Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name EPCAMP1
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:181522665-181523416  UCSC
Coordinates (T2T) chr4:184864834-184865585  UCSC
Coordinates (hg19) chr4:182443818-182444569  UCSC
Strand +
Parental Sequence NM_002354.3
Parental seq. overlap 686 bp
Parental seq. overlap (%) 44%
Genomic Region Intragenic (TENM3)
Retrocopy Summary EPCAMP1, located on chr4:181522665-181523416, is a retrocopy of the parental gene EPCAM. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name EPCAM
Full Name epithelial cell adhesion molecule
Also known as Ber-Ep4|BerEp4|DIAR5|EGP-2|EGP314|EGP40|ESA|HNPCC8|KS1/4|KSA|LYNCH8|M4S1|MIC18|MK-1|MOC-31|TACSTD1|TROP1
Coordinate chr2:47369311-47387020
Strand +
Gene summary This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes EPCAMP1
Bonobo Pan paniscus EPCAMP1
Gorilla Gorilla gorilla EPCAMP1
Orangutan Pongo abelii EPCAMP1
Gibbon Nomascus leucogenys EPCAMP1
Green monkey Chlorocebus sabaeus EPCAMP1
Crab-eating macaque Macaca fascicularis EPCAMP1
Rhesus Macaca mulatta EPCAMP1
Baboon Papio anubis EPCAMP1
Golden snub-nosed monkey Rhinopithecus roxellana EPCAMP1
Marmoset Callithrix jacchus EPCAMP1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>EPCAMP1
GCAGAATGATGTGGACATAGCTGATGTGGCTCATTATTTTGAAAAAGATGTTAAAGGTGAATCCTTGTTTCATTCTTCTAAGAAAATGGACCTGAGAGTAAATGGAGAACAACTGGATCTGGATCCTGGTCAAACTTTAATTTATTATGTTGATAGAAATGCACCTGAATTTTCAATGCAGGCTCTAAAAGCTGGTGTTTGTGCTGTTATTGTGGTTGTGATGATAGCAGTTGTTGCTGGAATTGTTGTGCTGGTTATTTCCAGAAAGAAGAGAATGGCAAAGTATGAGAAGGCTGAGATAAAGGAGATGGGTAGGATGCATAGGGAACTCAATGCATCAGTCCTATAATTTGAAGATTGTAGAAGAAGGGAAATCGCAAACGGACTCAGATTACAAATGTATGAGCATGGGACAAAGACATCTTTGAAGGTCACTATTTTGTTAGTTTAACATCATGTATTTGTACTAGTGAAGCCTGTACTCAATATATAAGCAGCTTGAAATTGGCTTTACCAATCTCAACATTTGACCACAAGCGTCTTTTATATATGCAGATCTAATATAAAACCCAGAACTTGGACTGCATAGTTAAAATTATTTATGCGTAACATTCAAATGAGTGCGTTAAATATGCTTCCACAGTAGAGTTTGAAAAACTACTATCTGATTTGTGATTGAAAGCTGCCTTTCTATTTACTTGAGTCTATTTCATGCAAACTTTTTTATGAGCTATGAAATAAAACATTTTAAA
>NM_002354.3
acagagcgctagtccttcggcgagcgagcaccttcgacgcggtccggggaccccctcgtcgctgtcctcccgacgcggacccgcgtgccccaggcctcgcgctgcccggccggctcctcgtgtcccactcccggcgcacgccctcccgcgagtcccgggcccctcccgcgccccTCTTCTCGGCGCGCGCGCAGCATGGCGCCCCCGCAGGTCCTCGCGTTCGGGCTTCTGCTTGCCGCGGCGACGGCGACTTTTGCCGCAGCTCAGGAAGAATGTGTCTGTGAAAACTACAAGCTGGCCGTAAACTGCTTTGTGAATAATAATCGTCAATGCCAGTGTACTTCAGTTGGTGCACAAAATACTGTCATTTGCTCAAAGCTGGCTGCCAAATGTTTGGTGATGAAGGCAGAAATGAATGGCTCAAAACTTGGGAGAAGAGCAAAACCTGAAGGGGCCCTCCAGAACAATGATGGGCTTTATGATCCTGACTGCGATGAGAGCGGGCTCTTTAAGGCCAAGCAGTGCAACGGCACCTCCATGTGCTGGTGTGTGAACACTGCTGGGGTCAGAAGAACAGACAAGGACACTGAAATAACCTGCTCTGAGCGAGTGAGAACCTACTGGATCATCATTGAACTAAAACACAAAGCAAGAGAAAAACCTTATGATAGTAAAAGTTTGCGGACTGCACTTCAGAAGGAGATCACAACGCGTTATCAACTGGATCCAAAATTTATCACGAGTATTTTGTATGAGAATAATGTTATCACTATTGATCTGGTTCAAAATTCTTCTCAAAAAACTCAGAATGATGTGGACATAGCTGATGTGGCTTATTATTTTGAAAAAGATGTTAAAGGTGAATCCTTGTTTCATTCTAAGAAAATGGACCTGACAGTAAATGGGGAACAACTGGATCTGGATCCTGGTCAAACTTTAATTTATTATGTTGATGAAAAAGCACCTGAATTCTCAATGCAGGGTCTAAAAGCtggtgttattgctgttattgtggttgtggtgatagcagttgttgctggaattgttgtGCTGGTTATTTCCAGAAAGAAGAGAATGGCAAAGTATGAGAAGGCTGAGATAAAGGAGATGGGTGAGATGCATAGGGAACTCAATGCATAACTATATAATTTGAAGATTATAGAAGAAGGGAAATAGCAAATGGACACAAATTACAAATGTGTGTGCGTGGGACGAAGACATCTTTGAAGGTCATGAGTTTGTTAGTTTAACATCATATATTTGTAATAGTGAAACCTGTACTCAAAATATAAGCAGCTTGAAACTGGCTTTACCAATCTTGAAATTTGACCACAAGTGTCTTATATATGCAGATCTAATGTAAAATCCAGAACTTGGACTCCATCGTTAAAATTATTTATGTGTAACATTCAAATGTGTGCATTAAATATGCTTCCACAGTAAAATCTGAAAAACTGATTTGTGATTGAAAGCTGCCTTTCTATTTACTTGAGTCTTGTACATACATACTTTTTTATGAGCTATGAAATAAAACATTTTAAACTGAA

Publications

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