Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name NDUFB5P1
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:180573564-180573822  UCSC
Coordinates (T2T) chr4:183915627-183915885  UCSC
Coordinates (hg19) chr4:181494717-181494975  UCSC
Strand -
Parental Sequence NM_002492.4
Parental seq. overlap 219 bp
Parental seq. overlap (%) 5.2%
Genomic Region Intergenic
Retrocopy Summary NDUFB5P1, located on chr4:180573564-180573822, is a retrocopy of the parental gene NDUFB5. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NDUFB5
Full Name NADH:ubiquinone oxidoreductase subunit B5
Also known as CISGDH|SGDH
Coordinate chr3:179604794-179627647
Strand +
Gene summary The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NDUFB5P1
Bonobo Pan paniscus NDUFB5P1
Gorilla Gorilla gorilla NDUFB5P1
Orangutan Pongo abelii NDUFB5P1
Gibbon Nomascus leucogenys NDUFB5P1
Green monkey Chlorocebus sabaeus NDUFB5P1
Crab-eating macaque Macaca fascicularis NDUFB5P1
Rhesus Macaca mulatta NDUFB5P1
Baboon Papio anubis NDUFB5P1
Golden snub-nosed monkey Rhinopithecus roxellana NDUFB5P1
Marmoset Callithrix jacchus NDUFB5P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NDUFB5P1
TTATTGAAATTCCACATTTTGTTGACTGGGATTCCAGCAGCAGCTTGCATAACTTTGGTGAATGGATGCATGGGTGAAGCTGAACTAGCAGAAAGTCCAAAAGCCTATATCCCAGAACATTGGGAATACTATAAGCATCCTATATCAAGACGGATTGCCCACAGTTTCCATAATAGTCCTGAAAAGAACTATGAAAGAGCAGTGACCGTCATTCAGATCGAAGCCAAAAAGGCTGAATTACAGTTAAAGCAGCTGGAAA
>NM_002492.4
CTTCCTCCTGCCCGTAGTAGCCATGGCGGCCATGAGTTTGTTGCGGCGGGTTTCGGTTACTGCGGTGGCAGCTCTGTCTGGCCGGCCCCTTGGCACTCGCCTCGGATTTGGGGGCTTCCTCACTCGTGGCTTTCCGAAGGCTGCTGCTCCTGTTCGACACAGTGGAGACCATGGGAAAAGACTATTTGTCATCAGACCTTCTAGATTCTATGACAGGCGTTTTTTGAAGTTATTGAGATTCTACATTGCATTGACTGGGATTCCAGTAGCAATTTTCATAACTCTGGTGAATGTATTCATTGGTCAAGCTGAACTAGCAGAAATTCCAGAAGGCTATGTCCCAGAACACTGGGAATATTATAAGCATCCCATATCAAGATGGATTGCCCGTAATTTCTATGATAGTCCTGAAAAGATATATGAAAGAACAATGGCCGTCCTTCAGATTGAAGCTGAAAAGGCTGAATTACGGGTAAAGGAGCTGGAAGTGCGAAAATTGATGCATGTGAGAGGAGATGGACCCTGGTATTACTATGAGACAATTGACAAGGAACTTATTGATCATTCTCCGAAAGCAACTCCTGACAATTAAGCATTTTTTTCTCCAAATACAAAGTATATTCTCTTTATTGGAAAATAAATTAATAAATATATTCTGTATTTTTGCTCTCCGTGAAAAACAAAAGAGCCTCTGACATTACTGTCTCTCAGTGTTGGTTCAGATTGAGGCTTTTGTTTGAGGAGTTTGGCTTCCAGTCCCCAAAGAAGGTTTAAAATGTACTAATAAAAACTGGAGAAATAGGAATTTGTGAACTCCTAAAATTGTAGCAACTTTGAAAGGTTAGTGTTTTATTTACCTGACAAATGGAAGTTATAGAAGTCTAATAATGTTAAGCACCAGTAATTATAGTATTTTGTACAAATGCCTGTACTGTAGATGTCTGTATTATTGAGGGGCAACTCAGGATTTTAAGTTCCATAAAGTATTGAACCAACTCTAAAATGTTAACTCCTTAATAAACAGATTCTCAGTAAACAAATTTTAAAGTTTATAATGCTTTCATGGTTTTTTTTTTTGCCATGTATTGTTCTTTTTTAAACTacacacagacacacagacacgtacacacacacacacacacacacacacacacacGCTCTTTTCCTAGATGCAATCTCTGGGATCCCTTAGAGTCCTTTTTTGGGGAAGTAGTTGCACTAGGTAATGTGATTCCTGCAGAGATTATAAAATGTGAGTAAAAGCTAAAAATGACTcatttattaagcatttattgtctgctagacactatattaaATAACTGCATTTTTTAACATTATtttcttttctttttttttttttttttttttgacgaaatcttgcactgtcacccaggctagagtgcagtgccgtgatctcggctgcaacctccgcctcccgggttcaagcaattcttgtctcagcctcccaagtagctgggattacaggcacccaccaccacacccggctaatttttgtatttttcagtaaagactgtttcgctgtgttggccaggctggtcttgaacttctgacctcaggtgattggcctgtctccacttcccaaagtgctgattacaggcctgagccactgcacccAACATTATTTTCAAAATGACAAGAGGTAGTATTTAGTACCTGAGGCTCAGATGTTAAACACAAACTCAGTATTTACAAAAATAAACATTTAAAACATTTACACTTCAACTTCCAAAATGGCTTTTTACCATAAACATTCAGGATTTTCAAACCTGTAACAGCTTATCAATGCATCTCATCTTAGAAGTATGTTTTACATTCTTCATAAAAATAAAAATGAACCCAGGCTTCCTAAGATTCAGGCCAGTGGGTCTCCACTTAAGGCCAAATGGAGAAATAATTTTTTGCTGCCTAAACACACAAGTGAATTGAAAAGCCACAGGCCATTCATTCAACAAATAACTttattatttttattgataatgtacttgtaatgtgctattttgatacatgtatgcaaagtataatggtcaaatcagggtatttgaatatacatatatttcaaaatatagttatatatttcaaaataagatatagcaagttagaagtatatataagtatattattatatgttattgttaactataatttacctactgtactatcaaatactagaacttattccttgtatctaaatgtattcttgtaaccattaactaacttttctgaatttcctactctccccttcccttcccagccttgtaaccacctttctactctgcctccatgagacccattttttaatctcccacatatgagtgagaacattcaatatttgtctttctaggcttggcttatttcacttacattaatgacctccagttccatccatgttgctacaaatgacagaatcccattctttttcataatattgtccatacataccacattttctatatccatttatctgttgatggacacaggttgcaaagggattgctggattgtatgataattctatgtgtagtttcttgaggaaccttcatggtgttcttcatagtggttgtactactgtacattcctaccaatggtggatgagcgttcccctttctccacatcctcacaagcatttgttattttttcttttttttcaaatgaacattttaactggggtgagatatcttaatgtggtattggtttacatttccctaattatggttgagcattttttcacatatctaatggccattcatatgtcttcctttgagaaatgtctatacagatctctggccctttttttaaattttttttttttttgAATTGGGGTCACCCAGTCTGGAGGTGATCTGGgcttccacatcctgggctcaagtgatcattccacctcaggatgacccaaatagctaggaccaaaggcgagtgccaccatgctcagctaatttttttgtattttttgtagcgactgggtttcaccatgttgcccaggctggtcttgaactcctgtgctcaagtgatccgctcaccttggcctctcaaagtgcaggtactttaggcgtgCCTGGCCTTTTTGTCCAttttatttttttgagatggagtcttgctgtgtcacccaggctggagtgcagtggtgcgatctcgactcagtgcaacctccgcctcccaggttcaagcaattctcctgcctcagcctcctgagtagctgggattacaggtgtgcaccaccacacccagctaatttttttgtatttttagtagagagggggtgtcaccatgttggccagggtgatcttgaacttctgaccttgtgatccacccaccttggtctcccaaagtgctgggattacaggtgtgagccactgcgcccagcctgtccattttttaatcaggttatgggttttttgctattgaattgtttgagttccttatatattctggttatgaatcccttgttagatgGtgtgttaggccattcttgtgttgctataaagaaaatcctgagtctgggtaatttataaagaaaaaaggtgtaaatggctcatagttctgcagactgtacaggaagcatggcaccagcattgcttggcttctggggaggcctcaaggaactttcactcatagcagaaagcaaagcaggagcaggcacatcacatggcaagagagcaagagagagaggtggaggagatgccacacactgttttaaacaaccagatctctcaggaactcattgttgttagaaaaggaattaaaagaaatcaaagagtgtgtaagcagaaactcagttgtacgtaagaaaacccaattccccctgagaaagagaaagagctggagtcctttaaaaattcactgcctgtttttctggtggctagtgagtgttagctctcctcccttcccaggcattgtgaagaccctgtttccctagctgtgcagctgcaaggtcactagacagataaactcaagtcgcaaaacatgtttttccttgaaaagtaagaaatgatgtaatgcatgtcttgactgaataactgtctttgtttcttgcttctgtaatatgcttccccctgcacagatctccccctgccccacgaaatgcttaaaagctaacttaactctttgttcagggctcagtcctttggatgttaatctgactgggccggagcacctaaataataaatattctcctgaacccca

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