Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PNPT1P1
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:3980564-3984291  UCSC
Coordinates (T2T) chr3:3976516-3980242  UCSC
Coordinates (hg19) chr3:4022248-4025975  UCSC
Strand -
Parental Sequence NM_033109.5
Parental seq. overlap 3013 bp
Parental seq. overlap (%) 65.9%
Genomic Region Intergenic
Retrocopy Summary PNPT1P1, located on chr3:3980564-3984291, is a retrocopy of the parental gene PNPT1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PNPT1
Full Name polyribonucleotide nucleotidyltransferase 1
Also known as COXPD13|DFNB70|OLD35|PNPASE|SCA25|old-35
Coordinate chr2:55634061-55693851
Strand -
Gene summary The protein encoded by this gene belongs to the evolutionary conserved polynucleotide phosphorylase family comprised of phosphate dependent 3'-to-5' exoribonucleases implicated in RNA processing and degradation. This enzyme is predominantly localized in the mitochondrial intermembrane space and is involved in import of RNA to mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency-13 and autosomal recessive nonsyndromic deafness-70. Related pseudogenes are found on chromosomes 3 and 7. [provided by RefSeq, Dec 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PNPT1P1
Bonobo Pan paniscus PNPT1P1
Gorilla Gorilla gorilla PNPT1P1
Orangutan Pongo abelii PNPT1P1
Gibbon Nomascus leucogenys PNPT1P1
Green monkey Chlorocebus sabaeus PNPT1P1
Crab-eating macaque Macaca fascicularis PNPT1P1
Rhesus Macaca mulatta PNPT1P1
Baboon Papio anubis LOC101023568P1
Golden snub-nosed monkey Rhinopithecus roxellana PNPT1P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PNPT1P1
CAGTTTTAAATCTCATAAAAAATAAGTAAATCTGGCTCCGGCCGCTGAGTGATGGTCCCTTCTGTCTGCCAGGGTGGGATCGGGCACTCATCCAGTTGCAGGTGCGAGCACTATTGAGTAGCACAGGGTCTCAAGCTGTGGCCATGGACTTGGGCAACAGGAAATTAGAAATATCCTCTGGAAAGCTGGCCAGATTTGCAAATGGCTCTGCTGTAATACAGTCAGGTGACACTGCGGTAATGGCCACAGCCGTCAGTAAAACAAAACCTTCCCCTTCCCAGTTTATGCCTTTGGTGGTTGACTACGGACAAAAGGCTGCTGCAGTAGGTAGAATTCCCACAAACCCTCTGAGAAGAGAGATTAGTACTTCTGATAAAGAAATTCTTACACGTTGAATAGTAGATTGTTCAGTTAGACCTATCTTTCCAGCTGGCTACTTCTGTGATATACAGGTTCTGTGTAATCTGTTAGCAGTAGATGGTATTAATGAACTTGATGTCCTAGCAATTAATGGCAACCTCTGTAGCCCTCTCATTATCAGATATTCTTTGGAATGGACCTGTTGGGACAGTATGAATAGGAATGACTGATGGAGAATGTGTTGTTAACCCAACAAGAAAAGAAATGTCTTCTAGTACTTTAAATGTAGTGGTTGCTGGAGCACCTAAAAGTCAGACTGTCATGTTGGAAGCCTCTGCAGAGAACATTTTACAGCAGGACTTTTGCCACGCTATCAAAGTGGGAGTGAAATATACCCAGCAAATAATTCAGGGCATCCAGCAGCTGGTAAAAGAAATTGGTGTTACCAAGAGGACACCTCAGAAGTTATTTACCCCTTCACAAGAGATTGTGAAACATGCTCATAAACTCACTATGGAGAGACTCTATGCAGTTTTTACAGATTATGAACATGATAAAATTTCCAGAGATGAAGCTGTTAACAAAATAAGATTAGATACAGAGGAACAACTAAAAGAAATATTTCCAGAGGTCGATCTATATGAGATAATAGAATCCTTCAATACTGTTGCAAAGAAAGTTTTTAGAAGTATTATTTTGAATGAATACAAAAGATGCGATGGTCGGGATTTGACTTTACTTCGGAATATAAGTTGTGAGGTAGATATGTTTAAAACCCTTCATGGATCAGAATTATTTCAAAGAGGACAAACACAGCTGCTTTGTGCTGTTACATTTGATTCATTAGAATCCAGTATTAAGTTGGATCGAGTTATAACAACTATAAATGGGATAAAAGATAAAAATTTCATGCTGCACTATGAGTTTCCTCCTTATGCAACTAATGAAATTGTCAAAGTCACCGGTATAAATAGAAGAGAACTTGGGCCTGATGCTCTTGCTGAGAAAGCTTTGTATCCTGTTATTCCCAAAGATTTTCCTTTTGCCATAAGAGTTACATCTGAAGTCCTAGAGTCAAATGGGTCATCTTCTATGGCATCTGCATGTGGTGGAAGTTTAGCATTAATGGATTCAGGGCTTCCAATTTAATCTGCTGTCACAGGTGTAGCAATGGGATTGGCCACCAAAACCGATCTTGAGAAGGGTGAAATAGAAGATTATCATTTGCTAACAGATATTCTGGGAATTGAAGCTTACAATGGTGACATGGACTTCAAAATAGCTGGCACTAATAAAGGAATAACTGCATTACAGGCAGATATTAAATTACCTGGAATAACAATGAAAATTGTAATGGAGGCTATTCAACAAGCTTCAGTGGCAAAAAGGAGATTTTACAGATCATGAACAAAGCTATTTCAAAACCTCAAGCATCTAGAAAAGAAAATGGACCTGTTGTAGAAACTGTTCAGGTTCCATTATCAAAATGAGAAAAATTTGTTGGACCAGGTGGATATAACTTAAAAAACTTCAGGCTGAAACAGTTGTAACTATTAGTCAGGTGGATGAAGAAACGTTTTCTATATTTGCACCAACACCCGGTGCTATGCATGAGGCAAGAGACTTCATTGCTGAAATCCGCAAGGATGATCAGGAGCAGCAATTAGAATTTGGAGCAGTGTGTACTGCCACAATAACTGAAAGCAGAGATACTGGTGTAATGGTAAAATTATATCCAAATATGATTTTGGTACTGCTTTATAACACACAACTTGATCAATGAAATATTAAACATCCTACTGCCCTAGGATTAGAAGTTGGCCAAGAAATTCAGGTGAAATACTTTGGATGTGACCCAGCTGATGGAAGAATGAGGCTTTCTCATAAAGTGCTTCAGTCTTCAGCTACAACTGTTGTCAGAACTTTGAATGACAGAAGTAGTATTGTACTGGGAGAACCTATTTCACAGTCATCATCTAATAATTCTCAGTGATCTTTTTAAAGAGAATTCTAGAATTCTATGTTTTCTAGGGTAATGTGCTATAGAGCAAAATTTTAGTAGTATCTTCCGTTGTGTAGCTGTGTATACAGTATAAATATATTCTAATTATTTGTATTAAAATGCTCATTTACATGTGCCAATTTTTAAATTCAAGAGTAACCCATATTCGCTTAATCTTATTTACATTATAAATCAAGAAATATTATTAAAAGTAAGTCATCCATACATCTTAGAAAAGATTACATACTTTTTTTTCTATAATTCTGAAATATATGAAAAACTTAGATATATGTCATATATGTTATTATAACAGATCTCTTCCTATATCTCATTTGTCTTCTTTATATACAGTAGTGACAATTTACCCTCAGTCATCCTATAGCTCACCTCTTTGCCCAACAACTTTACTTGCCTACGACTGTTCACAAACTGGAACAGGCCATATTCAAAGCCAGTGCCTATTTCTTCAGAATGGTTACTAGACATAGTAAGTTGAGGGAGCTAATCTGATACACTTTTAATAATACGATGCCTTCCAAGTTGGTTACAAAATCATGAACATAGTGGAATAAATATAAATGAGATTCTAACTAGGATGAGGTAGTAATTATGTATATTTTTCAAATTTACCTAAACATAGGAAAATTATTTACTTGTCTAATTGAACTAGGTCACTTTTTGAATATGTATATTGCTCTAATGTATGGAAGTTCTTAGTATAAGAGCTGGAGGAATCATCACTTTCAGTTAATAGATGTTTGAAATAGATGTTTAGAGGTTACTGATATACATGTCAACTTGTTCATTCCCATCATTTAAAATATCACCTTATAATTCCACACAAAAGTAAATGGTATGTGGACGTCATAATTTAGAATATGTTATCTTTTTAAAAATCTt
