RCPedia: Rtcs

Summary

Retrocopy Name	FKBP4P1	Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species	Homo sapiens
Coordinates (hg38)	chr4:118192726-118194895 UCSC
Coordinates (T2T)	chr4:121497696-121499865 UCSC
Coordinates (hg19)	chr4:119113881-119116050 UCSC
Strand	-
Parental Sequence	NM_002014.4
Parental seq. overlap	1980 bp
Parental seq. overlap (%)	53.2%
Genomic Region	Intragenic (NDST3)
Retrocopy Summary	FKBP4P1, located on chr4:118192726-118194895, is a retrocopy of the parental gene FKBP4. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	FKBP4
Full Name	FKBP prolyl isomerase 4
Also known as	FKBP51\|FKBP52\|FKBP59\|HBI\|Hsp56\|PPIase\|p52
Coordinate	chr12:2794970-2805423
Strand	+
Gene summary	The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008]

Homology

Species	Scientific Name	Retrocopy
Chimpanzee	Pan troglodytes	FKBP4P1
Bonobo	Pan paniscus	FKBP4P1
Gorilla	Gorilla gorilla	FKBP4P2
Orangutan	Pongo abelii	FKBP4P1
Green monkey	Chlorocebus sabaeus	FKBP4P1
Crab-eating macaque	Macaca fascicularis	FKBP4P1
Rhesus	Macaca mulatta	FKBP4P1
Baboon	Papio anubis	FKBP4P1
Golden snub-nosed monkey	Rhinopithecus roxellana	FKBP4P1
Gibbon	Nomascus leucogenys	Without Homology
Marmoset	Callithrix jacchus	Without Homology
Mouse lemur	Microcebus murinus	Without Homology
Mouse	Mus musculus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

Related Sequence

>FKBP4P1
GCAGAGGTGCTCCAGCCTCCATGTGGTCCGCAGTCAGCACCACAGCACCTGGCCTCCTGCACACCCTGAAGGTAGCACCCCTGCCTTTGGCTCAGAGTATGCTGGTGCCGGTGCCAGCTCCCAGAAAGGGTGCGCTGCGTGGAGATGACAGTTGAGGAGATGAAGGAGACTGAGAATGGGACACAGTTGGCGCCTCTTCCCATGGAGGGAGTGGACATTCGCCCAAACAGGAGGAAGGCATGCTGAAGGTCATCGAGAGAGGGCACAGGTACAGAGATGCCCATGATTGGGGACTGAATCTTTGTCCACTACACTGGCTGGCTGTTAGATGGCACAAACTTTGACCCCAGTCTGGATCACAAGGACAAATTCTCCTTTGACCTGGGAAAAGGGGAGGTCAACAAGGCTTGGGACATTGCCATAGCAGCCATGAAGGCAGGGGAGGTGTGCCATATCACCTGCAAACCAGAATATGCCTTCGGTGCAGCAGGCAGTCCTCCAAAGATCTCCCCAATGCCACACTCGTGTTTGAGGTGGAGTTGTTTGAGTTTAAGGGAGAAGATCTGACGGAAGAAGAAGATGGCGGAATCATCTACAGAATTACAGACTTGCGGTGAAGGCTATCCCAGGCCCAATGAGGGTGCTATCATGGAGATTGCACTGGAAGGGTGCTACAAGGACTAGTTCTTTGAACATCAGGAGAATCTGGATCTGCCTTATGGTCTGGAGAGGGCCATTCAGTGCATGTAGAAAGGAGAACATTCCATTGTGTACCTCAAACCCAGCTATGCTTTTGGCAGTGTTAGGAAGGAAAAGTTCCAAATCCCACCAAATGCCTAGCTGAAATATGAATTACACCTCAAGAGTTTTGAAAAGACCAAGGAGTCTTGGGAGATGAATTCAGAAGAGAAGCTGGAGCAGAGCACCACAGTGAAAGAGTGGGACACTGTGTACTTCAAGGAAGGCAAATACAAGCAAGCTTTACTATAATATAAGAGGATTGTGTCCTGGGTAGAATATGAGTCTAGTTTTTCCAATGAGGAAACACAGAAGGCACAGGCCCTTCAACTGGCCTCTTACCTCAACCTGGCCATGTGTCATCTGAAACTACAGGCCTTCTCTGCTGCCACTGAAAGCTGTAACAAGGCCCTGGAACTGGGCAGCAACAACGAGAAGGGCCTCTTCCATTGGGGAGAGGCCCACCTGGCTGTGAATGACTTTGAACTGGCACAGGCTGACTTCCAGAAGGTCTTGCAGCTCTACCCCAACAACGAAGCCGCCAAGGCCCAGCTGGCTGTGTGCCAGCAGCAGATCTGCAGGCAGCTTGCCTGGGAGAAGACGCTCTACGCCAACACGTTTGAGAGGCTGGCTGAGGAAGAGAACAAGGCCAAGGCAGAGGCTTCCTCAGGAGACAATCTCACTGACACAGAGATGGAGGAGCAGAAGAGCAACACCACAGAGAGCCAGTCTCAAGTGGAGACAGAAGCATAGCCCCTCTCCACCAGCCCTACTCCTGTGGCTGCCTGCCCCCCGTCTCCCTACTCTGCCCTGTTAGTTTTGTAAAAACTGAAGAATTTTGAGTGAATTAGACCTTTATTTTTCTATCTGGTTGGATGGTGGCTTTAGGGGGAAGGGGGAAAGGAGTAGGCTGGGAGATTGAGGTGGGGAATCATTTTAGGTGGTGTCACCCCCTCTTCCCTTCCCCCATTGCACATGAACATATGTCCATCCATACATGCTCATTAGAGTGTTAATTTATTTTGCTCCTTCTGTTTGTTAGGTCCATTTTCCAGGGGTAGAAGAGGCAAGTGGTAGGGATGGGGTCTGATATGAACCCAGGGTGGAGAAGGAGACTCCTGGGCAGCTGTTTTCCTCATCCTTTCCCTCTCCCAGTCCATTTCCAAATGTGGCCTCCATGTGGGTGTTAGGGACATGGGAAGAAACACCATTTCTTCTCTGTTCCCTTCCTCACCCCAGATGGCATGGCTGATGCTGTCTCCTGGTGTCATGGTGACCACCCCCTGTCCCCCGTTCTGGTATTTCCCCTGTCAGTTTTCCCTCTCAGCCAGGTTGTGTCCCCAAACCCCCTCAGCCTCTTCTTTGCATGTTGATGAAGGTCCAGGCTTGCCTGAAGTTCCATGCTAGAGCAATAAAGTGGa

