Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name GK3P
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Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:165276515-165279758  UCSC
Coordinates (T2T) chr4:168622504-168625751  UCSC
Coordinates (hg19) chr4:166197667-166200910  UCSC
Strand -
Parental Sequence NM_001128127.3
Parental seq. overlap 1922 bp
Parental seq. overlap (%) 33.8%
Genomic Region Intragenic (KLHL2)
Retrocopy Summary GK3P, located on chr4:165276515-165279758, is a retrocopy of the parental gene GK. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name GK
Full Name glycerol kinase
Also known as GK1|GKD
Coordinate chrX:30653348-30731462
Strand +
Gene summary The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes GKP2
Bonobo Pan paniscus GKP2
Gorilla Gorilla gorilla GKP1
Orangutan Pongo abelii GKP1
Gibbon Nomascus leucogenys GKP1
Green monkey Chlorocebus sabaeus GKP1
Crab-eating macaque Macaca fascicularis GKP1
Rhesus Macaca mulatta GKP1
Golden snub-nosed monkey Rhinopithecus roxellana GKP2
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.511.5
log10(TPM+1)

Related Sequence

>GK3P
TTTTAACATCCACAGTTAAGGTTGGGCCAGCTACCTTTGGGGCTGACCCCCTCCATTGCCATAACATCCTGCTCCATTCCCTCTAAGATGTACGAAGAATTCAGATCCTCACCATTGGAATCTTCCATCAAACATACTCAAACACTACTGGAACAGGACTTGAGTCTTTGCATGACATATACTTGATTAAAAGGTTATTACTAACCTGTTAAAAATGAGCAGCTCTTCGCTTTTAACAGATACCCCAAAAGTCTTCTTTTCTACATAGTAGAAGACGGAAACACCTTTACTGAATGTTTGAATAGAAATATCTACTAAATTATTAAAATAGACATTTAGTGTTCTCATAGCTTGGATATTTTTCTGAAAAGTATTTGCCAAAACTGAAATCCTTCCAATATTTTCCATGGTCCCATTAATTATAATGACTTTCTGTCTAGATCTTATAGGAAAGGATACTTTCTTTTTTCTTCCATCTTTCCTTTTTATATTTTTTACTTTGTATGTATAACATATATGCCTATATATTTTATACACTGAGGGTAGCCCATTTATAAATTAAGAGCACATTATATTCAGAAGGTTCTAACAGGGCTGGTCTTAAGTGAACCACTATGTATATCAATATGTTGGAAAACAGCTGTATACATTTTTGGGCAATGGTTATGCATAATATCTACCAGAATTTTTTTCTTAAACAGCCAACATTTAAAATTTATGTTTTATGTCCATAAAAGAAAATATACTTTATTGTGACTTCAACTATATTTCTTATCCCTTACATTTTTATTTAATTGTCTTAGCCTAAAAAAAGAAGAAACTGTGGAATACTACAGTAAATACTGTTTTCAAACACAAGCAATAATTCAAATAGTTTTCTTTTGAATTAATTTTAGACATATTTTGGATCCTATTGAGGGGATAAGAGGATGTCAAAAAAGTTAAATACCTAAGTAGAAAAAAATATAGAAATAAAGCCAGGAATCTCTTTCAGTTCAAATGTTATCAATTGTGAATAAGAAATTGCTATCTGGGATGACAAAATTATCTCTGCTTAGTATCTTATTATAACTGAAAAAAGGTTTATCATTATAAATGCCTTCCAAGGAAACCAAGAATTTCTCAAAATATTTAATGTCACATATTATAAGAAGTCACCTAATCTAGCTTCTTAACGTCAATCTTTAAAAATATCTTAAAATTACTTTGTTTTGTAATAAACAGTGAAAAAAAAAGGAAACCGGCCGCAAACGCGGGCGGACCTGAAGCTGGTTTCATGGCAGCCTCAAAGAAGGCAGTTTTGGGGCCATTGGTGGGGGCAGTGGACCAAGGCACCAGTTCCACGCGCTTTTTGGTTTTCAATTCAAGAACAGCTGAACTACTTAGTCATCATCAAGTGGAAATAAAACAAGAGTTCCCAAGAGAAGGATGGGTGGAACAGGACCCTAAGGAAATTCTACATTCTGTCTATGAGTGTATAGAGAAAACATGTGAGAAACTTGGACAGCTCAATATTGGTATTTCCAACATAAAAGCTATTGGTGTCAGCAACCAGAGGGAAACCACCGTAGTCTGGGACAAGATAACTGGAGAGCCTCTCTACAATGCTGTGGTGTGGCTTGATCTAAGAACACAGTCTACCGTTGAGAGTCTTAGTAAAAGAATTCCAGGAAATAATAACTTTGTCAAGTCCAAGACAGGCCTTCCACTTAGCACTTACTTCAGTGCAGTGAAACTTCGCTGGCTCCTCGACAATGTGAGAAAAGTTCAAAAGGCCGTTGAAGAAAAACGAGCTCTTTTTGGGACTATTGATTCATGGCTTATTTGGAGTTTGACAGGAGGCGTCAATGGAGGTGTCCACTGTACAGATGTAACAAATGCAAGTAGGACTATGCTTTTCAACATTCATTCTTTGGAATGGGATAAACAACTCTGTGAATTTTTTGGAATTCCAATGGAAATTCTTCCACATGTTCGGAGTTCTTCTGAGATCTATGGCCTAATGAAAGCGGGGGCCTTGGAAGGTGTGCCAATATCTGGGTGTTTAGGGGACCAGTCTGCTGCACTGGTGGGACAAATGTGCTTCCAGATTGGACAAGCCAAAAATACGTATGGAACAGGATGTTTCTTACTATGTAATACAGGCCATAAGTGTGTATTTTCTGATCATGGCCTTCTCACCACAGTGGCTTACAAACTTGGCAGAGACAAACCGGTATATTACGCTTTGGAAGGTTCTGTAGCTATAGCTGGTGCTGTTATTCGCTGGCTAAGAGACAATCTTGGAATTATAAAGACCTCAGAAGAAATTGAAAAACTTGCTAAAGAAGTAGGTACTTCTTATGGCTGCTACTTCGTCCCAGCATTTTCGGGGTTATATGCACCTTATTGGGAGCCCAGCGCAAGAGGGATAATCTGTGGACTCACTCAATTCACGAATAAATGCCATATTGCTTTTGCTGCATTAGAAGCTGTTTGTTTCCAAACTCGAGAGATTTTGGATGCCATGAATCGAGACTGTGGAATTCCACTCAGTCATTTGCAGGTTGATGGAGGAATGACCAGCAACAAAATTCTTATGCAGCTACAAGCAGACATTCTGTATATTCCAGTAGTGAAGCCCTTGATGCCCGAAACCACTGCACTGGGTGCTGCCATGGCGGCAGGGGCTGCAGAAGGAGTCGACGTATGGAGTCTTGAACCTGAGGATTTGTCCGCCGTCACGATGGAGCGGTTTGAACCTCAGATTAATGCTGAGGAAAGTGAAATTCGTTATTCTACATGGAAGAAAGCTGTGATGAAGTCAATGGGTTGGGTTACAACTCAATCTCCAGAAGGTGGTGACCCTAGTGTCTTCTGTAGTCTGCCCTTGGGCTTTTTTATAGTGAGTAGCATGGCAATGTTAATCGGAGCAAGGTACATCTCAGGTATTCCATAAAACCTACCAACTCATGGATTCCCAAGATGCGAGCTTTTTACATAATGAAAGAACAACCCAGCAATTGTCTCTTAATGCGATGACACTATTCATAGACTTTGATTTTATTTATAAGCCACTTGCTGCGTGACCCTCCAAGTAGACCTGTGGCTTAAAATAAAGAAAATGCAGCAAAAAGAATGCTATAGAAATATTTGGTTCAGCGGACTCGCGCGGCCTCGCTCTTTGGACTCGt
>NM_001128127.3
GCGTTCAGCGGACGCGCGCGGCCTCGATCTCTGGACTCGTCACCTGCCCCTCCCCCTCCCGCCGCCGTCACCCAGGAAACCGGCCGCAATCGCCGGCCGACCTGAAGCTGGTTTCATGGCAGCCTCAAAGAAGGCAGTTTTGGGGCCATTGGTGGGGGCGGTGGACCAGGGCACCAGTTCGACGCGCTTTTTGGTTTTCAATTCAAAAACAGCTGAACTACTTAGTCATCATCAAGTAGAAATAAAACAAGAGTTCCCAAGAGAAGGATGGGTGGAACAGGACCCTAAGGAAATTCTACATTCTGTCTATGAGTGTATAGAGAAAACATGTGAGAAACTTGGACAGCTCAATATTGATATTTCCAACATAAAAGCTATTGGTGTCAGCAACCAGAGGGAAACCACTGTAGTCTGGGACAAGATAACTGGAGAGCCTCTCTACAATGCTGTGGTGTGGCTTGATCTAAGAACCCAGTCTACCGTTGAGAGTCTTAGTAAAAGAATTCCAGGAAATAATAACTTTGTCAAGTCCAAGACAGGCCTTCCACTTAGCACTTACTTCAGTGCAGTGAAACTTCGTTGGCTCCTTGACAATGTGAGAAAAGTTCAAAAGGCCGTTGAAGAAAAACGAGCTCTTTTTGGGACTATTGATTCATGGCTTATTTGGAGTTTGACAGGAGGAGTCAATGGAGGTGTCCACTGTACAGATGTAACAAATGCAAGTAGGACTATGCTTTTCAACATTCATTCTTTGGAATGGGATAAACAACTCTGCGAATTTTTTGGAATTCCAATGGAAATTCTTCCAAATGTCCGGAGTTCTTCTGAGATCTATGGCCTAATGAAAGCTGGGGCCTTGGAAGGTGTGCCAATATCTGGGTGTTTAGGGGACCAGTCTGCTGCATTGGTGGGACAAATGTGCTTCCAGATTGGACAAGCCAAAAATACGTATGGAACAGGATGTTTCTTACTATGTAATACAGGCCATAAGTGTGTATTTTCTGATCATGGCCTTCTCACCACAGTGGCTTACAAACTTGGCAGAGACAAACCAGTATATTATGCTTTGGAAGGTTCTGTAGCTATAGCTGGTGCTGTTATTCGCTGGCTAAGAGACAATCTTGGAATTATAAAGACCTCAGAAGAAATTGAAAAACTTGCTAAAGAAGTAGGTACTTCTTATGGCTGCTACTTCGTCCCAGCATTTTCGGGGTTATATGCACCTTATTGGGAGCCCAGCGCAAGAGGGATAATCTGTGGACTCACTCAGTTCACCAATAAATGCCATATTGCTTTTGCTGCATTAGAAGCTGTTTGTTTCCAAACTCGAGAGATTTTGGATGCCATGAATCGAGACTGTGGAATTCCACTCAGTCATTTGCAGGTAGATGGAGGAATGACCAGCAACAAAATTCTTATGCAGCTACAAGCAGACATTCTGTATATACCAGTAGTGAAGCCCTCAATGCCCGAAACCACTGCACTGGGTGCGGCTATGGCGGCAGGGGCTGCAGAAGGAGTCGGCGTATGGAGTCTCGAACCCGAGGATTTGTCTGCCGTCACGATGGAGCGGTTTGAACCTCAGATTAATGCGGAGGAAAGTGAAATTCGTTATTCTACATGGAAGAAAGCTGTGATGAAGTCAATGGGTTGGGTTACAACTCAATCTCCAGAAAGTGGTGACCCTAGTATCTTCTGTAGTCTGCCCTTGGGCTTTTTTATAGTGAGTAGCATGGTAATGTTAATCGGAGCAAGGTACATCTCAGGTATTCCATAAAACCTACCAACTCATGGATTCCCAAGATGTGAGCTTTTTACATAATGAAAGAACCCAGCAATTCTGTCTCTTAATGCAATGACACTATTCATAGACTTTGATTTTATTTATAAGCCACTTGCTGCATGACCCTCCAAGTAGACCTGTGGCTTAAAATAAAGAAAATGCAGCAAAAAGAATGCTATAGAAATATTTGGTGGTTTTTTTTTTTTTTAAACATCCACAGTTAAGGTTGGGCCAGCTACCTTTGGGGCTGACCCCCTCCATTGCCATAACATCCTGCTCCATTCCCTCTAAGATGTAGGAAGAATTCGGATCCTTACCATTGGAATCTTCCATCGAACATACTCAAACACTTTTGGACCAGGATTTGAGTCTCTGCATGACATATACTTGATTAAAAGGTTATTACTAACCTGTTAAAAATCAGCAGCTCTTTGCTTTTAACAGACACCCTAAAAGTCTTCTTTTCTACATAGTTGAAGACAGCAACATCTTCACTGAATGTTTGAATAGAAACCTCTACTAAATTATTAAAATAGACATTTAGTGTTCTCACAGCTTGGATATTTTTCTGAAAAGTTATTTGCCAAAACTGAAATCCTTCAGATGTTTTCCATGGTCCCACTAATTATAATGACTTTCTGTCTGGATCTTATAGGAAAAGATACTTTCTTTTTTCTTCCATCTTTCCTTTTTATATTTTTTACTTTGTATGTATAACATACATGCCTATATATTTTATACACTGAGGGTAGCCCATTTATAAATTAAGAGCACATTATATTCAGAAGGTTCTAACAGGGCTGGTCTTAAGTGAACCACTGTGTATATAAATATGTTGGAAAACAGCTGTATACATTTTTGGGCAACGGTTATGCATAATATTTACCAGGAGAATTTTTTTCTTAACAAGCCAACATTTAAAATTTATGTTTTATGTCAATAAAAGAAAATATACTTTATTGTGACTTCAACTATATTTCTTATCCCTTACATTTTTATTTAATTGTCTTAGCTTAAAAAAAGAAGAAACTGTGGAATACTACAGTAAATATTGTTTTCAAACACAAGCAATAATTCAAATAGTTATTTTTCTTTTGAATTAATTTTAGACATATTTTGGATCCTATTGAGGGGATAAGAGGATGTCAAAAAAGTTAAATACCTAAGTAGAAAAAAATATAGAAATAAAGCCAAGAATCTCTTTCAGTTCAAATGTTATCAATTGTTAATAAGAAATTGCTATCTGGGATGACAGAATTACCTCTGCTTAGTATCTCATTATAACTGAAAGAAGGTTTATCATTACAAATACCTTCCAATGAAACCAAGAATTTCTCAAAATATTTAATGTCACATATTATAAGAAGTTACCTAATCCTGCTTCTTAACATCAATTTTTAAAAATATCTTAAAATTACTTTGTTTTGTAGTAAACAGTGAAGAAAAGATTGCCTCCTAATTATTTTTTTCAATGAGTGCTGAATGGGAAAACATTTATATCTTACTATAAAAGGTTCTGTTTTGTTTGGAATCAATGGTAGCTTTATTGACTGTTCTGATTGTGCTGTTTCTAATTTATTGAATCTGCTAGGTTTTATTGATGCAGCCACCACTTAAGTGACATAAATATTATAGAAAGGTACTGTGAAATGATCACTTTGTGGCAGGGGTACTTTTAAACATAAATGTTTCTACAAAAGTAGGTTGAGTTCATTGTAAATAATTGTGAAAGCCACTGTTCAAATAATTTTAAGATTACATTAATTTTTCTATAAATTGGAAGATTTATAAATGTTTGAAATTGTACACATTGATATTTAATGACAAATTTACTTAAAATAAATTGACCCCTTGTTCTTACTTGCATTTCTCATTTACAGACTAGAACTTAGTTGAAAGTTAAATTAAGAAAGATGTTTCAGAggccgggcacggtggctgacgcctgtaatcccagcactttgggaggccgaggtgggcagatcacctgaggtcaggagttcgggactagcctaaccgacatggagaaaccctatctctactaaaaaaaaaaaaaGATGTTTCAGGACATGTGAAACTTGGCTGTTAGCGCTTGATAGGGCACACTCTGAAGAGTTAACCAACAGCCAAAGAAGTAATTTCTGTAATGATGAACACTTTAATCATTCTATTAGAAGAAACTACACTGTCCCATCTCAGCATTTGCAAAAAATAATGTTGGTAAGGTCAGCAGCCATTATCAACAGGGCCTTGCATGGCTAACTTTGACCACCATTTTTCTCTCAACCTGATAGGCAACACCTCAATCCTTTGTTCTCCAACTAATCAGTAAAATAAGTAATGCATCTCTGCTTCTGTAATGATATCTTAGAATTTTTAGTATGTTTCTTTTGAAGTGCCCAAAGCCCAATTCTTTGGGATATCTTTTGGGTATCTGGTATCATGTGGGAGTGAAGAAAGAAAGTTTTTGGAGAAACCAACAAATGAAAGCTGTGATAGCACAGAAGCTAATGGCATTGACAGTGGAGTAGGTAGTATTTAATCTGTAGTGTTTACAACATAGTAGATAGAAGTACAAAAATTTTTTTAACTATAACTCTTTAATAGCTTGTTTTATCTAGTAATATTTAAATAATGAAGTTTCCTTGATCCTTTGCTTTTGCAACCTAACAACTTTAATAATAAGTTCACACAATAAACAAATTAGTAGAAAA

Publications

PMID - Link Title
35384245Physical and functional interactome atlas of human receptor tyrosine kinases.
33961781Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
31900314AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair.
30021884Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
28514442Architecture of the human interactome defines protein communities and disease networks.
12477932Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
9847074Toward a complete human genome sequence.
7987308The glycerol kinase gene family: structure of the Xp gene, and related intronless retroposons.
8125298Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.