Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HBS1LP1
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:2088015-2090692  UCSC
Coordinates (T2T) chr4:2086794-2089471  UCSC
Coordinates (hg19) chr4:2089742-2092419  UCSC
Strand -
Parental Sequence NM_001145207.2
Parental seq. overlap 2519 bp
Parental seq. overlap (%) 92.1%
Genomic Region Intragenic (POLN)
Retrocopy Summary HBS1LP1, located on chr4:2088015-2090692, is a retrocopy of the parental gene HBS1L. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HBS1L
Full Name HBS1 like translational GTPase
Also known as EF-1a|ERFS|HBS1|HSPC276|eRF3c
Coordinate chr6:134960378-135054826
Strand -
Gene summary This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, May 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes HBS1LP1
Bonobo Pan paniscus HBS1LP1
Gorilla Gorilla gorilla HBS1LP1
Orangutan Pongo abelii HBS1LP1
Gibbon Nomascus leucogenys HBS1LP1
Green monkey Chlorocebus sabaeus HBS1LP1
Crab-eating macaque Macaca fascicularis HBS1LP1
Rhesus Macaca mulatta HBS1LP1
Baboon Papio anubis HBS1LP1
Golden snub-nosed monkey Rhinopithecus roxellana HBS1LP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HBS1LP1
TGGCACCTTATCAGTATCTAAGCGGAGTGTTTTGGAAGGAGTTAAGGGGCTGTAGCAAACGCCCTCTCCACCGTCATGGCCCAGCATCGGAATGTTCGAGGCTGTGACTGCGATGAAGATCTTGAAGATGATGATCACCATGGCCAGTCTGTAGAGGATGATTCTTGTATTTTGCTATCAACAGCTGCTCAGTTTATTTATTCACAGCGTGACAAACCTTCCGTTGAGCCTATAGAAGAATACGATCATGAAGATCTGAAAGAATCTTTCAATTATGTTTCGAACCATCAGCTCAGTGGATTTAATCAAGCTCGTTTTTATTCATGCCTTGATCACATGAGAGAAAGTACTTGGAGATGCTGTGCCAGATGAAATATTGATTGAATCAGTTCTGAAGAACAAGTTTGATGTGCAGAAGCCTTTGTCAGAGGTTCTGGAACAAGATAGCATGTAGAATTTGAAGGACAAGAATGAGGGAAGAGTATCTACAGGAAAGATAGCAAAAGGTAAGGAGTCTTATTTTCTTCTTCTGAAGTTTCAGCTGATAATGTTCAAAGTTCTTATCCTCAGTTAGCAAATCATTTGGATTATAGTAGCAAACCCTTTGATTTTTCTAGCTCAGTAGGAAAATATGGATTATCTCATAATTCTTCAGTTCCAAGTCACTGTTTACTCCATAGGAAAAAGAAACTTGACAGACTTAAAAGTGAAAAGAAACCAGAATCATGTAGGTTAACAAAAGAACTTTCACTAGCTAACTTAATTCCTGATATGTCAAGAGATTCCTGTGAAAGTCAGCCATCAGTCAGATTGTCATCTACAGACAGTCTGGAAAGTCTGCTTTCAAAGAACCTAGATGCTGATTTGTTGAGACTTCATCCATCTGAATGTGCTTCCAAAGATGATTCTGCATTCAAAGAAATACCAGATTTAAAGTCCATAATGATAAAGAGCACAACACTGAATAATTCTTCATATATTCAAAGTAATTCACTATCTGATTTTTAAAACATTCCAGTACAGGACAGTTTAGGAAGTTCAGATAATCCTTTGTGCTTAACTAGCTTGTTGGAAAATATGACTGTTGATAATTTAAATGCTAGTAAAGAAACTGAAGTTGGAAGTGTTTCTTTAGTTGAACAAAGTGCCAAGAATTACATTTTTAAAAATGATAATTTGCAGTTTTCCCAGTGTGAAAGTCCATCCCTAACTGAACTGTTTCGGGAACACAAAGAAAACAATATAAGCCAGTGCTTTACTTTGTCTGACCTTTGTAACCAGTCATCTGTCAGTTTCACAGATCTAAGTTTGGGATCCTTTCCCCTGTCACAATTAGCAAATCACTGTCAGTCTTCACCAGGAATATCAGAATTAACAGGATCTATGTTGTCATTGGCATTTCCTAAAGCTTCTCCCACAAGAGACCTTGAGAATTTGTCACTTTCTGAATTGATTGCAGAAACAATTGATGTATACAACTCTCAGATTAAGAAAGAGTCCTTTGAGGTCAGTTTATCTGAAGTGAGGTCTCCTGGAATAGATTCAAATATTGATCTTAGGGTCCTTATAAAAAAAACCCAGATTTTCTTCCAAAGCCTATAGTAGACCAATCCATTGCTCCTTCATCACGAACTAAAGTTCTAAGTTCAAAGCTAGGGAAGAAATCCAATTTTGCTAAGGATAATGAGAAAAACAATAAAGGCTGTCTGACTAGGAAACCACCTTTTTCTCTGTCTCGGACCAAGGCCGTTGCTGCTAGACCTTCAGCTTTTGCCTCAACACTGTGTCTTCGTTACCCACTAAAAAGCTGCAAGCGACGCACCCTTGACCTCTGTAAGACTTTTCTTTATAGTAGACAAGTTCAAGATGTAAAGGACAAAGAAATAAGTCCTCTTGTAGCGATAATACCATTTGACTTCAAATCAGCATCACCTGATGACATTGTAAAAGCTAATAAAAAAAAAGCATTTACTAGAGAATAGTAACAAAAGAAAACTTGATGGCTGTTGTACAGCTTTTTATTTTTAATTAAAGTCTTAGAGGATCACTTTATATTATGGGATTCAAATTGTGATTTTCATGAAAATTGTTGTAGATCAGTTGATTAGCTAATGCGTATTTTTGCACTGAATTTTTTTTAAACTATGTCTTCTTTCAGTGATAACAGGCTTTATTTAAGTTGGTAACCTATACTGAGTATATGTTTACAAAGTGGATATGGAAACTGGATGTTGTGAAATCAGACCTCAGATATTTTTGTTTGAAGCATTCAACTTTCTATGTTTTTTATGATGAAATATTTTTTTCTATGAGATATTTTTGTGCTTTGTTCATAAACGAAAATGCCAGCACTTGGAATTATTATAGTTTAGTGTGAAGATTATTCTTATGTGGCACAGCATAGTTGAGACATTATGTTTTAAAATACGATATAATTCCTAGTTTCATTATTTTTCTGTAGATAAATACTAAAATTTTTCTATTAGAAAATCTTAAAATTCCTGACCTTTGAGAGTACTGTGGAGATTGTTGAAATACATTTTTAATGATAATAAAATGAAAATCTTTTAAGGGACCATGTAAATATAGAAGTTGGATTTATATGTGAATTATTTTTATACATTTTTAAAAACCATTTGTCCTAAATAAACACTTCAa
>NM_001145207.2
GGCGCAGAGGCCTGCGGGAAGCCAAGATGGCGCATAGGGGTTCTCCAGGCTGCAGTTGGCGCCTTATCAGTATCTAAGCGGAGTGTTTTGGAAGGAGTTAAGGGGCTGTGGCAAACGCCCTCTCCGCCGTCATGGCCCGGCATCGGAATGTTCGAGGCTATAACTACGATGAAGATTTTGAAGATGATGATCTCTACGGCCAGTCTGTAGAGGATGATTATTGTATTTCGCCGTCAACAGCTGCTCAGTTTATTTATTCACGGCGTGACAAACCTTCCGTTGAGCCTGTGGAAGAATATGATTATGAAGATCTGAAAGAATCTTCCAATTCTGTTTCAAACCATCAGCTCAGTGGATTTGATCAAGCTCGTCTTTATTCATGCCTTGATCACATGAGAGAGGTACTTGGAGATGCTGTGCCAGATGAAATATTAATTGAAGCAGTTCTGAAGAACAAGTTTGATGTGCAGAAGGCTTTGTCAGGGGTTCTGGAACAAGATAGAGTGCAGAGTTTGAAGGACAAGAATGAGGCAACAGTATCTACAGGAAAGATAGCAAAAGGAGTCTTATTTTCTTCTTCTGAAGTTTCAGCTGATAATGTTCAAAGTTCTTATCCTCAGTCAGCAAATCATTTGGATTATAGTAGCAAACCCTTTGATTTTGCTAGCTCAGTAGGAAAATACGGATTATCTCATAATTCTTCAGTTCCAACTCACTGTTTACTCCATAGAAAAAAGAAACTTGACACACGTAAAAGTGAAAAGAAACTAGAATCATGTAAGTTAACAAAAGAACTTTCACTAGCTAACCTAATTCATGATATGTCAAGAGATTCCTGTGAAAGTCAGCCATCAGTCAGATTATCATCTACAGACAGTCTGGAAAGTCTGCTTTCAAAGAACCTAGATGCCGATTTGTTGAGACCTCATGCATCTGAATGCATTTCCAAAGATGATTCTGCATTCAAAGAAATACCAGATTTAAAGACCATAATCATAAAGGGCACAACACCGAATAATTCTTTATATATTCAAAATAATTCACTGTCTGATTTTCAAAACATTCCAGTACAGGACAGTTTAGGAAGTTCAAATAATCCTTTGTACTTAACTAGCTCGTTGGAAAATATGACTGTTGATAATTTAAATGCTAGTAAAGAAACTGAAGTTGGAAATGTTTCTTTAGTTGAACAAAGTGCCAAGAATCACACTTTTAAAAATGATAATTTGCAGTTTTCTCAGTGTGAAAGTCCATCCCTAACTGAACTGTTTCAGGAACACAAAGAAAACAATATAAGCCAGTGCTTTACTTTATCTGACCTTTGTAACCAGTCATCTGCCAGTTTCACAGATCTAAGTTTGGGATCCTTTCCCCTGTCACAATTAGCAAATCGCTGTCAGTCTTCACCCGGAATATCAGAATTAACAGGATCTCTGTCGTCATTGGCATTTCATAAAGCTTCTCCCACAAGAGACCTTGAGAATTTGTCACTTTCTGAATTGATTGCAGAAACAATTGATGTAGACAACTCTCAGATTAAGAAAGAGTCCTTTGAGGTCAGTTTATCTGAAGTGAGGTCTCCTGGAATAGATTCAAATATTGATCTTAGTGTCCTTATAAAAAACCCAGATTTTGTTCCAAAGCCTGTAGTAGACCCATCCATTGCTCCATCATCACGAACTAAAGTTCTAAGTTCAAAGCTAGGGAAGAATTCCAATTTTGCTAAGGATAATAAGAAAAACAACAAAGGCTCTCTGACTAGGAAACCACCTTTTTCTCTCTCTTGGACCAAGGCCCTTGCTGCTAGACCTTCAGCTTTTGCCTCAACACTGTGTCTTCGTTACCCACTGAAAAGCTGCAAGCGACGCACCCTTGACCTCTATAAGACTTTTCTTTATAGTAGACAAGTTCAAGATGTAAAGGACAAAGAAATAAGTCCACTTGTAGCAATAACACCATTTGACTTCAAATCAGCATCACCTGATGACATTGTAAAAGCTAATCAAAAAAAAGCATTTACTAGAGAATAGTAACAAAAGGAAAACTTGATTGCTGTTGTAGAGCTTTTTATTTTTAATTAAAGTCTTCAGAGGATCACTTTATATTATGGGATTCAAATTCTGATTTTTATGAAAATTGTCGTAGGTCAGTTGATTAGTTGATACGTATTTTTGCACTGATTTTTTTTTTAACTATGTCTTCTTTCAGTGATAACTGGCTTTATTTAAGTTGGTAACCTATACTGAGTATATGTTTACAAAGTGGATATGGAAACTTGATGTTGTGAAATCAGACCTCATATATTTTTGTTTGAAGCATTCAACTTTCTATGTTTTTTATAATGAAATATTTTTTTCTATGAAATATTTTTGTGCTTTGTTCTTAAACGAAAATGCCAGCACTTGGGATTATTATAGTTTAGTGTGAAGATTATTCTTATGTGGCACAGCATAACTGAGATGTTATATTTTAAAATATGATATAATTCCTAGTTTCATTATTTTTCTGTAAATACTAAAATTTTTCTATTAGAAAATCTTAAAATTCCTGACTTTTGAGAGTACTGTGGAGATTGTTGAAATACATTTTTGATAATAATAAAATGAAAATCTTTTAAGGGACCATGTAAATATAGAAGTTGGATTAATATGTGAATTATTTTTATACATTTTTAAAAACCATTTGTCCTAAGTATACACTTTAAAATAAATATATAAAAAGTG

Publications

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