Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RPL14P3
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:140366234-140366882  UCSC
Coordinates (T2T) chr4:143686011-143686659  UCSC
Coordinates (hg19) chr4:141287388-141288036  UCSC
Strand -
Parental Sequence NM_003973.5
Parental seq. overlap 422 bp
Parental seq. overlap (%) 5.9%
Genomic Region Intragenic (SCOC)
Retrocopy Summary RPL14P3, located on chr4:140366234-140366882, is a retrocopy of the parental gene RPL14. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RPL14
Full Name ribosomal protein L14
Also known as CAG-ISL-7|CTG-B33|L14|RL14|hRL14
Coordinate chr3:40457339-40468587
Strand +
Gene summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in the cytoplasm. This gene contains a trinucleotide (GCT) repeat tract whose length is highly polymorphic; these triplet repeats result in a stretch of alanine residues in the encoded protein. Transcript variants utilizing alternative polyA signals and alternative 5'-terminal exons exist but all encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RPL14P4
Bonobo Pan paniscus RPL14P4
Gorilla Gorilla gorilla RPL14P4
Orangutan Pongo abelii RPL14P4
Gibbon Nomascus leucogenys RPL14P1
Green monkey Chlorocebus sabaeus RPL14P3
Crab-eating macaque Macaca fascicularis RPL14P2
Rhesus Macaca mulatta RPL14P2
Baboon Papio anubis RPL14P2
Golden snub-nosed monkey Rhinopithecus roxellana RPL14P2
Marmoset Callithrix jacchus RPL14P3
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RPL14P3
AAAGTTCTAGCAAAAAGATGACCGCTGCAGGCAAGAAGGCTCCAGCTTAGAAGCTTCCTGCCCAGAAAGCCACAGGCCAGAAGGCAGCGCCTCCTCCAAAAGCTCAGAAGGGTCAAAAAGCTCCAGCCCAGAAAGCACCTGCTCCAAAAGCGTTTGGCAAGAAAGACTTCTTGCCAAACGCCACCAACATGGTGTTCAGGCGCTTCGTGGAGGTTGGCCGTGTGGGCTACATCCCCTCTGGACCTCGTGCCAGAAAATTGGTTGCAACTGTAGATGTTATTGATCAAAACAGGGCTTTGGTTGATGGACCTTGCACTCAAGTGAGGAGACAGACCATGCCTTTCAAGTGCATGCAGCTCACTGATTTCAACCTCAAGTTTCCACACAGAGCCCACCAGAAGTATGTCAGACAAGCCTGGCAGAAGGCAAACATCAATACAAAATGGGCAGCCACACGATGGGCCAAGAAGATTGAAGCCAGAGAAAGGAAAGCCAAGATGACAGATTTTGATCATTTTAAAGTTATGAAGGCAATGAGGAACAGAATAATCAAGAATGAAGTTAAGAAGCTTCAAAAGGCAGCTCTCCAAAAGCTTCTCCCAAAAAAGCACc
>NM_003973.5
