Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name EI24P3
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:44523972-44525823  UCSC
Coordinates (T2T) chr3:44539713-44541562  UCSC
Coordinates (hg19) chr3:44565464-44567315  UCSC
Strand -
Parental Sequence NM_004879.5
Parental seq. overlap 1188 bp
Parental seq. overlap (%) 45.3%
Genomic Region Intergenic
Retrocopy Summary EI24P3, located on chr3:44523972-44525823, is a retrocopy of the parental gene EI24. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name EI24
Full Name EI24 autophagy associated transmembrane protein
Also known as EPG4|PIG8|TP53I8
Coordinate chr11:125569216-125584684
Strand +
Gene summary This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes EI24P3
Bonobo Pan paniscus EI24P3
Gorilla Gorilla gorilla EI24P3
Orangutan Pongo abelii EI24P3
Gibbon Nomascus leucogenys EI24P1
Green monkey Chlorocebus sabaeus EI24P4
Crab-eating macaque Macaca fascicularis EI24P2
Rhesus Macaca mulatta EI24P1
Baboon Papio anubis EI24P2
Golden snub-nosed monkey Rhinopithecus roxellana EI24P2
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>EI24P3
GGTCTGAAGAGATGGGACAGGAAGAAAGAGAAAGACCTCACAGCCAGATCTTCAGACCTTCTGGGTTTTGGGGAGAGATTTTCTTTCTTCCCTTTGAAGGAGAAAAAGCTATTTTCACTGGTACATTTAAACTCCCCCAACTAGGCAGAGGTACCAATTCTGGACAAGTGCCACTGCAACACACAGCGATTTTTCTAGCATTTGCCAGTCCCTATGGCTGGATTGATTTGAATATTTTGTTTTTCTCCCTGTGCCATTTACCTTCCCACCTTTCCTTCCTGCCTTCTACCACCCTTGGGTGAATGAAATTTGTAATTCCAGCTGTTGCATTTTGTGGATTTGTTATTTTTGTCGTTTTTCTGTGAAGCACAAACATTGGATGTGGGAGGTAAAGGAGTGTCTCAGTTGCTCCTGGTCACTCCCTTTATAGCCATCACTGTCTTGTTTCTTGTAACTCAAGTTAGGTTTTGGTCTCTCTTGCTCCACTGCCTCCTTCATGATGAGAGATTGGGGGCACTTATATCTCCTCTGCGTAGTTGATAGTTTGGGTACTGACGACATGGCTGACAGTGTCAAAACCTTTCTCCAGGACCTTTCCAGGGGAGTCAAAGACTTCATCTGGGATATTTGTACCATCTCCAGCTAGACACTCCAATCCATCAAAAGAGGGGAGCAGCGTGGAAGAAGGGCAAGCATTGTCCTGGCACAGAGAATACCCCAGAGTATAGAGTGGGAGCAAGAGAGTGAGCCAGCAAGTGTTAGTAGAATTTTCCAGTGTTGCGCTTGGAGGGGTGGACTGCTCTGGTTCAGTCTACTCTTGCTTTATCGGGTGTTTATTCCTGGGCTTCAGTGAGTAACAGCGTGAATTACTTATGATCCATCACTGTGTGGAGATGCTTGGTCATGGCTGGAATTTTTCCTCGTATAAATTTCCAGGCCTTTGGGTGCTCCCCTTGTACATGCCTAGCAAAGTTGTGAATGCCATGTGGTTCCAAGATACAGCTGACCTGGCATTTGAAGCATCAGGGAGGAAGCCTCACCCATTCCCTAGTGTCCACAAAATAACTGCTGACATGCTCTCCAATCTTTTGCTGCAGGCTCTTTTCCCCATTCAAGGAATGTCTGTGAGTCTCTTTCCCACCCACCTTGTTGGTCAGCTGGTTACTCTCCGGCGTTTGTCTCTTCTTGACTCATTCTACTGCTTCAAATATGGTTGGTTCAGTAAAGGAATTGAAATGCACCAGCGGTTCCTCTAACACAGAGAGGAACTGGCTTTACTACTTTGGGTTTGGTTTTTTTGGCTTTTCTCACAGCAATGCAGTCCTCATATATTTTCCATGGCTGCCTTTTCTCTATCCTCTTTCCTTTATTCATTATCAGTGCAATGAGGCAAAGATCCCCGGCCAAGCATACCTCTTTGAGTTGCACCTCTCCTCCTTCGTGGTCTTCTTAAGCAACAGACTCTTCCACAAGACACTCTCACCTGCAGTCTGCCTTGAGCAGCTCAGCCTCTGCAGAGAAGTTCCCTTCACCACATATGTCTCTACCCAGATTGAAGGCTACTGAAGGCCTGAGTCACCTGCCATCGAGGGGATGGGTGGGATTGGAAGGAGGCTGTGGCAGCTCTTTTCCCATTTTACCTCCCCCTGCCAGGAAAGGCACGATTCATCCTGCCAAAGGCCCTCTGCATATTCCCTCTCTGAGGAATTGGAATCTTTATCTCTGGTGCACGTAAGGTAGAATCTTCCTGACACCAGCGTGTGGATTTTTAACACCACTGAGAGTCTGAAAGGACCACAGt
