Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CABYRP1
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Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr18). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:54047665-54048862  UCSC
Coordinates (T2T) chr3:54081519-54082716  UCSC
Coordinates (hg19) chr3:54081692-54082889  UCSC
Strand -
Parental Sequence NM_153768.3
Parental seq. overlap 1053 bp
Parental seq. overlap (%) 46.9%
Genomic Region Intergenic
Retrocopy Summary CABYRP1, located on chr3:54047665-54048862, is a retrocopy of the parental gene CABYR. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CABYR
Full Name calcium binding tyrosine phosphorylation regulated
Also known as CABYRa|CABYRc|CABYRc/d|CABYRe|CBP86|CT88|FSP-2|FSP2
Coordinate chr18:24138956-24161600
Strand +
Gene summary To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CABYRP1
Bonobo Pan paniscus CABYRP1
Gorilla Gorilla gorilla CABYRP1
Orangutan Pongo abelii CABYRP1
Gibbon Nomascus leucogenys CABYRP1
Green monkey Chlorocebus sabaeus CABYRP1
Crab-eating macaque Macaca fascicularis CABYRP1
Rhesus Macaca mulatta CABYRP1
Baboon Papio anubis CABYRP1
Golden snub-nosed monkey Rhinopithecus roxellana CABYRP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.10.2
log10(TPM+1)