>NM_002014.4
CCTACCCCAGCTCTCGCGCCGCGTGCAGAGGTGCTCAAGCCTCCTCGCGGTCCGCAGTCAGTGCCGccgcgcccggcctcccgcacgccccgcaggtagcgcccccgcccgcggcccagagtgcgctcgcgccggcaccagctcccgGATAAACGGCGCGCCGCGCGGAGATGACAGCCGAGGAGATGAAGGCGACCGAGAGCGGGGCGCAGTCGGCGCCGCTGCCCATGGAGGGAGTGGACATCAGCCCCAAACAGGACGAAGGCGTGCTGAAGGTCATCAAGAGAGAGGGCACAGGTACAGAGATGCCCATGATTGGGGACCGAGTCTTTGTCCACTACACTGGCTGGCTATTAGATGGCACAAAGTTTGACTCCAGTCTGGATCGCAAGGACAAATTCTCCTTTGACCTGGGAAAAGGGGAGGTCATCAAGGCTTGGGACATTGCCATAGCCACCATGAAGGTGGGGGAGGTGTGCCACATCACCTGCAAACCAGAATATGCCTACGGTTCAGCAGGCAGTCCTCCAAAGATTCCCCCCAATGCCACGCTTGTATTTGAGGTGGAGTTGTTTGAGTTTAAGGGAGAAGATCTGACGGAAGAGGAAGATGGCGGAATCATTCGCAGAATACAGACTCGCGGTGAAGGCTATGCTAAGCCCAATGAGGGTGCTATCGTGGAGGTTGCACTGGAAGGGTACTACAAGGACAAGCTCTTTGACCAGCGGGAGCTCCGCTTTGAGATTGGCGAGGGGGAGAACCTGGATCTGCCTTATGGTCTGGAGAGGGCCATTCAGCGCATGGAGAAAGGAGAACATTCCATCGTGTACCTCAAGCCCAGCTATGCTTTTGGCAGTGTTGGGAAGGAAAAGTTCCAAATCCCACCAAATGCTGAGCTGAAATATGAATTACACCTCAAGAGTTTTGAAAAGGCCAAGGAGTCTTGGGAGATGAATTCAGAAGAGAAGCTGGAACAGAGCACCATAGTGAAAGAGCGGGGCACTGTGTACTTCAAGGAAGGTAAATACAAGCAAGCTTTACTACAGTATAAGAAGATCGTGTCTTGGCTGGAATATGAGTCTAGTTTTTCCAATGAGGAAGCACAGAAAGCACAGGCCCTTCGACTGGCCTCTCACCTCAACCTGGCCATGTGTCATCTGAAACTACAGGCCTTCTCTGCTGCCATTGAAAGCTGTAACAAGGCCCTAGAACTGGACAGCAACAACGAGAAGGGCCTCTTCCGCCGGGGAGAGGCCCACCTGGCCGTGAATGACTTTGAACTGGCACGGGCTGATTTCCAGAAGGTCCTGCAGCTCTACCCCAACAACAAAGCCGCCAAGACCCAGCTGGCTGTGTGCCAGCAGCGGATCCGAAGGCAGCTTGCCCGGGAGAAGAAGCTCTATGCCAATATGTTTGAGAGGCTGGCTGAGGAGGAGAACAAGGCCAAGGCAGAGGCTTCCTCAGGAGACCATCCCACTGACACAGAGATGAAGGAGGAGCAGAAGAGCAACACGGCAGGGAGCCAGTCTCAGGTGGAGACAGAAGCATAGCCCCTCTCCACCAGCCCTACTCCTGCGGCTGCCTGCCCCCCAGTCTCCCCACTCCACCCTGTTAGTTTTGTAAAAACTGAAGAATTTTGAGTGAATTAGACCTTTATTTTTCTATCTGGTTGGATGGTGGCTTTAGGGGAAGGGGGAAAGGTGTAGGCTGGGGGATTGAGGTGGGGAATCATTTTAGCTGGTGTCAGCCCCTCTTCCCTTCCTCCATTGCACATGAACATATGTCCATCCATATATATTCATCAGAATGTTAATTTATTTTGCTCCCTCTGTTAGGTCCATTTTCTAAGGGTAGAAGAGGCAAGTGGTAGGGATGAGGTCTGATAAGAACCCAGGGTGGAGAGGGAGACTCCTGGGCAGCCGTTTTCCTCATCCTTTCCCTCTCCCAGTCCATTTCCAAATGTGGCCTCCATGTGGGTGCTAGGGACATGGGAAAAACCACTGCTATGCCATTTCTTCTCTCTGTTCCCTTCCTCACCCCCGACGGTGTGGCTGATGATGTCTTCTGGTGTCATGGTGACCACCCCCTGTTCCCTGTTCTGGTATTTCCCCTGTCAGTTTCCCCTCTCGGCCAGGTTGTGTCCCAAAATCCCCTCAGCCTCTTCTCTGCACGTTGCTGAAGGTCCAGGCTTGCCTCAAGTTCCATGCTTGAGCAATAAAGTGGAAACAATAAAACCTGGGTGTCAGACAACCCTTTCTGTTCAGCCTTGGAGTGGTGGGTATGGGTGGGTACATAATGGGTAGTAGCACAATCAAGGGGTCACCCACTTAGTTCCAGTTGAGCTTAAATAAGTGAGCATCTCATGTAGATGCCATAGTTGGGCAGGAAGCAGCCCCACCATGCATGGCTTCCTGAGCACTGCACAGGCTGCCGCTGGGATTTGTGTCTATGGCTTCGCCCAAGGTTCCCAGCACTCCCTCCCTCCAGCAACCTGGCAGTTTTAGTGCCTCTGGTTTTCTTCCCTGACACTTAGGAAGACGAAAGTATAAAGATCTAGAAGACTGGGACACCATGCATGTTCATTTTGAAGTTGGAATTGGTCTTCTGCCTACCTCTGATCTGGCAGAGGTATCTGCATTTTGGTTTGTTAACAAGGTAAAACTCCTGGTGTCACTGACCTCCTCCTGTCAGATAACTTACATGATTAAGGTTAAGAGTAAAGCAGAGTGTTCACGTCCAGCTTCCTTCTCAGCCTTAACAGGAAAAGGCTTGTGCTTTTTTTCTAACTATGCTTTGACCCTTAACTCCTATGGCATGATGGGGCCCTGGGAGAAGCCAGGCAGCACAAGCCAGTCATGCTGAGCTGCCTCCAGATAATCCTGGCTCCAGGCCAGAGCCCGTGTCTGCCCTCATCCCTCTCTCCTACTGTGAGCTCTCCAGTCCTTTCCCAACAGCGATGTGGTTGTCTGCTTAGCCACATGCCTGTATAGTTCCTTCCAGAAGAAATGTATAATGGTGGAAGATGTATTTCTGTGTGAAAATTTTCACCAAGTCATACAACACAGCTGATGCTGGAGCCAGGATTAAAATTGGGGTGTACAAGTCTCCCAGTGTgagtatcccttgagcccaagacaccaaggatgcagagaactgtgactgtgccactgcacgccagcctgggcaagagagtgagaccatctcttttttaaaaaaGTCCCTGTGTAACTGCTTTCTTACTGGGCTTACCTCACATCACAGCCCTGTGTTTGTGGTTTGTGTCTGGGTCCTCTTGGTATTTCAAAAGTAGTAGATTCTTACGCCTGCAGCCAACAATAATCACTAACtcaagcatttatggagtaagcctagcactgtactgacagcatcacatgagtgaaactgaatccttgcaaccatcctacaaagaaggtataactttaataaccctatttacagataagaaaaccaagactcagaagttaaatgGAAAGGTGAGGTCTCTGAACTAATCCAGACTCTCCCATGAGGTTcctttggcaagtcctgggcttctgtcctcatctgcaaaatcgaaagcattcctgaggtttcttccagctctgcatcctgtaggattccaagaATGTAAAACTGCATGTAACCGTGGAACATCTAGAGATAAGTCTTAGTTTATGTAACATTAAAACTGTCTAGTGAGGATGTTTTGTTAAAA

