Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name H1-8P1
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:69535544-69536519  UCSC
Coordinates (T2T) chr3:69572397-69573372  UCSC
Coordinates (hg19) chr3:69584695-69585670  UCSC
Strand -
Parental Sequence NM_153833.3
Parental seq. overlap 865 bp
Parental seq. overlap (%) 70.8%
Genomic Region Intragenic (FRMD4B)
Retrocopy Summary H1-8P1, located on chr3:69535544-69536519, is a retrocopy of the parental gene H1-8. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name H1-8
Full Name H1.8 linker histone
Also known as H1.8|H1FOO|H1oo|osH1
Coordinate chr3:129543175-129555185
Strand +
Gene summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The related mouse gene is expressed only in oocytes. [provided by RefSeq, Oct 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes H1FOOP1
Bonobo Pan paniscus LOC100993446P1
Gorilla Gorilla gorilla LOC101136093P1
Orangutan Pongo abelii LOC100450433P1
Gibbon Nomascus leucogenys LOC100595969P1
Green monkey Chlorocebus sabaeus LOC103228065P1
Crab-eating macaque Macaca fascicularis LOC102128013P1
Rhesus Macaca mulatta LOC702823P1
Baboon Papio anubis LOC101019083P1
Golden snub-nosed monkey Rhinopithecus roxellana LOC104676630P1
Marmoset Callithrix jacchus LOC103788347P4
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>H1-8P1
GAGGCGCTGCAGGCTGGGGAGTAGCGCTAGGGCACGTTGGCGGTGGCCGTCAAGCTCTACATCCTGCACAAGTACCCAACGGTGGACGTCCTCCGCTTCAGGTATCTGCTGAAGCAGGCGCTGGCCACTGGCATGTGCCGCAGCCTCCTCGCCAGGCCCCTCAACTCCGAAGCAAGGGGGGCCACTGGCAGCTTCAAATTAGATCCCAAGCACAAGAGGAAAATCCAGCCCAGGGAGATGGCCCCCTGATGGTCCCCAGGAGAGCGGAAAAGGCCAAGGGGAAGGACGCCAAGAAACCAAGTGAGGCCAAGGAGGATCCTCCTAACGCGGGCAAGGTGAAGAAGGCAGCGAAGAGGCCAGCAGAGGTGCAGAAGGCTCCTCCCAAGCCAGGTGCAGCCACAGAGAAGGCCGGCAAGCAAGGCAGTGTGGGCAAGGACACCAGGCCACAGCCCGGTGAGGCTAGGAAGGCACCCCTAAGCCAGACAAGGCCACGCAGGTCCCTTCCAGTGCCAGCGGGCTTAGTAGGAAGGCAAAGGCCCGAGGCAGCAGGAGCAGCCAAGGAGATGCTGGGGACCACAGGAAAATGAAAGCTGGGAGTAAGAGTTCAAAACCCACTGTCAGCAAGGTCAAGAATGGCATTGCTTCCTCGACCAGAAGGTGGTAGCCAAGACCAAGGCTCCTAAAGGGGCAGCTGCCCAGGGGCCAAACACCAAGGCTGCTTCTCCTGCTAAGGGCAGTGGGTCCAAGGTGGTGCCTGCACACCTGTCTAGGAAGACAGAGACCCCCAAGTGCCCGTGAAAGGCTGGACTGCCCATTACGGTCTCCTCATCTGACGTATCTAGCCAGAGGGCTGTATCCTAGGGCCGGAGGCAGGGGCGGAGAGACCGAGCCACTGCCCTGATTTTTATTCTTCAGCAAACCACTGCTTTATTTATTTCATTGTAAGCTATTTATCAATAAAGACTTTTGTTTCTTC
>NM_153833.3
CTCACACCCGGGTGAGGGGTCTGCTGGCTGCACCTGTCGGTCTCATGGCTCCTGGGAGCGTCACCAGCGACATCTCACCCTCCTCGACTTCCACAGCAGGATCATCCAGGTCTCCTGAATCTGAAAAGCCAGGCCCGAGCCACGGCGGTGTCCCACCAGGAGGCCCGAGCCACAGCAGCCTCCCGGTGGGACGCCGCCACCCCCCGGTGCTACGCATGGTGCTGGAGGCGCTGCAGGCTGGGGAGCAGCGCCGGGGCACGTCGGTGGCAGCTATCAAGCTCTACATCCTGCACAAGTACCCAACAGTGGACGTCCTCCGCTTCAAGTACCTGCTGAAGCAGGCGCTGGCCACTGGCATGCGCCGTGGCCTCCTCGCCAGGCCCCTCAACTCCAAAGCCAGGGGGGCCACTGGCAGCTTCAAATTAGTTCCCAAGCACAAGAAGAAAATCCAGCCCAGGAAGATGGCCCCCGCGACGGCTCCCAGGAGAGCGGGTGAGGCCAAGGGGAAGGGCCCCAAGAAACCAAGTGAGGCCAAGGAGGACCCTCCCAACGTGGGCAAGGTGAAAAAGGCAGCCAAGAGGCCAGCAAAGGTGCAGAAGCCTCCTCCCAAGCCAGGCGCAGCCACAGAGAAGGCTCGCAAGCAAGGCGGCGCGGCCAAGGACACCAGGGCACAGTCGGGAGAGGCTAGGAAGGTGCCCCCCAAGCCAGACAAGGCCATGCGGGCACCTTCCAGTGCTGGTGGGCTCAGCAGGAAGGCAAAGGCCAAAGGCAGCAGGAGCAGCCAAGGAGATGCTGAGGCCTACAGGAAAACCAAAGCTGAGAGTAAGAGTTCAAAACCCACGGCCAGCAAGGTCAAGAATGGTGCTGCTTCCCCGACCAAAAAGAAGGTGGTGGCCAAGGCCAAGGCCCCTAAAGCTGGGCAGGGGCCAAACACCAAGGCTGCTGCTCCTGCTAAGGGCAGTGGGTCCAAGGTGGTACCTGCACATTTGTCCAGGAAGACAGAGGCCCCCAAGGGCCCTAGAAAGGCTGGGCTGCCCATCAAGGCCTCATCATCCAAAGTGTCCAGCCAGAGGGCTGAAGCTTAGGGCCAGAGGCAGGGGCGGAGAGAGACCGAGCCTCTGCCCTAGTTTTTATTCTTCAACTAACCACTGCTCTATTTATTTCATTGTAAGCTATTTATCAATAAAGACTTTTGTTTCTTTTTCCTCACAA

Publications

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