Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RPL32P12
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:13648078-13648455  UCSC
Coordinates (T2T) chr4:13627781-13628158  UCSC
Coordinates (hg19) chr4:13649702-13650079  UCSC
Strand -
Parental Sequence NM_000994.4
Parental seq. overlap 343 bp
Parental seq. overlap (%) 16.4%
Genomic Region Intergenic
Retrocopy Summary RPL32P12, located on chr4:13648078-13648455, is a retrocopy of the parental gene RPL32. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RPL32
Full Name ribosomal protein L32
Also known as L32|PP9932
Coordinate chr3:12834485-12841582
Strand -
Gene summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L32E family of ribosomal proteins. It is located in the cytoplasm. Although some studies have mapped this gene to 3q13.3-q21, it is believed to map to 3p25-p24. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RPL32P9
Bonobo Pan paniscus RPL32P9
Gorilla Gorilla gorilla RPL32P10
Orangutan Pongo abelii RPL32P12
Gibbon Nomascus leucogenys RPL32P34
Green monkey Chlorocebus sabaeus RPL32P38
Crab-eating macaque Macaca fascicularis RPL32P12
Rhesus Macaca mulatta RPL32P13
Baboon Papio anubis RPL32P9
Golden snub-nosed monkey Rhinopithecus roxellana RPL32P6
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RPL32P12
TTCTCTCTTCCTTGGCACTGCCTATGGAGGCGGCAGCCATCTCCTCCTCAGCATCATGGCCACCTTCATACCCCTTGTGAAGCCCAAAATAGTCAAAAAGAGAACCAAGAAATTCATCGGGCACCGGTCAGACTGATATGTCAAAATTAAGCGTGACTGGCAGAAACCCAGAGGTAGTGACAACAGGGTTCATAGAAGGTTCAAGCTCCAGATCTTGATGCCCAACATTACTTATGGGAGCAACAAAAAAACAAAGCATATGCTGCCCAGTGGCTTCCAGAAGTTCCTGGCCCACAAGGTCAAGGAGCAGGAAGTGCTGCTGATGTGCAACAAATCTTACTGTGCTGAGATTGCTCACAATGTTTCCTCCAACAACCC
>NM_000994.4
AGCCCTTGCGCGCCACCGTCCCTTCTCTCTTCCTCGGCGCTGCCTACGGAGGTGGCAGCCATCTCCTTCTCGGCATCATGGCCGCCCTCAGACCCCTTGTGAAGCCCAAGATCGTCAAAAAGAGAACCAAGAAGTTCATCCGGCACCAGTCAGACCGATATGTCAAAATTAAGCGTAACTGGCGGAAACCCAGAGGCATTGACAACAGGGTTCGTAGAAGATTCAAGGGCCAGATCTTGATGCCCAACATTGGTTATGGAAGCAACAAAAAAACAAAGCACATGCTGCCCAGTGGCTTCCGGAAGTTCCTGGTCCACAACGTCAAGGAGCTGGAAGTGCTGCTGATGTGCAACAAATCTTACTGTGCCGAGATCGCTCACAATGTTTCCTCCAAGAACCGCAAAGCCATCGTGGAAAGAGCTGCCCAACTGGCCATCAGAGTCACCAACCCCAATGCCAGGCTGCGCAGTGAAGAAAATGAGTAGGCAGCTCATGTGCACGTTTTCTGTTTAAATAAATGTAAAAACTGCCATCTGGCATCTTCCTTCCTTGATTTTAAGTCTTCAGCTTCTTGGCCAACTTAGTTTGCCACAGAGATTGTTCTTTTGCTTAAGCCCCTTTGGAATCTCCCATTTGGAGGGGATTTGTAAAGGACACTCAGTCCTTGAACAGGGGAATGTGGCCTCAAGTGCACAGACTAGCCTTAGTCATCTCCAGTTGAGGCTGGGTATGAGGGGTACAGACTTGGCCCTCACACCAGGTAGGTTCTGAGACACTTGAAGAAGCTTGTGGCTCCCAAGCCACAAGTAGTCATTCTTAGCCTTGCTTTTGTAAAGTTAGGTGACAAGTTATTCCATGTGATGCTTGTGAGAATTGAGAAAATATGCATGGAAATATCCAGATGAATTTCTTACACAGATTCTTACGGGATGCCTAAATTGCATCCTGTAACTTCTGTCCAAAAAGAACAGGATGATGTACAAATTGCTCTTCCAGGTAATCCACCACGGTTAACTGGAAAAGCACTTTCAGTCTCCTATAACCCTCCCACCAGCTGCTGCTTCAGGTATAATGTTACAGCAGTTTGCCAAGGCGGGGACCTAACTGGTGACAATTGAGCCTCTTGACTGGTACTCAGAATTTAGTGACACGTGGTCCTGAttttttttggagacggggtcttgctctcacccaggctgggagtgcagtggcacactgactacagccttgacctccccaggctcaggtgatcttcccacctcagccttccaagtagctgggactacagatgcacacctccaaacctgggtagtttttgaagtttttttgtagaggtggtctagccatgttgcctaggctcccgaactcctgagctcaagcaatcctgcttcagcctcccaaagtactgggattacaggcatCTTCTGTAGTATATAGGTCATGAGGGATATGGGATGTGGTACTTATGAGACAGAAATGCTTACAGGATGTTTTTCTGTAACCATCCTGGTCAACTTAGCAGAAATGCTGCGCTGGGTATAATAAAGCTTTTCTACTTCTAGTCTAGACAGGAATCTTACAGATTGTCTCCTGTTCAAAACCTAGTCATAAATATTTATAATGCAAACTGGTCAtttttgggattttgtttttgagactcattctgtcaccccggctggagtgcagtggcttgatcttggctccctgcaacttctgcctcctgggttcaggcgattcGATTAACAATTGGAGACGAGTCGTGCAGAGGAAAGAAGTAACTTAGAATCTAATCTTTATTAACCTGGGATATCACAGAAAATACTTGGGCCTGCCACTTGTATTTCTTTGTCCTCAATACTGAACACTAGACACATTTGAAACCTTCCTCAGAAGGAAACAAACCAACTGGTTATGCCTGGGTGGTGGCATGGAAGATGCCCATTGTTGCCCAATTTGCTAATAAGTATTTTGAAATTAGAAATGAAACATGAGGTCCAAGCCTGTCCAGTTCCCTACCCAACCCATTCCTCCTCCCTGGAAAAAAGAAACCCGTATCATCTTCCAAATTTCTGATTCATCACTGCCACTTAAAAA

Publications

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