>NM_002014.4 

CCTACCCCAGCTCTCGCGCCGCGTGCAGAGGTGCTCAAGCCTCCTCGCGGTCCGCAGTCAGTGCCGccgcgcccggcctcccgcacgccccgcaggtagcgcccccgcccgcggcccagagtgcgctcgcgccggcaccagctcccgGATAAACGGCGCGCCGCGCGGAGATGACAGCCGAGGAGATGAAGGCGACCGAGAGCGGGGCGCAGTCGGCGCCGCTGCCCATGGAGGGAGTGGACATCAGCCCCAAACAGGACGAAGGCGTGCTGAAGGTCATCAAGAGAGAGGGCACAGGTACAGAGATGCCCATGATTGGGGACCGAGTCTTTGTCCACTACACTGGCTGGCTATTAGATGGCACAAAGTTTGACTCCAGTCTGGATCGCAAGGACAAATTCTCCTTTGACCTGGGAAAAGGGGAGGTCATCAAGGCTTGGGACATTGCCATAGCCACCATGAAGGTGGGGGAGGTGTGCCACATCACCTGCAAACCAGAATATGCCTACGGTTCAGCAGGCAGTCCTCCAAAGATTCCCCCCAATGCCACGCTTGTATTTGAGGTGGAGTTGTTTGAGTTTAAGGGAGAAGATCTGACGGAAGAGGAAGATGGCGGAATCATTCGCAGAATACAGACTCGCGGTGAAGGCTATGCTAAGCCCAATGAGGGTGCTATCGTGGAGGTTGCACTGGAAGGGTACTACAAGGACAAGCTCTTTGACCAGCGGGAGCTCCGCTTTGAGATTGGCGAGGGGGAGAACCTGGATCTGCCTTATGGTCTGGAGAGGGCCATTCAGCGCATGGAGAAAGGAGAACATTCCATCGTGTACCTCAAGCCCAGCTATGCTTTTGGCAGTGTTGGGAAGGAAAAGTTCCAAATCCCACCAAATGCTGAGCTGAAATATGAATTACACCTCAAGAGTTTTGAAAAGGCCAAGGAGTCTTGGGAGATGAATTCAGAAGAGAAGCTGGAACAGAGCACCATAGTGAAAGAGCGGGGCACTGTGTACTTCAAGGAAGGTAAATACAAGCAAGCTTTACTACAGTATAAGAAGATCGTGTCTTGGCTGGAATATGAGTCTAGTTTTTCCAATGAGGAAGCACAGAAAGCACAGGCCCTTCGACTGGCCTCTCACCTCAACCTGGCCATGTGTCATCTGAAACTACAGGCCTTCTCTGCTGCCATTGAAAGCTGTAACAAGGCCCTAGAACTGGACAGCAACAACGAGAAGGGCCTCTTCCGCCGGGGAGAGGCCCACCTGGCCGTGAATGACTTTGAACTGGCACGGGCTGATTTCCAGAAGGTCCTGCAGCTCTACCCCAACAACAAAGCCGCCAAGACCCAGCTGGCTGTGTGCCAGCAGCGGATCCGAAGGCAGCTTGCCCGGGAGAAGAAGCTCTATGCCAATATGTTTGAGAGGCTGGCTGAGGAGGAGAACAAGGCCAAGGCAGAGGCTTCCTCAGGAGACCATCCCACTGACACAGAGATGAAGGAGGAGCAGAAGAGCAACACGGCAGGGAGCCAGTCTCAGGTGGAGACAGAAGCATAGCCCCTCTCCACCAGCCCTACTCCTGCGGCTGCCTGCCCCCCAGTCTCCCCACTCCACCCTGTTAGTTTTGTAAAAACTGAAGAATTTTGAGTGAATTAGACCTTTATTTTTCTATCTGGTTGGATGGTGGCTTTAGGGGAAGGGGGAAAGGTGTAGGCTGGGGGATTGAGGTGGGGAATCATTTTAGCTGGTGTCAGCCCCTCTTCCCTTCCTCCATTGCACATGAACATATGTCCATCCATATATATTCATCAGAATGTTAATTTATTTTGCTCCCTCTGTTAGGTCCATTTTCTAAGGGTAGAAGAGGCAAGTGGTAGGGATGAGGTCTGATAAGAACCCAGGGTGGAGAGGGAGACTCCTGGGCAGCCGTTTTCCTCATCCTTTCCCTCTCCCAGTCCATTTCCAAATGTGGCCTCCATGTGGGTGCTAGGGACATGGGAAAAACCACTGCTATGCCATTTCTTCTCTCTGTTCCCTTCCTCACCCCCGACGGTGTGGCTGATGATGTCTTCTGGTGTCATGGTGACCACCCCCTGTTCCCTGTTCTGGTATTTCCCCTGTCAGTTTCCCCTCTCGGCCAGGTTGTGTCCCAAAATCCCCTCAGCCTCTTCTCTGCACGTTGCTGAAGGTCCAGGCTTGCCTCAAGTTCCATGCTTGAGCAATAAAGTGGAAACAATAAAACCTGGGTGTCAGACAACCCTTTCTGTTCAGCCTTGGAGTGGTGGGTATGGGTGGGTACATAATGGGTAGTAGCACAATCAAGGGGTCACCCACTTAGTTCCAGTTGAGCTTAAATAAGTGAGCATCTCATGTAGATGCCATAGTTGGGCAGGAAGCAGCCCCACCATGCATGGCTTCCTGAGCACTGCACAGGCTGCCGCTGGGATTTGTGTCTATGGCTTCGCCCAAGGTTCCCAGCACTCCCTCCCTCCAGCAACCTGGCAGTTTTAGTGCCTCTGGTTTTCTTCCCTGACACTTAGGAAGACGAAAGTATAAAGATCTAGAAGACTGGGACACCATGCATGTTCATTTTGAAGTTGGAATTGGTCTTCTGCCTACCTCTGATCTGGCAGAGGTATCTGCATTTTGGTTTGTTAACAAGGTAAAACTCCTGGTGTCACTGACCTCCTCCTGTCAGATAACTTACATGATTAAGGTTAAGAGTAAAGCAGAGTGTTCACGTCCAGCTTCCTTCTCAGCCTTAACAGGAAAAGGCTTGTGCTTTTTTTCTAACTATGCTTTGACCCTTAACTCCTATGGCATGATGGGGCCCTGGGAGAAGCCAGGCAGCACAAGCCAGTCATGCTGAGCTGCCTCCAGATAATCCTGGCTCCAGGCCAGAGCCCGTGTCTGCCCTCATCCCTCTCTCCTACTGTGAGCTCTCCAGTCCTTTCCCAACAGCGATGTGGTTGTCTGCTTAGCCACATGCCTGTATAGTTCCTTCCAGAAGAAATGTATAATGGTGGAAGATGTATTTCTGTGTGAAAATTTTCACCAAGTCATACAACACAGCTGATGCTGGAGCCAGGATTAAAATTGGGGTGTACAAGTCTCCCAGTGTgagtatcccttgagcccaagacaccaaggatgcagagaactgtgactgtgccactgcacgccagcctgggcaagagagtgagaccatctcttttttaaaaaaGTCCCTGTGTAACTGCTTTCTTACTGGGCTTACCTCACATCACAGCCCTGTGTTTGTGGTTTGTGTCTGGGTCCTCTTGGTATTTCAAAAGTAGTAGATTCTTACGCCTGCAGCCAACAATAATCACTAACtcaagcatttatggagtaagcctagcactgtactgacagcatcacatgagtgaaactgaatccttgcaaccatcctacaaagaaggtataactttaataaccctatttacagataagaaaaccaagactcagaagttaaatgGAAAGGTGAGGTCTCTGAACTAATCCAGACTCTCCCATGAGGTTcctttggcaagtcctgggcttctgtcctcatctgcaaaatcgaaagcattcctgaggtttcttccagctctgcatcctgtaggattccaagaATGTAAAACTGCATGTAACCGTGGAACATCTAGAGATAAGTCTTAGTTTATGTAACATTAAAACTGTCTAGTGAGGATGTTTTGTTAAAA

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