Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TCTN2P1
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:104649535-104649954  UCSC
Coordinates (T2T) chr4:107960510-107960928  UCSC
Coordinates (hg19) chr4:105570692-105571111  UCSC
Strand -
Parental Sequence NM_001143850.3
Parental seq. overlap 354 bp
Parental seq. overlap (%) 12.2%
Genomic Region Intergenic
Retrocopy Summary TCTN2P1, located on chr4:104649535-104649954, is a retrocopy of the parental gene TCTN2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TCTN2
Full Name tectonic family member 2
Also known as C12orf38|JBTS24|MKS8|TECT2
Coordinate chr12:123671108-123708405
Strand +
Gene summary This gene encodes a type I membrane protein that belongs to the tectonic family. Studies in mice suggest that this protein may be involved in hedgehog signaling, and essential for ciliogenesis. Mutations in this gene are associated with Meckel syndrome type 8. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TCTN2P1
Gorilla Gorilla gorilla TCTN2P1
Gibbon Nomascus leucogenys TCTN2P1
Green monkey Chlorocebus sabaeus TCTN2P1
Crab-eating macaque Macaca fascicularis TCTN2P1
Baboon Papio anubis TCTN2P1
Golden snub-nosed monkey Rhinopithecus roxellana TCTN2P1
Marmoset Callithrix jacchus TCTN2P1
Bonobo Pan paniscus Without Homology
Orangutan Pongo abelii Without Homology
Rhesus Macaca mulatta Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TCTN2P1
ATCCACATCCTCATCTCAGATGCTGGGGCAGTGGAAGGGATTACTCAGCAGGGGATACTTGGCATAGAGACAAGTTTCTCCTCAGTTAACTGGCAGTACCAGTGTGTGTGGGCTTACTTGTGGGGATAAGGCTGACCTTCTCCTTATCAGTAGATCAGTCAAGTTTGTTAAAATTCCTGCACAGTTATCCTGCCCCCAAAAAGATTACAAATCAATTATACAGAGTATGACTAACAGAAATAAAGTGTACTGGCTGCAGCTTCTATATCCATGGACTCTGTATTAAGGGGAACCATATTCTTAGTGTGTTGCCAAGGGCTTACAGTTGCTGTTGTTTCTCACATTGGCCATGTTTCTCCATAACCCCTGAACCAGAATATACAAAGCCTGGAGTTAGACAACCATCTGACt
>NM_001143850.3
ATAGCTCCGGGCGTTCGCTTGCAAGATGGCGGCGGCGGGGCAGTGGCTGCTGCGTTTTCGTGTCTGAGTCCTTCCTGGGTTCTAATGAGGGCGCGGTTCTGCTGTGCCCGGCCCGCGAGGTCTAAGGCATGGGCTTCCAGCCTCCGGCCGCTCTTCTTTTGAGGCTTTTCCTTCTGCAGGGCATCCTGAGGCTTCTGTGGGGGGACCTGGCTTTCATCCCTCCTTTTATCCGAATGTCCGGCCCTGCGGTCAGCGCGTCCCTGGTCGGAGACACCGAGGGTGTGACCGTGTCCCTGGCAGTGCTGCAGGACGAGGCGGGAATATTGCCAATTCCGACGTGTGGAGTGCTGAACAATGAGACGGAAGACTGGAGCGTGACTGTGATCCCCGGTGCGGTGTTGGAAGTGACAGTGAGGTGGAAGAGAGGTCTGGACTGGTGTTCCTCCAATGAGACAGATTCCTTCTCAGAGTCCCCCTGTATCCTCCAGACCCTTCTGGTTTCAGCATCTCATAATTCATCCTGTTCAGCACATCTACTCATTCAAGTGGAAATTTATGCCAACTCTTCTCTGACCCATAATGCCTCAGAGAACGTGACTGTCATTCCTAACCAGGTGTATCAGCCCCTTGGCCCTTGTCCTTGTAATTTAACAGCTGGAGCCTGTGATGTTCGCTGCTGCTGTGACCAGGAATGCTCATCAAATTTAACAACGCTGTTCAGACGGTCCTGCTTCACCGGCGTGTTTGGAGGAGACGTCAATCCTCCTTTTGATCAGCTCTGCTCTGCTGGGACGACGACACGTGGTGTCCCCGATTGGTTTCCCTTTCTGTGTGTGCAGTCCCCCCTTGCCAACACACCCTTCCTTGGTTACTTCTATCATGGTGCTGTTTCCCCCAAACAGGACTCTTCCTTTGAAGTATATGTGGATACTGACGCAAAAGACTTTGCAGACTTTGGTTACAAACAAGGAGATCCCATTATGACTGTAAAGAAGGCATATTTTACTATTCCGCAGGTGTCCCTGGCTGGGCAGTGTATGCAGAACGCCCCAGTGGCATTTCTTCACAATTTTGATGTTAAATGCGTTACTAATTTGGAACTATACCAAGAACGAGATGGTATTATCAATGCGAAGATAAAGAATGTTGCCTTAGGAGGCATAGTTACACCAAAAGTGATCTATGAGGAAGCAACTGACCTAGACAAATTCATCACCAATACAGAAACTCCTTTAAATAACGGATCAACCCCTAGAATTGTGAATGTGGAAGAACATTATATTTTCAAATGGAATAATAATACCATCAGTGAAATAAATGTTAAAATTTTTAGGGCAGAGATTAATGCCCACCAGAAAGGGATAATGACACAGAGATTTGTAGTAAAATTTTTAAGCTATAATAGTGGTAATGAAGAAGAATTATCTGGAAATCCAGGTTACCAACTTGGCAAGCCTGTCCGAGCTCTAAATATCAACAGGATGAATAATGTCACGACTTTACATCTTTGGCAATCGGCTGGAAGGGGTCTGTGTACATCAGCAACTTTCAAACCCATTTTATTTGGAGAAAATGTACTCTCTGGATGCCTGTTAGAAGTCGGGATTAATGAAAATTGTACTCAGCTCAGGGAGAATGCTGTTGAAAGACTTGATTCATTAATACAAGCGACTCACGTTGCAATGAGAGGCAACTCCGATTACGCTGATCTTAGTGATGGCTGGCTCGAAATAATACGTGTAGATGCCCCTGATCCAGGTGCAGACCCGCTGGCTAGCAGTGTGAACGGCATGTGCCTGGATATTCCTGCTCACCTGAGCATCCGCATCCTCATCTCGGATGCTGGCGCGGTGGAAGGGATTACTCAGCAGGAGATACTCGGTGTAGAGACAAGGTTCTCCTCAGTGAACTGGCAGTACCAGTGTGGGCTTACCTGTGAGCACAAGGCCGACCTTCTCCCTATCAGTGCATCCGTCCAGTTTATTAAAATTCCTGCACAGTTACCCCACCCCCTGACAAGATTCCAGATCAATTATACAGAGTATGACTGCAACAGAAATGAGGTGTGTTGGCCGCAGCTTCTATATCCATGGACTCAGTATTATCAAGGGGAGCTGCATTCTCAGTGTGTTGCTAAGGGCTTACTGTTGCTGTTGTTCCTCACATTGGCCTTGTTCCTCAGCAACCCCTGGACCAGAATATGCAAAGCCTATAGTTAGACAACCACCTGGCttttatttttttgagatggagttttgctcttgttgcccaggctgaagtgatctcggctcaccacaacctcctcctcttgggttcaagcgattctcctgcctcagcctccggagaactgggattacaggcatgcaccaccacgcccggctaattttgtatttttagtagagacagggttccaccgtattggccaggctgctctcgaactcctgacctcatgatccgcccatcttggcctcccaaagtgctgagattacaggcatgagccaccgcacccggcctttttttttttttttttttttttgaggcggggtctctgtcacccaggctggagtgcagtgcacaatctcggctcactgcaatctctgcctcccaagcaatcctcccacctcagcctctggtgtagctgggaccacagatgctccaccatgcctggctgtatttttggtaaagacggggtttcgccttgttgcccagggtggtctgtaactcctgagctcagatgatctgcccacctcggcctcccaaagtgctgggatcacagacgtgagccactgcgtccggtcCATCTGACTTCTCAAAGACTTTAGACCTTGACTTCAGTGATTTGTTGTAGTCTTGTATGCTTCTCTATAAAATTTTAATAAATGAAATGTCTTATTTTTGTAGAAAA

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