Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name KRT18P51
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:144572237-144572986  UCSC
Coordinates (T2T) chr4:147889604-147890353  UCSC
Coordinates (hg19) chr4:145493389-145494138  UCSC
Strand +
Parental Sequence NM_199187.2
Parental seq. overlap 692 bp
Parental seq. overlap (%) 48%
Genomic Region Intergenic
Retrocopy Summary KRT18P51, located on chr4:144572237-144572986, is a retrocopy of the parental gene KRT18. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name KRT18
Full Name keratin 18
Also known as CK-18|CYK18|K18
Coordinate chr12:52948855-52952906
Strand +
Gene summary KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes KRT18P18
Bonobo Pan paniscus KRT18P19
Gorilla Gorilla gorilla KRT18P19
Orangutan Pongo abelii KRT18P19
Gibbon Nomascus leucogenys KRT18P26
Green monkey Chlorocebus sabaeus KRT18P14
Crab-eating macaque Macaca fascicularis KRT18P22
Rhesus Macaca mulatta KRT18P22
Baboon Papio anubis KRT18P13
Golden snub-nosed monkey Rhinopithecus roxellana KRT18P12
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>KRT18P51
TCATCCATGGGCTCTACAAGGTCATTGATGACACCAATGTCACTCAGCTGTAGCTGGAGGCAGAGATTGAGGCTCTCAAGGAGGAGCTGCTCTTCATGAAGAAGAACCACGAAGAGGAAGTAAAAGGCCTACAAGCCCAGAGTGCCAGCTCTGGTTTGACCCTGGAGGTAGGTGCCCCCAAATCTCAGAACCTAGCCAAGATCATGGCAGGCATCCTGGCCCAATACAAAGAGATGGCTCAGAAGATCTGAAAGGAGCTGGACAAGTATTGGTCTCAGCAGATTGAGGAGAGCGCCACAGTGGTCACCACGCAGCCTGCCAAGGTTGGAGCTGCTGAGATGATGCTCACAGAGCTGAGACATACAGTCCAGTCTTTGGAGATCGACCTGGACTCCTTGAGAAATCTGAAGGCCAGCTTGGAGAACAGCCTGAGTGAGGTGGAGGCCCGCTATACCCTGCAGATGGAGCAGCTCAACGGCATCCTGCTGCACCCGGAGTCAGAGCTGGCACAGACCCAGAGGGACAGTGCCAGGCCCAGGAGTACGAGGCCCTGCTGAACATCAAGGTCAAGCTGGAGGCTGAGATCACCACCTACTGCCGCCTGCTGGAAGATGACGAGGACTTCAATCTTGGTGATGCCCTGGACAACAGCAACTCCATGAAACCATCAAAAAGACCACCACCTGCTGGATAGTGGATGGCAAAGTGGTGTCTGAGACCAATGATACCAAAGTTCTGAGACATTAAGCC
>NM_199187.2
ATTTCCTGCCCTGAAAGCAGCCTCGAGGGCCAACAACACCTGCTGTCCGTGTCCATGCCCGGTTGGCCACCCCGTTTCTGGGGGCATGAGCTTCACCACTCGCTCCACCTTCTCCACCAACTACCGGTCCCTGGGCTCTGTCCAGGCGCCCAGCTACGGCGCCCGGCCGGTCAGCAGCGCGGCCAGCGTCTATGCAGGCGCTGGGGGCTCTGGTTCCCGGATCTCCGTGTCCCGCTCCACCAGCTTCAGGGGCGGCATGGGGTCCGGGGGCCTGGCCACCGGGATAGCCGGGGGTCTGGCAGGAATGGGAGGCATCCAGAACGAGAAGGAGACCATGCAAAGCCTGAACGACCGCCTGGCCTCTTACCTGGACAGAGTGAGGAGCCTGGAGACCGAGAACCGGAGGCTGGAGAGCAAAATCCGGGAGCACTTGGAGAAGAAGGGACCCCAGGTCAGAGACTGGAGCCATTACTTCAAGATCATCGAGGACCTGAGGGCTCAGATCTTCGCAAATACTGTGGACAATGCCCGCATCGTTCTGCAGATTGACAATGCCCGTCTTGCTGCTGATGACTTTAGAGTCAAGTATGAGACAGAGCTGGCCATGCGCCAGTCTGTGGAGAACGACATCCATGGGCTCCGCAAGGTCATTGATGACACCAATATCACACGACTGCAGCTGGAGACAGAGATCGAGGCTCTCAAGGAGGAGCTGCTCTTCATGAAGAAGAACCACGAAGAGGAAGTAAAAGGCCTACAAGCCCAGATTGCCAGCTCTGGGTTGACCGTGGAGGTAGATGCCCCCAAATCTCAGGACCTCGCCAAGATCATGGCAGACATCCGGGCCCAATATGACGAGCTGGCTCGGAAGAACCGAGAGGAGCTAGACAAGTACTGGTCTCAGCAGATTGAGGAGAGCACCACAGTGGTCACCACACAGTCTGCTGAGGTTGGAGCTGCTGAGACGACGCTCACAGAGCTGAGACGTACAGTCCAGTCCTTGGAGATCGACCTGGACTCCATGAGAAATCTGAAGGCCAGCTTGGAGAACAGCCTGAGGGAGGTGGAGGCCCGCTACGCCCTACAGATGGAGCAGCTCAACGGGATCCTGCTGCACCTTGAGTCAGAGCTggcacagacccgggcagagggacagcgccaggcccaggAGTATGAGGCCCTGCTGAACATCAAGGTCAAGCTGGAGGCTGAGATCGCCACCTACCGCCGCCTGCTGGAAGATGGCGAGGACTTTAATCTTGGTGATGCCTTGGACAGCAGCAACTCCATGCAAACCATCCAAAAGACCACCACCCGCCGGATAGTGGATGGCAAAGTGGTGTCTGAGACCAATGACACCAAAGTTCTGAGGCATTAAGCCAGCAGAAGCAGGGTACCCTTTGGGGAGCAGGAGGCCAATAAAAAGTTCAGAGTTCATTGGA

Publications

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