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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TUBAP10
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:124435672-124437122  UCSC
Coordinates (T2T) chr4:127738206-127739656  UCSC
Coordinates (hg19) chr4:125356827-125358277  UCSC
Strand -
Parental Sequence NM_006000.3
Parental seq. overlap 1220 bp
Parental seq. overlap (%) 58.3%
Genomic Region Intergenic
Retrocopy Summary TUBAP10, located on chr4:124435672-124437122, is a retrocopy of the parental gene TUBA4A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TUBA4A
Full Name tubulin alpha 4a
Also known as ALS22|H2-ALPHA|TUBA1
Coordinate chr2:219249710-219254740
Strand -
Gene summary Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TUBA4AP1
Bonobo Pan paniscus LOC100995882P1
Gorilla Gorilla gorilla TUBA4AP1
Orangutan Pongo abelii TUBA4AP1
Gibbon Nomascus leucogenys TUBA4AP2
Green monkey Chlorocebus sabaeus TUBA4AP2
Crab-eating macaque Macaca fascicularis TUBA4AP1
Rhesus Macaca mulatta TUBA4AP1
Baboon Papio anubis LOC101006121P1
Golden snub-nosed monkey Rhinopithecus roxellana LOC104660054P1
Marmoset Callithrix jacchus TUBA4AP1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TUBAP10
CCATGTGTGAGTACATTTCAGTCCATATGGGGCAGGCAGGTGTCCAGATGGGCAATGCTAACCTGTTGGGAGCTCTACTGCCTGGAACATGAGATTCAAACTGATGGGCAGAAGCCCAGTGAAAAGACTATTGGTGAAGGGGATAGTCAACCTTCACCAGCTTCTTCTGTGAAACCAGTGCTAGAAAACATGTGTCCTGACTGTTTTGTGGATCTGGAGCCTATGGCCATTGATGAAATCTGAAATGGCCTATAACAACAGTTCTTCCACCCAGAGTAGCTCATCACTGTAAAAGAGGATGCTCTCAACAACGATGTCCGTGGTCACTATACCATTGGCAAAGAGATCAATGACCCAGTGCTGGACTGGACCTGGAAGCCGTCTGACCAATGCACAGGACTTCAGGACTTCCTGGTGTTCCACAGCTTTGACAGGGGCACTGGCTCTGGCTTTACCTCACTCCTAATGGAGCAGCTCTCTGGTACAATGGCAAAATCTAAGCTGTAATTCTCCAACTACTCAGCCCTGCAGGTGTCCACAGCCATAGTTGAGCCCTACAACTTCATCCTGACCACTCACTCACACCACCCTAGAGCACTCAGCTTGTGCCTTCATGGTGGACGACAAAGCCATCTATGACAATTGCTGCCACAACCTGGACATTGAGTCCCCAACCTACACCAACCTCAACTTCCTCATTAGCAAAGTAATCTCCTCCACTACAGCTTCTCTGCACTTTGACAAGGCCCTCAACATGGATCTGACAGAGTTTCAGATCAACCTGGTGGCCAGCACTCGCATCTACATCCCCCCGGCCATCTATGTGCCAGTCATCTGCAGAGAAGGTGTACCACAACAGCTGTTTTTGGCAGGGATCGCCAATGCCTGCTTTCAGCCTGCCAGCCAGATGGCAAAGTGTGATGGTATGGCACTTTAGGGAATATGGCTTACTGGTATGGCAAGTGTATGGCCTACTGCCTGTTGTACCACAGAGATGTACCCAAGGATGTCAATGCTGCCATTGCCACCATCAAGACCAAGTGCAGCATTCAGCTTGTGTACTGCTGCCCCACAGGCCTCAAGGTTGGTATCAACTAACCGCTGCCCACTGTGGTGCCTGGGGGTGACCTGGGCCAAGGTACAGTGTGACGTGTGCCTGCTGAACAACACAATTGCCATTGCCAAGGCCTGGGCCCACCTGGACCACAAGTTCAAGCTGATGTATGTCAAGAGGGCGTTTGTACACTGGGAAGCTGGTGAGGGCATGAAGAATGGTGAGTTCTCCAAGGCTCAGGGAGGATATGGCCACCCTGGAGAAGGATTATGAGGAAGTAGGCAACGACTCCTCTGAGGATGAGAATGAGGGAGAAGAATAGAACAACTGCCTGGAGCCTATTCATTATGGTTATTGCAAAATCCTTTGGAAATAAACAGTCTCCTTGCATGGTTt
>NM_006000.3
GCAGTTCTCACTGAGACCTGTCACCCCGACTCAACGTGAGACGCACCGCCCGGACTCACCATGCGTGAATGCATCTCAGTCCACGTGGGGCAGGCAGGTGTCCAGATGGGCAATGCCTGCTGGGAGCTCTATTGCTTGGAACATGGGATTCAGCCTGATGGGCAGATGCCCAGTGACAAGACCATTGGTGGAGGGGACGACTCCTTCACCACCTTCTTCTGTGAAACTGGTGCTGGAAAACACGTACCCCGGGCAGTTTTTGTGGATCTGGAGCCTACGGTCATTGATGAGATCCGAAATGGCCCATACCGACAGCTCTTCCACCCAGAGCAGCTCATCACTGGGAAAGAGGATGCTGCCAACAACTATGCCCGTGGTCACTATACCATTGGCAAGGAGATCATTGACCCAGTGCTGGATCGGATCCGCAAGCTGTCTGACCAGTGCACAGGACTTCAGGGCTTCCTGGTGTTCCACAGCTTTGGTGGGGGCACTGGCTCTGGCTTCACCTCACTCCTGATGGAGCGGCTCTCTGTTGACTATGGCAAGAAATCCAAGCTGGAATTCTCCATCTACCCAGCCCCCCAGGTGTCTACAGCCGTGGTCGAGCCCTACAACTCTATCCTGACCACCCACACCACCCTGGAGCACTCAGACTGTGCCTTCATGGTGGACAACGAAGCAATCTATGACATCTGCCGCCGCAACCTAGACATCGAGCGCCCAACCTACACCAACCTCAATCGCCTCATTAGCCAAATTGTCTCCTCCATCACAGCTTCTCTGCGCTTTGACGGGGCCCTCAATGTGGACCTGACAGAGTTCCAGACCAACCTGGTGCCCTACCCTCGCATCCACTTCCCCCTGGCCACCTATGCACCAGTCATCTCTGCAGAAAAGGCATACCACGAGCAGCTGTCGGTGGCAGAGATCACCAATGCCTGCTTTGAGCCTGCCAACCAGATGGTAAAGTGTGATCCCCGGCACGGCAAGTACATGGCCTGCTGCCTGCTGTACCGTGGAGATGTGGTGCCCAAGGATGTCAACGCTGCCATTGCCGCCATCAAGACCAAGCGCAGCATTCAGTTTGTGGACTGGTGCCCCACAGGCTTCAAGGTTGGTATCAACTACCAGCCTCCCACTGTGGTGCCTGGGGGTGACCTGGCCAAGGTGCAGCGTGCCGTGTGCATGCTGAGCAACACGACCGCCATCGCCGAGGCCTGGGCCCGCCTGGACCACAAGTTCGACCTGATGTATGCCAAGAGGGCGTTTGTGCACTGGTATGTGGGTGAGGGCATGGAGGAGGGTGAGTTCTCCGAGGCCCGTGAGGATATGGCTGCCCTGGAGAAGGATTATGAGGAGGTGGGCATCGACTCCTATGAGGACGAGGATGAGGGAGAAGAATAAAGCAGCTGCCTGGAGCCTATTCACTATGTTTATTGCAAAATCCTTTCGAAATAAACAGTTTCCTTGCACGGTTTCTTGTTCCCTCTGAGtgcttgagcttctgctgccttccccttcatgctgctgctgctctgtttgctgTTCATGACCCTTATCCCTTCCATCGCTGAAGGTGAGACCTGCAAAGGGGTTCTTGCCAGGCCCAGGAAGCATAACCCCAGGGACTTTAAATTGAAGTCCTAGGGTTACTCAGTATAGGGAGGAAATGAGGACCAAAATCCAGGCACAAACTGTTGAAGGATGAGTCTTCAGCTCCTTTCCAAGTAGGAGTATAATCCAGTGGTTTCTGTCTTTGAAAGTTAGACTGCTACCCTGTTCTTCCTGCTGCCTCTACATTTACCAACTCTGGAAGCAAGGCTTGGCCCAGGCTCCTCTGTGCATTATGAGGGTTTGGGAGTGGGGCTGGGCTGGCCCAGAGTTCCTGGGCATGGAGCCACGTCATAAGCTTGGGGGATGGGAGGGAACACAGGCGATCTCCTAGAGTTGTTTGTGCCACTGCACCTCTGAGCAGCTTTGCATAGCTTCCTGTCTTGCTGCTTTGCTGGAGCTGGGGCTGTGCCATTAAAAGTCAGGTCATCTCCC

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