Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RTN3P1
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:145375405-145377957  UCSC
Coordinates (T2T) chr4:148692862-148695418  UCSC
Coordinates (hg19) chr4:146296557-146299109  UCSC
Strand +
Parental Sequence NM_006054.4
Parental seq. overlap 2442 bp
Parental seq. overlap (%) 95%
Genomic Region Intergenic
Retrocopy Summary RTN3P1, located on chr4:145375405-145377957, is a retrocopy of the parental gene RTN3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RTN3
Full Name reticulon 3
Also known as ASYIP|HAP|NSPL2|NSPLII|RTN3-A1
Coordinate chr11:63681315-63759891
Strand +
Gene summary This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RTN3P1
Bonobo Pan paniscus RTN3P1
Gorilla Gorilla gorilla RTN3P1
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RTN3P1
CAGTCTGTCGGAGTCTGTCCTCAGAGCAGGCAGAGTAAAGGGACTTGAACGAGCCAGTTGCCAGATTATTCTATTTCCCCTCCCTCTCTCCCGCCCCCTATCTCTTTTCACCCTTCTCCCACCCTCGCTCACGTAGCCATGGCGGAGCCATCGGCGGCCACTCAGTCCCCTTCCATCTCCTCGTCGTCCTCCGGAGCCGAGACGTCCGCATCCGGCGGCAGCGGAAGCCCAGGAGCCTGCCCTGCCCTGGGGACGAAGAGCTGCAGCTCCTCCTGTGCGGTTCACGATCTGCTTTTCTGGAGAGATGTAAAGAAGACTGGGTTTGTCTTTGCCACCACGCTGATCATGCTGCTTTCCCTGGCAGCTTTCAGTGTCATCAGTGTGGTTTCTTACCTCATCCTGGCTCTTCTCTCTGTCACCATCAGCTTCAGGATCTACAAGTCCGTCATCCAAGCTGTACAGAAGTCAGAAGAAGGCCATCCAATCAAAGCCTACCTGGACGTAGACATTACTCTGTCCTCGGAAGCTTTCCATAATTACATGAATGCTGCCGTGGTGCACATCAACAGGGCCCTGAAACTCATTATTCTTCTCTTTCTAGTAGAAGATCTGGTTGACTCCTTGAAGCAGGCTGTCTTCATGTGGCTGATGACCTATGTTGGTGCTTTTTTTAACGGAATCACCCTTCTAATTCTTGCTGAACTGCTCATTTTCAGTGTCCCGATTGTCTATGAGAAGTACAAGACCCAGATTGATCACTATGTTGGCATCGCCCGACATCAGACCAAGTCAATTGTTGAAAAGATCCAAGCAAAACTCCCTGGAATCGCCAAAAAAAAGGCAGAATAAGTACATGGAACCAGAAATGCAACAGTTACTAAAACACCATTTAATAGTTATAACGTCGTTGCTTGTACTGTGAACGAACATACTCAGTGTCAGCTTGAGCCTGCATTCCAAGCTTTTTTTTTAATTTGGTGTTTTCTCCCATCCTTTCCCTTTAACCCTCAGTATCAAGCACAAAAACTGATGGACTGATAAAAGAACTATCTTAGAACTCAGAAGAAGAAAGAATCAAATTCATAGGATAAGTCAACACCTTAATGGTGGTAGAGCCTTTACCTGTAGCTTGAAAGGGGAAAGATTGGAGGTAAAAGAGAAAATGAAAGATAGAACACCTCTGGGTCCTTCTATCCAGTTTTCAGCACTAGTCTTACTCAGCTATCCATTATAGTTTTGCCCTTAAGAAGTAATGATTAACTTATGAAAAAATTATTTGGGGACAGGAGTGTGATGCCTTCCTTGTTTTTGTTTTTTTTTTTGCAGCCCTCAAATCCTATCTTCCTGCCCCACAATGTGAGCAGCTACTCCTGATACTCCTTTTCTTTAATGATTTAACTTTCAACTTGATGAATAACTTATAAGTGATAGTGATAATTCCTGATTCCAAGAATGCCATCTGATAAGAAAGAATAGAAATGGAAAGTGGGACTGAGAGGGAGTCAGCAGGAATGCTGCAGTGGCCGTCACTCCCTCTGCCACTATCCCCAGGGAAGGAAAGGCTCCGCCATTTGGGCAAGTGGTTTCTACATCACTGGACACCAGTTCTGAGCGTTAGTTTGAGAACTCGTTCCCGAATGTGCTTTCCTCCCTCTCCCCTGCCCGCCTCAAGTTTAATAAATATGGTTGTACTTTTCTTATTATAAAATAAATGTCTGTAACTGCTGTGCACTGCTGTAAACTTGTTAGAGAAAAAATAACCTGCATGTGGGCTCCTCAGTTATTGAGTTATTGTGATCCTATCTCAGTCTGGGGGGGAACATTCTCAAGAGGTGAAATACAGAAAGCCTTTTTTTCTTGATCTTTTCCCAGTTGTTCTTTTCTTGATCTTTTCCCGAGATTCAAATGTCCGATTCCCATTTGGGGGCAAGTTTTTTTCTTCACCTTCAATATGAAAATTCAGCGAAATTGAAAGAAAAATCATCTGTGAGTTCCTTCAGGTTCTCACTCATAGTCATGATCCTTCAGAGGGAATATGCACTGGCGAGTTTAAAGTAAGGGCTATGATATTTGATGGTCCCAAAGTACGGCAGCTGCAAAAAGTAGTGGAAGGAAATTGTCTTTCTACGTGTTTTGGGAAAATTAATTAGGAATTTGGATGGGTAAAAGGTACCCTTGCCTTACTTCATCTTATTTTCTTAGCCCCCTTTGAGTGTTTTAACTGGTTTCATGTCCTAGTAGGAAGTGCATTCTCCATCCTCATCCTCTGCCCTCCCAGGAAGTCAGTGATTGTCTTTTTGGGCTTCCCCTCCAAAGGACCTTCTGCAGTGGAAGAGCCTCATCCAGTTATTTTCTTTTGTTGCTGCTGTGTTTAGATAATTGAAGAGATCTTTGTGCCACACAGGATTTTTTTTTTTAAGAAAAACCTGCAGATGAAAAATTACTAATGAAACTGTGTGTACGTGTCTGTGCATGCAACATAAAAATACAGTAGCACCTAAGGAGCTTGAATCTTGGTTCCTGTAAAATTGCAAATTGATGTGGTATTAATA
>NM_006054.4
AGTCTGTCGGAGTCTGTCCTCGGAGCAGGCGGAGTAAAGGGACTTGAGCGAGCCAGTTGCCGGATTATTCTATTTCCCCTCCCTCTCTCCCGCCCCGTATCTCTTTTCACCCTTCTCCCACCCTCGCTCGCGTAGCCATGGCGGAGCCGTCGGCGGCCACTCAGTCCCATTCCATCTCCTCGTCGTCCTTCGGAGCCGAGCCGTCCGCGCCCGGCGGCGGCGGGAGCCCAGGAGCCTGCCCCGCCCTGGGGACGAAGAGCTGCAGCTCCTCCTGTGCGGTGCACGATCTGATTTTCTGGAGAGATGTGAAGAAGACTGGGTTTGTCTTTGGCACCACGCTGATCATGCTGCTTTCCCTGGCAGCTTTCAGTGTCATCAGTGTGGTTTCTTACCTCATCCTGGCTCTTCTCTCTGTCACCATCAGCTTCAGGATCTACAAGTCCGTCATCCAAGCTGTACAGAAGTCAGAAGAAGGCCATCCATTCAAAGCCTACCTGGACGTAGACATTACTCTGTCCTCAGAAGCTTTCCATAATTACATGAATGCTGCCATGGTGCACATCAACAGGGCCCTGAAACTCATTATTCGTCTCTTTCTGGTAGAAGATCTGGTTGACTCCTTGAAGCTGGCTGTCTTCATGTGGCTGATGACCTATGTTGGTGCTGTTTTTAACGGAATCACCCTTCTAATTCTTGCTGAACTGCTCATTTTCAGTGTCCCGATTGTCTATGAGAAGTACAAGACCCAGATTGATCACTATGTTGGCATCGCCCGAGATCAGACCAAGTCAATTGTTGAAAAGATCCAAGCAAAACTCCCTGGAATCGCCAAAAAAAAGGCAGAATAAGTACATGGAAACCAGAAATGCAACAGTTACTAAAACACCATTTAATAGTTATAACGTCGTTACTTGTACTATGAAGGAAAATACTCAGTGTCAGCTTGAGCCTGCATTCCAAGCTTTTTTTTTAATTTGGTGTTTTCTCCCATCCTTTCCCTTTAACCCTCAGTATCAAGCACAAAAATTGATGGACTGATAAAAGAACTATCTTAGAACTCAGAAGAAGAAAGAATCAAATTCATAGGATAAGTCAATACCTTAATGGTGGTAGAGCCTTTACCTGTAGCTTGAAAGGGGAAAGATTGGAGGTAAGAGAGAAAATGAAAGAACACCTCTGGGTCCTTCTGTCCAGTTTTCAGCACTAGTCTTACTCAGCTATCCATTATAGTTTTGCCCTTAAGAAGTCATGATTAACTTATGAAAAAATTATTTGGGGACAGGAGTGTGATACCTTCCTTGGTTTTTTTTTGCAGCCCTCAAATCCTATCTTCCTGCCCCACAATGTGAGCAGCTACCCCTGATACTCCTTTTCTTTAATGATTTAACTATCAACTTGATAAATAACTTATAGGTGATAGTGATAATTCCTGATTCCAAGAATGCCATCTGATAAAAAAGAATAGAAATGGAAAGTGGGACTGAGAGGGAGTCAGCAGGCATGCTGCGGTGGCGGTCACTCCCTCTGCCACTATCCCCAGGGAAGGAAAGGCTCCGCCATTTGGGAAAGTGGTTTCTACGTCACTGGACACCGGTTCTGAGCATTAGTTTGAGAACTCGTTCCCGAATGTGCTTTCCTCCCTCTCCCCTGCCCACCTCAAGTTTAATAAATAAGGTTGTACTTTTCTTACTATAAAATAAATGTCTGTAACTGCTGTGCACTGCTGTAAACTTGTTAGAGAAAAAAATAACCTGCATGTGGGCTCCTCAGTTATTGAGTTTTTGTGATCCTATCTCAGTCTGGGGGGGAACATTCTCAAGAGGTGAAATACAGAAAGCCTTTTTTTCTTGATCTTTTCCCGAGATTCAAATCTCCGATTCCCATTTGGGGGCAAGTTTTTTTCTTCACCTTCAATATGAGAATTCAGCGAACTTGAAAGAAAAATCATCTGTGAGTTCCTTCAGGTTCTCACTCATAGTCATGATCCTTCAGAGGGAATATGCACTGGCGAGTTTAAAGTAAGGGCTATGATATTTGATGGTCCCAAAGTACGGCAGCTGCAAAAAGTAGTGGAAGGAAATTGTCTACGTGTCTTGGAAAAATTAGTTAGGAATTTGGATGGGTAAAAGGTACCCTTGCCTTACTCCATCTTATTTTCTTAGCCCCCTTTGAGTGTTTTAACTGGTTTCATGTCCTAGTAGGAAGTGCATTCTCCATCCTCATCCTCTGCCCTCCCAGGAAGTCAGTGATTGTCTTTTTGGGCTTCCCCTCCAAAGGACCTTCTGCAGTGGAAGTGCCACATCCAGTTCTTTTCTTTTGTTGCTGCTGTGTTTAGATAATTGAAGAGATCTTTGTGCCACACAGGATTTTTTTTTTTTTTTAAGAAAAACCTATAGATGAAAAATTACTAATGAAACTGTGTGTACGTGTCTGTGCGTGCAACATAAAAATACAGTAGCACCTAAGGAGCTTGAATCTTGGTTCCTGTAAAATTTCAAATTGATGTGGTATTAATAAAAAAAAAAAAAA

Publications

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