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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name EIF3KP3
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:116043378-116044088  UCSC
Coordinates (T2T) chr4:119346463-119347173  UCSC
Coordinates (hg19) chr4:116964534-116965244  UCSC
Strand -
Parental Sequence NM_013234.4_2
Parental seq. overlap 628 bp
Parental seq. overlap (%) 81.3%
Genomic Region Intergenic
Retrocopy Summary EIF3KP3, located on chr4:116043378-116044088, is a retrocopy of the parental gene EIF3K. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name EIF3K
Full Name eukaryotic translation initiation factor 3 subunit K
Also known as ARG134|EIF3-p28|EIF3S12|HSPC029|M9|MSTP001|PLAC-24|PLAC24|PRO1474|PTD001
Coordinate chr19:38619188-38636954
Strand +
Gene summary The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 [PubMed 14519125]).[supplied by OMIM, Mar 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes EIF3KP2
Bonobo Pan paniscus EIF3KP2
Gorilla Gorilla gorilla EIF3KP2
Orangutan Pongo abelii EIF3KP2
Gibbon Nomascus leucogenys EIF3KP3
Green monkey Chlorocebus sabaeus EIF3KP1
Baboon Papio anubis EIF3KP2
Golden snub-nosed monkey Rhinopithecus roxellana EIF3KP2
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>EIF3KP3
CAGTGTCAGCCTCCAGCCCTGGTTGCGGAAGGTGACAGTAGTCATGGCCATATTTCAGCAAATGAGAGCCAATGGGGGCAAGTTGGTTAAGGACATCAACAGATACAATCCTGGCCACCCTGGAACACTACATGGAGACGCAGGCCAAGGAGAATGCCTATGATCTAGAAGACAACCTGGCTGTCCTAAAGCTGTACCAGTTCAACCTAGCATTTTTTCAGACCACGGTCACTGCCCAGATCCTGCTGAAGGCCCTCAACACCTGCCGCACACCAACTTCACCCTGTCCACGTGCATGATCCACCAGCACAACAAGAAGAGCAGGCAATCCAACAGATTTTGCACCTCGGGGACTTGCTGGAGACTTGCCACTTCCAGGCCTTCTGGCAAGGAAAACATGGTCCTGTTGGAAGGTATAACCGGCTTTGAAGACTCTGTCTGAAAGTTTATCTGCCATGTCATGGGTATCACTTACCAGCACATGGGATGCTGGCTGCTTGGTAAAATGTTTGGTGATCTGTTAGCCAGCCAGCTAAAGGTGTAGATGAGCAAATATGGCTGGAGCGCTAACGAGTCAGGGCCGATCTTCATCTGTAACCAGGAAGAGAGCATTAAACCCTAGAATACTCTAGAGAAGATTGACTTTGACAGTGTGTCCAGCATCATCGCCTCCTCCCAGTAACTGCAGGTGTTTAATAAAGATGTGTTGAT
>NM_013234.4_2
CTCTTCCTGTTCCCGTCCTTGAGGACGCCGTGCCGGGTCAGTGTTAGCCTCCAGCCCTGGTTGTGGAAGGCGACAGAAGTCATGGCGATGTTTGAGCAGATGAGAGCCAACGTGGGCAAGTTGCTCAAGGGTATCGACAGGTACAATCCTGAGAACCTGGCCACCCTGGAGCGCTATGTAGAGACGCAGGCCAAGGAAAATGCCTATGATCTGGAAGCCAACCTGGCTGTCCTGAAGCTGTACCAGTTCAACCCAGCCTTCTTTCAGACCACGGTCACCGCCCAGATCCTGCTGAAGGCCCTCACCAACTTGCCGCACACAGACTTCACCCTGTGCAAGTGCATGATCGACCAGGCACATCAAGAAGAACGGCCAATCCGACAGATTTTGTACCTCGGGGACCTGCTGGAGACCTGCCATTTCCAGGCCTTCTGGCAAGCCCTGGATGAAAACATGGACCTCTTGGAAGGTATAACTGGCTTTGAAGACTCTGTCCGAAAGTTTATCTGCCATGTTGTGGGTATCACTTACCAGCACATTGACCGCTGGCTGCTGGCCGAGATGCTCGGGGATCTGTCGGACAGCCAGCTAAAGGTGTGGATGAGCAAATACGGCTGGAGTGCCGACGAGTCGGGGCAGATCTTCATCTGTAGCCAAGAAGAGAGCATTAAACCCAAGAACATTGTGGAGAAGATTGACTTTGACAGTGTGTCCAGCATCATGGCCTCCTCCCAGTAACTTCAGGTGTTTAATAAAGATGTGTTGACTCAGC

Publications

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