>NM_033109.5
GTTGACCGCGTGCCGGGTGTCATGGCGGCCTGCAGGTACTGCTGCTCGTGCCTCCGGCTCCGGCCCCTGAGCGATGGTCCTTTCCTTCTGCCACGGCGGGATCGGGCACTCACCCAGTTGCAAGTGCGAGCACTATGGAGTAGCGCAGGGTCTCGAGCTGTGGCCGTGGACTTAGGCAACAGGAAATTAGAAATATCTTCTGGAAAGCTGGCCAGATTTGCAGATGGCTCTGCTGTAGTACAGTCAGGTGACACTGCAGTAATGGTCACAGCGGTCAGTAAAACAAAACCTTCCCCTTCCCAGTTTATGCCTTTGGTGGTTGACTACAGACAAAAAGCTGCTGCAGCAGGTAGAATTCCCACAAACTATCTGAGAAGAGAGATTGGTACTTCTGATAAAGAAATTCTAACAAGTCGAATAATAGATCGTTCAATTAGACCGCTCTTTCCAGCTGGCTACTTCTATGATACACAGGTTCTGTGTAATCTGTTAGCAGTAGATGGTGTAAATGAGCCTGATGTCCTAGCAATTAATGGCGCTTCCGTAGCCCTCTCATTATCAGATATTCCTTGGAATGGACCTGTTGGGGCAGTACGAATAGGAATAATTGATGGAGAATATGTTGTTAACCCAACAAGAAAAGAAATGTCTTCTAGTACTTTAAATTTAGTGGTTGCTGGAGCACCTAAAAGTCAGATTGTCATGTTGGAAGCCTCTGCAGAGAACATTTTACAGCAGGACTTTTGCCATGCTATCAAAGTGGGAGTGAAATATACCCAACAAATAATTCAGGGCATTCAGCAGTTGGTAAAAGAAACTGGTGTTACCAAGAGGACACCTCAGAAGTTATTTACCCCTTCGCCAGAGATTGTGAAATATACTCATAAACTTGCTATGGAGAGACTCTATGCAGTTTTTACAGATTACGAGCATGACAAAGTTTCCAGAGATGAAGCTGTTAACAAAATAAGATTAGATACGGAGGAACAACTAAAAGAAAAATTTCCAGAAGCCGATCCATATGAAATAATAGAATCCTTCAATGTTGTTGCAAAGGAAGTTTTTAGAAGTATTGTTTTGAATGAATACAAAAGGTGCGATGGTCGGGATTTGACTTCACTTAGGAATGTAAGTTGTGAGGTAGATATGTTTAAAACCCTTCATGGATCAGCATTATTTCAAAGAGGACAAACACAGGTGCTTTGTACCGTTACATTTGATTCATTAGAATCTGGTATTAAGTCAGATCAAGTTATAACAGCTATAAATGGGATAAAAGATAAAAATTTCATGCTGCACTACGAGTTTCCTCCTTATGCAACTAATGAAATTGGCAAAGTCACTGGTTTAAATAGAAGAGAACTTGGGCATGGTGCTCTTGCTGAGAAAGCTTTGTATCCTGTTATTCCCCGAGATTTTCCTTTCACCATAAGAGTTACATCTGAAGTCCTAGAGTCAAATGGGTCATCTTCTATGGCATCTGCATGTGGCGGAAGTTTAGCATTAATGGATTCAGGGGTTCCAATTTCATCTGCTGTTGCAGGCGTAGCAATAGGATTGGTCACCAAAACCGATCCTGAGAAGGGTGAAATAGAAGATTATCGTTTGCTGACAGATATTTTGGGAATTGAAGATTACAATGGTGACATGGACTTCAAAATAGCTGGCACTAATAAAGGAATAACTGCATTACAGGCTGATATTAAATTACCTGGAATACCAATAAAAATTGTGATGGAGGCTATTCAACAAGCTTCAGTGGCAAAAAAGGAGATATTACAGATCATGAACAAAACTATTTCAAAACCTCGAGCATCTAGAAAAGAAAATGGACCTGTTGTAGAAACTGTTCAGGTTCCATTATCAAAACGAGCAAAATTTGTTGGACCTGGTGGCTATAACTTAAAAAAACTTCAGGCTGAAACAGGTGTAACTATTAGTCAGGTGGATGAAGAAACGTTTTCTGTATTTGCACCAACACCCAGTGCTATGCATGAGGCAAGAGACTTCATTACTGAAATCTGCAAGGATGATCAGGAGCAGCAATTAGAATTTGGAGCAGTATATACCGCCACAATAACTGAAATCAGAGATACTGGTGTAATGGTAAAATTATATCCAAATATGACTGCGGTACTGCTTCATAACACACAACTTGATCAACGAAAGATTAAACATCCTACTGCCCTAGGATTAGAAGTTGGCCAAGAAATTCAGGTGAAATACTTTGGACGTGACCCAGCCGATGGAAGAATGAGGCTTTCTCGAAAAGTGCTTCAGTCGCCAGCTACAACCGTGGTCAGAACTTTGAATGACAGAAGTAGTATTGTAATGGGAGAACCTATTTCACAGTCATCATCTAATTCTCAGTGATTTTTTTTTTTAAAGAGAATTCTAGAATTCTATTTTGTCTAGGGTGATGTGCTGTAGAGCAACATTTTAGTAGTATCTTCCATTGTGTAGATTTCTATATAATATAAATACATTTTAATTATTTGTACTAAAATGCTCATTTACATGTGCCATTTTTTTAATTCGAGTAACCCATATTTGTTTAATTGTATTTACATTATAAATCAAGAAATATTTATTATTAAAAGTAAGTCATTTATACATCTTAGAAAAAATTACATAGTTTTGTTTTTACAATTCTGAAATATATGAAAAACTTAGATAGAATATGTCATATGTTATTATAACAGATCTCTTCCTACATCTTATTTTTCTTCTTTGTATACAGTAGTGACAGTTTACCTTCAGTCATCCTACAGGTCACCTCTGTGCCCAACAACTTTACTTGCCTACAACGGTTCACAAACTGGAACAGGCCATATTCAAAGCCAGTGCCTATTTCTTCAGAACTGTTAACAGATATAGTGAGTTGAGGGAGCTAATCTGATACACTTTTGATAATATAATGCCTTTCAAATTAGTTACCAAATCATAAACAGAGTGGAATAAATATAAATGAGATTCTAACTAGGATGAATGTGGTAGTAATGATGTATATTTTTCAAATTTACCTAAACAGAAAGATTATTggctaaggcaggcggatcatgagatcaggagatcgagaccatcctggctaacacggtgaaaccccgtctctactaaaagtgcaaaaattagccgggcgtggtggcgcatgcctgtaatcctagctactcaggaggctgaggcagaagaatcacttcaacccaggaggtggaggttgtagtgagccgagattgcgccattgcactccagctcaggcaacaagagcaaaactccgtctcaaaaaaaaaaaaaaaaTTGTTTACTTATCAAATTGAACTAGGTCAATTTGAATATGTGTATTGCTCTAATGTATGGAAGTTCTTAGTATAAGAGCTGAAGGATCATGACTTTCGGTTAATAGATGTTTGAAATAGATGTTTAGAGGTTACTGATACACATGTCAAGTTGTTCATTCCCATCATTTAAAATATCACCTTATAATTCCACAGAAAAGTAAATGGTATGTGGACGTCATAATTTAGAATGTGTAATCTTTTTTAAAATCTtataaaaatacactggactcagtggtacgtgcctgtagtcccagctacttggaaggctgaagtgggaaggtcactagagcccagaagttcgacactgtagtgtgcaacaatcatacctgtgaatagctactgtactccagcctgggcaacatagcaggactcttatctctaaaaaaaaTTTTAAATCTTATAAAAATGTAGGTATATCTggccaggcatggtggctcacacctgtaatcccaacactttgggaggtcaaggcgggtagatcacctgaggtcaggagttcgagaccagcctggccaacatggtgaaaccccatctctactaaaaatacaaaaattagctgggtgtggtggcgggcgcctgtaatcccagctactcaggaggctgaggcaggagaatctcttgaacctgggaggcagaggtggcagtgagctgagatcgcaccactgcactccagcctgggcaaaaagagtaaaactccatctcaaaaaaaaaaaTGGTgggcacagaagctcatgcctgtaattccagcactttgggaggccgaggcgggtggattacatgaggtcaggaattcaagaccagcctggccaacacggtaaaaccccatctctactaaaaatacaaaaattagctgggcatggtggcaggcacctgtaatcctagctactcgggaggctgaggcaggagaatcacttgagcctgggaaatggaggttgcagtgagccgagattgcgccattgcactccagcctgggcgacagagcaagactccgtctccagaaaaaaaaaaaaaaaaGGTAAATTCATGACTCAGGGTTAACTAGTTCATAAAATATTACAAATTTATCTGGCTAAACCAAAGATTTTTAAGTCAATAAACATTGATTATATATCTATTGTGTGTAAAATAGCATGTTAGGCAATGTTGATATACTTCTGaaatattaaagattaattgaaaatgaaagattaaatttaTTTGCTTTCTACACTTGA

Publications

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