Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name IGBP1P5
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:27585137-27586305  UCSC
Coordinates (T2T) chr4:27570503-27571671  UCSC
Coordinates (hg19) chr4:27586759-27587927  UCSC
Strand +
Parental Sequence NM_001370194.1
Parental seq. overlap 758 bp
Parental seq. overlap (%) 54.8%
Genomic Region Intergenic
Retrocopy Summary IGBP1P5, located on chr4:27585137-27586305, is a retrocopy of the parental gene IGBP1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name IGBP1
Full Name immunoglobulin binding protein 1
Also known as ALPHA-4|IBP1|MRXS28|alpha4
Coordinate chrX:70133447-70166324
Strand +
Gene summary The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes IGBP1P2
Bonobo Pan paniscus IGBP1P2
Gorilla Gorilla gorilla IGBP1P2
Orangutan Pongo abelii IGBP1P2
Gibbon Nomascus leucogenys IGBP1P5
Green monkey Chlorocebus sabaeus IGBP1P3
Crab-eating macaque Macaca fascicularis IGBP1P2
Rhesus Macaca mulatta IGBP1P3
Baboon Papio anubis IGBP1P4
Golden snub-nosed monkey Rhinopithecus roxellana IGBP1P3
Marmoset Callithrix jacchus IGBP1P2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>IGBP1P5
CCTCCCCAAGATGGCTGCTGAAGACAAGCTACTGCTGCCGCGGCTCCCCGAGCTGTTCAAAACTGGCAAAGTTTCTGGACGAAGCAGAAGTAGCTGCTGAACCTGCTGGTTCCTGGATAGTCCAGGAGAAAGTGTTCAAGGGCCTGGACCTCCTTGAGAAAGCTGTCAAAATGTTATCACAGCTTGACTCCTTCAGCCGAAATGAAGACATGTAAGAGATTGCTTCCACTGACCTGAAGTGCCTGTTGGTGCCCTCACCATGAAATAAGTCAACCCCAGCAAGCGTCTGGATCATTTGCAGCGGGCTCCAAAACGCTTTATAAACTACTTAACTCAGTGCCGTTACTATCATGTGGCAGAGTTTGAGCTGCCCAAAATGAGAACAACTCAGCTGAAAATCACACTACTAATTCCTCCATTGCTATCCTAGCCTCATTTCTATGGCATCTCAAAGACAGGCTAAAATAGAGAGATACAAACAGAAGAAGGAGTTGGAGCATAGGTTATCTGCATTGTAATCTGTTGTGGAAAGTGGTCAATCAGACGATGAATGTGTTCGGGAATATTATCTTCTTCACCTTCAGAGGTGGTTTGGTATCAGCTTAGAAAAGATTGAGAGCATTGACCAGGAAATAAAAATCCTGAAAGAAAGAGAGTCTTCAAGAGAGCCCTCAACTTCTAACACATCTCGCCAGGAAAGGCTTCCAGTGATACCCTTCATTCTCGCCCGGGACATATCCAAGCCAGCGTATTTGGAGCTGGTTATCCAAGTCTGGCAACTATGATGGTGAGTGACTGTCATGAACAACATCAGAAATATGGAATGGAGAATTACCAAATCAGGGAATATCCAAGGCAACATCAGAGGAATTCAGAAAAGCAGCTCaACAAACACTCTACAGAGCTTGGGAATGGGATGACTGTCAGAACATCCATCCTAGGGGCAATGGCAACCGACAGAACATGGGCTGATCTTCCCACAATGTAACAGGACTGCAAGGTGCACACTTCCCCCCTCCAAGGAAAACCATGCAGTCTTCCCCTCCCTGGGCTCCCACTTCAGCTGTGTACAATGAAGTCAAAGATGCTAAATCTTACTTTGCATTCAATAAAGTGTCAAGTGATT
>NM_001370194.1
CTCTCTCCCCAAGATGGCTGCTGAGGACGAGTTACAGCTGCCGCGGCTCCCCGAGCTGTTCGAAACTGGTAGACAGTTACTGGACGAAGTAGAAGTGGCGACTGAACCCGCCGGTTCCCGGATAGTCCAGGAGAAGGTGTTCAAGGGCTTGGACCTCCTTGAGAAGGCTGCCGAAATGTTATCGCAGCTCGACTTGTTCAGCCGAAATGAAGATTTGGAAGAGATTGCTTCCACCGACCTGAAGTACCTTTTGGTGCCAGCGTTTCAAGGAGCCCTCACCATGAAACAAGTCAACCCCAGCAAGCGTCTAGATCATTTGCAGCGGGCTCGAGAACACTTTATAAACTACTTAACTCAGTGCCATTGCTATCATGTGGCAGAGTTTGAGCTGCCCAAAACCATGAACAACTCTGCTGAAAATCACACTGCCAATTCCTCCATGGCTTATCCTAGTCTCGTTGCTATGGCATCTCAAAGACAGGCTAAAATACAGAGAGTATTTGGAGCTGGTTATCCAAGTCTGCCAACTATGACGGTGAGTGACTGGTATGAGCAACATCGGAAATATGGAGCATTACCGGATCAGGGAATAGCCAAGGCAGCACCAGAGGAATTCAGAAAAGCAGCTCAGCAACAGgaagaacaagaagaaaaggaggaagaggatgatgaacaaACACTCCACAGAGCCCGGGAGTGGGATGACTGGAAGGACACCCATCCTAGGGGCTATGGGAACCGACAGAACATGGGCTGATCTTCCCACAACACCACAGGACTGCAGGGTGCACAACTCCCCTGCCAAGGAAAACCATGCAGTCCTCCCCTCCCTGGTCTCCTGCTTCAGCTCTGTACAACGAGGGCAAAGATGCTAAATCTTGCTTTGCATTCAGTAAAGTGTCAAGTGATTAAGTGTGTATTTGTACCCTAGATGATATGAACCAGCAGTCTTGTTTTGGCATCATCCTCATCATGTTGTATTCCAGCTTCTTAAGTGGAAGGAAAAGAGTGCTGAGAAATGGCTCTGTATAATCTATGGCTATCCGAATTCTCTGAAAAAATAATAAAAGTCCCCTCTATTATATGAGCCTGTACAGAAA

Publications

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