Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Summary

Retrocopy Name CICP29
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:119403080-119403910  UCSC
Coordinates (T2T) chr4:122708185-122709015  UCSC
Coordinates (hg19) chr4:120324235-120325065  UCSC
Strand +
Parental Sequence NM_001379480.1
Parental seq. overlap 660 bp
Parental seq. overlap (%) 7.9%
Genomic Region Intergenic
Retrocopy Summary CICP29, located on chr4:119403080-119403910, is a retrocopy of the parental gene CIC. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CIC
Full Name capicua transcriptional repressor
Also known as MRD45
Coordinate chr19:42268530-42295796
Strand +
Gene summary The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]

Homology

Species Scientific Name Retrocopy
Bonobo Pan paniscus CICP1
Chimpanzee Pan troglodytes Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CICP29
TGGCCAGTGAGGACATAGCGAATGACGAGGAGCACATGGTCATCCATGAGGAGGAGGGGGTGATGATGTCATTGCTGATGACGGCTTTAGCACCACTGACACTGATCTCAAGTTCAAGGAGTGGGTGACCGACTGAGAGTGGGGACAGCTCTGGGGAGGAGCCAGAGCGCAACAAGGGCTTTCATGGGAAGGTATTTGCACCTGTCATTCCTTCCTCCTTTACTCCTGCCGCCCCTTGCTGAATCCTGAGCCCCCAGGGTCCCCCGATCCACCTGCAGTTTTTGGCAAAGTCTATGGTCCCACCCCGTCCTTCTCCTACACATTCTCGGATGCTTCCTCCTCAACCTTGGCACCCACCTCCTTCTTACTGGGCCCAGGAGCCTTCAAAGCCCAGGAGTCTGGTCAGGGCAGCAGAGCGGGCCCCCTACGGCCCCTACCCCTGGGGATGGGGGCCCAGGGACGCCTTCCAAGGTGACCTGTTTCCTCCCAATGGATCCTGCCACCTTCTGGTGCAAGAGACCTGAAAGTGTGGGCGACCTGGAGCTACCAGGCCCCTCAGTCATTGTGGTCCCTCCCAACACTAAGGCTTTCCTAGGCAGGAGCTGGGCTGAGCCACCCAGGGGGCAGAGCCTGAAGAGGAGAAACTGGGCTTTGGGGGTTGGGGCAGAGGGAACCCCACGGACATGGATCCCGCACTGGCGGACCCCACCACACCCAAATGCAAGATGAGAAGATGCTCCAGCTGCAGCCCAAAGCCCAACACCCCCAAGTGTGCCATGTGTGATGGGGACAGCTTCCCCTTTGCCTGTACAGGTGGAGAAGCCGAGGACG
>NM_001379480.1
