Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MESTP3
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr4:28822010-28824230  UCSC
Coordinates (T2T) chr4:28807733-28809953  UCSC
Coordinates (hg19) chr4:28823632-28825852  UCSC
Strand -
Parental Sequence NM_177524.2
Parental seq. overlap 2046 bp
Parental seq. overlap (%) 83.4%
Genomic Region Intergenic
Retrocopy Summary MESTP3, located on chr4:28822010-28824230, is a retrocopy of the parental gene MEST. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MEST
Full Name mesoderm specific transcript
Also known as PEG1
Coordinate chr7:130486175-130506465
Strand +
Gene summary This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15. [provided by RefSeq, Dec 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MESTP2
Bonobo Pan paniscus MESTP2
Gorilla Gorilla gorilla MESTP2
Orangutan Pongo abelii MESTP2
Green monkey Chlorocebus sabaeus MESTP4
Crab-eating macaque Macaca fascicularis MESTP4
Rhesus Macaca mulatta MESTP5
Baboon Papio anubis MESTP2
Golden snub-nosed monkey Rhinopithecus roxellana MESTP2
Gibbon Nomascus leucogenys Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MESTP3
TTCTCCCAAACATGGGGTCCTGTAGCCCAGGTCTTACCCAAATCAGGATGAGGTAGTGGGGGGTCCAGGTGGGGCTGTTGGCCGTGACCCTGCTTGCTGCGTACCTGCACATCCCAACTCTTCAGCTGTCCCCTACCCTTCACTCATAGAAGTCTTCAGTAAAGTTTTTCACTTACAAGGGACTGCGTATCTTCTACCAAGACATTGTGGGTGTGGTTGGAAGTCCGGAGATAGTTGTGCTTTTACATGGCTTTCCAACATCCAGCTACGATTGGTACAAGATTTGGGAAGTCTGACCTTGAGGTCTTATCGAGTGATTGCCCTTGATTTCTTAGGCTTTGGCTTCAGTGACAAACAGAGACCACATCACTATTCCATATTTGAGCAGGCCAGCATCGTGGAAGCTCTTTGGGGCATCTGGGGCTCCAGAACCGCAGGATCAACCTTTAGTCTTATGACTATGGAGATACCGTTGCTCAGGAACTTCTCTACAGGCACAAGCAGAATCTGTCTGGTCGGCTTACCATAAAGAGTCTCTGTCTGTCAAATGGAGGTATCTTTCCTGAGACTCACCATCCACTCCTCTAGAAGCCACTCAAAGATGGACGTGTGCTGTCACCCGTCCTCACGCAGCTGATGAACTCTGTATTCTCTCGAAGTCTCATCCCAGTCTGTGGGCCGTATACTCGGCACTCTGAGACTGAGCTATGGGACATGTGGGCAGGGATCCGCAACAACGATGGGAACTTAGTCATTGACAGTCTGTTACAGTACATCAATCGGAGGAAGAAGTTTAGAAGGCACTGGGTGGGAGCTCTTGCCTCTGTAACTATCCCCATTCATTTTATCTATGGGCCATTGGATCCTGTGAACCCCTATCCAGGGTTTTTGGAGCTGTACAGGAAAATGCTGCTGTGGTCCACATTAGCCACGATCTACAGCTAGAGGATCCCATGGGCTTCTTTGGGCTTCATCAACTCCTTCTGAGCTGGAAAGAGTAACTTCCCTGTATTACCTCCCCTACTCCCTTATCTGTTGTGTATTCCACTTAGGAAGAAATGCCCAAAAGAGATCCTGGCCTTCAAACACTATTCTCTCACAAATCCACTTTACTCAAATCGGTGAACAGTATATAGGAATAAGCCAGCAGAAACTCTGACTAAGGTTGACATAATAGTCCACTTCCCATTACTTTGATATCTTATCAATGTATGGACTGGGCTTTGTTTTTGTGTTATTAGGAAATTCTGATGAGCATTACTATTCACTGATGTAGAAAGACATTTTTTTGCATAAAAGACTTTTTAAGACTTTGGACTTCTCTGAAGTATTTAGAACTGTTCATTTCTGGCCCAGCCCCAACAGGAATTCTACAGTAACAATGAAGAGAAGGGCACCTCCTTCCCTGTCCTTGAATGGCTTTATGGGCACATGCTTTTTAAAAGTTCCTTAAGCAACAGAGCTGAGTTCCCTTTGTCATACCTTTGGATTTAGTTTCATCAGCTGTTTTTAATTATAAACATTTTGTTAAAATAGATATTGGTTTAAATAAAATAGTATTCTATGTATGATTTAAGACTGTGATTTACCTACACATTACATATATTTTATAAGGATATTAAACCAGTGTACCCTTACTCTGCCAGATTAGTGAACCTAATTAAACATGTTTGATTTCTGAATAAATTGACCTAAACCCAAACTATTTACAGAATTTCCTAAAATCACAGGACATTAAGGACCAATAGCATCTGTGCCAGAGATTTACTGTTATTAGCTAAGAAGAGCAATTCTAACAGCAAATAACAGTCTGAGATTCCTCACACCTCAGGGCTTAGGAGCATGTCTCTCTTGAGCTACCATAGAGGGGAAGGGATTGTTTTGTAGTGAAGTCACCATGCTGAATGTACACTGATTCCTTTGTGATGGCTGCTTACCTCCCCAGTGCCTGTCCCAGGGAGGCTTTCCAATGTAACTCAGTAATTCCTGTACTTTATAGGCAGGAAAGTTCCAGAAACTTTAAGAACAAATTCTGAAGGATCTATGAGCAAATGGTGCTGAATACTACTTTTTAAAATCCACATTTCATTGCCTTTCAAAGCAGGATTATTAAGTGATTATTTAAAATTTGTTTTATTTAAATTAGCAACTTCAAGCATAACAACTTTGAAACTGGAATAAGTGTTTATTTTCTATTAATAAAAATGAACTGTGGCAAAAA