>NM_004879.5
AGTGCGGGCGCAGCGGCCCCGGCCCTGGAAGCGCCCCGGCGGAGCTGGCCTGCGGTGGGCTAGGGGCAGGGCCGGAGCCGCGGCGGCGGAGCTGTGGATCCTTCATGATGAGAGATTTGGGGACACTTCTCTCTCCTGTGTGTAGTTGATAGTTTGGTGGTGAAGAGATGGCTGACAGTGTCAAAACCTTTCTCCAGGACCTTGCCAGAGGAATCAAAGACTCCATCTGGGGTATTTGTACCATCTCAAAGCTAGATGCTCGAATCCAGCAAAAGAGAGAGGAGCAGCGTCGAAGAAGGGCAAGTAGTGTCTTGGCACAGAGAAGAGCCCAGAGTATAGAGCGGAAGCAAGAGAGTGAGCCACGTATTGTTAGTAGAATTTTCCAGTGTTGTGCTTGGAATGGTGGAGTGTTCTGGTTCAGTCTCCTCTTGTTTTATCGAGTATTTATTCCTGTGCTTCAGTCGGTAACAGCCCGAATTATCGGTGACCCATCACTACATGGAGATGTTTGGTCGTGGCTGGAATTCTTCCTCACGTCAATTTTCAGTGCTCTTTGGGTGCTCCCCTTGTTTGTGCTTAGCAAAGTGGTGAATGCCATTTGGTTTCAGGATATAGCTGACCTGGCATTTGAGGTATCAGGGAGGAAGCCTCACCCATTCCCTAGTGTCAGCAAAATAATTGCTGACATGCTCTTCAACCTTTTGCTGCAGGCTCTTTTCCTCATTCAGGGAATGTTTGTGAGTCTCTTTCCCATCCATCTTGTCGGTCAGCTGGTTAGTCTCCTGCATATGTCCCTTCTCTACTCACTGTACTGCTTTGAATATCGTTGGTTCAATAAAGGAATTGAAATGCACCAGCGGTTGTCTAACATAGAAAGGAATTGGCCTTACTACTTTGGGTTTGGTTTGCCCTTGGCTTTTCTCACAGCAATGCAGTCCTCATATATTATCAGTGGCTGCCTTTTCTCTATCCTCTTTCCTTTATTCATTATCAGCGCCAATGAAGCAAAGACCCCTGGCAAAGCATAtCTCTTCCAGTTGCGCCTCTTCTCCTTGGTGGTCTTCTTAAGCAACAGACTCTTCCACAAGACAGTCTACCTGCAGTCGGCCCTGAGCAGCTCTACTTCTGCAGAGAAGTTCCCTTCACCGCATCCGTCGCCTGCCAAACTGAAGGCTACTGCAGGTCACTGAGTTGCCTGCCATCCAAAGGGGATGGGCGGGATTGGAAGAAGCTGTGGCAGCTCTTTTCCCTGTTCACCTCCCGCCTGCCAGGGAAGGCAGGACCCGCTCTGCCAAGGGCCCTCTGCGTATTCCCTTCTCTCTGAGGAATTGAAATTTTTGTCTCTGGTGCACGTAAGGCAGAATGTTCCCTGACACCAGTGTGTGGATTTTTAACATCACCGTGAGTCTGAAAGGACCACAGGTTTTTCTGCAGCTATTTTCTAGCATTTGCCAGTCCCTGTGCCTGGACTGATTGGAACACTTTGTTTTTCTCCCTGTGCCATTTACCCTTCCACCTTTCCATCCTGCCTTCTACCACCCTTGGATGAATGGATTTTGTAATTCTAGCTGTTGTATTTTGTGAATTTGTTAATTTTGTTGTTTTTCTGTGAAACACATACATTGGATATGGGAGGTAAAGGAGTGTCCCAGTTGCTCCTGGTCACTCCCTTTATAGCCATTACTGTCTTGTTTCTTGTAACTCAGGTTAGGTTTTGGTCTCTCTTGCTCCACTGCaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaGCCTGAAGAGATGAGATAGGAGGAAAGACCTCACAGCCAGATCTGCTGGGTTTTGAGGAGTGATTTTCTTTCTTCCCCTTGAAGGGGAAAAAGCTATTTTCATTGGTACATTTAAAGTCCCCCAACTATGGGGAGGTACCAATTCTGGACAAGTGCCACTACAACAACACTAAACCTGAACTTTTCAACTCCGTTGGTGGTGGGAGGCAGCGGGCAGAAATTTACTGTTGGCCACTGCCAGGTCTATTTCATATTTCAAAGGAATATTGGGTGCTGCATATAGGAACTGAAGGGGTCAATGTATTAAACCTGTGATTGGTTGTTTTCCTGTCATTTTGAGAGACTAAATGTGGGGGGCAGATGTCAAAATACCTGTACAATTTTAAAATGTCACAATTAAACATGAGCTGGTTTCCCACAAA

Publications

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