Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name LYPLA1P2
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:110943457-110945866  UCSC
Coordinates (T2T) chr4:114245020-114247429  UCSC
Coordinates (hg19) chr4:111864613-111867022  UCSC
Strand -
Parental Sequence NM_006330.4
Parental seq. overlap 2263 bp
Parental seq. overlap (%) 89.8%
Genomic Region Intergenic
Retrocopy Summary LYPLA1P2, located on chr4:110943457-110945866, is a retrocopy of the parental gene LYPLA1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name LYPLA1
Full Name lysophospholipase 1
Also known as APT-1|APT1|LPL-I|LPL1|hAPT1
Coordinate chr8:54046367-54101947
Strand -
Gene summary This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes LYPLA1P1
Bonobo Pan paniscus LYPLA1P1
Gorilla Gorilla gorilla LYPLA1P1
Orangutan Pongo abelii LYPLA1P1
Green monkey Chlorocebus sabaeus LYPLA1P1
Crab-eating macaque Macaca fascicularis LYPLA1P2
Rhesus Macaca mulatta LYPLA1P2
Baboon Papio anubis LYPLA1P1
Golden snub-nosed monkey Rhinopithecus roxellana LYPLA1P1
Gibbon Nomascus leucogenys Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>LYPLA1P2
GCACGCCCTTGGGCCGCGGCCGGGCGCCAGCTCTTCCTTCCGTTTGCGCTGTGAGCTGAGCCGGTGTATGTGCAGCAATAACATGTCAGCCCCGCTGCCAGCCATCGTGCCCGCCACCTGGAAGGCCACCGCGGCGGTGATTTTCCTTCATGGATTGGGAGATACTGGGCACCGATGGATAGAAGCCTTTGCAGGTATCAGAAGTTCACATATCAAATATATCTGCCTGCATGCTCCTGTTATGCCTTTACATTAAATATGAACATGGCTGTGCCTTCATGGTTTGATATTATTGGGCTTTCACCAGATTCACAGGAGGACGAACCTGGGATTAAACAGGCAGCAGAAAATATAAAAGCTTTGATCGATCAAGAAGTGAAGAATGGCATTCCTTCTAACCGAATTATTGTAGGAGGATTTTCTCAGGGAGGAGCTTTATCTTTATATACTGCCCTTACCACGTAGCAGAAACTGGCGGATGTCACTGCGCTCAGTTGCTGGCTTCCACTTCGGGCTTCATTTCCACAGGGTCCTATCAGGGGCGCTAACAGAGATATTTCTATTCTCCAGTGCCACGGAGATTGTGACCCGTTAGTTCCCCTGATGTTTGGTTCTCTTACGGTTGAAAAACTAAAAACTTTGGCGATCCAGCCAATGTGACCTTTAAAACCTATGATGGTATGATACATAGCTCATGTCAACAGGAAATGATGGATGTCAAGCAATTCATTGATAAACTCCTACTTCCAATTGATTGACGTCACTAAGAGGCCTTGTGTAGAAGTACACCAGCATCACTGTAGTAGAGTATAAACCTTTTCCCATGCCCAGTCTTCAAATTTCTAATGCTTACAGTGTTAAAATGTTTTGCAAATACACGCCAATGACACAGATCAAATAACGTCTCCTCATAAGAAATTTATGACCTTTTAAGTTTCTATACATGTATTCTTATAAGAAGATCCAGGATATACTATGTTAAAATAGATGAAGCAGGTAGCTTCTTTTTTCTCAAATGTAATTCAGCAAAATAATACAATACTGCCACCAGATTTTTTATTACATCATTTGAAAATTAGCAGTATGCTTACTGAAAATTTGTTCGGATATAAATGAGCAGTTAAGATGTAAACAATTTATGCATGCTGTGACTTGGTCTATGGATTTATTCCAAAATTGCTTAGTCACGACGCAGTGTCTGTATTTTTATATATGTATTCATATATACATGATTGTAATACATAATAAGAATGAAGTGGTATTACATTATTCCTAATAATACAGATAATGCTATTCATTGTCAAAAAAGAGTAAAATTGTTGTCTTCAATTAATGACCCTTTTATTTTGGGACCAGGATTTTCTTTTCCCTGATATTATTTCTATTTAATATTCTTTTCTCTCAAGGAAAAAAAAGTTCATTCTTTCTTTATTGTCCTTCATAGTAGGCCAAATATTGCCTCTCTGCCATAGACAGCTACTGTCAATACATGCCGTAATTTGACATTCTGAGTCACAGATATAAGGTATTTAAAATCTATTTATGCTTTATAGAGAAACCAGACATTATGCACTACTTATTTCCAATTATATTCAAATTTACACCTATTTAGTTATTAGGATCTTCAGCCCAGGTAACAGGAATAATTCTGTGTTTTTATTTTTCTGTAAACAACTGAAAGAATAATTAGATCATATTCTAGTATGTTCTGAAATATCTTTAAGACTGATCTTAAAAACTAATTTCTAAGATGATTTCATCTCCTTATAGCATAGAATTTACTTTGTACACATGTTTGAAACCAACTACTGTAGAAGATGAGAAATCTATTGTAATTGTTTGCTTTATTTTCATCTGCCAGTGGACTTATTTGAAATTTTCACTTTAGTCAAATTATTTTTTATATTAGTTTTTCATGCAAACATAAAAATAGCAATCATTTTAAATTGTCAAAATTTCCAGATTACTGGTAAAAATTATTTGAAAACAAACTTATGGGTAATAAAGACTAGTCAGAGCCCTATACATAAAGTGTATTTACCATACAGATTAATATTAAGCAAAAATGTATGCTTGATATTTCTGAACTGTGTTAATTTTTCTGCTGTATTCCAGCTGAACAACATTAAGAATGCATTTTTATAAACTGGTGCTAATCAATAATGAAAATAATTTAGTAATGGAATATATAGGATGTTAATAATGAAGCCATATGTTTTTGTCTGGATTTAAAAATTTTAAACATGTCATTTTTCTTTACCTTAAAGAATATAAACTGTTGTTTCAGTTCTGCAGATCAGCAAGATACTACTTATGGCAAGAAATATTCCTTTGAAATGTTGTGCTGTAATGTGGGAAAATGTAAATGTTTTTCATGGTTTTATCAATGTAAAATAAATTTAATTCTGAA
>NM_006330.4
GTTGGCGCGCACGCGCCTGAGCGTGCGCCCGGTGGGGCCGGCCGGGACTCGCCGCTCGCACGCCCTTGGGCCGCGGCCGGGCGCCCGCTCTTCCTTCCGCTTGCGCTGTGAGCTGAGGCGGTGTATGTGCGGCAATAACATGTCAACCCCGCTGCCCGCCATCGTGCCCGCCGCCCGGAAGGCCACCGCTGCGGTGATTTTCCTGCATGGATTGGGAGATACTGGGCACGGATGGGCAGAAGCCTTTGCAGGTATCAGAAGTTCACATATCAAATATATCTGCCCGCATGCGCCTGTTAGGCCTGTTACATTAAATATGAACGTGGCTATGCCTTCATGGTTTGATATTATTGGGCTTTCACCAGATTCACAGGAGGATGAATCTGGGATTAAACAGGCAGCAGAAAATATAAAAGCTTTGATTGATCAAGAAGTGAAGAATGGCATTCCTTCTAACAGAATTATTTTGGGAGGGTTTTCTCAGGGAGGAGCTTTATCTTTATATACTGCCCTTACCACACAGCAGAAACTGGCAGGTGTCACTGCACTCAGTTGCTGGCTTCCACTTCGGGCTTCCTTTCCACAGGGTCCTATCGGTGGTGCTAATAGAGATATTTCTATTCTCCAGTGCCACGGGGATTGTGACCCTTTGGTTCCCCTGATGTTTGGTTCTCTTACGGTGGAAAAACTAAAAACATTGGTGAATCCAGCCAATGTGACCTTTAAAACCTATGAAGGTATGATGCACAGTTCGTGTCAACAGGAAATGATGGATGTCAAGCAATTCATTGATAAACTCCTACCTCCAATTGATTGACGTCACTAAGAGGCCTTGTGTAGAAGTACACCAGCATCATTGTAGTAGAGTGTAAACCTTTTCCCATGCCCAGTCTTCAAATTTCTAATGTTTTGCAGTGTTAAAATGTTTTGCAAATACATGCCAATAACACAGATCAAATAATATCTCCTCATGAGAAATTTATGATCTTTTAAGTTTCTATACATGTATTCTTATAAGACGACCCAGGATCTACTATATTAGAATAGATGAAGCAGGTAGCTTCTTTTTTCTCAAATGTAATTCAGCAAAATAATACAGTACTGCCACCAGATTTTTTATTACATCATTTGAAAATTAGCAGTATGCTTAATGAAAATTTGTTCAGGTATAAATGAGCAGTTAAGATATAAACAATTTATGCATGCTGTGACTTAGTCTATGGATTTATTCCAAAATTGCTTAGTCACCATGCAGTGTCTGTATTTTTATATATGTGTTCatatatacataatgattataatacataataagaatGAGGTGGTATTACATTATTCCTAATAATAGGGATAATGCTGTTTATTGTCAAGAAAAAGTAAAATCGTTCTCTTCAATTAATGGCCCTTTTATTTTGGGACCAGGCTTTTATTTTCCCTGATATTATTTCTATTTAATACTCTTTTCTCTCAAGAAAAAAAAAAAAGTTTGTTTTTTCTTTATTGTCCTTCATAGCAGGCCAAGTATTGCCTCTCTGCAATAGACAGCTACTGTCAATACATGCTGTAATTTGACATTCTGGGTCACAGATATAAGGTATTTAAAATCTATTTATGCTTTATAGAGAAACCAGACATTAAAACTTCATGCACTACTTATTTCGAATTACTGTACCTTATCCAAATTTACACCTAGCTATTAGGATCTTCAACCCAGGTAACAGGAATAATTCTGTGGTTTCATTTTTCTGTAAACAACTGAAAGAATAATTAGATCATATTCTAGTATGTTCTGAAATATCTTTAAGACTGATCTTAAAAACTAACTTCTAAGATGATTTCATCTTCTCATAGTATAGAGTTTACTTTGTACACGTTTGAAACCAACTACTGTAGAAGATGAGGAATCTATTGTAATTTTTTGCTTTATTTTCATCTGCCAGTGGACTTATTTGAAATTTTCACTTTAGTCAAATTATTTTTTGTATTAGTTTTTGATGCAGACATAAAAATAGCAATCATTTTAAATTGTCAAAATTTCCAGATTACTGGTAAAAATTATTTGAAAACAAACTTATGGGTAATAAAGGCTAGTCAGAACCCTATACCATAAAGTGTAGTTACCATACAGATTAATATGTAGCAAAAATGTATGCTTGATATTTCTCAACTGTGTTAATTTTTCTGCTGTATTCCAGCTGACCAAAACAATATTAAGAATGCATCTTTATAAATGGGTGCTAATTGATAATGGAAATAATTTAGTAATGGACTATACAGGATGTTAATAATGAAGCCATATGTTTATGTCTGGATTTAAAAATTTTAAACAATCATTTACTATGTCATTTTTCTTTACCTTGAAGAACATAAACTGTTATTTCACTTCTACAAATCAGCAAGATATTATTTATGGCAAGAAATATTCCATTGAAATATTGTGCTGTAACATGGGAAAGTGTAAATGTTTTTCATGGTTTCTATCAATGTGAAATAAAATTTAATTCTGACTTTTCTGTGA

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