CTTCTCGCCTAACGCCGCCAACATGGTGTTCAGGCGCTTCGTGGAGGTTGGCCGGGTGGCCTATGTCTCCTTTGGACCTCATGCCGGAAAATTGGTCGCGATTGTAGATGTTATTGATCAGAACAGGGCTTTGGTCGATGGACCTTGCACTCAAGTGAGGAGACAGGCCATGCCTTTCAAGTGCATGCAGCTCACTGATTTCATCCTCAAGTTTCCGCACAGTGCCCACCAGAAGTATGTCCGACAAGCCTGGCAGAAGGCAGACATCAATACAAAATGGGCAGCCACACGATGGGCCAAGAAGATTGAAGCCAGAGAAAGGAAAGCCAAGATGACAGATTTTGATCGTTTTAAAGTTATGAAGGCAAAGAAAATGAGGAACAGAATAATCAAGAATGAAGTTAAGAAGCTTCAAAAGGCAGCTCTCCTGAAAGCTTCTCCCAAAAAAGCACCTGGTACTAAGGGTActgctgctgctgctgctgctgctgctgctgctAAAGTTCCAGCAAAAAAGATCACCGCCGCGAGTAAAAAGGCTCCAGCCCAGAAGGTTCCTGCCCAGAAAGCCACAGGCCAGAAAGCAGCGCCTGCTCCAAAAGCTCAGAAGGGTCAAAAAGCTCCAGCCCAGAAAGCACCTGCTCCAAAGGCATCTGGCAAGAAAGCATAAGTGGCAATCATAAAAAGTAATAAAGGTTCTTTTTGACCTGTTGACAAATGTATTTAAGCCTTTGGATTTAAAGCCTGTTGAGGCTGGAGTTAGGAGGCAGATTGATAGTAGGATTATAATAAACATTAAATAATCAGTTCCtttttttttttttttttttttgagatggagtctcgttctgttgctcaggccggactgcagtggcgctatctcggctcactgtaagttccacctcccgggttcatgccattctcctgcctcagcctcctgagcagctgggactacaggtgcccgccaccgcgcctggctaattttttgtatttttagtagagacggggtttcaccgtgttagccaggatggtctcgctctcctgacctcgtgatccgcccgcctcggcctcccaaagtgctaggattgcaggcatgagccgccgcgcctggccTAAATAATCAGTTCTTTAATCTCACTCTCTGCCCATACTTGGATAGGTAGTGCAAAATCATTGCAGTCATAATTGATCATGTCATGAGAAATCATGATAACTTAGAACACCAAGTGACACAAGTGACATTTTTTTCTTATGGTCACCTTGGCTTCAGAACATCTTTTTTCCTTGTACAAATATGTTTGCCATAAATAGGTAAAGTGACAGCCTCTTGATGCTCAAGAGTCTAGCAGAtttattttatttatttattttttttttttggagacagagtcttgctgtgttgcccaggctggagtgcagtggtgcgatctcagctccctccaccttccgggttcaagtgattctcctgccttggcttcccaggtagctgggactacaggcgcccaccaccatgcccagctaattttttttgtagagactgggtttcactatgttggccaggctggttttgaactcctgacctcgtgatccgcctgtctcggcctcccagagcgggggattataggcatgggccactgcacttggcctttttttgtttttttgagacagagtcttgatcttatcacccaggctggagtgcagtggcacgatcttggctcagcgcaacctctgcctcctgggctcaagcggttctcctgctcagccttctgagtagttgggactataggtgtgtgccaccacgtctggctagtttttgtatttttagtggagatggggtttcaccatgttggccatgctggtctcgagctcctgacctcaggtgatacacccgccttggcctcccaaagtgctggaattacaggtgtgagccactgtgcccggccTGCAAATTTTCTTATAAAAAGTAAACTAGGAAAATAGGGCAAGTATAAAAATTGcaggttgagcatatttctaatccaaaaagctctaacctctgaaactgagctatgacactacaatttaaaaatccctagcctacccgcatggtgggttatggtcaaaatacaggtacacagcactattcagtgtccctgaggaagaaatagttaaccttcagggtacatgtatatgaagcataaatgaatttcctgtatagacctaggtcccatccccaaagtgtcatgtatatgcacttaactccaacatcagaacacatctcgtcctaagtgtttcagataagagatacttatcctgTGTATAGTAGGTTGGACTTCTGTTTCTCTCTACCACAAGATACAGGTAATTTGGGGCAGTAAAAGATCCTGGATAGATTTAAAAATACTACAAAGCTGTACATGAAACAGGATTACttttttttttttttttgagacagagccttactcttgcccaggctggaatgtagtggcacgatctcagctcactgcgacctccacctcccaggttcaagttgttctgcctcagcctcccaagtagcaggggttaaatgcgtgtaccaccatgcccctctaatattgtattagagatggggttttgccatgtcagccagactggtcttgaactcctgacctcaggtgatctgtccgccttggcctcccaaagtgctgggattacaggcgtgagccaccgcttctggccAGGAATACATTTTAAATAAATTTGTTTCCTAACCAAAAGCTAGCTTCAGGCGTCACTGGGGTAAAGGAAAAAGCACATTGATTTGCTTGATAATAGGCAAGTGGTATGGTGTAATAAGGAAAATATGGATGATTTCGGATTACCTGTTCTACTCTGGGAGGTAGAGAATTGTCTAGAGAAAGTGGCATCTATACCTAAAATAAGAAGAAGGTGGTGTAAGGGGAAGAATGACACGAGATAGGAAATAAACGAACTGATAGTGTAGAGGACTGGCTCGGGACCACATCAAGGAAGTAGGTTAGTGGTTAGATCGTGTAGGGGAACACGGGAAGCTACTGAGGGTTTTTTAAAATGGCGTGATATCTCAGATTTAGATCATTGAACTGTTAAGACTGAATCTTATGGGATCAAGACTGGGAATGCTCGGGTTGGCAGTATGAAGTTTGGCAGTAATCCAAGGAAGTGACAGTGGTAATGCCATTTAGGTGGTCTTGATCATGCATTGGACTGCAGAAATAAGGGAGAAAACAATGTGTCAGGGTTTCTGGTTTGTACCTCTGGTTCATTGGTTGTGAGGGAACATGAGGCAGGGTAAAGTTTATCTAGGTAAAATGAGTTAGTTTTCATGTAGACTATCTGGGTGTATATGCAAAGACTGcagacaatctatactaaaatcctggctctgcctcttgaaagctatgtagtttaggcacatagtcaaaatccagtttcctcatctatGTGGTACGCTTCAGAGTAGTTAATCATGATATGTAGTCCAGTGACTGGTTCCCTTGGTAAGAGCTGTGATAATGACACAAGGAGGAGAGGTTTCAGGACAGACTTGGGATTCATGAATATGTAAGTGGTCACTGATTCCCCAGGGGTAGGATGACAACAATCAAGAGACGAATAGAGGTTGGAAAGGAGTCATGAGGGGTGGGAAACTAGCAGGGGCACATGGAAGCTAGGGAAAGAATTTTGCTTGAGATCGTCAAAGTGAGGGGAAGAGGGTAGTAAGCAAAGGAGAAATGTTATATGGGGTTCGGAGGTTTTGTGTTTGTAAATCTGGAGTGATGGGCATGTTCAAATGCTTCTGGGAAAGGAGCTAATAGGAGAGAAACTTAgcccttcgaaaaacaggaagggatggatcctaggggagaggaggaaggattggctttagaggaaagatgtcctttacgtgaggaaaaggaagaaaaggtgggtttagatactaaatctgtaggtttgctgttaggaaattaaggacttttcacctttatctctgaaatttctctggagttagcaaggcaaggtcatacactgagaaggagggatgaggcagtgtagatttgcagaCATACAGGTTGTAATTCCTTATGGAGGAAAGGGGAGAGCACTTTTGTCAGACTGCCTGTGGCTTTGAGAGCCCTTTGGCTACAGTCCATGAGGTGCTCAGAGGATGAGAAAGCTTCAGGGTAGAAGCAGTATTCAAGCTGCACCTAGAAAACAGTGCAATACAGAACAGTGGAAATTGGAAATTCCAATCTTGGAATCTCTAGGAAAGTAACTGAGGCATACGATGCCTGAAAAGGAGTAGAAAATAAAATTAATAAGGTGGGACCATATGATAAGAGATTTGAggccgggcactgtggctcacacctgtaatcccagcactatgggaggctgaggcaggcggatcacctgaggtcaggggtccgagaccagcttggccaacatggtgaaaccccgtctttactaaaaatacaaaaattagacaggcatggtggagcatgcctgtaatcccagctacttgggaggctgaggcgggagaatcgcttgaacccaggaggtggaggttgcagtgagctgacattacgccatagcactccagcttgggcgacagagggagactctgtctcaaaaaaaaGACTTGAGCAAGGGCGTAATCTTCAGGAAGGTCAGTCTGGTAGCATAGTGTGGATTGGGTTGGGGGATGGGGAAGGAGAGCAGAAAATTATTGAAATATCCAGGTGCATAAAAGTCTACTTTGATTATGGAGAACTACACACTTGTTCAGTCACCCTCATTGGAGACGGGGGATGGCATACGAAAAGAATGCTGATTTCAggctgggcacggtggctcatgcctttaatcccagcactttgggaggctgaggcaggtgaatcaggggttcaagaccagcctggccaatgtggtgaaaccctgtctctactaaaaatcaaaaaAAAAAAAAAAAAAATGGCTGATTTCAGAGTCATATTCAGGTTTAAATTCTGTCATTCAGCCCAAACTCATTACTTTATGTTACTTATGGGAAcctcatctaaaaagcaaggatcctgatacctgcctcatattgtggcaaggatcaaatgagtcaaataagatgcttgtgaaagtgAGGACAGGATCTATCCTCAACACCTAGTGCAATTCTTTTTACACATTAGGTACTTAGTAATTTGGGTTGAATTGTGTTGAACTAACCTGGCGGTATAGGCAAAATTTGGAAGTTTGGTTTTCAGAAAGTCTTGACTTCCTCTTATCTCTAAGTAATTGGCATGTCCTCTAATTCATATTTTCCCCCCTCATCTGTTGGGTGAAATACTGTTTATCCTTTAGTACTAAAATTAAAAGTTACCTCATTCTTCTAGCTAGCTGATTTTTTtttttaatctaggctaaatcatgaatacatttacatttaaataaaatattacagttgaaagtaaagggtcctttcattatctccacttccaattccagtaccctGTGTAAAGGAAAACATATACATCTTGCAGACATTTTTTAATGTGTTTGTAATATAGGTACATAAAAATATATGTGCTTGTTTTAAGCAAATTTCATACTCTGCAACTTGCCTTTTTTCTTAATACGTTCTGGAGATCTTATCTAGTCAGCCTCTAAATTAGAGTTCTTCAGAAAACCAATGGGatggatgaatggactcaagagattgtggaaaccaagaagtcccacaaaataccatctgcaagctggagaaccaggaaagctgattgggataattcaaactgggtccagaggcctgagaactggaagggccagtggtgtaagtcctggtctgagaccaaaggcttgatcaagaatcaagagcatcaacaaccgagggcaggagaggatgggtttcccagattaaaaaagcaaattcacgcttcctcccccattttgttctatttgaaccttccgtggataggatgatgcccacctgcattggtgaaggtcatctttactcagtctacccattcaaatgccaatctcttccagaggtaatctcacagatttagaaatgtttcgccagctagctgaacaatccttagcccagtcaagtgcacacataaccataacaattcttactaatctacctcattcttttttatcttctgcataataatccacaacatgaatgttcacgtttgacctctattgatagacatttcggatgatgccaatttctttttctggtttttgttttttgtgtgtgtgtgttttttttttttttgagacgaggtcttgctctcgcccaggctggagtgcagtgggtggggtgatctcggctcactgcaacctctgcctcccgggttcaagcagttctcctgcctcaacctcctgagtagctgggattacaggagtgtgccaccacacctggctaatgtttgtattgttagtagatacagggtttcaccctgttagccaggatggtggatgggcatttgaatgggtagactgagtgatcctgacctcgtgatccactccccagtctcccaaagtactgggattacaggcgtgagccacggcaccaggccctctttttctatttaaacagtgcttccgtgaatgtccttgtgtacacctccttctgtacacaatgatgtttatctgatgcacattgccaatcagtgcacttgctggattgaagaatgtgagtgtttgtatcactctttcagtaggctgtaccaatttagacttgctctaccaatttagatttccatcagcagtaaacaaagacattcctgcctggcagtcttgaactcctgctattatctcttaaatttttgccagtgtgtgaaaagtagtatcttactttaacttgtattttcctggtccaatagtgcactaaatgcccgagttctgtatttattctatttggatagccATTAGATAGCCATTAAGTCCACTCATAGAGTTATTTTAAATGTTTTCCTTTAGTTTCCAACCAcattttcaaataaaatttagaattagcttgtcaa

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