Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name WWP1P1
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:98657472-98661623  UCSC
Coordinates (T2T) chr3:101361552-101365703  UCSC
Coordinates (hg19) chr3:98376316-98380467  UCSC
Strand +
Parental Sequence NM_007013.4
Parental seq. overlap 3873 bp
Parental seq. overlap (%) 79.2%
Genomic Region Intergenic
Retrocopy Summary WWP1P1, located on chr3:98657472-98661623, is a retrocopy of the parental gene WWP1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name WWP1
Full Name WW domain containing E3 ubiquitin protein ligase 1
Also known as AIP5|Tiul1|hSDRP1
Coordinate chr8:86342547-86468503
Strand +
Gene summary WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes WWP1P1
Bonobo Pan paniscus WWP1P1
Gorilla Gorilla gorilla WWP1P1
Orangutan Pongo abelii WWP1P1
Gibbon Nomascus leucogenys WWP1P1
Green monkey Chlorocebus sabaeus WWP1P1
Crab-eating macaque Macaca fascicularis WWP1P1
Rhesus Macaca mulatta WWP1P1
Baboon Papio anubis WWP1P1
Golden snub-nosed monkey Rhinopithecus roxellana WWP1P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>WWP1P1
CCGGGGTGGGGGTCGGGGGAGAGTCAGGTGTCGGCGAGCTGGAGCTCGGTGTGCCGGCACCCAGTGACTGCTGGCGGCCTGGGCTGCTGGGGCCGACGCCTGGGTGGCTGCCGCCGCCGCACCTGCTGCGAGATAGTGATCTTCGTCGCGGAAGGGTGAGGGCGCCCACTGCAGGAGGAGGTGCAGGTGCCGCGGCCGCCTGGCTGCCGGGAGCCGAAAGCTTCGCGCtTTTAGCTGAATTTTGGAACATGGCCACTGCCTCACCAAAGTCAGATACTACTAATAACCACAGTGGAAGGTTGCAGTTACAGGTAACTGTTTCTAGTGCCAAACTTAAGAGAAGAAAGAACTGGTTCGGAACAGCAATATATACAGAAGTAGTTGTAGATGAGGAAATTAGGAAAACAGCAAAATCCAGTAGTTCTTCTAATCTAAAATGGGATGAACAGCTAACTGTAAATGTTACGCCACAGACTACATTGGAATTTCGAGTTTGGAGTCATCACACTTTAAAAGCAGATGCTTAATTAGGAAATGCAACGACAGATCTGAAACAAGCTCTGTTGATACACAATAGAAAACTGGAAAGAGTGAAAGAACAATTAAAACTTTCCTTAGAAAACAAGAATGGCATAGCACAAACTGGTGAATTGACAGTTGTGCTTGATGGATTGGTGATTGAGCAAGAAAATATAACAAACTGCAGCTCAACTCCAGCCATAGAAATACAGCAAAATGGTGATGCCTTACATGAAAATGGAGAGCCTTCAGCAAGGACAACTGCCAGGTTGGCTATTGAAGGCACGAATGGAATAGATAATCATGTACCTACAAGCACTCTAGTCCAAAACTCATGCTGCTCGTATGTAGTTAATGGAGACAACATACCTTCATCTCCATCTCAGGTTGCTGCCAGACCCAAAAATACACCAGCCCCAAAACTACTCACATCTGAGCCTGCCGATGACACTGTTAATGGAGAATCATCCTCATTTGCACCAACTGATAATGCTTCTGTCATGGGTATTCCAGTAGTGTCTGAAGAAAATGCCTTGTCTCCAAATTGCACTAGTACTACTGTTGAAGATCCTCCAGTTCAAGAAATACTGACTTCCTCAGAAAACAATGAATGCATTCCTTCTACCAGTGCAGAATTGGGATCTGAATCTAGAAGTATATTAGACCCTGACACCTCTAATTCTGGAAGTAGTTCTGCTTTTGAAACAGCCAAATCAAGACAGCCAGATGGGTGTATGGATCCAGTATAGCAGGAGTCTGGGAATGCCAACACAGAAACCTTGCCATCAGGGTGGGAACAAAGAAAATATCCTCATGGTAGAACCTATTATGTGGATCATAATACTCAAACTACCACACGGGAGAGACCACAACCTTTACCTTCAGGTTGGGAAAGAAGAGTTGATGATCGTGGAAGAGCTTATTATGTGGATCATAACACCAGAAGAACAACATGGCAGCGGCCTACCATGGAATGGGTCAGAAATTTTGAACAGTGGCAATCTCAGCAGAACCAACCTCAGGGAGCTATGCAACAGTTTAACCAATGATACCTCTATTCAGCTTCAATGTTAGCCGCAGAAAATGACCCTCATGGACCTTTGCCACCAGGCCGGGAAAAAAGAGTGGATTCAACAGACAGGGTTTACTTTGTGAATCGTAATACAAAAACAACCCAGTGGGAAGATCCAAGAACTCAAGGCTTACAGAATGAAGAACCTCTGCCAGAAGGCTGGGAAATAAGATATACTCGTGAAGGTGTAAGGTACTTTGTTAATCACAATGCAAGAACAACAACATTCAAAGATCCTTGCAATGGGAAGTCATCCATAACTAAAGGTGGTCCACAAATTGATTATGAACACAGCTTTAGGCGGAAACTTGCTCACTTCCGTTATTTGTGCCAGTCTAATGCACTACCCAGTCATGTAAAGATCAATGTGTCCCGGCAGACATTGTTTGAAGATTCCTTCCAACAGATTATGGCATTAAAACCTTATGACTTGAGGAGGTGCTTATATGTAATATTTAGAGGAGAAGAAGGACTTGATTATGGTGGCCTAGCAAGAGAATGGCTTTTCTTGCTTTCACATGAAGTTTTGAACCCAATGTAATGCTTATTTGAGTATGTGGGGAAGAACAACTATTCTCTGCAGATAAATCCAGCATCAACCATTAATCCAGACCATCTTTCATACTACTGTTTCATTGGTCGTTTTATTGCCATGGCACTATTTCATGGAAAGCTTATAGATACTGGTTTCTCTTTACCATTCTACAAGCATATGTTAAGTAAAAAACTTACTATTAAGGATTTGGAATCTATTGATACTGAATTTTATAACTCCCTTATCTGGATAAGAGATAACAACATTGAAGAATGTGGCTTAGAACTGTACTTTTCTGTTGACATGGAGAGTTGGGGAAAAGTTACTTCACATGACCTGAAGTTGGGAGTTTCCAATATTCTGGTGACTGAGGAGAACAAAGATGAATATATTGGTTTAATGACAGAATGGCATTTTTCTCGAGGAGTACAAGAACAGACCAAAGCTTTCCTTGATGGTTTTAATGGAGTTGTTCCTCATCAGTGGCTACAGTACTTCAATGAAAAAGAATTAGAGGTTACGTTGTGTGGCACACAGCAGGTTGACTTGGCAGATTGGCAGAGAAATACTGTTTATCAACATTATACAAGAAACAGCAAGCAAATCATTCGGTTCTGGCAGTTTGTGAAAGAGACAGACAATGAAGTAAGAATGCTACTATTGCAGTTCGTCACTGGAACCTGCCGTTTATCTCTAGGAGGATTTGCTGAGCTCATGGGAAGTAATGGGCCTCAAAAGTTTTGCATTGAAAAAGTTGGCAAAGATACTTGGTTACCAAGAAGCCATACATGTTTTAATCTCTTGGATCTACCACCATATAAGAGTTATGAACAACTAAAGGAAAAACTTCTTTTTGCAATAGAAGAGACAGAGGGATGTGGACAAGAATGAATGTGGCTTCTTATTTTGGAGGATCTCTTGCATTCAAATACCCCAGCCAAGAAAAATTGCACATAGTGTATATAAGCTGTTCATTCTGTACAGTGAATTTTCTGAACCTCTCAAAGTATGTTTTCCATTCTTCCACAGCAATATGCAAAACATATTTCATCCTTTTCTACTTTATTTGTTGTCCTTTGAAATGATTGACCAGGAAAAAGATCATCCTTAAATTTTGAAGCAAGTGAGAGACTTTATTAAAAATACATATGTATCTATATAAGCATATGTGATAGTGGCTCTAGTTTTATAGAGTTGCAAGTGTATTAAACATGACAGCTGTTCATTCATAAAGATCTGGATTTGCTTTACCTTGTTAATATTATCTAGGCGAAAAAGTGCAAATTGCTCCATGTTCTTCTCTCCCTTGTGTAACATCTCCTGAGGGTGTTTATTTGTATGTCTGTTCAGGAAGGTATTAAGGGCTTAGGCCAAATCTTACTTTGAGTATGTTAAAAAAAAAATGCTGCTGGCTTTTCTGAAGACAGGTGCTTGAACCTGTCAGTTGGTTTTAAATAAATAGTTGAAAATTTTTCTTTCTCTGTTACATCAGTAATATTGTCAAAGTAATGGATAAAACCATAACTTACACATGAAAGTCATATACCAGATCTGATACTATTTAGTTTATTATCAAAATTGGAAGGATTCATTGAGCAGCAAAGAAGTTTGTTTACATGATACTTTGAGATGCTAGATATTTGTGGAATTAAAAAGAATCAGGCACTGCTGTACTTTGTTTTTAAATCTGTGATTTTTTCAAATTTAATTCATAATAAATTGATGCAATTTCATACCTAGGAACATATAAAAGGTAATGTGAACTCTGCCACTTGTTTTGTGTTCAAAGTTTCGGTTTTATGAAGCCAGATGGATTGAAGAGTTACATAAGCATTTGAGTGCTCTAATATGAGGCTAACGATTTTCTGTTAGTGTTTGAATATCTTCATTCCTCTCAAATTCATAACAGTTCTATTTATCTGAATTAAATAAGCATATTAAAAA
>NM_007013.4
ATTCCGGGTCCGGAGTTGGAGGCTTTGGGCGGCCGCGGCGTAGCGCGCGGTGCCGGGGCCGGCGGGGAGGCGCGCGCTTAGGGCGCGGCGCCGGCGACGCGGCCACGCGGCGCGCTCCCGAGGAAgggaggtgtggggtcggctgggggtggcgcgtggacggggtgggggtggggggagggtcgggtgtcggcgagctccgcgtgcgggttccgagtggctgctggcggCCTGGGCTGCCGGGGCCGACGCCTGGGTGGCTGCTGCCGCCGCGCCTGCTGCGAGATGGCGATCTTGGGCGCGGAAGGGTGAGGGCGCCCGCCGCAGGAGGAGGTGCCGCTGCCGTGGCCGCCCGGCTGCCGGGAGCCGACAGCTTCGCGCCGGggttgtctcctcacagactatgagctccttgaaagagggaatcgtgtcttactcatctttgtatccccagtgtctagcagttcctgatacataGTTTTAGCTGAATTTTGGGACATGGCCACTGCTTCACCAAGGTCTGATACTAGTAATAACCACAGTGGAAGGTTGCAGTTACAGGTAACTGTTTCTAGTGCCAAACTTAAAAGAAAAAAGAACTGGTTCGGAACAGCAATATATACAGAAGTAGTTGTAGATGGAGAAATTACGAAAACAGCAAAATCCAGTAGTTCTTCTAATCCAAAATGGGATGAACAGCTAACTGTAAATGTTACGCCACAGACTACATTGGAATTTCAAGTTTGGAGCCATCGCACTTTAAAAGCAGATGCTTTATTAGGAAAAGCAACGATAGATTTGAAACAAGCTCTGTTGATACACAATAGAAAATTGGAAAGAGTGAAAGAACAATTAAAACTTTCCTTGGAAAACAAGAATGGCATAGCACAAACTGGTGAATTGACAGTTGTGCTTGATGGATTGGTGATTGAGCAAGAAAATATAACAAACTGCAGCTCATCTCCAACCATAGAAATACAGGAAAATGGTGATGCCTTACATGAAAATGGAGAGCCTTCAGCAAGGACAACTGCCAGGTTGGCTGTTGAAGGCACGAATGGAATAGATAATCATGTACCTACAAGCACTCTAGTCCAAAACTCATGCTGCTCGTATGTAGTTAATGGAGACAACACACCTTCATCTCCGTCTCAGGTTGCTGCCAGACCCAAAAATACACCAGCTCCAAAACCACTCGCATCTGAGCCTGCCGATGACACTGTTAATGGAGAATCATCCTCATTTGCACCAACTGATAATGCGTCTGTCACGGGTACTCCAGTAGTGTCTGAAGAAAATGCCTTGTCTCCAAATTGCACTAGTACTACTGTTGAAGATCCTCCAGTTCAAGAAATACTGACTTCCTCAGAAAACAATGAATGTATTCCTTCTACCAGTGCAGAATTGGAATCTGAAGCTAGAAGTATATTAGAGCCTGACACCTCTAATTCTAGAAGTAGTTCTGCTTTTGAAGCAGCCAAATCAAGACAGCCAGATGGGTGTATGGATCCTGTACGGCAGCAGTCTGGGAATGCCAACACAGAAACCTTGCCATCAGGGTGGGAACAAAGAAAAGATCCTCATGGTAGAACCTATTATGTGGATCATAATACTCGAACTACCACATGGGAGAGACCACAACCTTTACCTCCAGGTTGGGAAAGAAGAGTTGATGATCGTAGAAGAGTTTATTATGTGGATCATAACACCAGAACAACAACGTGGCAGCGGCCTACCATGGAATCTGTCCGAAATTTTGAACAGTGGCAATCTCAGCGGAACCAATTGCAGGGAGCTATGCAACAGTTTAACCAACGATACCTCTATTCGGCTTCAATGTTAGCTGCAGAAAATGACCCTTATGGACCTTTGCCACCAGGCTGGGAAAAAAGAGTGGATTCAACAGACAGGGTTTACTTTGTGAATCATAACACAAAAACAACCCAGTGGGAAGATCCAAGAACTCAAGGCTTACAGAATGAAGAACCCCTGCCAGAAGGCTGGGAAATTAGATATACTCGTGAAGGTGTAAGGTACTTTGTTGATCATAACACAAGAACAACAACATTCAAAGATCCTCGCAATGGGAAGTCATCTGTAACTAAAGGTGGTCCACAAATTGCTTATGAACGCGGCTTTAGGTGGAAGCTTGCTCACTTCCGTTATTTGTGCCAGTCTAATGCACTACCTAGTCATGTAAAGATCAATGTGTCCCGGCAGACATTGTTTGAAGATTCCTTCCAACAGATTATGGCATTAAAACCCTATGACTTGAGGAGGCGCTTATATGTAATATTTAGAGGAGAAGAAGGACTTGATTATGGTGGCCTAGCGAGAGAATGGTTTTTCTTGCTTTCACATGAAGTTTTGAACCCAATGTATTGCTTATTTGAGTATGCGGGCAAGAACAACTATTGTCTGCAGATAAATCCAGCATCAACCATTAATCCAGACCATCTTTCATACTTCTGTTTCATTGGTCGTTTTATTGCCATGGCACTATTTCATGGAAAGTTTATCGATACTGGTTTCTCTTTACCATTCTACAAGCGTATGTTAAGTAAAAAACTTACTATTAAGGATTTGGAATCTATTGATACTGAATTTTATAACTCCCTTATCTGGATAAGAGATAACAACATTGAAGAATGTGGCTTAGAAATGTACTTTTCTGTTGACATGGAGATTTTGGGAAAAGTTACTTCACATGACCTGAAGTTGGGAGGTTCCAATATTCTGGTGACTGAGGAGAACAAAGATGAATATATTGGTTTAATGACAGAATGGCGTTTTTCTCGAGGAGTACAAGAACAGACCAAAGCTTTCCTTGATGGTTTTAATGAAGTTGTTCCTCTTCAGTGGCTACAGTACTTCGATGAAAAAGAATTAGAGGTTATGTTGTGTGGCATGCAGGAGGTTGACTTGGCAGATTGGCAGAGAAATACTGTTTATCGACATTATACAAGAAACAGCAAGCAAATCATTTGGTTTTGGCAGTTTGTGAAAGAGACAGACAATGAAGTAAGAATGCGACTATTGCAGTTCGTCACTGGAACCTGCCGTTTACCTCTAGGAGGATTTGCTGAGCTCATGGGAAGTAATGGGCCTCAAAAGTTTTGCATTGAAAAAGTTGGCAAAGACACTTGGTTACCAAGAAGCCATACATGTTTTAATCGCTTGGATCTACCACCATATAAGAGTTATGAACAACTAAAGGAAAAACTTCTTTTTGCAATAGAAGAGACAGAGGGATTTGGACAAGAATGAATGTGGCTTCTTATTTTGGAGGAGCTCTTGCATTTAAATACCCCAGCCAAGAAAAATTGCACAGATAGTGTATATAAGCTGTTCATTCTGTACAGTGAATTTTCCGAACCTCTCAAAGTATGTTTTCCGTTCTTCCACAGAAATATGCAAAACAGTTCATCCTTTTCTACTTTATTTATTGTTCCCTTGAAATGACTGACCAGGAAAAAGATCATCCTTAAATTTTGAAGCAAGTGAGAGACTTtattaaaaatacatatatatctatataaacatatatgataGTGGCTCTAGTTTTATAGAGCTCCAAGTGTATTAAACATGACAGCCATTCATTCATAAAGATCTGGATTTGCTTTACCTTGTTAATATTATCTAGGGGAAAAAGTGCAAATTGCTCCATGTTCTTCTCTCCCTTATGTAACATCTCCTGAGGGTGTTTAGTTGCATGGCTGTTCAGAAAGGTATTAAGGGCTTAGGCCAAATCTTACTTTGAGTATGTTAAAAAAAAAAAAATGCTGCTGGCTTTTCTGAAGACAGGTGCTTGAACTTGTCAGTTTGTTTTAAATAAATACAATAGTTGAAAATTTTTCTCTGTTACATCAGTAATATTGTTAAAGTAATGGATAGAACCATAACTTACACATGAAAGTCATATACTAGATCCAATACTATTTAGTTTATTATCGAAATTGGAAGGATTCATTGAGCAGCATAGAAGTTTGTTTACATGTTACTTTGAGATGCTAGGTATTTGTGGAATTAAAAAGAATCAGGCTCTTTTGTACTTTGTTTTTAAATCTGTGATGCTTTTCAAATTTAATTCATAATAAATTGATGCAATTTCATACTTAGGAACATACAAAAGGTAATGTAAACTCTGCCACTTTTTTGTGTTCAAAATTTTGGTTTTTATGAAGCCAGATGGATTGAAGAGTTACATAAGCATTTGAATGCTCTAATATAAGGCTAATGATTTTCTGTTAGTGTTTGAATATCTTCATTCCTCTCAAATTCATAACAGTTCTATTTAACTGAATTAAATAACCATATGAAAAATCTTTTGGGTCTCCCCCTTTTTACACAGATAATTATTTTTGTCATAACACTTTTTAATTGTTTTTCATCATAGGGGCCTTTGCTGAACTACAAAAATGTGTAACAAATTAAAATCTGATGTGAATGATATTAATGCTACTTTTAGCAAACTGGGCTTCCTAATACAAAATTTTAAATTTCCATTTGTATCATGCTTTTAATATGCACTGTAAATTTCATTAACTTAAACATTTTTTAATAGCCATGGAACTGACTTCTTAAAATCTGTTGCCTATAAATATTTCACTGCTAAGTACATACAGAAAAACAGTAATTATTGTTTTGCCAAAATTTTATTTTTCTACATATTGAGAGTGTGTTCTCCATTTTATTCAGAATTCATAGTAAAGACGAAAGAAAGGCAGAGATCTGCTTGGTTGAATAGACTCCTTTTCCAAATCCTTATTATGAACACTCTGGTAATTTTCAAGCCTAAAGAATTAAAAAAAAAATTCTAATGTATGTGACAGGTTATGTGATAGAGGGAAACTGGCCTTCAAAAAGGACTGCGT

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