Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SAT1P1
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Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:127498251-127498981  UCSC
Coordinates (T2T) chr4:130801210-130801940  UCSC
Coordinates (hg19) chr4:128419406-128420136  UCSC
Strand +
Parental Sequence NM_002970.4
Parental seq. overlap 608 bp
Parental seq. overlap (%) 57.7%
Genomic Region Intergenic
Retrocopy Summary SAT1P1, located on chr4:127498251-127498981, is a retrocopy of the parental gene SAT1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SAT1
Full Name spermidine/spermine N1-acetyltransferase 1
Also known as DC21|KFSD|KFSDX|SAT|SSAT|SSAT-1
Coordinate chrX:23783173-23786210
Strand +
Gene summary The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SAT1P1
Bonobo Pan paniscus SAT1P1
Gorilla Gorilla gorilla SAT1P1
Golden snub-nosed monkey Rhinopithecus roxellana SAT1P1
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Massive Mining of Publicly Available RNA-seq Data from Human and Mouse - (ARCHS4)

Related Sequence

>SAT1P1
TGAATGAGGAACCACCTCCTCCTGCCATTCAAGCATAGGGGCCTATTACATAAAGGGAAGAAAAATAAAAGAAGAAAATGGCTACATTTGTGATCCATCCTGCCATCACTGCTGACTCCAGTGGTATCTGTGGCTGATCAGGGAACTGGCTAAATATGAATATGTGGGAGACCAAGTAATATTAACTGAAAAAGATCTGCTAGAGAGTGGTTTCAGAGAGCATCCCTTCCACCACTGTGTGGTTGCAGAGATGCCCAAGAAACACTGGACTCTGGAAAGAAAGAATTACTGTTGGTTTCACCATGTACTGTTGTACCTATGACCCTTGAATTGGCAAGCTATTGTACTTCTTTGGATGAGTAATGAAAAAGGCTTTGGCATAAATCAGAAATTCTGAAGAATTTAAGCCAGGTCACAATGAAGTATCACTGTAGCACCATGCACTTCTTAGTAGCAGAATGAAATGAACCATCTGTTAACCTCTACAAAAGAAGAGGTGCCCAGGGAAGACAGCTGGAGACCCTTCAAAACCGACAAGGAGTACTTGCTAAAAATGGCAGCAAAGGACTGAAGCGGGGTGTAGATGATGACAACATCCATTCTACTTTAGAACAAATTCCCAACTTATCTTGCTTTCTCTCCTGTTTATAGTCAAATAATAGAATGAACACTCATTTCAAAATTTCATTACCAGTGGCACTGTTGCATGTTTGGAATGTCGTCTCTTTAAA
>NM_002970.4
GCGCAGCTCTTAGTCGCGGGCCGACTGGTGTTTATCCGTCACTCGCCGAGGTTCCTTGGGTCATGGTGCCAGCCTGACTGAGAAGAGGACGCTCCCGGGAGACGAATGAGGAACCACCTCCTCCTACTGTTCAAGTACAGGGGCCTGGTCCGCAAAGGGAAGAAAAGCAAAAGACGAAAATGGCTAAATTCGTGATCCGCCCAGCCACTGCCGCCGACTGCAGTGACATACTGCGGCTGATCAAGGAGCTGGCTAAATATGAATACATGGAAGAACAAGTAATCTTAACTGAAAAAGATCTGCTAGAAGATGGTTTTGGAGAGCACCCCTTTTACCACTGCCTGGTTGCAGAAGTGCCGAAAGAGCACTGGACTCCGGAAGGACACAGCATTGTTGGTTTTGCCATGTACTATTTTACCTATGACCCGTGGATTGGCAAGTTATTGTATCTTGAGGACTTCTTCGTGATGAGTGATTATAGAGGCTTTGGCATAGGATCAGAAATTCTGAAGAATCTAAGCCAGGTTGCAATGAGGTGTCGCTGCAGCAGCATGCACTTCTTGGTAGCAGAATGGAATGAACCATCCATCAACTTCTATAAAAGAAGAGGTGCTTCTGATCTGTCCAGTGAAGAGGGTTGGAGACTGTTCAAGATCGACAAGGAGTACTTGCTAAAAATGGCAACAGAGGAGTGAGGAGTGCTGCTGTAGATGACAACCTCCATTCTATTTTAGAATAAATTCCCAACTTCTCTTGCTTTCTATGCTGTTTGTAGTGAAATAATAGAATGAGCACCCATTCCAAAGCTTTATTACCAGTGGCGTTGTTGCATGTTTGAAATGAGGTCTGTTTAAAGTGGCAATCTCAGATGCAGTTTGGAGAGTCAGATCTTTCTCCTTGAATATCTTTCGATAAACAACAAGGTGGTGTGATCTTAATATATTTGAAAAAAACTTCATTCTCGTGAGTCATTTAAATGTGTACAATGTACACACTGGTACTTAGAGTTTCTGTTTGATTCTTTTTTAATAAACTACTCTTTGATTTAA

Publications

PMID - Link Title
No publications available for this retrocopy