Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ID2B
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:62123425-62124718  UCSC
Coordinates (hg19) chr3:62109099-62110392  UCSC
Strand -
Parental Sequence NM_002166.5
Parental seq. overlap 518 bp
Parental seq. overlap (%) 25.9%
Genomic Region Intragenic (PTPRG)
Retrocopy Summary ID2B, located on chr3:62123425-62124718, is a retrocopy of the parental gene ID2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ID2
Full Name inhibitor of DNA binding 2
Also known as GIG8|ID2A|ID2H|bHLHb26
Coordinate chr2:8682056-8684461
Strand +
Gene summary The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ID2P1
Bonobo Pan paniscus ID2P1
Gorilla Gorilla gorilla ID2P1
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ID2B
AGTGAAACCTTGTTAACTCTTTAATTAGAGTTTTCTTGTATAGTGGCAGAGATGTCTATTTCTGCATTAAAAAGTGTAATGATGTACTTATTCATGATAAACTTTTTATAAAAGTTTAAACTTTTAGTTGTAAACGTAACCCTTTTATACAAAATAAATCAAGTGTGTTTATTGAATGGTGATTGCCTGCTTTATTTCAGAGGACCAGTGCTTTGATTTTTATTATGCTATGTTATAACTGAACCCAAATAAATACAAGTTCAAATTTATGTAGACTGTATAAGATTATAATAAAACATGTCTGAAGTCATTCACAGAACCTTTTAAGCGCTGAACTTATTTTTCAACCATTTCACAAGGAGGACAAGTTGAATGGACCTTTTTAAAAAGAAAAAAAAAAGGGAAGGAAAACTAAGAATGATCATCTTCCCAGGGTGTTCTCTCACTTGGACTGTGATATTCGTTATTTATGAAAAAGACTTTTAAATGCCCTTTCTGCAGTTGGAAGGTTTTTTTCATATACTATTCCCACCATGGGGAGCGAAAACGTTAAAATCACAAGGAATTGCCCAATCTAAGCAGACTTTGCCTTTTTTCAAAGGTGGAGTGTCAATACCAGAAGGATCCAGTATTCAGTCACTTAAATGAAGTCTTTTGGTCAGAAATTACCTTTTTGACACAAGCCTACTGAATGCCGTGATTCTGAGCCAAGTCCGGTGCCAAGCGCAGCTAGCTCAGCAGGCGGCAGCGGTGGCCTGAGCTTCAGGACAGCCAGCTCCCTCCCGGTCTCACCTTCCCTCGCGGTCAGCATGAAAGCCTTCAGTCCCGTGAGGTCCATTAGGAAAAACAGCCTGTTGGACCACCGCCTGGGCATCTCCCAGAGCAAAACCCCGGTGGATGACCTGATGAGCCTGCTGTAAAACATGAATGACTGCTACTCCAAGCTCAAGGAGCTGGTGCCCAGCATCCCCCAGAACAAGAATGTGAGCAAGATGGAAATCCTGCAGCACGTCATCGACTACATCTTGGACCTGCAGATCACCCTGGACTTGCATCCCACTATTGTCAGCCTGCATCACCAGAGACCCGGGCAGAACCAGGCATCCAGGATGCCGCTGACCACCCTCAACACGGACATCAGCATCCTGTCCTTGCAGGCTTCTGAATTCCCTTCGGAGTTAATGTCAAATGACAGGAAAGCACTGTGTGGCTGAATAATCATGACTTCTTTTTTTTCTTTGCa
>NM_002166.5
ATTCTGAGCCGAGCCCGGTGCCAAGCGCAGCTAGCTCAGCAGGCGGCAGCGGCGGCCTGAGCTTCAGGGCAGCCAGCTCCCTCCCGGTCTCGCCTTCCCTCGCGGTCAGCATGAAAGCCTTCAGTCCCGTGAGGTCCGTTAGGAAAAACAGCCTGTCGGACCACAGCCTGGGCATCTCCCGGAGCAAAACCCCTGTGGACGACCCGATGAGCCTGCTATACAACATGAACGACTGCTACTCCAAGCTCAAGGAGCTGGTGCCCAGCATCCCCCAGAACAAGAAGGTGAGCAAGATGGAAATCCTGCAGCACGTCATCGACTACATCTTGGACCTGCAGATCGCCCTGGACTCGCATCCCACTATTGTCAGCCTGCATCACCAGAGACCCGGGCAGAACCAGGCGTCCAGGACGCCGCTGACCACCCTCAACACGGATATCAGCATCCTGTCCTTGCAGGCTTCTGAATTCCCTTCTGAGTTAATGTCAAATGACAGCAAAGCACTGTGTGGCTGAATAAGCGGTGTTCATGATTTCTTTTATTCTTTGCacaacaacaacaacaacaaATTCACGGAATCTTTTAAGTGCTGAACTTATTTTTCAACCATTTCACAAGGAGGACAAGTTGAATGGACCTTTTTAAAAAGAAAAAAAAAATGGAAGGAAAACTAAGAATGATCATCTTCCCAGGGTGTTCTCTTACTTGGACTGTGATATTCGTTATTTATGAAAAAGACTTTTAAATGCCCTTTCTGCAGTTGGAAGGTTTTCTTTATATACTATTCCCACCATGGGGAGCGAAAACGTTAAAATCACAAGGAATTGCCCAATCTAAGCAGACTTTGCCTTTTTTCAAAGGTGGAGCGTGAATACCAGAAGGATCCAGTATTCAGTCACTTAAATGAAGTCTTTTGGTCAGAAATTACCTTTTTGACACAAGCCTACTGAATGCTGTGtatatatttatatataaatatatctatTTGAGTGAAACCTTGTGAACTCTTTAATTAGAGTTTTCTTGTATAGTGGCAGAGATGTCTATTTCTGCATTCAAAAGTGTAATGATGTACTTATTCATGCTAAACTTTTTATAAAAGTTTAGTTGTAAACTTAACCCTTTTATACAAAATAAATCAAGTGTGTTTATTGAATGGTGATTGCCTGCTTTATTTCAGAGGACCAGTGCTTTGATTTTTATTATGCTATGTTATAACTGAACCCAAATAAATACAAGTTCAAATTTATGTAGACTGTATAAGATTATAATAAAACATGTCTGAAGTCAATACCTGAA

Publications

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