Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name NOB1P1
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:138560689-138562384  UCSC
Coordinates (T2T) chr4:141880029-141881724  UCSC
Coordinates (hg19) chr4:139481843-139483538  UCSC
Strand +
Parental Sequence NM_014062.3
Parental seq. overlap 1603 bp
Parental seq. overlap (%) 93.4%
Genomic Region Intergenic
Retrocopy Summary NOB1P1, located on chr4:138560689-138562384, is a retrocopy of the parental gene NOB1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NOB1
Full Name NIN1 (RPN12) binding protein 1 homolog
Also known as ART-4|MST158|MSTP158|NOB1P|PSMD8BP1
Coordinate chr16:69741871-69754926
Strand -
Gene summary In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).[supplied by OMIM, Nov 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NOB1P1
Bonobo Pan paniscus NOB1P1
Gorilla Gorilla gorilla NOB1P1
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NOB1P1
GCTCACGCAGACAACGTGGCTCCAGTGGAGCAAGTTGTGGCGGATGCTGGGGCTTTCCTTCGGGATGCGGCTCTGCAGGACATCGGGAAGAACATTTACATCATCCGGGAGGTGGTCACTGAGTTTCGGGACAAGGCCACATGCAGGCGGCTCGCTGTCCTGCCCTATGAGCTGCGGTTCAAGGAGCCCTTACCAGAATACGTGCAGCTGGTGACTGAGTTTTCAAAGAAAACAGGAGACTACCCCAGCCTCTCTGCCACGGACATCCAAGTGCTTGCGCTCACATACCAGTTGGAAGCAGAGTTTGTTGGGGTGTCTCACCTAAAACAAGAACCACAGAAGGTTAAACTGAGCTCATCGATTCAGCACCCAGAAACACCTCTGCACATTTCTGGTTTCCATCTGCCCTCCAAGCCTAAACCCCCACAAGAAACAGAAAAAGGACACCCAGCTTGTGAGCCTGAGAACCTGGAATTTAGTTCCTTCATGTTCCGGAGAAACCCTCTGCCCAACATCGATCATGAACTGCAGGAGCCGCTGATTGACAGAGGTGAGGACGTTCCAAGAAAACGGGTTTGAAGACAGAAAAGATGACAGCGATGACGACGGGGGTGGCTGGATAACCCCCAGTAACATCAAGCAGATCCAGCAGGAGCTGGAGCAGTGCGACGTCCCCGAGGACGTGCGGGTTGGCTGCGTGACCACAGACTTCCCCAGGCAGAATGTTCTGCTGCAGATGGGGCTGCACGTGCTGGCGGTGAACTGCATGCTGATTCGTGAGGCCCAGAGCTACGTCTGGGCTGCCACGGCTGTTTCAAGACAACGTCTGACATGAGCCGAGTGTTCTGTTCACACTGTGGGAACAAGACCCTGAAGAAAGTGTCCGTGACCATCAGTGACGACGGCACCCTGCACATGCACTTCTCCCGCAACCCCAAGGTGCTGAACGCCCGCGGCCTCCGGTACTCGCTTCCCACTCCCAAAGGGGGCACATACGCCATCAACCCCCATCTCACCGAGGATCAGCGCTTCCCTCAACCGCGACTCTCCCGAAAGGCCAGGCAGAAAACCAACGTGTTCGCCCCTGACTACATCGCCGGGATGTCGCCCTTTGTCGAGAATGACATCTCCAGCCGCTCAGCTACCCTACAGGTCCGGGACAGCACCTTGGGAGCTGGGCGGAGACGCTTAAATCCCAACGCTTCCAGAAAGAAGTTTGTGAAGAAAAGGTGAAGAGCGAGTTCCCGCAGGCAAATTGGATGGGCGTCTGGCCGCCGTGGAGTTCCGGTGACCCATTACCCCAGCCATGTCGTCTCCAGGACCACCCGATGGAAATTAACAGGCGGGCTTCACGGTGCGGTTCTGCCCGCCCATGCCCTGCCGGGTCTGCACGGAACTGGACTGTCCCATGGCCTGTGAGCATCGGAGCGCCTGGCTGCCTGCCAAGGAAGGGGAATTGGATAAAAACAGGAAGAACAATGCCCTGGAGCCAATCTTTAAGAAAGGAGTTTCCAAAGGATAATATTTTTCTAATAAATGCGGCTGCAAGCTCCTGTGCATTTTATTAAATAGGCCAAATTTTTGCTGCTTAGGTCATCTCAAGGCTGACACTTGAGCTGTGTGCCCAGTTCAGATTTATCTTTTTGCTAGAAAATACAAGGTTAT
>NM_014062.3
CTCTCACGCAGCCAACATGGCTCCAGTGGAGCACGTTGTGGCGGATGCTGGGGCTTTCCTGCGGCATGCGGCTCTGCAGGACATCGGGAAGAACATTTACACCATCCGGGAGGTGGTCACTGAGATTCGGGACAAGGCCACACGCAGGCGGCTCGCTGTCCTGCCCTACGAGCTGCGGTTCAAGGAGCCCTTACCGGAATACGTGCGGCTGGTGACTGAGTTTTCAAAGAAAACAGGAGACTACCCCAGCCTCTCTGCCACGGACATCCAAGTGCTTGCACTCACATACCAGTTGGAAGCAGAGTTTGTTGGGGTGTCTCACCTAAAACAAGAACCACAGAAGGTTAAGGTGAGCTCATCGATTCAGCACCCAGAAACACCTCTGCACATTTCTGGTTTCCATCTGCCCTACAAGCCTAAACCCCCACAAGAAACAGAAAAAGGACACTCAGCTTGTGAGCCTGAGAACCTGGAATTTAGTTCCTTCATGTTCTGGAGAAACCCTTTGCCCAACATCGATCATGAACTGCAGGAGCTGCTGATTGACAGAGGTGAGGACGTTCCAAGTgaggaggaggaggaggaagaAAACGGGTTTGAAGACAGAAAAGATGACAGCGATGACGACGGGGGTGGCTGGATAACCCCCAGTAACATCAAGCAGATCCAGCAGGAGCTGGAGCAGTGTGACGTCCCCGAGGACGTGCGGGTTGGCTGCCTGACCACAGACTTCGCCATGCAGAATGTTCTGCTGCAGATGGGGCTGCACGTGCTGGCGGTGAACGGCATGCTGATTCGTGAGGCCCGGAGCTACATCTTGCGCTGCCATGGCTGTTTCAAGACAACGTCTGACATGAGCCGAGTGTTCTGCTCACACTGTGGGAACAAGACCCTGAAGAAAGTGTCCGTGACCGTCAGCGACGACGGCACCCTGCACATGCACTTCTCCCGCAACCCCAAGGTGCTGAACCCCCGCGGCCTCCGGTACTCGCTTCCCACTCCCAAAGGGGGCAAATACGCCATCAACCCCCATCTCACCGAGGATCAGCGCTTCCCTCAGCTGCGACTCTCCCAAAAGGCCAGGCAGAAAACCAACGTGTTCGCCCCTGACTACATCGCCGGGGTGTCACCCTTTGTCGAGAATGACATCTCCAGCCGCTCAGCTACCCTGCAGGTCCGGGACAGCACCTTGGGAGCTGGGCGGAGACGCTTAAATCCCAACGCTTCCAGAAAGAAGTTTGTGAAGAAAAGGTGAAGAGCGAGTTCCCGCAGGCAAATTGGATGGGCGTCTGGCCGCCGTGGAGTTCCGGTGACCCATTTCCCCAGCCGTGTCGTCTCCAGGACCACCCGATGGAAATAACAGGCGGGCTTCACGGTGCGGCTCTGTCCGCCCATGCCCCGCTGGGTCTGCAGGGAACTGGACTGTCCCATGGCCTGTGAGCACCGGAGCGCCTGGCTGCCTGCCAAGGAAGTGCAATTGCATAAAAACAGAAAGAACAACGCCCTGGAGCCAATCTTCAAGAAAGGAATTTCCAAAGGATAATATTTTTCTAATAAATGCGGCTGCAACCTCCTGTGCATTTAATTAAATAGGCCAAATTTTTGCTGCTTAGGTCATCTCAAGGCTGATACTTGAGCTGTGTGCCCAGAGATCATGCATTTAGATTTATATTTTTGCCAGAAAATACAAGGTTATAATAAAACTAAGAACTACCA

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