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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DPPA3P3
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:51435952-51436115  UCSC
Coordinates (T2T) chr3:51466392-51466555  UCSC
Coordinates (hg19) chr3:51469963-51470126  UCSC
Strand +
Parental Sequence NM_199286.4
Parental seq. overlap 138 bp
Parental seq. overlap (%) 12.5%
Genomic Region Intragenic (DCAF1)
Retrocopy Summary DPPA3P3, located on chr3:51435952-51436115, is a retrocopy of the parental gene DPPA3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DPPA3
Full Name developmental pluripotency associated 3
Also known as Pgc7|STELLA
Coordinate chr12:7711433-7717559
Strand +
Gene summary This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DPPA3P1
Bonobo Pan paniscus DPPA3P1
Gorilla Gorilla gorilla DPPA3P1
Orangutan Pongo abelii DPPA3P2
Gibbon Nomascus leucogenys DPPA3P2
Green monkey Chlorocebus sabaeus DPPA3P6
Crab-eating macaque Macaca fascicularis DPPA3P2
Rhesus Macaca mulatta DPPA3P2
Golden snub-nosed monkey Rhinopithecus roxellana DPPA3P1
Marmoset Callithrix jacchus DPPA3P6
Baboon Papio anubis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DPPA3P3
GAGTGTTGTGTCAAGATCACCGATGTGCACATCACAAAGTTTGATCCGACCTTGGTCCCAGAGTCTTCATAAATGCTCACTGAAGAAAATTCCCAGGATGATTCGGGGGCCTCTCAAAACTTCTGCTTCAAGACGTTGATAAAGAACCTTAGTAACTTGACTAT
>NM_199286.4
GTCAGTTCTTTGACCATTCGTTGGAGCTCCGGTTTTCAGCCTCTTTCCGGGCTACCTGGTAGCAATTTGAGGCTCTGTCATCAGTTTCTGCTACGTTTCAAAGATCCTGGAGAAGCCTAGTGTTGTGTCAAGACGCCGATGGACCCATCACAGTTTAATCCAACCTACATCCCAGGGTCTCCACAAATGCTCACCGAAGAAAATTCCCGGGACGATTCAGGGGCCTCTCAAATCTCCTCCGAGACGTTGATAAAGAACCTTAGTAACTTGACTATCAACGCTAGTAGCGAATCTGTTTCCCCTCTATCGGAAGCTTTACTCCGTCGAGAGTCTGTAGGAGCAGCAGTCCTCAGGGAAATCGAAGATGAGTGGCTTTACAGCAGGAGAGGAGTAAGAACATTGCTGTCTGTGCAGAGAGAAAAGATGGCAAGATTGAGATACATGTTACTCGGCGGAGTTCGTACGCATGAAAGAAGACCAACAAACAAGGAGCCTAAGGGAGTTAAGAAGGAATCAAGACCATTCAAATGTCCCTGCAGTTTCTGCGTGTCTAATGGATGGGATCCTTCTGAGAATGCTAGAATAGGGAATCAAGACACCAAGCCACTTCAGCCATAAATCTTATTCTTGCACCTTTTTTTCTTGGTAGTAATTTTATATAGCAGGTTGAGAAAGCTACTCTATGCTAGTATAGACTATACACCAATAATTTTGATAATGAGTTCTAGGATGTATTTTTCTTGTATCTTTTTCTTCCTACTATGATACTAGTAATTCATAAGGGATCTGTGTAATCTGAATGTATTTGAATAACTTTAGCTCTACTGTTTGATTTGACCCAAAGAAGCCAAGATGATATAAGTATTCCCATGTGTCTTAGAAGCCCAAAGTCAGTGAGATGAAACCCAACATCAAGAAATTGAAGCAAAGTTACTTATGGATAAAGAAAGCATTAGGTAGTTGGGCTATAGCATAATTAGATTTTCTGGCTTTCAAAAATTTGGATTGCAATCACAGCAAACTTTGTTATTTTTACAGTTTTCAGTACAAAAGTGTTTATATAGAAACAATAAAGTTGACATTTGAGTACCTTTTAAAAA

Publications

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