Related Sequence

>CABYRP1
GCAAGGGGGCAACAAGGAAGCTCTTAAGAGCACAGCTGGAAAGAAGCTGAGTTACAGATATCCTGCCAAAATAATTTCTTCAAAGCCCAGACTTGCCGTACCCTATGGCCTCAAGACTCTGCTCAGGAAAATTAGCAAAGCCGTTCTCAAAACCAACCCACCGAACATGACCCAGTTTGCAGCAGTTTATTTTAAAGAACTTATTATGTATAGAGAAGGGACTACTTCTCTGGATGAAGTGGTCAGAGGGAACAGAATCTAAAGTGCCTACACAGATGGAAAAATCTACAAAGACAATGTAACCGGAACAGGATGTAGTGACAAAACCACCCAGTTTCCATCCATTTATGCTGAGCTAGGCACTGAGCAAACTGAAGCAGTTCGTGATCTTTCTTCCAAACCAGCCACCCCTAAGACTACTACCCCACCCTCATAACCATCTCCAACAGCTGTTTCACCAGAGTTTGCCTATGTCCCAGCTGACACAGCTCGGTTTGCTTCTCAGATATTAGCAATGGCAGCAAGTGAAGCAGGACAACCACGACGATATTCTAACATGTGGACCCCTTATTGTCTAACTGATAAGAATCAACAAAGTCACCCATCACTGCCACCTGCACCTGGGCCTTTTCCCCAAGCAACTCTGTCTATCTAATCCTAAGGATCCACAGTTTCTGCAGCATCCACCAACTTACAAGATGATCTCCAACTTACAAGATGATCGAAGATAGTAAGACCAGTGCCCCACCTTTTATCTTAGTAGGCTCAAATGCTCAGAAAGCAAAGGAATGGAAACCTCTTTCTGGACATGCTGTTGTTTCAAAGTCAGAAGTTTTGAAGAGATATGCTGCAGTATAAGTGCCCATTGCTGTTCCTGCAGATGAGAAATTCCAGAAACTTACCTTAAGCCCCCAGAATGCTCATCTTGCTACAAGTGGACAAGATGTCCCCAGGCCAGAAAGCCTTGTTTTTCTTTCTGTTGCTTTCTTAGTAGAAGGGGTAGCTTTAAAAAGTTCAGGATCTGGTGACAAATGTGCTCCCTTTGGAAGTTACAGTATTGCTTGGGAGATAACTGTGACTCATGCTCACAAAGTTCGCAAAGCAGAAACTTAAAACTGATCCAGAAATGACGCTGTTTGGGTCAACAAACGTTCAGGGAGGAGTCTGCCACCAAGTGTAACATATCAATAAACTTCAC
>NM_153768.3
AGGAGCCGCCGGCAAGGGGGCAACGAGGAAGCTCTTAAGAGCGCGGCCGGAAAGCAGTTGAGTTACAGACATCCTGCCAAAATGATTTCTTCAAAGCCCAGACTTGTCGTACCCTATGGCCTCAAGACTCTGCTCGAGGGAATTAGCAGAGCTGTTCTCAAAACCAACCCATCAAACATCAACCAGTTTGCAGCAGCTTATTTTCAAGAACTTACTATGTATAGAGTAGAGAAATGGTCAGAAGGAACGACACCACAGAAGAAATTAGAATGTTTAAAAGAACCAGGAAAAACATCTGTAGAATCTAAAGTACCTACCCAGATGGAAAAATCTACAGACACAGACGAGGACAATGTAACCAGAACAGAATATAGTGACAAAACCACCCAGTTTCCATCAGTTTATGCTGTGCCAGGCACTGAGCAAACGGAAGCAGTTGGTGGTCTTTCTTCCAAACCAGCCACCCCTAAGACTACTACCCCACCCTCATCACCACCTCCAACAGCTGTCTCACCAGAGTTTGCCTACGTCCCAGCTGACCCAGCTCAGCTTGCTGCTCAGATGTTAGGTAAAGTTTCATCTATTCATTCTGATCAATCTGATGTGTTAATGGTGGATGTGGCAACCAGTATGCCTGTTGTTATCAAGGAGGTGCCAAGCTCAGAGGCTGCTGAAGATGTCATGGTGGCTGCTCCTCTTGTGTGTTCTGGAAAGGTGCTAGAAGTGCAGGTTGTGAACCAAACATCTGTCCATGTAGATTTGGGTTCTCAACCTAAAGAAAATGAGGCTGAACCATCAACGGCTTCCTCAGTCCCCTTGCAGGATGAACAAGAACCTCCTGCTTATGATCAAGCTCCTGAGGTCACTTTGCAGGCTGATATTGAGGTTATGTCAACTGTTCATATATCATCTGTCTATAACGATGTGCCTGTGACTGAAGGAGTTGTTTATATCGAGCAACTGCCAGAACAAATAGTTATCCCTTTTACTGATCAAGTTGCTTGTCTTAAAGAAAATGAGCAGTCAAAAGAAAATGAGCAGTCACCACGAGTTAGTCCCAAATCTGTAGTAGAAAAGACCACCTCTGGCATGTCTAAAAAATCTGTAGAGTCTGTAAAACTTGCACAGTTGGAGGAGAATGCAAAATATTCCTCAGTATATATGGAGGCAGAAGCAACAGCTCTGCTCTCTGACACATCTTTGAAAGGTCAGCCTGAGGTACCTGCACAACTCCTGGATGCAGAAGGTGCTATCAAAATAGGCTCTGAAAAATCTCTGCACCTTGAAGTGGAGATCACTTCAATAGTCTCTGACAATACTGGGCAGGAGGAGTCTGGGGAAAACTCTGTACCCCAGGAGATGGAAGGCAAACCTGTGCTCTCTGGGGAAGCTGCAGAAGCAGTGCACTCAGGTACATCTGTAAAGTCATCTAGTGGCCCCTTCCCTCCTGCTCCAGAAGGCCTTACTGCACCAGAAATTGAACCAGAAGGGGAATCAACAGCTGAATAAGGTTTGATGAAGCCAGCAATGGCAACAAGTGAACGAGGACAACCACCACCATGTTCTAACATGTGGACCCTTTATTGTCTAACTGATAAGAATCAACAAGGTCACCCATCACCGCCACCTGCACCTGGGCCTTTTCCCCAAGCAACCCTCTATTTACCTAATCCTAAGGATCCACAGTTTCAGCAGCATCCACCAAAAGTCACTTTTCCAACTTATGTGATGGGCGACACCAAGAAGACCAGTGCCCCACCTTTTATCTTAGTAGGCTCAAATGTTCAGGAAGCACAGGGATGGAAACCTCTTCCTGGACATGCTGTCGTTTCACAGTCAGATGTCTTGAGATATGTTGCAATGCAAGTGCCCATTGCTGTTCCTGCAGATGAGAAATACCAGAAACATACCCTAAGTCCCCAGAATGCTAATCCTCCAAGTGGACAAGATGTCCCCAGGCCAAAAAGCCCTGTTTTCCTTTCTGTTGCTTTCCCAGTAGAAGATGTAGCTAAAAAAAGTTCAGGATCTGGTGACAAATGTGCTCCCTTTGGAAGTTACGGTATTGCTGGGGAGGTAACCGTGACTACTGCTCACAAACGTCGCAAAGCAGAAACTGAAAACTGATCCAGAAATGACGCTGTCTGGGTCAACATTTCAGGGAGGAGTCTGCCACCAGTGTAATGTATCAATAAACTTCATGCAAGCATA

Publications

PMID - Link Title
No publications available for this retrocopy