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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ACDP1
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:144920721-144921164  UCSC
Coordinates (T2T) chr4:148238090-148238533  UCSC
Coordinates (hg19) chr4:145841873-145842316  UCSC
Strand -
Parental Sequence NM_001082486.2
Parental seq. overlap 346 bp
Parental seq. overlap (%) 22.9%
Genomic Region Intergenic
Retrocopy Summary ACDP1, located on chr4:144920721-144921164, is a retrocopy of the parental gene ACD. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ACD
Full Name ACD shelterin complex subunit and telomerase recruitment factor
Also known as PIP1|PTOP|TINT1|TPP1
Coordinate chr16:67657512-67660811
Strand -
Gene summary This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ACDP1
Bonobo Pan paniscus ACDP1
Gorilla Gorilla gorilla ACDP1
Orangutan Pongo abelii ACDP1
Gibbon Nomascus leucogenys ACDP1
Green monkey Chlorocebus sabaeus ACDP1
Golden snub-nosed monkey Rhinopithecus roxellana ACDP1
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ACDP1
CTCAGCCCCTGGTCCCCTGCACCCCAGCTCCACACCTTAGCCATACACCCAACTCCCCACTCCAGAGCTATAGCCCCAGCCTCTCGCCCCTTGGCCATGTCCCCAGTCCACATCAGGCCCTTGTGACCAGGTCCCAGGAACATATCCTGGAGTTCAAGGAGCTAGAGTTGCCCAGCAAGAATCAGTGGCCTTCTCCAAGAACTGGAGCTACCAAGGGAGTCCAGGAGCCCTGCGCTCTCTGGAAACCCCCAAAGAGGCATTGTGATGGTTCTGCCTTCCAATATGAGTACGAGCCACCATGCATGTCCTTCTGTGCTCAGGTCCAAGCTGCAAGGCTCCCTTCCTAGCTTATGGCCTGTGCCTTGCATTTTCTGATGGAGCCACAGCCAGAGTCTGAGCCAACTCT
>NM_001082486.2
AAACCCGGGCCCGTTGCATCCGCTGGGTGTAGCCGTGGGGATGGCAGGTTCGGGGAGGCTGGTCCTACGGCCCTGGATTCGGGAGCTGATTCTGGGGTCAGAGACACCCTCCAGTCCACGAGCCGGGCAGCTGCTTGAGGTACTACAGGACGCCGAGGCCGCGGTCGCGGGCCCATCCCACGCCCCTGATACGTCCGACGTCGGGGCCACGCTGCTTGTGTCTGACGGGACCCACAGTGTCCGATGCCTGGTGACGCGGGAGGCCCTGGACACCTCGGACTGGGAGGAGAAGGAGTTCGGCTTCCGCGGGACAGAGGGCCGGCTGCTGCTGCTGCAGGACTGCGGGGTTCATGTCCAGGTCGCTGAGGGCGGCGCGCCCGCAGAGTTCTATCTCCAGGTGGACCGCTTCAGCCTGCTGCCCACGGAGCAGCCCCGGCTACGGGTGCCTGGTTGCAACCAAGACTTAGATGTTCAGAAAAAGCTCTATGACTGCCTTGAGGAGCACCTTTCAGAGTCCACCTCGTCCAATGCAGGCCTATCACTGTCCCAGCTTCTGGATGAAATGCGGGAGGACCAGGAGCATCAGGGGGCACTCGTGTGCCTGGCTGAAAGCTGCCTGACACTGGAGGGCCCTTGCACAGCACCCCCTGTCACCCACTGGGCTGCCTCACGATGCAAGGCCACGGGAGAAGCTGTGTACACTGTCCCCAGCTCAATGCTGTGCATCTCTGAGAATGACCAGCTAATTCTGAGCTCTCTAGGCCCCTGTCAGAGGACACAGGGCCCTGAGCTGCCCCCACCAGACCCGGCTCTGCAGGACCTATCTCTGACCCTCATAGCCTCTCCTCCTTCCTCACCCAGTTCCTCAGGAACCCCGGCCTTACCCGGCCACATGTCATCCGAGGAAAGTGGTACCAGCATCAGCCTTCTGCCTGCCCTGTCCTTGGCTGCTCCAGACCCAGGGCAGAGAAGCAGCTCCCAGCCCTCACCAGCCATCTGCTCAGCCCCTGCCACCCTGACCCCCAGGTCCCCACACGCCAGCCGTACCCCCAGCTCCCCACTCCAGAGCTGCACTCCCAGTCTCTCACCCCGTAGCCATGTCCCCAGTCCACACCAGGCTCTTGTGACCAGGCCCCAGAAACCTAGCCTGGAGTTCAAGGAGTTTGTAGGGTTGCCCTGCAAGAATCGGCCGCCTTTTCCCAGGACCGGAGCTACCAGGGGAGCCCAGGAGCCCTGCTCTGTCTGGGAACCCCCAAAGAGGCATCGTGATGGTTCTGCCTTCCAGTATGAGTATGAGCCACCCTGCACGTCCCTCTGTGCTCGGGTCCAAGCTGTCAGGCTTCCTCCCCAGCTCATGGCCTGGGCCTTGCACTTTCTGATGGATGCACAGCCAGGGTCTGAGCCAACTCCGATGTGAGACGTCACGCAGGACAGATACCGCTCCACACTCTGCTTCCTTTGAGTTTTTTAATAAAATAATCTCATGCGGCAGGAGAGGAGAGGATCAGGGA

Publications

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