGCCTCTGCATCAGTTTGTACAAAGACCACTTTTCCCACTACCTGCAGCCTTTTATCACCCAGTGAGATACATGTTTATTCAAACACAAGATACCCCAAATCCAAACAGCTTAAAGTTTATACCAGGAAAACCAGTTCTTGAGACAAGGACCATGGATTTTCCCACCCCAGCTGCAGCATTTCGCTCCCCTCTGGCTAGGCAGTTATTTAGGATTGAAGGAGTAAAAAGTGTCTTCTTTGGACCAGATTTCATCACTGTCACAAAGGAAAATGAAGAATTAGACTGGAATTTACTGAAACCAGATATTTATGCAACAATCATGGACTTCTTTGCATCTGGCTTACCCCTGGTTACTGAGGAAACACCTTCAGGAGAAGCAGGATCTGAAGAAGATGATGAAGTTGTGGCAATGATTAAGGAATTGTTAGATACTAGAATACGGCCAACTGTGCAGGAAGATGGAGGGGATGTAATCTACAAAGGCTTTGAAGATGGCATTGTACAGCTGAAACTCCAGGGTTCTTGTACCAGCTGCCCTAGTTCAATCATTACTCTGAAAAATGGAATTCAGAACATGCTGCAGTTTTATATTCCGGAGGTAGAAGGCGTAGAACAGGTTATGGATGATGAATCAGATGAAAAAGAAGCAAACTCACCTTAAAATAATCTGGATTTTCTTTGGGCATAACAGTCAGACTTGTTGATAATATATATCAAGTTTTTATTATTAATATGCTGAGGAACTTGAAGATTAATAAAATATGCTCTTCAGAGAATGATATATAAATATTGCATGTTTGCTTTACCTCATATGAGTTATTTATAACCTCTTGAATCATCTTCTGTACACGTGGATTTTATCCAAGGATATTTTTATTTTTGTCCCTCATTTCCCATGGCTCTTTCTTTGCATATGTGTGAAGGAGTTTAAAATACATTTCCCCCCATCTAATTTATTTACTTTTTTCCATACAGGAAGAAACAGAATGCTTTTTAGAATATTCTAAAATAGCTTTTTGTGAAATATCTAAAACTATTTTTACTGAAGTTTTTAGCTTAAGAAACAGCTAAACAAGtctgttttaaaaatggtatctggctactagcccccaattaagtagcaaagaactgcttaagaccaaaaaaaagaaatcaaa

Publications

PMID - Link Title
No publications available for this retrocopy