ACCATTTTGTGTGTTGGAGTAAAAAAAAAAGGGAGAATCGAGAGGGAGAGCCGGAGGGGGGGCGGGGAGGGACCGGACCGGACCGAGCCGGGGCCACGGCCCCCCGCCCCGAAACCCCGCCGAGCCCAAGGTGGACAAAAATGAAGCCAATGAAGAAGGCATGCACTGGCCTTTCAGGTCCTGGCAGTGGCAGCAAGTCCCCCCCAGCCACCAGGGCCAAGGCTCTGAGGCGGCGAGGGGCTGGGGAGGGTGACAAGCCAGAGGAGGAGGATGACGAGGCACAGCAGCCGCAACCACAGTCCGGGCCCgaagaggctgaggaaggggaggaggaggaggctgagcggggccctggggctgaAGGTCCTCCACTGGAGCTGCACCCTGGCGACCCGGCTCCAGGCCCAGCAGAGGACCCCAAAGGGGATGGGGAGGCAGGCCGCTGGGAGCCCTCACTCAGCCGCAAGACAGCCACGTTCAAGTCTCGAGCGCCCAAGAAGAAGTATGTGGAGGAGCACGGAGCTGGCAGCAGTGGGGTGGCTGGGGCCCCTGAAGAGCGGGTGCGGACCCCTGAGGAGGCCAGTGGCCTGGGGGTGCCTCCACGGCCACCCACCTCCACTCGTTCCTCCTCCACTGACACAGCCAGCGAGCACTCGGCGGACCTGGAGGATGAGCCGGCTGAGGCTTGTGGTCCAGGCCCTTGGCCCCCTGGCAGCACCAGTGGCAGCTATGACCTGCGGCAGCTGCGGTCCCAGCGGGTGCTGGCTCGGCGTGGTGATGGCCTTTTCCTGCCGGCTGTGGTGCGCCAGGTGCGCCGAAGCCAGGACCTGGGCGTGCAGTTCCCTGGTGACCGAGCCCTGACTTTCTATGAGGGGGTGCCAGGCGCTGGTGTGGATGTAGTTTTGGATGCCACACCCCCACCAGGTGCCCTGGTGGTGGGCACAGCTGTCTGTACCTGTGTGGAGCCCGGCGTGGCTGCCTACCGGGAAGGTGTGGTGGTGGAGGTGGCCACCAAGCCAGCTGCCTACAAGGTCCGTCTCAGCCCTGGCCCCAGCTCCCAGCCAGGCCTACCAGGCAGCCTCCCGCAGCCCCCACAGCCACTGCACCGTGAGCCAGAGGAGGCTGTGTGGGTGGCCCGCTCCAGCCTACGCCTGCTGCGCCCCCCCTGGGAACCTGAGACCATGCTGAGGAAGCCCCCTACAGGCCCTGAGGAAGAGCAGGCAGAGCCTGGGGCCACCCTGCCACCCTGCCCTGCTGCCCTGGACCCCAAACAGCCCGAGGATGCTGAGGTCTCTAAGATCAGCTTTGGTGGCAACCTGGGTACTCACTGTGAGGAGGGCGAGGAGAAGCACCCTCCAGCCCTGGGTACCCCAGCCCTGCTCCCACTGCCCCCACCCCAGCTCCTGTCACCACCACCCAAGTCTCCAGCCTTTGTGGGCCCCGGCCGCCCTGGCGAGCAGCCCTCGCCCTGCCAGGAGGGGAGCCAGGGCGGCAGCCGCAGCAGCAGCGTGGCCTCCCTGGAAAAGGGGACAGCACCGGCAGCCCGGGCCCGCACGCCACTGACAGCCGCCCAGCAGAAGTACAAGAAGGGCGATGTGGTCTGCACACCCAGCGGAATACGAAAGAAGTTCAACGGCAAGCAGTGGCGCCGGCTGTGCTCACGAGATGGCTGCATGAAGGAGTCACAGCGGCGAGGCTACTGCTCACGCCACCTGTCCATGCGAACCAAAGAGATGGAAGGCCTGGCAGACAGTgggcctggcggggcgggccggcccgcggccgtggcAGCCCGTGAGGGCAGCACGGAGTTTGACTGGGGTGATGAGACGTCGAGGGACAGTGAGGCCAGCAGTGTGGCGGCTCGTGGAGACTCACGGCCACGCCTGGTGGCCCCTGCTGACTTGTCACGCTTTGAGTTCGACGAGTGTGAGGCGGCCGTGATGCTGGTGTCGCTGGGCAGctcgcgctcaggcacgccctccttctcacccgtctccactcaatcgcccttctcgccagccccatcaccctcaccctcaccactcTTCGGCTTCCGCCCTGCCAACTTTAGCCCCATCAATGCCTCACCAGTCATCCAGCGCACTGCAGTCCGCAGTCGCCACCTGAGCGCCAGCACCCCTAAGGCAGGCGTGCTGACGCCACCAGACCTGGGCCCCCACCCACCGCCACCTGCCCCCCGAGAGCGCCACTCCTCTGGAATCCTACCCACCTTCCAGACCAACCTGACCTTCACCGTGCCCATCAGCCCTGGGCGACGGAAGACAGAGCTGTTGCCGCATCCAGGGGCCTTGGGGGCCCCTGGCGCAGGGGGTGGAGGAGCCGCCCCAGACTTTCCCAAGAGTGACAGCTTAGACTCTGGTGTGGACTCAGTGTCCCACACACCTACACCCTCCACGCCGGCTGGCTTCCGGGCCGTGTCCCCTGCTGTGCCCTTCTCTCGCTCCCGCCAGCCCTCACCATTGCTGCTGTTGCCACCCCCTGCCGGCCTGACCTCGGATCCAGGGCCCTCTGTGCGCAGGGTGCCTGCTGTGCAGCGGGACTCACCTGTTATTGTCCGCAACCCTGATGTGCCACTGCCCTCCAAATTCCCTGGGGAGGTGGGCACTGCTGGTGAGGTGCGGGCTGGGGGACCTGGGCGGGGCTGCCGTGAAACCCCAGTGCCCCCTGGGGTGGCCAGTGGGAAGCCTGGCCTGCCCCCACCTCTGCCAGCCCCCGTGCCCATCACCGTGCCTCCAGCTGCACCAACTGCCGTGGCCCAGCCGATGCCCGCCTTTGGCCTGGCTTCTTCACCCTTTCAGCCTGTGGCCTTCCACCCCTCACCTGCTGCCCTGTTGCCCGTTTTGGTGCCCAGCAGCTATACCAGCCACCCTGCCCCCAAGAAGGAAGTCATCATGGGCCGGCCTGGAACAGTGTGGACGAATGTGGAACCTCGCTCTGTGGCTGTGTTCCCTTGGCACTCCTTAGTCCCCTTCCTGGCACCCAGCCAGCCTGACCCCTCCGTGCAGCCGAGCGAGGCCCAGCAACCTGCCAGCCACCCAGTGGCCTCCAACCAGAGCAAAGAACCTGCTGAGTCGGCAGCTGTTGCTCATGAACGGCCACCAGGTGGGACAGGGAGTGCTGACCCTGAGCGGCCCCCTGGAGCCACATGCCCTGAGAGCCCAGGACCCGGACCCCCACACCCTTTGGGGGTGGTGGAATCTGGTAAGGGTCCGCCTCCCACCACGGAGGAGGAGGCCTCCGGCCCCCCAGGAGAGCCCCGGCTGGACAGTGAGACAGAGAGTGACCATGATGATGCCTTCCTCTCCATCATGTCTCCTGAGATCCAGTTGCCTCTACCGCCCGGAAAACGTCGGACCCAGTCCCTCAGTGCCCTACCCAAGGAACGGGACTCATCTTCTGAGAAGGATGGACGCAGCCCCAACAAGCGGGAGAAGGACCACATCCGGCGGCCCATGAATGCCTTCATGATCTTCAGCAAGCGGCACCGGGCCCTGGTCCACCAGCGTCATCCCAACCAGGACAACCGGACCGTCAGCAAGATCCTGGGCGAGTGGTGGTATGCCCTGGGGCCCAAGGAGAAGCAGAAGTACCACGACCTGGCCTTCCAGGTGAAGGAGGCCCACTTCAAGGCCCACCCAGATTGGAAGTGGTGCAACAAGGACCGAAAGAAGTCCAGCTCAGAGGCCAAGCCCACGAGCCTGGGGCTGGCAGGAGGGCACAAGGAGACGCGGGAGCGGAGCATGTCGGAGACGGGCACTGCTGCTGCCCCTGGGGTGTCCTCTGAGCTCCTGTCCGTTGCAGCCCAGACACTCCTGAGCTCAGACACCAAGGCTCCGGGGAGCAGCTCCTGTGGGGCAGAACGGCTACACACAGTTGGGGGACCTGGCTCAGCCCGGCCCCGAGCTTTCTCCCACAGCGGGGTACACAGCCTGGACGGCGGAGAAGTAGACAGTCAGGCGCTACAGGAACTGACGCAGATGGTGTCTGGCCCTGCATCGTACTCTGGCCCAAAGCCTTCTACCCAGTATGGAGCTCCAGGACCCTTTGCAGCCCCTGGTGAGGGAGGTGCCTTGGCGGCCACTGGGCGGCCCCCGCTGCTGCCCACCCGAGCTTCTCGTTCTCAGCGTGCGGCCAGTGAGGACATGACGAGTGATGAGGAGCGCATGGTCATCTGTGAGGAGGAAGGGGATGATGATGTCATTGCTGACGATGGCTTCGGCACCACTGACATTGATCTCAAGTGCAAGGAGCGGGTGACCGACAGCGAGAGTGGGGACAGCTCTGGGGAGGACCCAGAGGGCAACAAGGGCTTTGGTCGGAAGGTGTTTTCACCTGTGATCCGTTCCTCCTTTACCCACTGCCGCCCCCCACTGGACCCTGAGCCCCCAGGGCCCCCGGATCCTCCTGTAGCCTTTGGCAAAGGCTATGGTTCCGCCCCATCCTCCTCTGCGTCCTCGCCTGCTTCCTCCTCAGCCTCGGCAGCCACCTCCTTCTCACTGGGCTCAGGAACCTTCAAGGCCCAGGAGTCTGGTCAGGGCAGCACAGCGGGCCCCCTACGGCCCCCACCCCCTGGGGCTGGGGGTCCAGCGACACCTTCCAAGGCAACCCGGTTCCTCCCAATGGATCCTGCCACCTTCCGGCGCAAGAGACCCGAAAGTGTGGGTGGCCTGGAGCCACCAGGCCCCTCAGTCATCGCGGCCCCTCCCAGCGGAGGAGGAAACATCCTGCAGACACTGGTGCTGCCCCCAAACAAGGAGGAGCAAGAGGGCGGCGGAGCCAGAGTGCCCTCCGCCCCCGCCCCATCACTGGCCTATGGGGCCCCAGCAGCTCCCCTGTCCCGTCCTGCCGCCACCATGGTCACCAATGTGGTGCGGCCTGTCAGCAGCACTCCTGTGCCCATCGCCTCTAAGCCCTTCCCCACCTCTGGCCGGGCTGAGGCGTCTCCAAATGACACAGCAGGTGCCAGGACTGAAATGGGCACTGGGTCTCGGGTGCCTGGGGGCTCCCCGCTGGGTGTCAGCTTAGTGTATTCGGACAAGAAGTCGGCAGCAGCCACCTCACCAGCCCCACACTTGGTGGCTGGACCCCTGCTGGGCACTGTGGGGAAGGCGCCTGCCACTGTCACTAACCTACTGGTGGGCACCCCGGGGTATGGGGCCCCTGCGCCCCCTGCTGTCCAGTTCATTGCCCAGGGGGCCCCTGGTGGTGGGACCACTGCGGGCTCAGGAGCAGGTGCTGGGAGTGGCCCCAATGGGCCAGTACCCCTGGGCATCCTGCAACCAGGTGCCCTGGGCAAGGCTGGGGGAATCACCCAGGTACAGTACATCCTGCCCACGCTGCCCCAGCAGCTTCAGGTGGCACCTGCCCCAGCACCAGCCCCTGGGACCAAGGCAGCGGCTCCCAGCGGCCCTGCACCCACCACCAGCATCCGTTTCACCCTCCCACCGGGCACTTCCACCAACGGCAAAGTCCTGGCTGCCACTGCACCCACTCCTGGCATCCCCATCCTGCAGTCTGTACCCTCCGCCCCACCCCCCAAAGCCCAGTCAGTTTCTCCCGTGCAGGCCCCGCCCCCGGGTGGCTCAGCCCAGCTGCTGCCTGGGAAGGTCCTAGTGCCTCTGGCCGCCCCTAGCATGTCAGTGCGGGGTGGAGGGGCCGGCCAGCCACTGCCACTGGTGAGCCCGCCCTTCTCAGTACCTGTGCAGAATGGTGCCCAGCCCCCCAGCAAGATCATCCAGCTGACCCCGGTGCCTGTGAGCACACCCAGCGGCCTGGTGCCGCCCCTGAGCCCAGCCACACTCCCTGGACCCACCTCTCAGCCTCAGAAGGTCCTGTTGCCCTCCTCCACCAGAATCACCTATGTGCAGTCAGCGGGCGGGCACGCGCTGCCCCTGGGTACCAGCCCTGCGTCCAGCCAGGCTGGAACAGTCACCTCGTACGGGCCCACGAGCTCTGTAGCTCTAGGCTTCACCTCGCTGGGGCCCAGCGGCCCCGCCTTCGTGCAGCCCCTGCTCTCAGCAGGCCAAGCCCCACTGCTGGCTCCCGGTCAGGTGGGCGTGTCACCTGTGCCCAGTCCCCAGCTGCCGCCTGCCTGTGCAGCCCCCGGAGGTCCTGTCATAACAGCATTTTACTCTGGCAGCCCTGCACCCACCTCCTCAGCACCCCTGGCCCAGCCATCCCAGGCCCCCCCAAGCCTGGTCTACACTGTGGCCACCAGCACAACCCCACCTGCAGCCACCATTCTGCCCAAGGGCCCGccagcccctgccactgccaccccagccccgactagccctttccccagcgccaCAGGTTCCATGACCTACAGCTTAGTGGCCCCCAAGGCCCAGCGGCCCAGCCCGAAGGCCCCCCAGAAAGTGAAGGCAGCCATCGCCAGCATTCCCGTGGGGTCCTTTGAGGCAGGTGCCTCTGGGCGGCCTGGCCCTGCACCCCGGCAGCCTCTGGAGCCTGGCCCAGTCCGAGAGCCAACTGCCCCAGAGTCTGAGCTTGAGGGGCAGCCCACACCACCAGCCCCTCCACCCCTGCCAGAGACCTGGACTCCCACGGCCCGGAGCAGCCCCCCACTGCCCCCACCTGCTGAGGAGCGGACCAGCGCCAAGGGCCCTGAGACCATGGCCAGCAAATTCCCCAGCTCATCTTCAGACTGGCGCGTCCCTGGGCAGGGCCTGGAGAATCGTGGGGAGCCTCCCACTCCTcccagcccggccccagctccagctgtagccccTGGTGGCAGCAGCGAGAGCAGCAGTGGGCGGGCAGCCGGGGACACCCCGGAGCGCAAGGAGGCGGCTGGTACTGGCAAGAAGGTGAAGGTGCGGCCCCCGCCCCTGAAGAAGACCTTTGACTCTGTGGACAACAGGGTCCTGTCAGAAGTGGACTTCGAAGAGCGCTTTGCTGAGTTGCCTGAGTTTCGGCCTGAGGAGGTGCTGCCCTCCCCCACCCTGCAGTCTCTGGCCACCTCACCCCGGGCCATCCTGGGCTCTTACCGCAAGAAGAGGAAGAACTCCACGGACCTGGATTCAGCACCCGAGGACCCCACCTCGCCCAAGCGCAAGATGAGAAGACGCTCCAGCTGCAGCTCGGAGCCCAACACCCCCAAGAGTGCCAAGTGCGAGGGGGACATCTTCACCTTTGACCGTACAGGTACAGAAGCCGAGGACGTGCTTGGGGAGCTAGAGTATGACAAGGTGCCATACTCCTCCCTGCGGCGCACCCTGGACCAGCGCCGGGCCCTGGTCATGCAGCTCTTTCAGGACCATGGCTTCTTCCCGTCAGCCCAGGCCACAGCCGCCTTCCAGGCCCGCTATGCAGACATCTTTCCCTCCAAGGTTTGTCTGCAGTTGAAGATCCGTGAGGTGCGCCAGAAGATCATGCAGGCTGCCACTCCCACGGAGCAGCCCCCTGGAGCTGAGGCTCCTCTCCCTGTACCGCCCCCCACTGGCACCGCTGCTGCCCCTGCCCCCACTCCCAGCCCCGCAGGGGGCCCTGACCCCACCTCACCCAGCTCGGACTCTGGCACGGCCCAGGCTGCCCCGCCACTGCCTCCACCCCCAGAGTCGGGGCCTGGACAGCCTGGCTGGGAGGGGGCTCCCCAGCCCTCCCCCCCACCCCCAGGTCCCTCCACAGCTGCCACAGGCAGGTGAGGGACCCCTGAGAAGATGCCAGGACTTATAGTACCCCCTCAGGACATGGACAGTATGTGGGGGCAGGAAGGTTATCTCCTCCCGGGTAAAGCCATTTCGTCCTCTCCAGTTTGGGGCGGAATGAGGCCTGCTCCTCTTGTAAATACCCCCTTCCCTCGAAGCTCCCTCCCGGTGCTGGGGGGCAGCTGAGGGGCTGCAGGGGCAGTCTCCCTCCTCCAAGCCCCTGTACATAACCTGGAGCGTGTGACCTTCAGAGCTTTTCACTTTATGCAAAATGGCTCCTGTGAGGGCTGCAAGCTGGAGGGTGGTGCAGGCCTTGGGCCACAGGGAGGCGCCTGTGGAATAGGGGGAGTTCATGCACCCCTTTTTTCCCCAGAGGGGCTGGACTCAGGTTAGTTTGGGGGTGGGGGCTCCTGCACTTTGCCACAGGCACGGGGAGGGTTTTCTCCTCACCCCCTCTGCCCTCCCAACTTGGGTTGTACTTTCTAAGAAGGTGATTCCCCCTGCCCTTGCCCCCTTCCCCAGAACAAAACATGTTGATCATGTGCAATATTTCTTACTGTGCCGAGAAGCCGCAATGAGCGAGATTAAAGCTGTTTAACACA

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