RCPedia: Rtcs

Summary

Retrocopy Name	RARRES2P1	Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species	Homo sapiens
Coordinates (hg38)	chr3:75658514-75659104 UCSC
Coordinates (T2T)	chr3:75711708-75712298 UCSC
Coordinates (hg19)	chr3:75707665-75708255 UCSC
Strand	+
Parental Sequence	NM_002889.4
Parental seq. overlap	500 bp
Parental seq. overlap (%)	72%
Genomic Region	Intragenic (FRG2C)
Retrocopy Summary	RARRES2P1, located on chr3:75658514-75659104, is a retrocopy of the parental gene RARRES2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	RARRES2
Full Name	retinoic acid receptor responder 2
Also known as	HP10433\|TIG2
Coordinate	chr7:150338329-150341685
Strand	-
Gene summary	This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. [provided by RefSeq, Nov 2014]

Homology

Species	Scientific Name	Retrocopy
Chimpanzee	Pan troglodytes	RARRES2P2
Bonobo	Pan paniscus	RARRES2P1
Gorilla	Gorilla gorilla	RARRES2P2
Orangutan	Pongo abelii	RARRES2P3
Green monkey	Chlorocebus sabaeus	RARRES2P1
Crab-eating macaque	Macaca fascicularis	RARRES2P1
Rhesus	Macaca mulatta	RARRES2P1
Marmoset	Callithrix jacchus	RARRES2P2
Gibbon	Nomascus leucogenys	Without Homology
Baboon	Papio anubis	Without Homology
Golden snub-nosed monkey	Rhinopithecus roxellana	Without Homology
Mouse lemur	Microcebus murinus	Without Homology
Mouse	Mus musculus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Related Sequence

>RARRES2P1
GGGCCGGGGTGACAGGGGAAGCCTGAGATGGCTGCGGATCTCGCTGGCCCAGTGGGTGGGCGCGGGGGACGCGGGAGGGGCCGAGCTCACCGGGCCAGCGCCGGGGCCTGCAGGTGGCCCTGGAGGAATCTTCAAGCACCCGCCCGTGCAGCGGGCCTTCCGGGAGACCAGTGTGGACAGCGCCCTGGACACGCCCTTCCCAGCTGGAACATTTGTGAGGCTGGAATTTAAGCTCCGGCAGACAGAGAAGCGGCCGGAGGAAAGACTGGAAGAAACCCAAGTGCAAAGTCCAGCCCGAGAGGAGGAAGCAGAAATGCCTGACCTGCGTCAAACTGGAATGTGAGGATAAGGTTCTGGGCAGGATGGTCGCTGCCCTCCAGAGGCGCAGACTCGGCGGGAGCCTGAGGAGCACCAGGAGGCCGGGTGCAGCCGGGCGGGGCGGGCGGTGAGGACCCCACAGCTGCTGCTTCCCTGCACAGTTCGCCTTCTCCAAGGCCCGGCCCCCAGCGGAGCCCAGCACTGAATCGCATGGCGCCCCCTGGAGCCCTGGCGGGGGTAACCAGTGGAAGACCCCACCTCCCAGGGAGAGGA

>NM_002889.4
AAGATTTCAGCTGCGGGACGGTCAGGGGAGACCTCCAGGCGCAGGGAAGGACGGCCAGGGTGACACGGAAGCATGCGACGGCTGCTGATCCCTCTGGCCCTGTGGCTGGGTGCGGTGGGCGTGGGCGTCGCCGAGCTCACGGAAGCCCAGCGCCGGGGCCTGCAGGTGGCCCTGGAGGAATTTCACAAGCACCCGCCCGTGCAGTGGGCCTTCCAGGAGACCAGTGTGGAGAGCGCCGTGGACACGCCCTTCCCAGCTGGAATATTTGTGAGGCTGGAATTTAAGCTGCAGCAGACAAGCTGCCGGAAGAGGGACTGGAAGAAACCCGAGTGCAAAGTCAGGCCCAATGGGAGGAAACGGAAATGCCTGGCCTGCATCAAACTGGGCTCTGAGGACAAAGTTCTGGGCCGGTTGGTCCACTGCCCCATAGAGACCCAAGTTCTGCGGGAGGCTGAGGAGCACCAGGAGACCCAGTGCCTCAGGGTGCAGCGGGCTGGTGAGGACCCCCACAGCTTCTACTTCCCTGGACAGTTCGCCTTCTCCAAGGCCCTGCCCCGCAGCTAAGCCAGCACTGAGATGCGTGGTGCCTCCAGGACCGCTGCGGGTGGTAACCAGTGGAAGACCCCAGCCCCCAGGGAGAGGAACCCGTTCTATCCCCAGCCATGATAATAAAGCTGCTCTCCCA

>NM_002889.4 

AAGATTTCAGCTGCGGGACGGTCAGGGGAGACCTCCAGGCGCAGGGAAGGACGGCCAGGGTGACACGGAAGCATGCGACGGCTGCTGATCCCTCTGGCCCTGTGGCTGGGTGCGGTGGGCGTGGGCGTCGCCGAGCTCACGGAAGCCCAGCGCCGGGGCCTGCAGGTGGCCCTGGAGGAATTTCACAAGCACCCGCCCGTGCAGTGGGCCTTCCAGGAGACCAGTGTGGAGAGCGCCGTGGACACGCCCTTCCCAGCTGGAATATTTGTGAGGCTGGAATTTAAGCTGCAGCAGACAAGCTGCCGGAAGAGGGACTGGAAGAAACCCGAGTGCAAAGTCAGGCCCAATGGGAGGAAACGGAAATGCCTGGCCTGCATCAAACTGGGCTCTGAGGACAAAGTTCTGGGCCGGTTGGTCCACTGCCCCATAGAGACCCAAGTTCTGCGGGAGGCTGAGGAGCACCAGGAGACCCAGTGCCTCAGGGTGCAGCGGGCTGGTGAGGACCCCCACAGCTTCTACTTCCCTGGACAGTTCGCCTTCTCCAAGGCCCTGCCCCGCAGCTAAGCCAGCACTGAGATGCGTGGTGCCTCCAGGACCGCTGCGGGTGGTAACCAGTGGAAGACCCCAGCCCCCAGGGAGAGGAACCCGTTCTATCCCCAGCCATGATAATAAAGCTGCTCTCCCA

Publications

PMID - Link	Title
No publications available for this retrocopy