Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HADHAP1
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:165403686-165406380  UCSC
Coordinates (T2T) chr4:168749730-168752424  UCSC
Coordinates (hg19) chr4:166324838-166327532  UCSC
Strand -
Parental Sequence NM_000182.5
Parental seq. overlap 2483 bp
Parental seq. overlap (%) 83.5%
Genomic Region Intragenic (CPE)
Retrocopy Summary HADHAP1, located on chr4:165403686-165406380, is a retrocopy of the parental gene HADHA. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HADHA
Full Name hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
Also known as ECHA|GBP|HADH|LCEH|LCHAD|MTPA|TP-ALPHA
Coordinate chr2:26190635-26244632
Strand -
Gene summary This gene encodes the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities. Mutations in this gene result in trifunctional protein deficiency or LCHAD deficiency. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HADHAP1
Bonobo Pan paniscus HADHAP1
Gorilla Gorilla gorilla HADHAP1
Orangutan Pongo abelii HADHAP1
Gibbon Nomascus leucogenys HADHAP1
Green monkey Chlorocebus sabaeus HADHAP1
Crab-eating macaque Macaca fascicularis HADHAP1
Rhesus Macaca mulatta HADHAP1
Baboon Papio anubis HADHAP1
Golden snub-nosed monkey Rhinopithecus roxellana HADHAP1
Marmoset Callithrix jacchus HADHAP2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HADHAP1
GCGCTCTCCACTGCTGTTCTCTTCAGCTCAACATGGTGGTCTACCGGGCGATTGGCAGCCTCAGCCACTTCTCTGCCTTCAGGATCCTCCGCTCCCAAGGTTATATACGCCGCAATTTTACAGGGTCCTTTGCTTTGCTGACCAGAACCCATATTAACTATGGAGTCAAAGGGGATGTGATAGTTATTTAAATTAACTCTCCCCATTCAAAGATAAATACGCTGAATAAACAAACAGCTGCATTCAGAGTTCACGGAAGTTATGAATGAAATCTGGGCTAGTGATCAAATCAGAAGTGCCATCCTTATCTCACCAAAGCCAGGCTGCTTTATTGTAGGTGCTGATATCAACATTTTAGCCACTTGCAAGACCCCTCAAGAAGTAACACAGATACCACAAGAAGCACAGAGAACATTTGAGAAACTTGAAAAGTCCATAAAGCCTGTTGTGACTGCCATCAGTGGATCCTGCCATTTTATGCCAATATAAAATAGCAACAAAAGACAGAAAAACAGTATTCGGTGCTCCTGAAGTCTTGCTGGGGATCTTACCAGGAGCAGGAGGCACACAAAGGCTGCCCAAAATGGTGGGTGTGCCTGCTGCTTTTGACATGATGCTGACTGGCAGAAACATCCGTGCAGACAGGGCAAAGAAAATGGGACTGGTTGACCAATTGGTGGAATCTCTGCGACCAGGACTAAAACTTCCAGAGGAATGGACAATCAAATACCTAGAAGAAGTTGCAATTACTTTCCCAAAGGACTAGCTGATAAGAAGATCTCTCCAAAGAGAGACAAGGGATTAGTGGAAAAATTAACAGCGTATGCCATGACTATTCCATTTGTCAGGCAACAGATTTACAAAAAAGTGGAAGAAAAAGTGTGAAAGCGGACTAAAGGGCTTTCCCTTTATCCCACACCTCTGAAAATAATTGATGTGGTAAAGACTGGAATTGAGCAAGGGAGCGATGCTGGTTATCTCTCTGAATCTCAGAAATTCGGAGAGCTTGCAATGACCAAAGAATCAAAGGCCTTGATGGGACTCTACCATGGTCAGGTCCTGTGCAAGAAGAATACATCTGGAGCTCCACAGAAGGATGTTAAGCATCTGGCTATTCCTGGTGCAGGGATGATGGGAGCAGGCATTGCCCAAGTCTCCGTGGATAAGGGGCGAAAGACTATACTTAAAGATGCCACACTCACTGGGTTAGGCTGAGGACAGCAACAAGTGTTCAAAGGATTGAATGACAAAGTAAAGAAGAAAGCTCTAACGTCATTTGAAAGGGATTCCATCTTCAGCAACTTGACTGGGAAGCTTGATTACCAAGGTTTTGAAAGACAGACATGGTGATGGATGCTGTCCATCCATCACAACTTCCTTAGTTTTAAGCACAGAGTGCTAAAGGAAGTAGAAGCAGTGATTCCAGATCACTACGTCTTTGCTAGTAACACATCTCCTCTCCCAGTCAGTGAAATCGCTGCTGTCAGCAAAAGACCTGAGAAGGTGATTGGCAGGCACTACTTCTCTCCCGCAGACAAGATGCAGCTGCTGGAGATGATCACAACCAAGAAGACTTCCAAAGACACCAGTGCTTCAACTGTAGCAATCGGTCTCAAGCAGGGGAAGGTCATCATTGTGGTTAAGGATGGACCTGGCTTCTATACTACCAGGTGTCTTGCACCCATGATGTCTGAAGTCATCTGAATCCTCCAGGAAGGAGTTGACCCAAAGAAGCTGGATTCCCTGACCACAAGCCTTGGCCTTCCTGTGGGTGCCGCCACACTGGTGGATGAAGTTGGCGTGGATGTAGCGAAACATGTGGCCAAAGATCTGGGCAAAGCCTTTGGGGAGCAGTTTGGAGGTGGAAACCCAGAACTACTGACATAGATGGTGTCCAAGGGCTTCCTAGGTCGCCAGTCTGGGAAGGGCTTTTCCATCTATCAGGAGAGTGTGAAGAATAAGAATTTGAATTCTGACATGAACGGTATTTTAGCAAGTCTGAAGATGCCTCCTAAGTCTGAAGTCTCCTCAGATGAAGACATCCAGTTCCGCCTGCTGACAAGATTTGTGAATGAGGCAGTCACGTGCCCGCAAGAGGGGATCTTGGCCACACCTGCAGAGGGAGACATTGGAGCCGTCTTCGGGCTCAGCTTCCCACCTTGTCTTGGAGGGCCTTTCTGCTTTGTGGATCTGTATGAAGCCCAGAAGATAGTGGACCGGCTCAAGAAGTATGAGGCTGCCTATGGAAAAGAGTTCACCCCAAGCCAGCTGCTAGCTGACCACACTAACAGCCCTAACAAGAAGTTTCATCAGTGAGCAGGCCTCATGCCTCACTCAGTCAGTGCACTAACCCCAGCTGCCGGCAGTGCTGGTTCTCCAACAGAGTGGCATCTAGATTTATCAGAGTAACGAGAAGGAAGACAAACTCCGGCATTGGGTTTGCTCCCTGATTAAAGTGCCTTCAGCCAAGATCATCTCCCCCTCCTGGTGAAATCTGACTGTGAATTAGAGTTTGCGCTATTGGAAGGTGGAACCCACTGTGCTCATTGTATAAGCCCTGAGGCCTAGAGTGGCAGCCAAGAGCCATCTGGAGCCATCTCTTTGCCTGTTCCTGTCAGGAGGCCAGGGTGGCCAGGGGTGGTGAGGGCAATTCTGCACCCAGACAAACACATAACAATAAAAACCAAACTCTGTa
>NM_000182.5
AGAGGCGCTCTCCACTGCTGTCCTCTTCAGCTCAAGATGGTGGCCTGCCGGGCGATTGGCATCCTCAGCCGCTTTTCTGCCTTCAGGATCCTCCGCTCCCGAGGTTATATATGCCGCAATTTTACAGGGTCTTCTGCTTTGCTGACCAGAACCCATATTAACTATGGAGTCAAAGGGGATGTGGCAGTTGTTCGAATTAACTCTCCCAATTCAAAGGTAAATACACTGAGTAAAGAGCTACATTCAGAGTTCTCAGAAGTTATGAATGAAATCTGGGCTAGTGATCAAATCAGAAGTGCCGTCCTTATCTCATCAAAGCCAGGCTGCTTTATTGCAGGTGCTGATATCAACATGTTAGCCGCTTGCAAGACCCTTCAAGAAGTAACACAGCTATCACAAGAAGCACAGAGAATAGTTGAGAAACTTGAAAAGTCCACAAAGCCTATTGTGGCTGCCATCAATGGATCCTGCCTGGGAGGAGGACTTGAGGTTGCCATTTCATGCCAATACAGAATAGCAACAAAAGACAGAAAAACAGTATTAGGTACCCCTGAAGTTTTGCTGGGGGCCTTACCAGGAGCAGGAGGCACACAAAGGCTGCCCAAAATGGTGGGTGTGCCTGCTGCTTTGGACATGATGCTGACTGGTAGAAGCATTCGTGCAGACAGGGCAAAGAAAATGGGACTGGTTGACCAACTGGTGGAACCCCTGGGACCAGGACTAAAACCTCCAGAGGAACGGACAATAGAATACCTAGAAGAAGTTGCAATTACTTTTGCCAAAGGACTAGCTGATAAGAAGATCTCTCCAAAGAGAGACAAGGGATTGGTGGAAAAATTGACAGCGTATGCCATGACTATTCCATTTGTCAGGCAACAGGTTTACAAAAAAGTGGAAGAAAAAGTGCGAAAGCAGACTAAAGGCCTTTATCCTGCACCTCTGAAAATAATTGATGTGGTAAAGACTGGAATTGAGCAAGGGAGTGATGCCGGTTATCTCTGTGAATCTCAGAAATTTGGAGAGCTTGTAATGACCAAAGAATCAAAGGCCTTGATGGGACTCTACCATGGTCAGGTCCTGTGCAAGAAGAATAAATTTGGAGCTCCACAGAAGGATGTTAAGCATCTGGCTATTCTTGGTGCAGGGCTGATGGGAGCAGGCATCGCCCAAGTCTCCGTGGATAAGGGGCTAAAGACTATACTTAAAGATGCCACCCTCACTGCGCTAGACCGAGGACAGCAACAAGTGTTCAAAGGATTGAATGACAAAGTGAAGAAGAAAGCTCTAACATCATTTGAAAGGGATTCCATCTTCAGCAACTTGACTGGGCAGCTTGATTACCAAGGTTTTGAAAAGGCCGACATGGTGATTGAAGCTGTGTTTGAGGACCTTAGTCTTAAGCACAGAGTGCTAAAGGAAGTAGAAGCGGTGATTCCAGATCACTGTATCTTTGCCAGTAACACATCTGCTCTCCCAATCAGTGAAATCGCTGCTGTCAGCAAAAGACCTGAGAAGGTGATTGGCATGCACTACTTCTCTCCCGTGGACAAGATGCAGCTGCTGGAGATTATCACGACCGAGAAAACTTCCAAAGACACCAGTGCTTCAGCTGTAGCAGTTGGTCTCAAGCAGGGGAAGGTCATCATTGTGGTTAAGGATGGACCTGGCTTCTATACTACCAGGTGTCTTGCGCCCATGATGTCTGAAGTCATCCGAATCCTCCAGGAAGGAGTTGACCCGAAGAAGCTGGATTCCCTGACCACAAGCTTTGGCTTTCCTGTGGGTGCCGCCACACTGGTGGATGAAGTTGGTGTGGATGTAGCGAAACATGTGGCGGAAGATCTGGGCAAAGTCTTTGGGGAGCGGTTTGGAGGTGGAAACCCAGAACTGCTGACACAGATGGTGTCCAAGGGCTTCCTAGGTCGTAAATCTGGGAAGGGCTTTTACATCTATCAGGAGGGTGTGAAGAGGAAGGATTTGAATTCTGACATGGATAGTATTTTAGCGAGTCTGAAGCTGCCTCCTAAGTCTGAAGTCTCATCAGACGAAGACATCCAGTTCCGCCTGGTGACAAGATTTGTGAATGAGGCAGTCATGTGCCTGCAAGAGGGGATCTTGGCCACACCTGCAGAGGGAGACATCGGAGCCGTCTTTGGGCTTGGCTTCCCGCCTTGTCTGGGAGGGCCTTTCCGCTTTGTGGATCTGTATGGCGCCCAGAAGATAGTGGACCGGCTCAAGAAATATGAAGCTGCCTATGGAAAACAGTTCACCCCATGCCAGCTGCTAGCTGACCATGCTAACAGCCCTAACAAGAAGTTCTACCAGTGAGCAGGCCTCATGCCTCGCTCAGTCAGTGCACTAACCCCAGCTGCCGGCAGTGCTGGTTCTCCAACAGAGTGGTGTCTAGATTTATCAGAGTAACGAGAAGACAAACTCCGGCACTGGGTTTGCTCCCTGATTAAAGTGCCTTCAGCCAAGACCATCTCTCCCTCCTGGTGAAGTGTGACTTCGAATTAGTTTGCACTTCCTGTTGGAAGGTAGAGCCCACTGCTCATTGTATAAGCCCCGAGGCCTAGAGTGGCAGCCAAGAGCCATCTGAAGCCACCTCTCTGCCTGTTCCTCCCAAGAGGCCAGGGTGGCCAGGGGTGGTGAGGGCAGTTCTGCACCCAGCCAAACACATAACAATAAAAACCAAACTCTGTGTCAGCATCTTTGCCCTTCTGGTTTAAACGCCTCCTTCAAAAAGCAATCTGGAAGAAAGCCCTGTGCTTTGGGGGAGTAAGAATGTGTGTGCAGAATTCTAGGCAGCACCTTAGGGAGGGACTGGGATGAGAGAAAGTGGGACCTGGTGGGCTCAACCACACACACCTGTCTGTGCAGATGCTTTGCCCAGGCTTCTCACCACGGTGTACCGGGATATTAAACCTCTTTCCCCAGCCTGGA

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