Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RPF2P2
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:115628988-115629623  UCSC
Coordinates (T2T) chr4:118931745-118932380  UCSC
Coordinates (hg19) chr4:116550144-116550779  UCSC
Strand +
Parental Sequence NM_032194.3
Parental seq. overlap 544 bp
Parental seq. overlap (%) 14.8%
Genomic Region Intergenic
Retrocopy Summary RPF2P2, located on chr4:115628988-115629623, is a retrocopy of the parental gene RPF2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RPF2
Full Name ribosome production factor 2 homolog
Also known as BXDC1|bA397G5.4
Coordinate chr6:110982038-111028263
Strand +
Gene summary Enables 5S rRNA binding activity. Involved in protein localization to nucleolus; regulation of signal transduction by p53 class mediator; and ribosomal large subunit biogenesis. Located in chromosome; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RPF2P1
Bonobo Pan paniscus RPF2P1
Gorilla Gorilla gorilla RPF2P1
Orangutan Pongo abelii RPF2P1
Gibbon Nomascus leucogenys RPF2P3
Green monkey Chlorocebus sabaeus RPF2P2
Crab-eating macaque Macaca fascicularis RPF2P1
Rhesus Macaca mulatta RPF2P1
Baboon Papio anubis RPF2P1
Golden snub-nosed monkey Rhinopithecus roxellana RPF2P1
Marmoset Callithrix jacchus RPF2P3
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RPF2P2
CAAAAAGAAAAATATTATAAGACTGTTCTAGAATCAGATATCACTGGAATTCTTCAAAGAAGTCAGATTGTTCCTTATTCACATACGGCTCCCATAATAAGAAATGAACAAATAATCTAATAAGAGATCACATGTATGGCTATCTTTTGCTAGATATGATAGAATTAGGCTTTGAGAAATTTGTCTCATTAATAGACATTAAGAACAGTAAATGCCCTGAGAAAACAAAACCCATGATAATATTTGCTGGTGAGGATTTTGTTGTAAAAGAAGACTATAAGGCTAAAGAGTCTTCTTACTGATTTCTTCAGCAGCCCAGGAGTATCAAATAGCCTCCCAACTGGATCAGAGTATGTTTTACACTTCACCACTCAGTAAGGGAAGATTTATTTTCGAAGCTATGAGTTACTGCTGAAGAAATCTGTTGCAGAATACCACAGATTGAAGTGGAGATATGGAAACCTCATTGGATCGGGTTCCGAGGAGGACACACCTGGCATCAGATGAACTTTATAAATTATCTATGCAAATGCCAACAACTTTCAAGCCAAAGAGGAAGAAAATTATCTCCCATGATACTTTTGGTATAATTTGTGGAAGGATTCACATGCAGAAGTAAGGCCTAAGCAAACTACA
>NM_032194.3
GTTCCGGCGCACGTAATCGCCGAGGGCACGTGCATGCCCCCTGGTTAAGAGTTGCAGGTAGCGGTAGCGATGGACACTCTGGATCGAGTAGTAAAGCCCAAAACGAAAAGAGCCAAGAGATTCCTTGAGAAGAGAGAACCGAAACTCAATGAAAATATTAAAAATGCCATGCTGATTAAAGGGGGAAATGCAAATGCAACAGTGACAAAAGTACTTAAAGATGTGTATGCACTGAAAAAACCATACGGTGTACTATATAAAAAGAAAAATATTACAAGACCTTTTGAGGATCAGACATCACTGGAATTCTTTTCAAAGAAGTCAGATTGTTCTTTATTCATGTTTGGCTCCCATAATAAGAAGCGGCCAAATAATCTAGTAATAGGTCGTATGTATGACTACCATGTGCTGGATATGATTGAATTAGGTATTGAGAATTTTGTCTCTCTAAAAGACATTAAGAACAGTAAATGTCCTGAGGGAACAAAACCCATGCTGATATTTGCTGGCGATGATTTCGATGTAACAGAAGATTATAGAAGACTAAAAAGTCTTCTTATTGATTTCTTCAGAGGCCCCACAGTATCAAATATCCGCCTGGCTGGATTAGAGTATGTTCTGCACTTCACTGCACTGAATGGGAAGATTTACTTTCGAAGCTATAAGTTGCTGTTGAAGAAATCTGGTTGCAGAACACCACGGATTGAATTGGAAGAGATGGGACCCTCATTGGATCTGGTTCTGAGGAGGACACACCTGGCATCGGATGACCTTTATAAATTATCTATGAAAATGCCAAAAGCTCTCAAGCCAAAGAAGAAGAAAAATATTTCCCATGATACTTTTGGTACAACTTATGGAAGGATTCATATGCAGAAGCAAGACCTAAGCAAACTACAAACCAGGAAAATGAAGGGGTTGAAGAAGCGACCTGCAGAAAGGATAACAGAAGACCACGAGAAAAAGTCAAAAAGAATTAAAAAAAATTGATGGAACTTAGCCAGCCACTACTGTTTCATTGTGTTCTACTTAAGAGAATTATCAAGCGTCAATCCATTCAGAGTTTCTTATAAGATCTTATTATATATTTTTATAACATGATAATTTTACGATATATTATTATGAACAGTAATATACTAGTATTAAGTGTAAAGTAAGCCTTTTATTTGAGACATTACACCCTGGTGTGCCATTTTCTCTTGTGATATCCCCTGCCCTCCACAAATTCTTCTTTCTCATTGGGTGGATGGATGGGTGAGGAGGGATCTCCATAACCATTGGGATTTTTTTGAATTTCTGGCCTTAGCTAAAGAAAGCCACAGAAAGCCGGACCCGCAGGAGCTGTGTAAACAATCTCAGTATGAATTACCTGGAAAGTTAACCTCCTCTCCCAACATGGATCTACATTCTGATTTTTATTTTCTACTTTTATTTTGCCTGAAATCCTACTCGTTGACATTTGAGATTTTAAGCTTTGTGGCTGAAAATATATAGATCTCTGAGAGGGATGTCTGCTATCTGATTATTGATAAATTACACTACTGTTGATTGTTTTAAGAGACTCTACTACTAAGTAGAGCCCACCCCGCTTCTCTGAGACGAAACCTGTGTTTTTTGGTTGGtttgtttttaagagatggggtcttgttctgtcacctagggtggagtgcagtggcacaatcacagctcactgcagccctgaactcctgggctcaagtaatcctcctgcctgagcctcttacgtagctgggattacaggcatgagccactgagccctactttttttttttaaagcaatgaggtcttgctgtgttgcccaggctggactcaaattcctgggctcaagtgatcctcccacttcaccttcctgagcagccggaactacagatgttggtccactgcacctggcAGAAAAGAAGTTTTGATAGGGGCAGAAATGAAAAAGGAGAAAACAGGTGAGTTTTAAGGTGCAGGGCACTTTAGGGTACTGGGTAGCCCTAGGTAGCTAAAGGTTGCATGAAGGCCCTGGGCGTTTGCAGATGGTGTAGAAGCCAGCCAAAGCCTAACTACTTGTTTTGAAAGTTTCTTGAAGACAGGCCTTGTGCCTAGGAAAACAGAAGCTTTCTTCTTCCTTCTACTAGTATTGCATACTTGTTTTTCTGGAATAGGGTGTTAAGTTCCTTGATTCAGTCCTTGACAAGGAATCTCCTTTATACAAGTGCCAGTAATGTTGTAAAGGTACAGACATACGCAAATCATAATTTGTTACATGAAGTACCAGTGCtttcttttttgttgttttttgagacagagtctcgctctgtcgctcaggctggagtgcagtggcgcgatttcagttcactgcaacctccacctcccaggttcaagcattcttctgcctcagcctcccgagtagctgggattacaggcacccaccaccacgcctggctgattttttgtagagacagggtttcacTTCAATTCCATGTTAGAGAGCTCCGTGCCTGTGTATACATGCCTTTATGTAAGCTTGCTCAGCTACAGATCAACAATGCTGGCACTAAGCAAAAGTTCGAGCCTCAGCTTTACCTTCTACCCTTTCCCTTCTCTTTTGAATCCATTCCTTAGCTTTCCCTAGTCCTCTCCGGATAGCTGTTACTCTCCTCTTGCCAGAAAAATGAAGGAGCTGGTATCATTTATACTTTTTGTTTGATTATACGTTTAACCAAAGACCATACAGTCTCGTACCTGAATCAGACATTTGCACTTTATATCTAAATGAGAAGAAGGGGCTCAGATAAGTCGTTTGCTGCCATCTGGAGGTAGATGGACAATAGCTGAGAAGGGGAGCCATGAAAAGAACATCAGGAGTGATGGACGCATAGTCCTTCCCCAAAGCCTCGCTCATCACTGGTAGGAGGCAAAGCAGTGGGTCCTCCTCACCAGCCGCTTACGGGACCCTGCCATGCCTGGACCCCTCTATCAGGAAGACCTACCCCAGCACTACTGGAAAATCAGCCAATCTTAACCCAAAGATGGCCATGATTTCTGTATGTGAGACGTCTTAAGGGTGTTTTTGTTTGTTTTAATCAGCCCTCTTGTTTGAGATTTGGCAATACATTTCTGTTTTCTAGGTAATTTCTGTGTCTGATGGTAGAGGATCTAATAAGTATTGGAATGCTTCCTATTTGCTGATAGAAGTACCAAATAGTATTATTGAAGTCTAACAAAGACTTTTTGTTGAGAACACCTTGTAGTGTTGTACTATCTGGAACTCTTGAGCTGCCATTTATATCACTTTTTGTGGAGAGCACATCTTGATTTTCAGTTGTCCTTACTTTAGAATACAACACACATAAATTGGAGACTATGTATTCATTTCAATGGAGGTGGTAAATTGCCTGTTTTAAGTTTTACTTAATGTTGGGTTTTGGTAGATGAGGAAAGCATTTTGGTTATTTGTTTTGTTTTAAATACCAAATTTCTTATATTTTTTCTGGAATATTAATACTATTACCAAGCTATTATTTCATGGAATTTGGGTTTCTTTTTTTTTGTTTTTTTAAAATTAAGTGCTGTTTGTTTTCTTGGTTATTGAACATAATCCAAAGTAGAGATGTTATTACTCAATTCAAGAAAAGAAAGGGCTAATAAAACTTAACTTCAAGTCA

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