>NM_177524.2
GGCGCTGACGCCTGGCAGGGAGAAGGCGGCAGCACATGCTGGGCTCGGGGGCGATGGGCTTGTGCGCGGACCTGGCGACGCTCTAGCCCCGAGCCGCGTATTCGTGGCCGGGTCCTCCCTGGGAACAGGGTGAAGGCCGAGAACCTCTGGCCTCAGGAAGCGCATGCGCAACCGGTTCTCCGAAACATGGAGTCCTGTAGGCAAGGTCTTACCTGAATCAGGATGAGGGAGTGGTGGGTCCAGGTGGGGCTGCTGGCCGTGCCCCTGCTTGCTGCGTACCTGCACATCCCACCCCCTCAGCTCTCCCCTGCCCTTCACTCATGGAAGTCTTCAGGCAAGTTTTTCACTTACAAGGGACTGCGTATCTTCTACCAAGACTCTGTGGGTGTGGTTGGAAGTCCAGAGATAGTTGTGCTTTTACACGGTTTTCCAACATCCAGCTACGACTGGTACAAGATTTGGGAAGGTCTGACCTTGAGGTTTCATCGGGTGATTGCCCTTGATTTCTTAGGCTTTGGCTTCAGTGACAAACCGAGACCACATCACTATTCCATATTTGAGCAGGCCAGCATCGTGGAAGCGCTTTTGCGGCATCTGGGGCTCCAGAACCGCAGGATCAACCTTCTTTCTCATGACTATGGAGATATTGTTGCTCAGGAGCTTCTCTACAGGTACAAGCAGAATCGATCTGGTCGGCTTACCATAAAGAGTCTCTGTCTGTCAAATGGAGGTATCTTTCCTGAGACTCACCGTCCACTCCTTCTCCAAAAGCTACTCAAAGATGGAGGTGTGCTGTCACCCATCCTCACACGACTGATGAACTTCTTTGTATTCTCTCGAGGTCTCACCCCAGTCTTTGGGCCGTATACTCGGCCCTCTGAGAGTGAGCTGTGGGACATGTGGGCAGGGATCCGCAACAATGACGGGAACTTAGTCATTGACAGTCTCTTACAGTACATCAATCAGAGGAAGAAGTTCAGAAGGCGCTGGGTGGGAGCTCTTGCCTCTGTAACTATCCCCATTCATTTTATCTATGGGCCATTGGATCCTGTAAATCCCTATCCAGAGTTTTTGGAGCTGTACAGGAAAACGCTGCCGCGGTCCACAGTGTCGATTCTGGATGACCACATTAGCCACTATCCACAGCTAGAGGATCCCATGGGCTTCTTGAATGCATATATGGGCTTCATCAACTCCTTCTGAGCTGGAAAGAGTAGCTTCCCTGTATTACCTCCCCTACTCCCTTATGTGTTGTGTATTCCACTTAGGAAGAAATGCCCAAAAGAGGTCCTGGCCATCAAACATAATTCTCTCACAAAGTCCACTTTACTCAAATTGGTGAACAGTGTATAGGAAGAAGCCAGCAGGAGCTCTGACTAAGGTTGACATAATAGTCCACCTCCCATTACTTTGATATCTGATCAAATGTATAGACTTGGCTTTGTTTTTTGTGCTATTAGGAAATTCTGATGAGCATTACTATTCACTGATGCAGAAAGACGTTCTTTTGCATAAAAGACTTTTTTTTAACACTTTGGACTTCTCTGAAATATTTAGAAGTGCTAATTTCTGGCCCACCCCCAACAGGAATTCTATAGTAAGGAGGAGGAGAAGGGGGGCTCCTTCCCTCTCCTCGAATGACGTTATGGGCACATGCCTTTTAAAAGTTCTTTAAGCAACACAGAGCTGAGTCCTCTTTGTCATACCTTTGGATTTAGTGTTTCATCAGCTGTTTTTAGTTATAAACATTTTGTTAAAATAGATATTGGTTTAAATGATACAGTATTTTAGGTATGATTTAAGACTATGATTTACCTATACATTATATATATTTTATAAAGATACTAAACCAGCATACCCTTACTCTGCCAGAGTAGTGAAGCTAATTAAACACATTTGGTTTCTGAATAAATTGAACTAAATCCAAACTATTTCCTAAAATCACAGGACATTAAGGACCAATAGCATCTGTGCCAGAGATGTACTGTTATTAGCTGGGAAGACCAATTCTAACAGCAAATAACAGTCTGAGACTCCTCATACCTCAGTGGTTAGAAGCATGTCTCTCTTGAGCTACAGTAGAGGGGAAGGGATTGTTGTGTAGTCAAGTCACCATGCTGAATGTACACTGATTCCTTTATGATGACTGCTTAACTCCCCACTGCCTGTCCCAGAGAGGCTTTCCAATGTAGCTCAGTAATTCCTGTTACTTTACAGACAGGAAAGTTCCAGAAACTTTAAGAACAAACTCTGAAAGACCTATGAGCAAATGGTGCTGAATACTTTTTTTTTAAAGCCACATTTCATTGTCTTAGTCAAAGCAGGATTATTAAGTGATTATTTAAAATTCGTTTTTTTAAATTAGCAACTTCAAGTATAACAACTTTGAAACTGGAATAAGTGTTTATTTTCTATTAATAAAAATGAATTGTGACAAAAGTGGA

Publications

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