Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MTRF1LP3
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:188738370-188742024  UCSC
Coordinates (T2T) chr4:192091501-192095156  UCSC
Coordinates (hg19) chr4:189659524-189663178  UCSC
Strand +
Parental Sequence NM_001114184.3
Parental seq. overlap 1907 bp
Parental seq. overlap (%) 51.5%
Genomic Region Intergenic
Retrocopy Summary MTRF1LP3, located on chr4:188738370-188742024, is a retrocopy of the parental gene MTRF1L. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MTRF1L
Full Name mitochondrial translation release factor 1 like
Also known as HMRF1L|MRF1L|mtRF1a
Coordinate chr6:152987362-153002709
Strand -
Gene summary The protein encoded by this gene plays a role in mitochondrial translation termination, and is thought to be a release factor that is involved in the dissociation of the complete protein from the final tRNA, the ribosome, and the cognate mRNA. This protein acts upon UAA and UAG stop codons, but has no in vitro activity against UGA, which encodes tryptophan in human mitochondrion, or, the mitochondrial non-cognate stop codons, AGA and AGG. This protein shares sequence similarity to bacterial release factors. Pseudogenes of this gene are found on chromosomes 4, 8, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MTRF1LP3
GGGGGCGCTGCCCGGTGGCTCTGGCCCCGCCGGGCCGTTGGCCCAGCCCGCCGGCCCCTGAGCTCCGGTAGCCCGCCGCTGGAGAAGCTGTTCGCCCGGGGCGGGCCCTTGCGGACCTTCCTCGAGCGCCAGGCGGGGTCTGAAGCCCATTTGAAGGTCAGGAGGCCCGAGTTGCTGGCGGTGATCAAACTGCTGAACGAGAAGGAGCAGGAGCTGCGGGAGACTGAGCACTTGCTGCACGATGAGAATGAAGGTTTAAGGAAACTTGCAGAGAATGAAATCACTTTGTGTCAAAAAGAAATAACTCAGCTGAAGCATCAGATTATCTTACTTTTGGTTCCCTCAGAAGAAACAGATGAAAATGATTTGATCCTGGAAGTAACTGCAGGAGTTGGAGGTCAGGAGGCAATGTTGTTTACATCAGAGATATTTGATATGTATCAGCAATATGCTGCATTTAAAAGATGGCATTTTGAAACCCTGGAATATTTTCCAAGTGAAGTAGGTGGCCTTAGACATGCATCTGCCAGCATTGGGGGTTCAGAAGCCTATAGGCACATGAAATTTGAAGGAGGTGTTCACAGAGTACAAAGAGTGCCAAAGACAGAAAAGCAAGGCTGCGTCCATACTAGCACCATGACTGTAGCAATATTACCCCAGCCTACTGAGATTAATCTGGTGATTAATCCGAAAGATTTGAGAATTGACACTAAGCGAGCCAGTGGAGCTGGGGAGCAGCATGTAAATACCACGGACAGTGCTGTCCGGATAGTTCATCTTCCAACAGGTGTTGTTTCTGAATGTCAACAAGAGAGATCTCAGCTGAAAAATAAAGAGCTGGCTATGACAAAGTTACGTGCAAAACTGTACAGCATGCATGTAGAAGAAGAAATAAATAAAAGACAGAATGCTAGAAAAATTCAGATTGGAAGTAAAGGAAGATCAGAGAAAATAAGAACATATAATTTTCCACAGAACCGGGTCACAGATCACAGAATAAACAAGACGCTGCATGATCTTGAAACTTTTATGCAAGGAGATTATCTACTGGATGAACTTGTACAGTCATTGAAGGAATACGCCAATTATGAATCTTTAGTAGAAATTATTTCCCAAAAAGTTTAAGTTGATTTGTTATTTATAGACTTTCGTAGCTTAGAAAAATTCTACAGTACATCCACATAGGGTGAAAGTACCCTTACTCTCTTGAAAAACGTGAGTTAACACAGTTGGAGGTAATATGCATATTCTGAAGTCATAGATAATTTACACAGATCTCTCTCAATGCATTAGCAAAAATCATACAATATAGCATATAACGTTAGCAACACAGTAATCATGATGTGGTGGTAAATCTTGGACGCTACCTTACAATAACTAGACAAAGGAAAATCATCCTTTGTCCTGTTCTGTGTAAATATTTAATGAATGATCAAAACTTCAGTTTAAATATTATGAAAAACTTTAAACATAAAGTAGTAGAAATAAGACAGTAAATACTGTATCCTAATATGGATCAGGTCTTACAAGCAAAGAACCTCACACTCTCAACTGGTAAGCCAGAAGCCTCTTGCTAGGGTGTGAGCAAAACTTGGACAGGAACTCTCAGTAGATGTTTGTGTTTGTCAAGATTCTCCTTATAATTGGAAAATCAGAGCAAAAGTTAAATCTCTAAAAAAAAAAAATGAAGATACCATACCTGAACACCTGAACATTCTTCACAAGGTAGTAAATGCACTGCTTTATTCTGGTCTCAGTATTGTGTGCTTAATAAGGAAATGAGAAAGGGTGGATCAGGGCATAGGATGAACAAGTTACTGCTAGACCTCTCACAATGCCACTAATGGATAAAAAAACACCTTAAGTATTTGTCTAGAAATCTGGTGCATTGTTCAGAAAGAACCAAAATTCAAAATAATTTCAAAGGGCCTAAAGCACTAGTTAATCAAAATTCATTAGTTTTTAATGGTACTACCACTCTCAAATTTAAAATGTCATCTTACGTTCCTCTTCCTCGCATTGGATTTATTGCTAAAACCTGGTAAACACTTTTAA
>NM_001114184.3
AGGGTCCGCGATCTCGGACTAAGGATGCGGTCCCGGGTTCTGTGGGGCGCTGCCCGGTGGCTCTGGCCCCGCCGGGCCGTTGGCCCAGCCCGCCGGCCCCTGAGCTCCGGTAGCCCGCCGCTGGAGGAGCTGTTCACCCGGGGCGGGCCCTTGCGGACCTTCCTCGAGCGCCAGGCGGGGTCTGAAGCCCATTTGAAGGTCAGGAGGCCCGAGTTGCTGGCGGTGATCAAACTGCTGAACGAGAAGGAGCGGGAGCTGCGGGAGACTGAGCACTTGCTGCACGATGAGAATGAAGATTTAAGGAAACTTGCAGAGAATGAAATCACTTTGTGTCAAAAAGAAATAACTCAGCTGAAGCATCAGATTATCTTACTTTTGGTTCCCTCAGAAGAAACAGATGAAAATGATTTGATCCTGGAAGTAACTGCAGGAGTTGGAGGTCAGGAGGCAATGTTGTTTACATCAGAGATATTTGATATGTATCAGCAATATGCTGCATTTAAAAGATGGCATTTTGAAACCCTGGAATATTTTCCAAGTGAACTAGGTGGCCTTAGACATGCATCTGCCAGCATTGGGGGTTCAGAAGCCTATAGGCACATGAAATTTGAAGGAGGTGTTCACAGAGTACAAAGAGTGCCAAAGACAGAAAAGCAAGGCCGCGTCCATACTAGCACCATGACTGTAGCAATATTACCCCAGCCTACTGAGATTAATCTGGTGATTAATCCGAAAGATTTGAGAATTGACACTAAGCGAGCCAGTGGAGCTGGGGGGCAGCATGTAAATACCACGGACAGTGCTGTCCGGATAGTTCATCTTCCAACAGATTGGAAGTAAAGGAAGATCAGAGAAAATAAGAACATATAATTTTCCACAGAACCGGGTCACAGATCACAGAATAAACAAGACGCTGCATGATCTTGAAACTTTTATGCAAGGAGATTATCTACTGGATGAACTTGTACAGTCATTGAAGGAATACGCCGATTATGAATCTTTAGTAGAAATTATTTCCCAAAAAGTTTAAGTTGATTTGTTATTTATAGACTTTCGTAGCTTAGAAAAATTCTACAGTACATCCACATAGGGTGAAAGTACCCTTACTCTCTTGAAAAACGTTGAGTTAACACAGTTGGAGGTAATATGCATATTCTGAAGTCATAGATAATTTACACAGATCTCTCTCAATGCATTAGCAAAAATCATACAATATAcagatggtcctcgatttacattgtggttaattcccaataaacccatcataagttaaaaatGCATATAACGTTAGCAACACAGCAGTCTCCTAATTAATGACAGCTTGACTTAACAATTTTCCAACTTTACCATGGTGTGAAAGAGGTATGATTCCTAAGCCCTAAGGAgctcctcagcttgaaatggggctgcatccctataaacccatcataaagtcaaaaaatcctaaaacataagttggtgaccatctgTAATCATGATGTGGTGGTAAATCTTGGACGCTACCTTACAATAACTAGACAAAGGAAAATCATCCTTTGTCCTGTTCTGTGTAAATATTTAATGAATGATCAAAACTTCAGTTTAAATATTATGAAAAACTTTAAACATAAAGTAGTAGAAATAAGACAGTAAATACTGTATCCTAATAtccagtcaggatacagaaaccataccattaacttgaacagggataattttaatataaaaactgttaactgataatggtattaacttttaagagggatgaaagagagctatgatgtcctaggactgagagtaccccaggaaagaatacccttgaaagggtctccccttccccatggtgaagtcaggcctaatggagagagtggctacagcctactcagtgattgggaaattccctgtcttgccctgggccagagctggtgtaccgctggTGGATCAGGTCTTACAAGCAAAGAACCTCACACTCCCAACTGGTAAGCCAGAAGCCTCTTGCTAGGGTGTGAGCAAAACTTGGACAGGAACTCTCAGTAGATGTTTGTGTTTGTCAAGATTCTCCagacaaacttccttaaaaggattggcttgtgttgttattattaagtctaacaagtccaaaagctggagtgtgaggcaggaggctggaaacccaggaaagctgatggtgcaaggtccagtccaaaggtatctgttggaggattctcttgttctgggaagaggacggtctttttttctcttcagaccttcacctgactggatcaagcccactaacatcgaggaggacagtctgcattactcagagttcactgattgatttaaatgtcaatctcatataaaacaccctcacagaaacacctagaataatgtttgaccTTATAATTGGAAAATCAGAGCAAAAGTTAAATCTCAAAAAAAAAAAaaaaaaaagtatgacccagtagctaggcacctgtggccccgccaagttgacacataaaattaactgtcacaGTATCATCTTAGAAGTgaaagaagcccctttatcctgcagtgcccctctaccaccacctactgacaaagaacatggtgctatctggcatgggagaaatgttCAGTTtgctatggcttgtatgtgtcccctcaaattcaagtgttgccaatgtgacagcatcaagaggtggggtctttaagagatcactaggccatgagggattctcttaggactgggatgaaggcccataataaaagaggtttcggggagcatcctgctagcttgccttctgtatgtgagaacacagcaagaaagccctagtcaacaagtgccagctccttgatcttagacttcccatcctccagaactgtgagaaatacatttctgttccttacaaattacccagtctcctgtattctgttatagcagcacaaaATGAAGATACCATACCTGAACACCTGAACATTCTTCACAAGGTAGTAAATGCACTGCTTTATTCTGGTCTCAGTATTGTGTGCTTAATAAGGAAATGAGAAAGGGTGGATCAGGGCATAGGATGAACAAGTTACTGCTAGACCTCTCACAATGCCACTAATGGATAAgattgtattttcatcattcttgtctcttcggaagctaacaccatgctataataggcactaaatagatgtctAAAAACACCTTAAGTATTTGTCTAGAAATCTGGTGCATTGTTCAGAAAGAACCAAAATTCAAAATAATTTCAAAGGGCCTAAAGCACTAGTTAATCAAAATTCATTAGTTTTTAATGGTACTACCACTCTCAAATTTAAAATGTCATCTTACGTTCCTCTTCCTCGCATTGGATTTATTGCTAAAACCTGGTAAACACTTTTAAtccttttcaattccattaccactgctcttgtccagaattacttcgcagactaatagtcacctgacttctcccctgcatccgatttgctgtctaattctggttacaaataagtaactgccaaactaatctttctaaaaagcaagactgatctcgtcactcctttgctcaacaatgtaaaagctcccattgtctcccaaataaaaccagctttccactgtgtatacaatacatcca

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