Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DDX3P3
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:103572019-103575630  UCSC
Coordinates (T2T) chr4:106883926-106887537  UCSC
Coordinates (hg19) chr4:104493176-104496787  UCSC
Strand +
Parental Sequence NM_001356.5
Parental seq. overlap 3256 bp
Parental seq. overlap (%) 69.7%
Genomic Region Intergenic
Retrocopy Summary DDX3P3, located on chr4:103572019-103575630, is a retrocopy of the parental gene DDX3X. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DDX3X
Full Name DEAD-box helicase 3 X-linked
Also known as CAP-Rf|DBX|DDX14|DDX3|HLP2|MRX102|MRXSSB
Coordinate chrX:41333308-41351668
Strand +
Gene summary The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DDX3XP1
Bonobo Pan paniscus DDX3XP1
Gorilla Gorilla gorilla DDX3XP1
Orangutan Pongo abelii DDX3XP1
Gibbon Nomascus leucogenys DDX3XP1
Green monkey Chlorocebus sabaeus DDX3XP1
Crab-eating macaque Macaca fascicularis DDX3XP1
Rhesus Macaca mulatta DDX3XP1
Baboon Papio anubis DDX3XP1
Golden snub-nosed monkey Rhinopithecus roxellana DDX3XP1
Marmoset Callithrix jacchus DDX3XP1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DDX3P3
ATGAGAGGGCCTTCGCAGTGAAACAAACATATTAGCTCAGCAGTGGAAGACTCCTGGGTACTCTTCAGGGATGAGTCATGTGGTGATTGAAAATGTGCTTGGGCTGGACCAGCAGTTTGCTGGCCTAGACCTGGCCTATTCAGATAATCAGAGTGGGGGAAGTACAGCCAGCAAAGGGCACTATATCCCTTTTCGTTGAGGAACAGAGCAGCTACTAAGGATTCTACCATAAAGACAGTTTAGGGTGGCGTTCTAGCAAAGATAAGGATGCCTACAGCAGTTTTGAATCTCCTAATGATTCAAGCACTAAGTCTAGCTTCTTCAGAGATCATGGAAGTGGATCAAGGGGAGGGTTTGATAATCATGGATGGAGTGATTATGATGGCACTGGCAGCCATTGTGACAGAAGTGGCTTTGGCAAATTAGCATGTGGTGAAAACAGTCACTGGTGTGACAAATAAGATGAAGATGATTGGTCAAAACCACTCCCACCAAGTGAATGCTGGAACAGGAACTCTTTTCTGGAGGCAACACTGGGATTAATTTTGAGAAATACGATGACATTCTAGTTGAGGCAACAGACAGCAATTGTCCTCCACATATTGAAAGTTTCAGTGATGTTGAGATGGGAGAAACTATCATGGGAAACATGGAGGTTATTATACTAGCCTGACTCCAGTGCAAAAGCATGCTGTTACTATTAGAAAAGAGAAAAGAGACTTGATGGCTTGTGCCCAAACAGGGTCTGGAAAACTGCAGCATTTCTCTTGCCCATGTTGAGTCAGATGTATTCAGATGGTCCAAAGGAGGCTTTGAGGGCCATGAAGGAAAATTAAAGGTGAGGGCGCAGCAAACAGTACCCAATCTTCTTGGTATTAGCCCCAAGAAGAGAATTGGCAATACAGATCAATGAGAAAGCAAGAAAATTTTCGTACTGATCTAGAGTTCCTCCTTGTGTGATTTATGGTGGTGCTGTTATTGTTCAGCAGATTTGAGTCTTAGAAGGTGGATGGCACTTGCTACTAGCCACTCCAGGATATCTAGTGGATATGATGGAAAGAGGAAAGATTGGATTAAACTTTTATGAATACTTGGTGTTAGAAGAAGCTGATCAGATGTTGGATATGGGGTTTGAGCCTCAGATACATAGAAAAGTTGAACAAGATACCATGCCTCCAAAGGGTGTCCACCAAACTATGATGTTTAGTGCTACTTGGCCTAAGGACATACAGATGCTCGCTCATGATTTCTTCAATGAATATATTAATACCTTATTGGCTGTATGGAGGAGTTGGCTCTACCTCTGAGAACATCACAAAGAAAGTTGTTTGGGTGGAAGAATCAGACAAAGTTGTTTCTGCTTGACCTCCTAATACATCCACTTGATCCCAGGCAAGTACGCACTAACCTTAGGTTTATGGAGACCAAAAAGGGTTTTTATTCTCTAGAGGATATCTTATACCATGAAGGATAGTCATGTACCAGTATCTATGGACACCATTCTCAGAGGGATAGGGAAGAAGCTCTTCACCAGTTACCCTCAGGAAAAAGCCCAATGCTAGTGGCTATAGCAGTAGCAGTAAGAGGACTGGACCTTTCAAATGTGGAACATGTTATCAATTTTGATTTGCCAAGTGATATTGAAGAATATGTATATGGCATTGGCCATACAAGATGTGTAGAAAACCTTGGCCTGGCCACCTCGTTCTTTAATGAGGGGAACATAAATATCACTAAGGATTTGTTGCATCTTCTTGTTGAAGCTAAACAAGAAGTGCCATCTTGGTTAGAAAATATGGCTTATGAACACCACTACCAGGGTAGTAATTGTGGACGTTCTAAGAGTGGCAGATTTAGTGGAGGATTTGGTGCCAGAGGCTACTGACAAAATAGTGGTGCCAGCCGTTCCAGTTTCAGCAGCAGCCATGCAAGCAGCAGACACAGTGGTGAAGGTGGCCACGGCAGCAGCAGAAGATTTGGTGGAGGTGGCTATGGAGGCTTTTGCAACACTAATAGATATGGAGGAAATTATAACTCCCAGAGAGTTGACTGGTGGGTAACTGAGCCTGCTTTGCAGTAGGTCATCCTGCCAAACAAGCTAATATGGAAACCATATGTAACTTAGCTGGATGATACCTTGTGTAGCTTGAAGAACTTGCAGTATATTACCAGCTGTGATTCTCCACTAATTTTTTCTTTTTTAAGGGAGCTCAAGGTTCCACAAGAAGAAAAAAAGAACAATTAACAACCTTGTTTGGAAGGTGGTTTGAAGACTTCATTGCCATTGTTTGGATTAATTCCCCTCCTGCCTACCTCCAACCCAAACTGCATTTATAATTTTGTGACTGAGGATCATTTGTTTGTTAATGTTAACTTTAGATAACTTTTTATTTTGATGTCCTGTTGGCTCAATACATCAATTGTTTTGAAAAAATTACTGAACTTGGGCTAAAGTCAAACCTTGGGACACAGGTGTGATACAACTTAATAGGAACCATCGATTCATCCATAAATATTTTAAGGATAAACCTATTTGGTAGCCTCCATTAGGGCTTTTTGATACTTGAAAACTGGGGGAAAACAAACAACAAATCTTGTAAAGTATATTAATGGAATTAGTTTCTACTGCTGCAAACTGTATTAAGTTAAAGTTCTGATTTTCTCACTCTGTCCTGGATAGGTATTTGTAACCTCACAGCCTTTAAACAAGCCATTCCAGTCACGATGAGGTGATGTATGAATACATGCATACATTCAAACACTGTCTTCAAAGTTAACTCAAGTAAATACAGCAACTCCTCTTTCAGTGTTTAGGCAGATTATTAACTATGAGCTAGCCAAATGTGGGCATACTATTACAGGGAATGCTTAAAGATCCGGTAACTTGAAATAGGTTTTTAGGAGAACTCATCTGCTTAGACTTTTTAAATGCCTGCCATAAATGAAATTGAAATGGTAGATGGGGACCACAGCAAAGACCAACCCTCGTTAGGGCCCTGGATGATTTTTGGTCTAATAACACATGCTAGTGTTGATGTTTTCTGGTTAAGAGGGTATGAACAGGAAGAATTATGCAGCAGGCTTTACTTTAAATGCTGATTCACATGATTGTTCAAGCTGAGTTGAGATGCTAAACTGGCTTACTATAGACTTTGTAAAAATGGCTCCAGAAGAGTAACTAACTGAAATCTTTAAGCTCACACAGGTTGGAAATATGTACATAATTGCACAAGGTGTCAATTTACTCTACAGCGCAGTTTTAGTTGCATAGGTTTCCATTGTATTTATAGTCAATTTAAGTTAAATCTGGCCAAAGATGAGCATTGTTCACCACTAAAATGCCTCTGCCACTTTGAATTCTGATCTAATTTTGTGGCCAGAATGTGGTGATTAAAGCGCTCAGTCTTTTTACAGTGGCATAGGAAAATGGCAAAAATTTCCTAAAGTGCAGTAGATTTTCAAGTGTATTGTGCCTTGTTCTAGAACTTTTATTAAGTAGGTACACTTGACAGTATTGAGGTCATTTGTCATGGTGCTATTTAATTAGTCTAGGTTTAGGCCCTTGTACTTATTGTCCATAATTTGTACAAAGTACTTCTTTTATTGCACATT
>NM_001356.5
AGAGCCGCAGTTCTCCCGTGAGAGGGCCTTCGCGGTGGAACAAACACTCGCTTAGCAGCGGAAGACTCCGAGTTCTCGGTACTCTTCAGGGATGAGTCATGTGGCAGTGGAAAATGCGCTCGGGCTGGACCAGCAGTTTGCTGGCCTAGACCTGAACTCTTCAGATAATCAGAGTGGAGGAAGTACAGCCAGCAAAGGGCGCTATATTCCTCCTCATTTAAGGAACCGAGAAGCTACTAAAGGTTTCTACGATAAAGACAGTTCAGGGTGGAGTTCTAGCAAAGATAAGGATGCGTATAGCAGTTTTGGATCTCGTAGTGATTCAAGAGGGAAGTCTAGCTTCTTCAGTGATCGTGGAAGTGGATCAAGGGGAAGGTTTGATGATCGTGGACGGAGTGATTACGATGGCATTGGCAGCCGTGGTGACAGAAGTGGCTTTGGCAAATTTGAACGTGGTGGAAACAGTCGCTGGTGTGACAAATCAGATGAAGATGATTGGTCAAAACCACTCCCACCAAGTGAACGCTTGGAACAGGAACTCTTTTCTGGAGGCAACACTGGGATTAATTTTGAGAAATACGATGACATTCCAGTTGAGGCAACAGGCAACAACTGTCCTCCACATATTGAAAGTTTCAGTGATGTTGAGATGGGAGAAATTATCATGGGAAACATTGAGCTTACTCGTTATACTCGCCCAACTCCAGTGCAAAAGCATGCTATTCCTATTATCAAAGAGAAAAGAGACTTGATGGCTTGTGCCCAAACAGGGTCTGGAAAAACTGCAGCATTTCTGTTGCCCATCTTGAGTCAGATTTATTCAGATGGTCCAGGCGAGGCTTTGAGGGCCATGAAGGAAAATGGAAGGTATGGGCGCCGCAAACAATACCCAATCTCCTTGGTATTAGCACCAACGAGAGAGTTGGCAGTACAGATCTACGAGGAAGCCAGAAAATTTTCATACCGATCTAGAGTTCGTCCTTGCGTGGTTTATGGTGGTGCCGATATTGGTCAGCAGATTCGAGACTTGGAACGTGGATGCCATTTGTTAGTAGCCACTCCAGGACGTCTAGTGGATATGATGGAAAGAGGAAAGATTGGATTAGACTTTTGCAAATACTTGGTGTTAGATGAAGCTGATCGGATGTTGGATATGGGGTTTGAGCCTCAGATTCGTAGAATAGTCGAACAAGATACTATGCCTCCAAAGGGTGTCCGCCACACTATGATGTTTAGTGCTACTTTTCCTAAGGAAATACAGATGCTGGCTCGTGATTTCTTAGATGAATATATCTTCTTGGCTGTAGGAAGAGTTGGCTCTACCTCTGAAAACATCACACAGAAAGTAGTTTGGGTGGAAGAATCAGACAAACGGTCATTTCTGCTTGACCTCCTAAATGCAACAGGCAAGGATTCACTGACCTTAGTGTTTGTGGAGACCAAAAAGGGTGCAGATTCTCTGGAGGATTTCTTATACCATGAAGGATACGCATGTACCAGCATCCATGGAGACCGTTCTCAGAGGGATAGAGAAGAGGCCCTTCACCAGTTCCGCTCAGGAAAAAGCCCAATTTTAGTGGCTACAGCAGTAGCAGCAAGAGGACTGGACATTTCAAATGTGAAACATGTTATCAATTTTGACTTGCCAAGTGATATTGAAGAATATGTACATCGTATTGGTCGTACGGGACGTGTAGGAAACCTTGGCCTGGCAACCTCATTCTTTAACGAGAGGAACATAAATATTACTAAGGATTTGTTGGATCTTCTTGTTGAAGCTAAACAAGAAGTGCCGTCTTGGTTAGAAAACATGGCTTATGAACACCACTACAAGGGTAGCAGTCGTGGACGTTCTAAGAGTAGCAGATTTAGTGGAGGGTTTGGTGCCAGAGACTACCGACAAAGTAGCGGTGCcagcagttccagcttcagcagcagccgcgcaagcagcagccgcagTGGCGGAGGTGGCCACGGTAGCAGCAGAGGATTTGGTGGAGGTGGCTATGGAGGCTTTTACAACAGTGATGGATATGGAGGAAATTATAACTCCCAGGGGGTTGACTGGTGGGGTAACTGAGCCTGCtttgcagtaggtcaccctgccaaacaAGCTAATATGGAAACCACATGTAACTTAGCCAGACTATACCTTGTGTAGCTTCAAGAACTCGCAGTACATTACCAGCTGTGATTCTCCACTGAAATTTTTTTTTTAAGGGAGCTCAAGGTCACAAGAAGAAATGAAAGGAACAATCAGCAGCCCTGTTCAGAAGGTGGTTTGAAGACTTCATTGCTGTAGTTTGGATTAACTCCCCTCCCGCCTACCCCCATCCCAAACTGCATTTATAATTTTGTGACTGAGGATCATTTGTTTGTTAATGTACTGTGCCTTTAACTTTAGACAACTTTTTATTTTGATGTCCTGTTGGCTCAGTAATGCTCAAGATATCAATTGTTTTGACAAAATAAATTTACTGAACTTGGGCTAAAATCAAACCTTGGCACACAGGTGTGATACAACTTAACAGGAATCATCGATTCATCCATAAATAATATAAGGAAAAACTTATGCGGTAGCCTGCATTAGGGCTTTTTGATACTTGCAGATTGGGGGAAAACAACAAATGTCTTGAAGCATATTAATGGAATTAGTTTCTAATGTGGCAAACTGTATTAAGTTAAAGTTCTGATTTGCTCACTCTATCCTGGATAGGTATTTAGAACCTGATAGTCTTTAAGCCATTCCAGTCATGATGAGGTGATGTATGAATACATGCATACATTCAAAGCACTGTTTTCAAAGTTAATGCAAGTAAATACAGCAATTCCTCTTTCAACGTTTAGGCAGATCATTAATTATGAGCTAGCCAAATGTGGGCATACTATTACAGGGAAAGTTTAAAGGTCTGATAACTTGAAATAGGTTTTTAGGAGAATTCATCTACTTAGACTTTTTAAATGCCTGCCATAAATGAAATTGAAATGGTAGAATGGCTGACCACAGCAATGACCAGCCCTCATTAGGGCCCTGGATGATTTTTGGTCTAATAACGCATGCTAGTGTTGATGTTTTTTGGTCAAGAGGGTATGAACAGGAAGAATTAAATGCAGCAGGCTTTATTTTAAATGCCGATTCACATTACTCTGTTCAAGCTGCGTTGAGATGTTAAACTGGCTTACTATAGACTTCGTAAAAATGGCTCCAGAAGAGTAACAAACTGAAATCTTTGAGATCACACAGGTTGGAAATATGTACATAACTGCACAAGGTGTCAATTCTGCTCTACAGTGCAGTTTTAGTCAGTTTTAGTTGCATAGGTTTCCATTGTATTTATAGTCTGTTTATGCTAAATCTGGCCAAAGATGAGCATTGTCCACCACTAAAATGCCTCTGCCACTTTGAATTCTGTGCTAATTTTGTGGCCAGAATGCGGTGATCAAAACGCTCCATCTTTTTACAGTGGCATAGGAAGACGGCAAAAATTTCCTAAAGTGCAATAGATTTTCAAGTGTATTGTGCCTTGTTCTAAAACTTTTATTAAGTAGGTGCACTTGACAGTATTGAGGTCATTTGTTATGGTGCTATTTCAATTAGTCTAGGTTTAGGCCCTTGTACATTTTGCCCATAACTTTTTACAAAGTACTTCTTTTATTGCACATTCAGAGAATTTTATATATATGTCTTGTGTGCGTGTCCTTAAACTTCCAATCTTACTTTGTCTCTTGGAGATTGTTGAACGCAGCTTGTCTAGGAAGGGGATGGGACTAGATTCTAAAATTTATTTGGGACCATGGGAATGATAGTTGGGAAGAAAACTATTTGCACACGACAGATTTCTAGATACTTTTTGCTGCTAGTTTTATGTAATATTTATTGAACATTTTGACAAATATTTATTTTTGTAAGCCTAAAAGTGATTCTTTGAAAGTTTAAAGAAACTTGACCAAAAGACAGTACAAAAACACTGGCACTTGAATGTTGAATGTCACCGTATGCGTGAAATTATATATTTCGGGGTAGTGTGAGCTTTTAATGTTTAAGTCATATTAAACTCTTAAGTCAAATTAAGCAGACCCGGCGTTGGCAGTGTAGCCATAACTTTCTGATGTTAGTAAAAACAAAATTGGCGACTTGAAATTAAATCATGCCAAGGTTTTGATACACTTGTCTTAAGATATTAATGAAACACTTCAAAACACTGATGTGAAGTGTCCAGATTCTCAGAtgtttgttgtgtggattttgtttagttgtgtgtttttttttttttttCAGTGAATGTCTGGCACATTGCAATCCTCAAACATGTGGTTATCTTTGTTGTATTGGCATAATCAGTGACTTGTACATTCAGCAATAGCATTTGAGCAAGTTTTATCAGCAAGCAATATTTTCAGTTAATAAGGTTTCAAAAATCATGTAAGGATTTAAACTTGCTGAATGTAAAGATTGAACCTCAAGTCACTGTAGCTTTAGTAATTGCTTATTGTATTAGTTTAGATGCTAGCACTGCATGTGCTGTGCATATTCTGATTTTATTAAAATAAAAAGTTGAACTGCACAGTCTCCTTTGTTGTTGTCAATTGTGGTTTATTTTCAGAGGTGTAAATAAAGTGCTCTTGCCTGAAAAA

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